Gene: Hdhd2 (haloacid dehalogenase-like hydrolase domain containing 2) Rattus norvegicus
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Symbol:
Hdhd2 (Ensembl: Ier3ip1)
Name:
haloacid dehalogenase-like hydrolase domain containing 2 (Ensembl:immediate early response 3 interacting protein 1)
RGD ID:
1308579
Description:
Predicted to enable enzyme binding activity and phosphatase activity. Predicted to be active in cytoplasm. Orthologous to human HDHD2 (haloacid dehalogenase like hydrolase domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
haloacid dehalogenase-like hydrolase domain-containing protein 2; Ier3ip1; immediate early response 3-interacting protein 1; LOC361351; LRRG00122; RGD1308579; similar to RIKEN cDNA 3110052N05
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 18 72,763,313 - 72,801,679 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 18 72,749,976 - 72,801,679 (+) Ensembl GRCr8 mRatBN7.2 18 70,488,315 - 70,526,471 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 18 70,474,926 - 70,526,470 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 18 72,583,994 - 72,628,047 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 18 73,253,195 - 73,297,248 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 18 71,109,788 - 71,153,841 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 18 73,226,630 - 73,278,062 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 18 73,226,630 - 73,278,337 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 18 72,904,753 - 72,956,254 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 18 73,896,018 - 73,948,475 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 18 69,003,221 - 69,047,712 (+) NCBI Celera RGSC_v3.1 18 73,982,572 - 74,022,429 (+) NCBI Cytogenetic Map 18 q12.3 NCBI
JBrowse:
Imported Disease Annotations - CTD
Only show annotations with direct experimental evidence (0 objects hidden)
Hdhd2 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Hdhd2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hdhd2 Rat 1,2-dichloroethane decreases expression ISO Hdhd2 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of HDHD2 mRNA CTD PMID:28960355 Hdhd2 Rat 1,2-dimethylhydrazine decreases expression ISO Hdhd2 (Mus musculus) 6480464 1,2-Dimethylhydrazine results in decreased expression of HDHD2 mRNA CTD PMID:22206623 Hdhd2 Rat 17alpha-ethynylestradiol multiple interactions ISO Hdhd2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDHD2 mRNA CTD PMID:17942748 Hdhd2 Rat 17beta-estradiol decreases expression ISO Hdhd2 (Mus musculus) 6480464 Estradiol results in decreased expression of HDHD2 mRNA CTD PMID:39298647 Hdhd2 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Hdhd2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hdhd2 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Hdhd2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hdhd2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Hdhd2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDHD2 mRNA CTD PMID:17942748 Hdhd2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HDHD2 mRNA CTD PMID:33387578 Hdhd2 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Hdhd2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of HDHD2 mRNA CTD PMID:21570461 Hdhd2 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Hdhd2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hdhd2 Rat 2-hydroxypropanoic acid decreases expression ISO HDHD2 (Homo sapiens) 6480464 Lactic Acid results in decreased expression of HDHD2 mRNA CTD PMID:30851411 Hdhd2 Rat 4,4'-sulfonyldiphenol increases expression ISO Hdhd2 (Mus musculus) 6480464 bisphenol S results in increased expression of HDHD2 mRNA CTD PMID:39298647 Hdhd2 Rat 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Hdhd2 Rat 5-aza-2'-deoxycytidine multiple interactions ISO HDHD2 (Homo sapiens) 6480464 [Decitabine affects the methylation of HDHD2 gene] which affects the expression of HDHD2 mRNA CTD PMID:18559491 Hdhd2 Rat aflatoxin B1 decreases methylation ISO HDHD2 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of HDHD2 gene CTD PMID:27153756 Hdhd2 Rat all-trans-retinoic acid increases expression ISO HDHD2 (Homo sapiens) 6480464 Tretinoin results in increased expression of HDHD2 mRNA CTD PMID:23724009 Hdhd2 Rat all-trans-retinoic acid decreases expression ISO HDHD2 (Homo sapiens) 6480464 Tretinoin results in decreased expression of HDHD2 mRNA CTD PMID:33167477 Hdhd2 Rat benzo[a]pyrene increases methylation ISO HDHD2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of HDHD2 promoter CTD PMID:27901495 Hdhd2 Rat benzo[a]pyrene increases expression ISO