Zfp563 (zinc finger protein 563) - Rat Genome Database

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Pathways
Gene: Zfp563 (zinc finger protein 563) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Zfp563
Name: zinc finger protein 563
RGD ID: 1308729
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314584; RGD1308729; similar to ZFP-like protein
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8712,849,136 - 12,916,486 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl712,874,595 - 12,911,342 (+)EnsemblGRCr8
mRatBN7.2712,198,411 - 12,266,003 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl712,244,675 - 12,266,003 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx715,049,170 - 15,066,685 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,926,566 - 16,944,081 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0714,807,341 - 14,824,937 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0715,364,082 - 15,430,986 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl715,422,479 - 15,425,802 (+)Ensemblrn6Rnor6.0
Rnor_5.0715,528,924 - 15,601,988 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4713,827,402 - 13,845,718 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera710,341,907 - 10,359,385 (+)NCBICelera
RGSC_v3.1713,806,238 - 13,839,590 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Zfp563
584 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:476
Count of miRNA genes:260
Interacting mature miRNAs:331
Transcripts:ENSRNOT00000066520
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH144088  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,263,297 - 12,263,558 (+)MAPPERmRatBN7.2
Rnor_6.0715,428,281 - 15,428,541NCBIRnor6.0
Rnor_5.0715,599,283 - 15,599,543UniSTSRnor5.0
RGSC_v3.4713,843,013 - 13,843,273UniSTSRGSC3.4
Celera710,356,664 - 10,356,924UniSTS
RH 3.4 Map765.2UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 85 59 6 348 185 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066520   ⟹   ENSRNOP00000061844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl715,422,479 - 15,425,802 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103954   ⟹   ENSRNOP00000092542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl712,244,675 - 12,266,003 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150924   ⟹   ENSRNOP00000108913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,874,595 - 12,911,342 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171772   ⟹   ENSRNOP00000105383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,892,041 - 12,911,342 (+)Ensembl
RefSeq Acc Id: NM_001134561   ⟹   NP_001128033
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,898,891 - 12,916,486 (+)NCBI
mRatBN7.2712,248,407 - 12,266,003 (+)NCBI
Rnor_6.0715,413,928 - 15,430,986 (+)NCBI
Rnor_5.0715,528,924 - 15,601,988 (+)NCBI
RGSC_v3.4713,827,402 - 13,845,718 (+)RGD
Celera710,341,907 - 10,359,385 (+)RGD
Sequence:
RefSeq Acc Id: XM_017594799   ⟹   XP_017450288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,849,136 - 12,916,405 (+)NCBI
mRatBN7.2712,198,411 - 12,265,922 (+)NCBI
Rnor_6.0715,364,082 - 15,428,674 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078971   ⟹   XP_038934899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,849,136 - 12,916,405 (+)NCBI
mRatBN7.2712,198,411 - 12,265,922 (+)NCBI
RefSeq Acc Id: XM_039078972   ⟹   XP_038934900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,849,136 - 12,916,405 (+)NCBI
mRatBN7.2712,198,411 - 12,265,922 (+)NCBI
RefSeq Acc Id: XM_063263400   ⟹   XP_063119470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,849,136 - 12,916,405 (+)NCBI
RefSeq Acc Id: NP_001128033   ⟸   NM_001134561
- UniProtKB: A0A8I6AGR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450288   ⟸   XM_017594799
- Peptide Label: isoform X1
- UniProtKB: A6K982 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061844   ⟸   ENSRNOT00000066520
RefSeq Acc Id: XP_038934900   ⟸   XM_039078972
- Peptide Label: isoform X1
- UniProtKB: A6K982 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934899   ⟸   XM_039078971
- Peptide Label: isoform X1
- UniProtKB: A6K982 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092542   ⟸   ENSRNOT00000103954
RefSeq Acc Id: XP_063119470   ⟸   XM_063263400
- Peptide Label: isoform X1
- UniProtKB: A6K982 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108913   ⟸   ENSRNOT00000150924
Ensembl Acc Id: ENSRNOP00000105383   ⟸   ENSRNOT00000171772
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4J4-F1-model_v2 AlphaFold F1M4J4 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308729 AgrOrtholog
BioCyc Gene G2FUF-34788 BioCyc
Ensembl Genes ENSRNOG00000030273 Ensembl
  ENSRNOG00000062776 Ensembl
  ENSRNOG00000085163 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000150924 ENTREZGENE
  ENSRNOT00000150924.1 UniProtKB/TrEMBL
  ENSRNOT00000171772 ENTREZGENE
  ENSRNOT00000171772.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro GLI_C2H2-zinc-finger UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene 314584 ENTREZGENE
PANTHER PAIR-RULE PROTEIN ODD-PAIRED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN ZIC AND GLI UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp563 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030273 RatGTEx
  ENSRNOG00000062776 RatGTEx
  ENSRNOG00000085163 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6AGR4 ENTREZGENE
  A0ABK0LSD1_RAT UniProtKB/TrEMBL
  A0ABK0LTF2_RAT UniProtKB/TrEMBL
  A6K982 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-01-23 Zfp563  zinc finger protein 563   RGD1308729  similar to ZFP-like protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308729  similar to ZFP-like protein   RGD1308729_predicted  similar to ZFP-like protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308729_predicted  similar to ZFP-like protein (predicted)  LOC314584_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314584_predicted  similar to ZFP-like protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL