Sf3a2 (splicing factor 3A subunit 2)

Gene: Sf3a2 (splicing factor 3A subunit 2) Rattus norvegicus

Analyze

Symbol:

Sf3a2

Name:

splicing factor 3A subunit 2

RGD ID:

1308627

Description:

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Involved in positive regulation of neuron projection development. Located in nuclear speck. Orthologous to human SF3A2 (splicing factor 3a subunit 2); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC299620; splicing factor 3a, subunit 2, 66kDa

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SF3A2 (splicing factor 3a subunit 2)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Sf3a2 (splicing factor 3a, subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sf3a2 (splicing factor 3a subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SF3A2 (splicing factor 3a subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SF3A2 (splicing factor 3a subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sf3a2 (splicing factor 3a subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SF3A2 (splicing factor 3a subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SF3A2 (splicing factor 3a subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sf3a2 (splicing factor 3a subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FSD2 (fibronectin type III and SPRY domain containing 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SF3A2 (splicing factor 3a subunit 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Sf3a2 (splicing factor 3a, subunit 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	sf3a2 (splicing factor 3a, subunit 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRP11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Sf3a2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	repo-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sf3a2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,560,182 - 9,566,205 (-)	NCBI		GRCr8
mRatBN7.2	7	8,909,507 - 8,916,104 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,909,507 - 8,915,530 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	11,788,187 - 11,794,212 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	13,663,692 - 13,669,717 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,530,215 - 11,536,177 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,777,826 - 11,784,373 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,777,826 - 11,783,849 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	11,945,541 - 11,952,001 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	10,419,996 - 10,426,019 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	10,419,995 - 10,426,019 (-)	NCBI
Celera	7	7,092,245 - 7,098,268 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

progressive myoclonus epilepsy 9 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (EXP)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP,ISO)

dicrotophos (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

fenthion (ISO)

FR900359 (ISO)

furan (EXP)

hinokiflavone (ISO)

ivermectin (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloroethene (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

Triptolide (EXP)

troglitazone (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mRNA processing (IEA,ISO)

mRNA splicing, via spliceosome (ISO,ISS)

positive regulation of neuron projection development (IDA)

RNA splicing (IEA)

spliceosomal complex assembly (IBA,IEA)

U2-type prespliceosome assembly (ISO,ISS)

Cellular Component

catalytic step 2 spliceosome (IBA,IEA,ISO)

nuclear speck (IDA)

nucleus (ISO)

spliceosomal complex (IEA,ISO)

U2 snRNP (IBA,IEA,ISO,ISS)

U2-type precatalytic spliceosome (ISO,ISS)

U2-type prespliceosome (IBA,IEA)

U2-type spliceosomal complex (ISO)

Molecular Function

nucleic acid binding (IEA)

protein binding (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.	Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Nuclear fibroblast growth factor-2 interacts specifically with splicing factor SF3a66.	Gringel S, etal., Biol Chem. 2004 Dec;385(12):1203-8.
5.	Association of U2 snRNP with the spliceosomal complex E.	Hong W, etal., Nucleic Acids Res. 1997 Jan 15;25(2):354-61.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:9731529	PMID:11533230	PMID:11991638	PMID:12477932	PMID:15647371	PMID:22658674	PMID:22681889	PMID:29360106

Genomics

Comparative Map Data

Sf3a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,560,182 - 9,566,205 (-)	NCBI		GRCr8
mRatBN7.2	7	8,909,507 - 8,916,104 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,909,507 - 8,915,530 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	11,788,187 - 11,794,212 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	13,663,692 - 13,669,717 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,530,215 - 11,536,177 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,777,826 - 11,784,373 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,777,826 - 11,783,849 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	11,945,541 - 11,952,001 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	10,419,996 - 10,426,019 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	10,419,995 - 10,426,019 (-)	NCBI
Celera	7	7,092,245 - 7,098,268 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

SF3A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	2,236,824 - 2,248,655 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	2,236,824 - 2,248,655 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	2,236,823 - 2,248,654 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	2,187,816 - 2,199,678 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	2,187,815 - 2,199,677	NCBI
Celera	19	2,170,993 - 2,182,854 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	2,007,853 - 2,019,794 (+)	NCBI		HuRef
CHM1_1	19	2,236,320 - 2,248,181 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	2,210,388 - 2,222,298 (+)	NCBI		T2T-CHM13v2.0

Sf3a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	80,634,569 - 80,640,756 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	80,634,032 - 80,640,758 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	80,798,735 - 80,804,922 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	80,798,198 - 80,804,924 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	80,261,480 - 80,267,667 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	80,201,713 - 80,207,943 (+)	NCBI		MGSCv36	mm8
Celera	10	81,817,105 - 81,823,292 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Sf3a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	5,896,648 - 5,904,056 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	5,896,648 - 5,904,287 (-)	NCBI	ChiLan1.0	ChiLan1.0

SF3A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	6,621,344 - 6,633,517 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	5,850,687 - 5,862,859 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	1,247,812 - 1,259,984 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	2,219,326 - 2,231,343 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

SF3A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	56,789,450 - 56,796,004 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	56,788,577 - 56,795,262 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	56,584,524 - 56,595,530 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	57,522,321 - 57,533,330 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	57,522,324 - 57,532,588 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	56,574,342 - 56,585,347 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	57,059,470 - 57,070,468 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	57,259,967 - 57,270,974 (-)	NCBI		UU_Cfam_GSD_1.0

Sf3a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	216,492,208 - 216,499,676 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	1,335,166 - 1,342,575 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	1,335,143 - 1,342,573 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SF3A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	76,410,602 - 76,415,776 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	76,404,882 - 76,414,901 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	77,041,418 - 77,049,953 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SF3A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	2,034,892 - 2,047,653 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	2,041,384 - 2,047,542 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	6,673,327 - 6,689,638 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sf3a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	6,638,660 - 6,644,788 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	6,638,546 - 6,646,529 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sf3a2
25 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	119
Count of miRNA genes:	89
Interacting mature miRNAs:	93
Transcripts:	ENSRNOT00000026202
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat

Markers in Region

AA850581

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	8,915,186 - 8,915,349 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	11,783,506 - 11,783,668	NCBI	Rnor6.0
Rnor_5.0	7	11,951,221 - 11,951,383	UniSTS	Rnor5.0
RGSC_v3.4	7	10,425,676 - 10,425,838	UniSTS	RGSC3.4
Celera	7	7,097,925 - 7,098,087	UniSTS
RH 3.4 Map	7	26.6	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	35	32	31	7	31		3	66	27	35	3
Low		8	25	10	12	10	8	8	8	8	6	8	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000026202 ⟹ ENSRNOP00000026202

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	8,909,507 - 8,915,530 (-)	Ensembl
Rnor_6.0 Ensembl	7	11,777,826 - 11,783,849 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114856 ⟹ ENSRNOP00000094914

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	8,909,513 - 8,915,332 (-)	Ensembl

RefSeq Acc Id:

NM_001011986 ⟹ NP_001011986

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	9,560,182 - 9,566,205 (-)	NCBI
mRatBN7.2	7	8,909,507 - 8,915,530 (-)	NCBI
Rnor_6.0	7	11,777,826 - 11,783,849 (-)	NCBI
Rnor_5.0	7	11,945,541 - 11,952,001 (-)	NCBI
RGSC_v3.4	7	10,419,996 - 10,426,019 (-)	RGD
Celera	7	7,092,245 - 7,098,268 (-)	RGD

Sequence:

show sequence

CGGCATTCGGGGAGGTTAAGCCCAGTTACCGAGGCCTTGGTGTTGGTTTCTCCTGTCCCCTAAA
GTACCCAGGCCTGCATCATGGACTTTCAGCACCGACCTGGAGGCAAAACTGGGAGTGGGGGCGT
GGCCTCCTCCTCAGAGAGCAACCGGGATCGAAGAGAGCGCCTGCGGCAACTGGCCCTGGAAACC
ATCGACATCAATAAGGACCCGTATTTCATGAAGAACCACCTGGGATCCTATGAGTGCAAACTCT
GCTTGACTCTGCATAACAATGAGGGGAGCTACCTGGCCCATACCCAAGGGAAGAAACATCAGAC
TAACTTGGCCCGGCGAGCTGCCAAGGAGGCCAAAGAAGCCCCCGCCCAGCCTGCACCAGAGAAG
GTCAAGGTGGAGGTGAAGAAGTTTGTGAAGATTGGCCGCCCTGGCTACAAAGTGACCAAGCAGA
GGGACACAGAGATGGGCCAGCAGAGCCTACTGTTCCAGATTGACTACCCTGAGATTGCAGAGGG
TGTCATGCCCCGCCACCGCTTCATGTCTGCCTATGAGCAGAGGATCGAGCCCCCGGACCGCCGC
TGGCAGTACCTCCTCATGGCTGCTGAGCCCTATGAGACCATCGCCTTCAAGGTGCCGAGCCGCG
AGATCGACAAGGCTGAGGGCAAGTTTTGGACCCACTGGAACCGAGAGACCAAGCAGTTTTTTCT
TCAGTTCCACTTTAAGATGGAGAAGCCCCCAGCCCCTCCCAGCCTCCCAGCAGGACCCCCAGGC
GTCAAGCGGCCCCCGCCCCCACTCATGAACGGACTACCTCCTCGCCCACCACTCCCTGATGCCT
TGCCCCCACCTCCACCTGGTGGCCTGCCTCTTCCTCCTATGCCCCCCACTGGGCCTGCTCCCTC
TGGGCCCCCTGGACCTCCCCAGATGCCCCCACCAGCTCCTGGGGTACACCCCCCAGCCCCAGTA
GTACACCCACCAACATCTGGGGTCCATCCCCCAGCTCCTGGGGTGCACCCCCCAGCCCCAGTGG
TTCATCCACCAACATCTGGGGTCCATCCCCCAGCTCCTGGGGTCCATCCTCCAGCCCCTGGAGT
GCACCCTCCAGCCCCTGGAGTGCACCCACCAGCCCCTGGGGTGCACCCCCCAGCTCCAGGGGTC
CACCCCCCAGCTCCAGGGGTCCACCCCCCAGCTCCAGGGGTCCACCCCCCAGCTCCAGGGGTCC
ACCCTCCTCCATCAGCTGGAGTTCATCCTCAGGCTCCAGGGGTGCATCCACCTGCTCCTGCAGT
CCACCCTCAAGCCCCTGGTGTACACCCCCCAGCTCCTGGGATCCACCCTCAGGCACCAGGGGTG
CACCCCCAGCCTCCTCCTGGAGTCCACCCTGCTGCCCCAGGGGTCCATCCTCAGCCTCCAGGGG
TTCACCCTACTCCTATGCCCCCCATGCTAAGGCCCCCCCTTCCCTCGGATGGCCCTGGGAACAT
GCCTCCGCCTCCCCCAGGCAACTGAGTAGCCCGCCACCAGCCTCTGTGCTCTGTGTGCTCTTTT
CCCATGGCCAGTCCTTGGGAGGTTTTCTATTTTGTCCTGTCCTAAGTCAATTAAACAGCCTCCC
CCATGTCAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001011986	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79320	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026202
	ENSRNOP00000026202.2
	ENSRNOP00000094914.1
	ENSRNOP00055045006
	ENSRNOP00060035485
GenBank Protein	Q6AXT8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001011986 ⟸ NM_001011986

- UniProtKB:

Q6AXT8 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCLTLHN
NEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVTKQRDTEMG
QQSLLFQIDYPEIAEGVMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIAFKVPSREIDKAE
GKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPDALPPPPP
GGLPLPPMPPTGPAPSGPPGPPQMPPPAPGVHPPAPVVHPPTSGVHPPAPGVHPPAPVVHPPTS
GVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSA
GVHPQAPGVHPPAPAVHPQAPGVHPPAPGIHPQAPGVHPQPPPGVHPAAPGVHPQPPGVHPTPM
PPMLRPPLPSDGPGNMPPPPPGN

hide sequence

RefSeq Acc Id:

ENSRNOP00000026202 ⟸ ENSRNOT00000026202

RefSeq Acc Id:

ENSRNOP00000094914 ⟸ ENSRNOT00000114856

Protein Domains

Matrin-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AXT8-F1-model_v2	AlphaFold	Q6AXT8	1-471	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695004

Promoter ID:

EPDNEW_R5529

Type:

multiple initiation site

Name:

Sf3a2_1

Description:

splicing factor 3a, subunit 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	11,783,863 - 11,783,923	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308627	AgrOrtholog
BioCyc Gene	G2FUF-34967	BioCyc
Ensembl Genes	ENSRNOG00000019349	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055031432	UniProtKB/Swiss-Prot
	ENSRNOG00060024726	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000026202	ENTREZGENE
	ENSRNOT00000026202.4	UniProtKB/Swiss-Prot
	ENSRNOT00000114856.1	UniProtKB/TrEMBL
	ENSRNOT00055054436	UniProtKB/Swiss-Prot
	ENSRNOT00060042844	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.2690	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7135238	IMAGE-MGC_LOAD
InterPro	Matrin/U1-C_Znf_C2H2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Matrin/U1-like-C_Znf_C2H2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SF3A2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:299620	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94492	IMAGE-MGC_LOAD
NCBI Gene	299620	ENTREZGENE
PANTHER	SPLICING FACTOR 3A SUBUNIT 2	UniProtKB/Swiss-Prot
	SPLICING FACTOR 3A SUBUNIT 2	UniProtKB/Swiss-Prot
	SPLICING FACTOR 3A SUBUNIT 2	UniProtKB/TrEMBL
	SPLICING FACTOR 3A SUBUNIT 2	UniProtKB/TrEMBL
Pfam	SF3A2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-met	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sf3a2	PhenoGen
PROSITE	ZF_MATRIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019349	RatGTEx
	ENSRNOG00055031432	RatGTEx
	ENSRNOG00060024726	RatGTEx
SMART	CactinC_cactus	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZnF_U1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6GKY2_RAT	UniProtKB/TrEMBL
	Q6AXT8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-05-13	Sf3a2	splicing factor 3A subunit 2	Sf3a2	splicing factor 3a, subunit 2	Name changed	629549	APPROVED
2008-03-07	Sf3a2	splicing factor 3a, subunit 2	Sf3a2	splicing factor 3a, subunit 2, 66kDa	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Sf3a2	splicing factor 3a, subunit 2, 66kDa	Sf3a2_predicted	splicing factor 3a, subunit 2, 66kDa (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Sf3a2_predicted	splicing factor 3a, subunit 2, 66kDa (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)