Nprl3 (NPR3-like, GATOR1 complex subunit) - Rat Genome Database

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Gene: Nprl3 (NPR3-like, GATOR1 complex subunit) Rattus norvegicus
Analyze
Symbol: Nprl3
Name: NPR3-like, GATOR1 complex subunit
RGD ID: 1308665
Description: Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including TORC1 signaling; cellular response to amino acid starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within circulatory system development and roof of mouth development. Predicted to be part of GATOR1 complex. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 3. Orthologous to human NPRL3 (NPR3 like, GATOR1 complex subunit); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha globin regulatory element containing; alpha globin regulatory element containing gene; GATOR complex protein NPRL3; GATOR1 complex protein NPRL3; LOC360505; Mare; MGC124858; nitrogen permease regulator 3-like protein; nitrogen permease regulator-like 3; nitrogen permease regulator-like 3 (S. cerevisiae); RGD1308665; similar to CGTHBA protein (-14 gene protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,859,739 - 15,900,261 (+)NCBIGRCr8
mRatBN7.21015,355,361 - 15,395,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,355,355 - 15,395,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1020,101,453 - 20,141,828 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,590,342 - 19,630,715 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,083,192 - 15,123,623 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,620,824 - 15,661,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,620,871 - 15,661,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,515,994 - 15,556,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,602,474 - 15,642,898 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,601,253 - 15,643,813 (+)NCBI
Celera1015,022,975 - 15,063,389 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of mTORC1 by amino acids. Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:22538705   PMID:23723238   PMID:28199306  


Genomics

Comparative Map Data
Nprl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,859,739 - 15,900,261 (+)NCBIGRCr8
mRatBN7.21015,355,361 - 15,395,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,355,355 - 15,395,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1020,101,453 - 20,141,828 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,590,342 - 19,630,715 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,083,192 - 15,123,623 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,620,824 - 15,661,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,620,871 - 15,661,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,515,994 - 15,556,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,602,474 - 15,642,898 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,601,253 - 15,643,813 (+)NCBI
Celera1015,022,975 - 15,063,389 (+)NCBICelera
Cytogenetic Map10q12NCBI
NPRL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381685,386 - 138,673 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,271 - 138,677 (-)EnsemblGRCh38hg38GRCh38
GRCh3716135,385 - 188,672 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361675,800 - 128,672 (-)NCBINCBI36Build 36hg18NCBI36
Celera16337,330 - 390,318 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef1654,260 - 106,377 (-)NCBIHuRef
CHM1_116135,746 - 188,665 (-)NCBICHM1_1
T2T-CHM13v2.01678,987 - 132,241 (-)NCBIT2T-CHM13v2.0
Nprl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,181,963 - 32,217,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,175,628 - 32,217,707 (-)EnsemblGRCm39 Ensembl
GRCm381132,231,963 - 32,267,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,225,628 - 32,267,707 (-)EnsemblGRCm38mm10GRCm38
MGSCv371132,132,419 - 32,167,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,132,419 - 32,167,614 (-)NCBIMGSCv36mm8
Celera1134,649,697 - 34,684,772 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.83NCBI
Nprl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,025,194 - 17,070,753 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,025,232 - 17,068,399 (+)NCBIChiLan1.0ChiLan1.0
NPRL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218299,107 - 369,778 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,086,852 - 4,147,637 (-)NCBINHGRI_mPanPan1
PanPan1.11675,187 - 129,220 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1675,187 - 129,220 (-)Ensemblpanpan1.1panPan2
NPRL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,351,757 - 40,394,599 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,352,477 - 40,390,489 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,614,787 - 41,653,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,694,293 - 40,733,143 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,695,464 - 40,733,139 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,382,373 - 40,420,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,343,316 - 40,381,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,821,964 - 40,860,811 (+)NCBIUU_Cfam_GSD_1.0
Nprl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,649,923 - 112,685,617 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501747,736 - 787,244 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936501747,806 - 783,479 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPRL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,479,193 - 41,540,717 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,478,465 - 41,540,719 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,897,528 - 40,931,777 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPRL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1540,674 - 94,265 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,150 - 94,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606831,105,807 - 31,182,365 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nprl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913968,093 - 1,014,035 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913968,093 - 1,013,990 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nprl3
187 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:487
Count of miRNA genes:247
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000066430
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat

Markers in Region
RH135297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21015,379,447 - 15,379,658 (+)MAPPERmRatBN7.2
Rnor_6.01015,644,973 - 15,645,183NCBIRnor6.0
Rnor_5.01015,540,115 - 15,540,325UniSTSRnor5.0
RGSC_v3.41015,626,539 - 15,626,749UniSTSRGSC3.4
Celera1015,047,030 - 15,047,240UniSTS
Cytogenetic Map10q12UniSTS
RH141154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21015,395,505 - 15,395,686 (+)MAPPERmRatBN7.2
Rnor_6.01015,661,028 - 15,661,208NCBIRnor6.0
Rnor_5.01015,556,171 - 15,556,351UniSTSRnor5.0
RGSC_v3.41015,642,594 - 15,642,774UniSTSRGSC3.4
Celera1015,063,085 - 15,063,265UniSTS
RH 3.4 Map10157.6UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 18 12 7 12 3 66 23 40 10
Low 3 20 39 29 12 29 8 8 8 12 1 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001394235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000066430   ⟹   ENSRNOP00000060067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,355,381 - 15,395,809 (+)Ensembl
Rnor_6.0 Ensembl1015,620,908 - 15,661,331 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089435   ⟹   ENSRNOP00000071482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,355,355 - 15,395,810 (+)Ensembl
Rnor_6.0 Ensembl1015,620,871 - 15,661,214 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094811   ⟹   ENSRNOP00000096488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,355,381 - 15,395,809 (+)Ensembl
RefSeq Acc Id: NM_001394235   ⟹   NP_001381164
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,859,817 - 15,900,261 (+)NCBI
mRatBN7.21015,355,361 - 15,395,810 (+)NCBI
RefSeq Acc Id: NM_001394236   ⟹   NP_001381165
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,859,817 - 15,900,261 (+)NCBI
mRatBN7.21015,355,361 - 15,395,810 (+)NCBI
RefSeq Acc Id: NR_172092
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,859,817 - 15,900,261 (+)NCBI
mRatBN7.21015,355,361 - 15,395,810 (+)NCBI
RefSeq Acc Id: XM_006246011   ⟹   XP_006246073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,859,774 - 15,900,261 (+)NCBI
mRatBN7.21015,355,691 - 15,395,810 (+)NCBI
Rnor_6.01015,621,128 - 15,661,332 (+)NCBI
Rnor_5.01015,515,994 - 15,556,475 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246012   ⟹   XP_006246074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,879,053 - 15,900,261 (+)NCBI
mRatBN7.21015,373,515 - 15,395,810 (+)NCBI
Rnor_6.01015,639,793 - 15,661,332 (+)NCBI
Rnor_5.01015,515,994 - 15,556,475 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246016   ⟹   XP_006246078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,859,739 - 15,898,073 (+)NCBI
mRatBN7.21015,355,361 - 15,393,806 (+)NCBI
Rnor_6.01015,620,824 - 15,659,428 (+)NCBI
Rnor_5.01015,515,994 - 15,556,475 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086292   ⟹   XP_038942220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,859,774 - 15,900,261 (+)NCBI
mRatBN7.21015,355,664 - 15,395,810 (+)NCBI
RefSeq Acc Id: XM_039086294   ⟹   XP_038942222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,887,857 - 15,900,261 (+)NCBI
mRatBN7.21015,383,402 - 15,395,810 (+)NCBI
RefSeq Acc Id: XM_063269323   ⟹   XP_063125393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,859,739 - 15,899,111 (+)NCBI
RefSeq Acc Id: XM_063269324   ⟹   XP_063125394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,868,910 - 15,900,261 (+)NCBI
RefSeq Acc Id: XM_063269325   ⟹   XP_063125395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,877,766 - 15,900,261 (+)NCBI
RefSeq Acc Id: XR_010055203
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,859,739 - 15,899,087 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006246078   ⟸   XM_006246016
- Peptide Label: isoform X5
- UniProtKB: Q499Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246073   ⟸   XM_006246011
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006246074   ⟸   XM_006246012
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000071482   ⟸   ENSRNOT00000089435
RefSeq Acc Id: ENSRNOP00000060067   ⟸   ENSRNOT00000066430
RefSeq Acc Id: XP_038942220   ⟸   XM_039086292
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038942222   ⟸   XM_039086294
- Peptide Label: isoform X8
RefSeq Acc Id: ENSRNOP00000096488   ⟸   ENSRNOT00000094811
RefSeq Acc Id: NP_001381164   ⟸   NM_001394235
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K0K3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381165   ⟸   NM_001394236
- Peptide Label: isoform 2
- UniProtKB: A6HDB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125393   ⟸   XM_063269323
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063125394   ⟸   XM_063269324
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063125395   ⟸   XM_063269325
- Peptide Label: isoform X7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K0K3-F1-model_v2 AlphaFold A0A0G2K0K3 1-582 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697079
Promoter ID:EPDNEW_R7602
Type:initiation region
Name:Nprl3_1
Description:NPR3-like, GATOR1 complex subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,620,893 - 15,620,953EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308665 AgrOrtholog
BioCyc Gene G2FUF-25699 BioCyc
Ensembl Genes ENSRNOG00000020541 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066430 ENTREZGENE
  ENSRNOT00000066430.2 UniProtKB/TrEMBL
  ENSRNOT00000089435 ENTREZGENE
  ENSRNOT00000089435.2 UniProtKB/TrEMBL
  ENSRNOT00000094811.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7937864 IMAGE-MGC_LOAD
InterPro Galactose-bd-like UniProtKB/TrEMBL
  UPF0171 UniProtKB/TrEMBL
KEGG Report rno:360505 UniProtKB/TrEMBL
MGC_CLONE MGC:124858 IMAGE-MGC_LOAD
NCBI Gene 360505 ENTREZGENE
PANTHER GATOR COMPLEX PROTEIN NPRL3 UniProtKB/TrEMBL
  UPF0171 UniProtKB/TrEMBL
Pfam UPF0171 UniProtKB/TrEMBL
PhenoGen Nprl3 PhenoGen
RatGTEx ENSRNOG00000020541 RatGTEx
Superfamily-SCOP Gal_bind_like UniProtKB/TrEMBL
UniProt A0A0G2K0K3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AV56_RAT UniProtKB/TrEMBL
  A6HDB0 ENTREZGENE, UniProtKB/TrEMBL
  Q499Q8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-09 Nprl3  NPR3-like, GATOR1 complex subunit  Nprl3  nitrogen permease regulator-like 3 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Nprl3  nitrogen permease regulator-like 3 (S. cerevisiae)  Mare  alpha globin regulatory element containing gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Mare  alpha globin regulatory element containing gene  RGD1308665  similar to CGTHBA protein (-14 gene protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1308665  similar to CGTHBA protein (-14 gene protein)  RGD1308665_predicted  similar to CGTHBA protein (-14 gene protein) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308665_predicted  similar to CGTHBA protein (-14 gene protein) (predicted)  LOC360505_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360505_predicted  similar to CGTHBA protein (-14 gene protein) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL