Aldh7a1 (aldehyde dehydrogenase 7 family, member A1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Aldh7a1 (aldehyde dehydrogenase 7 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh7a1
Name: aldehyde dehydrogenase 7 family, member A1
RGD ID: 1308614
Description: Predicted to enable L-aminoadipate-semialdehyde dehydrogenase activity; betaine-aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in several processes, including lysine catabolic process; negative regulation of ferroptosis; and negative regulation of protein localization to plasma membrane. Predicted to be located in cytosol and mitochondrion. Predicted to be active in Golgi membrane and plasma membrane. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 4. Orthologous to human ALDH7A1 (aldehyde dehydrogenase 7 family member A1); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; choline metabolic pathway; glutaric aciduria type I pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde dehydrogenase family 7 member A1; aldehyde dehydrogenase family 7, member A1; alpha-AASA dehydrogenase; alpha-aminoadipic semialdehyde dehydrogenase; antiquitin; antiquitin-1; betaine aldehyde dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenease; LOC291450; P6c dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81852,208,035 - 52,240,293 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1852,204,161 - 52,240,467 (-)EnsemblGRCr8
mRatBN7.21850,003,242 - 50,042,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1850,009,934 - 50,042,193 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1852,048,134 - 52,080,362 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01852,756,122 - 52,788,453 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01850,554,002 - 50,586,230 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01851,619,007 - 51,651,267 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1851,619,007 - 51,651,267 (-)Ensemblrn6Rnor6.0
Rnor_5.01850,814,203 - 50,846,463 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41852,300,899 - 52,333,149 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1848,155,257 - 48,187,477 (-)NCBICelera
RGSC_v3.11852,346,394 - 52,378,655 (-)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allysine  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
dioscin  (EXP,ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
erianin  (ISO)
ethanol  (EXP,ISO)
fipronil  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
hexanal  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inulin  (ISO)
isobutanol  (ISO)
isoniazide  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (EXP)
Propiverine  (EXP)
quercetin  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO,ISS)
Golgi membrane  (IEA,ISO,ISS)
mitochondrion  (IEA,ISO,ISS)
nucleus  (IEA)
plasma membrane  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8088832   PMID:9417906   PMID:14651853   PMID:16491085   PMID:18614015   PMID:23376485   PMID:23533145   PMID:31505169  


Genomics

Comparative Map Data
Aldh7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81852,208,035 - 52,240,293 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1852,204,161 - 52,240,467 (-)EnsemblGRCr8
mRatBN7.21850,003,242 - 50,042,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1850,009,934 - 50,042,193 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1852,048,134 - 52,080,362 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01852,756,122 - 52,788,453 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01850,554,002 - 50,586,230 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01851,619,007 - 51,651,267 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1851,619,007 - 51,651,267 (-)Ensemblrn6Rnor6.0
Rnor_5.01850,814,203 - 50,846,463 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41852,300,899 - 52,333,149 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1848,155,257 - 48,187,477 (-)NCBICelera
RGSC_v3.11852,346,394 - 52,378,655 (-)NCBI
Cytogenetic Map18q12.1NCBI
ALDH7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385126,541,841 - 126,595,219 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5126,531,200 - 126,595,362 (-)Ensemblhg38GRCh38
GRCh375125,877,533 - 125,930,911 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365125,908,344 - 125,958,839 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345125,908,347 - 125,958,756NCBI
Cytogenetic Map5q23.2NCBI
HuRef5121,068,235 - 121,122,325 (-)NCBIHuRef
CHM1_15125,309,919 - 125,363,679 (-)NCBICHM1_1
T2T-CHM13v2.05127,058,709 - 127,112,081 (-)NCBIT2T-CHM13v2.0
Aldh7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391856,657,794 - 56,706,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1856,642,759 - 56,706,023 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381856,524,722 - 56,572,991 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1856,509,687 - 56,572,951 (-)Ensemblmm10GRCm38
MGSCv371856,685,390 - 56,732,593 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361856,651,105 - 56,698,241 (-)NCBIMGSCv36mm8
Celera1857,828,935 - 57,877,977 (-)NCBICelera
Cytogenetic Map18D3NCBI
cM Map1830.55NCBI
Aldh7a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555214,364,638 - 4,396,129 (-)Ensembl
ChiLan1.0NW_0049555214,365,075 - 4,396,105 (-)NCBIChiLan1.0ChiLan1.0
ALDH7A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24121,858,390 - 121,910,911 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15119,996,435 - 120,050,338 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05121,946,527 - 122,000,273 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15127,718,978 - 127,771,047 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5127,718,978 - 127,771,047 (-)EnsemblpanPan2panpan1.1
ALDH7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11115,828,581 - 15,878,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1115,815,936 - 15,878,516 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1114,623,590 - 14,671,820 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01116,555,891 - 16,604,274 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1116,489,913 - 16,604,251 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11115,287,402 - 15,335,601 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01115,133,391 - 15,181,763 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,729,874 - 15,778,117 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aldh7a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213138,385,899 - 138,424,789 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365756,467,340 - 6,506,006 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365756,467,224 - 6,506,052 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2129,662,969 - 129,709,705 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12129,663,226 - 129,709,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22134,953,156 - 134,988,290 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH7A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12329,539,897 - 29,589,004 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603448,486,643 - 48,538,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh7a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477415,048,627 - 15,101,856 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477415,048,825 - 15,099,443 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aldh7a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11575,264,713 - 75,297,436 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aldh7a1
281 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:70
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000020325
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020325   ⟹   ENSRNOP00000020325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,208,035 - 52,240,293 (-)Ensembl
mRatBN7.2 Ensembl1850,009,934 - 50,042,193 (-)Ensembl
Rnor_6.0 Ensembl1851,619,007 - 51,651,267 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098660   ⟹   ENSRNOP00000076493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,209,050 - 52,240,293 (-)Ensembl
mRatBN7.2 Ensembl1850,010,949 - 50,042,193 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102196   ⟹   ENSRNOP00000090040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,208,035 - 52,240,293 (-)Ensembl
mRatBN7.2 Ensembl1850,009,934 - 50,042,193 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113649   ⟹   ENSRNOP00000082430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,208,066 - 52,240,293 (-)Ensembl
mRatBN7.2 Ensembl1850,009,952 - 50,042,161 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116746   ⟹   ENSRNOP00000089973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,208,035 - 52,240,293 (-)Ensembl
mRatBN7.2 Ensembl1850,009,934 - 50,042,193 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116822   ⟹   ENSRNOP00000081693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,208,035 - 52,240,293 (-)Ensembl
mRatBN7.2 Ensembl1850,009,934 - 50,042,193 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000124695   ⟹   ENSRNOP00000103025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,210,322 - 52,240,293 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130937   ⟹   ENSRNOP00000099002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,208,035 - 52,240,467 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149095   ⟹   ENSRNOP00000105789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1852,204,161 - 52,240,293 (-)Ensembl
RefSeq Acc Id: NM_001271105   ⟹   NP_001258034
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81852,208,035 - 52,240,293 (-)NCBI
mRatBN7.21850,009,934 - 50,042,193 (-)NCBI
Rnor_6.01851,619,007 - 51,651,267 (-)NCBI
Rnor_5.01850,814,203 - 50,846,463 (-)NCBI
Celera1848,155,257 - 48,187,477 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001258034   ⟸   NM_001271105
- UniProtKB: Q64057 (UniProtKB/Swiss-Prot),   A6IX60 (UniProtKB/TrEMBL),   A0A8I6G8B0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020325   ⟸   ENSRNOT00000020325
Ensembl Acc Id: ENSRNOP00000089973   ⟸   ENSRNOT00000116746
Ensembl Acc Id: ENSRNOP00000081693   ⟸   ENSRNOT00000116822
Ensembl Acc Id: ENSRNOP00000082430   ⟸   ENSRNOT00000113649
Ensembl Acc Id: ENSRNOP00000076493   ⟸   ENSRNOT00000098660
Ensembl Acc Id: ENSRNOP00000090040   ⟸   ENSRNOT00000102196
Ensembl Acc Id: ENSRNOP00000099002   ⟸   ENSRNOT00000130937
Ensembl Acc Id: ENSRNOP00000105789   ⟸   ENSRNOT00000149095
Ensembl Acc Id: ENSRNOP00000103025   ⟸   ENSRNOT00000124695
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64057-F1-model_v2 AlphaFold Q64057 1-539 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700789
Promoter ID:EPDNEW_R11313
Type:initiation region
Name:Aldh7a1_1
Description:aldehyde dehydrogenase 7 family, member A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01851,651,190 - 51,651,250EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308614 AgrOrtholog
BioCyc Gene G2FUF-7445 BioCyc
BioCyc Pathway LYSINE-DEG1-PWY [L-lysine degradation XI (mammalian)] BioCyc
BioCyc Pathway Image LYSINE-DEG1-PWY BioCyc
Ensembl Genes ENSRNOG00000014645 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020325 ENTREZGENE
  ENSRNOT00000020325.8 UniProtKB/Swiss-Prot
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH UniProtKB/Swiss-Prot
  ALDH7A1-like UniProtKB/Swiss-Prot
KEGG Report rno:291450 UniProtKB/Swiss-Prot
NCBI Gene 291450 ENTREZGENE
PANTHER ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE UniProtKB/Swiss-Prot
  PTHR43521 UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PhenoGen Aldh7a1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014645 RatGTEx
Superfamily-SCOP Aldehyde_DH/Histidinol_DH UniProtKB/Swiss-Prot
UniProt A0A8I5Y576_RAT UniProtKB/TrEMBL
  A0A8I5ZX08_RAT UniProtKB/TrEMBL
  A0A8I6A967_RAT UniProtKB/TrEMBL
  A0A8I6AM79_RAT UniProtKB/TrEMBL
  A0A8I6G8B0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LCD5_RAT UniProtKB/TrEMBL
  A0ABK0LEE6_RAT UniProtKB/TrEMBL
  A0ABK0LML3_RAT UniProtKB/TrEMBL
  A6IX57_RAT UniProtKB/TrEMBL
  A6IX58_RAT UniProtKB/TrEMBL
  A6IX59_RAT UniProtKB/TrEMBL
  A6IX60 ENTREZGENE, UniProtKB/TrEMBL
  A6IX61_RAT UniProtKB/TrEMBL
  A6IX62_RAT UniProtKB/TrEMBL
  AL7A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aldh7a1  aldehyde dehydrogenase 7 family, member A1  Aldh7a1  aldehyde dehydrogenase family 7, member A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Aldh7a1  aldehyde dehydrogenase family 7, member A1  Aldh7a1_predicted  aldehyde dehydrogenase family 7, member A1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Aldh7a1_predicted  aldehyde dehydrogenase family 7, member A1 (predicted)      Symbol and Name status set to approved 70820 APPROVED