HDHD2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of HDHD2 protein CTD PMID:33278487 Hdhd2 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HDHD2 mRNA CTD PMID:25181051 Hdhd2 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Hdhd2 Rat bisphenol F increases expression ISO HDHD2 (Homo sapiens) 6480464 bisphenol F results in increased expression of HDHD2 protein CTD PMID:34186270 Hdhd2 Rat bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Hdhd2 Rat Butylbenzyl phthalate increases methylation ISO Hdhd2 (Mus musculus) 6480464 butylbenzyl phthalate results in increased methylation of HDHD2 intron CTD PMID:28392331 Hdhd2 Rat cadmium atom multiple interactions ISO HDHD2 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HDHD2 more ... CTD PMID:35301059 Hdhd2 Rat cadmium dichloride increases expression ISO HDHD2 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of HDHD2 protein CTD PMID:24527689 Hdhd2 Rat cadmium dichloride multiple interactions ISO HDHD2 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HDHD2 more ... CTD PMID:35301059 Hdhd2 Rat CGP 52608 multiple interactions ISO HDHD2 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to HDHD2 gene] CTD PMID:28238834 Hdhd2 Rat chlorpyrifos decreases expression ISO Hdhd2 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of HDHD2 mRNA CTD PMID:37019170 Hdhd2 Rat copper(II) sulfate decreases expression ISO HDHD2 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of HDHD2 mRNA CTD PMID:19549813 Hdhd2 Rat cyclosporin A decreases expression ISO HDHD2 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of HDHD2 mRNA CTD PMID:25562108 Hdhd2 Rat Dibutyl phosphate affects expression ISO HDHD2 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of HDHD2 mRNA CTD PMID:37042841 Hdhd2 Rat dicrotophos decreases expression ISO HDHD2 (Homo sapiens) 6480464 dicrotophos results in decreased expression of HDHD2 mRNA CTD PMID:28302478 Hdhd2 Rat dorsomorphin multiple interactions ISO HDHD2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Hdhd2 Rat folic acid increases expression ISO Hdhd2 (Mus musculus) 6480464 Folic Acid results in increased expression of HDHD2 mRNA CTD PMID:25629700 Hdhd2 Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of HDHD2 mRNA CTD PMID:33387578 Hdhd2 Rat glafenine increases expression EXP 6480464 Glafenine results in increased expression of HDHD2 mRNA CTD PMID:24136188 Hdhd2 Rat lead diacetate increases expression ISO Hdhd2 (Mus musculus) 6480464 lead acetate results in increased expression of HDHD2 mRNA CTD PMID:20542052 Hdhd2 Rat methidathion increases expression ISO Hdhd2 (Mus musculus) 6480464 methidathion results in increased expression of HDHD2 mRNA CTD PMID:34813904 Hdhd2 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of HDHD2 gene CTD PMID:35440735 Hdhd2 Rat nickel atom decreases expression ISO HDHD2 (Homo sapiens) 6480464 Nickel results in decreased expression of HDHD2 mRNA CTD PMID:23195993 Hdhd2 Rat okadaic acid decreases expression ISO HDHD2 (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of HDHD2 mRNA CTD PMID:38832940 Hdhd2 Rat paracetamol affects expression ISO Hdhd2 (Mus musculus) 6480464 Acetaminophen affects the expression of HDHD2 mRNA CTD PMID:17562736 Hdhd2 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of HDHD2 mRNA CTD PMID:33387578 Hdhd2 Rat PCB138 multiple interactions ISO Hdhd2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Hdhd2 Rat phenylmercury acetate decreases expression ISO HDHD2 (Homo sapiens) 6480464 Phenylmercuric Acetate results in decreased expression of HDHD2 mRNA CTD PMID:26272509 Hdhd2 Rat phenylmercury acetate multiple interactions ISO HDHD2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Hdhd2 Rat pirinixic acid increases expression ISO Hdhd2 (Mus musculus) 6480464 pirinixic acid results in increased expression of HDHD2 mRNA CTD PMID:23811191 Hdhd2 Rat rac-lactic acid decreases expression ISO HDHD2 (Homo sapiens) 6480464 Lactic Acid results in decreased expression of HDHD2 mRNA CTD PMID:30851411 Hdhd2 Rat rimonabant affects expression ISO Hdhd2 (Mus musculus) 6480464 Rimonabant affects the expression of HDHD2 mRNA CTD PMID:19030233 Hdhd2 Rat SB 431542 multiple interactions ISO HDHD2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Hdhd2 Rat sodium arsenite decreases expression ISO HDHD2 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of HDHD2 mRNA CTD PMID:38568856 Hdhd2 Rat sodium fluoride increases expression ISO Hdhd2 (Mus musculus) 6480464 Sodium Fluoride results in increased expression of HDHD2 protein CTD PMID:28918527 Hdhd2 Rat tamoxifen decreases expression ISO Hdhd2 (Mus musculus) 6480464 Tamoxifen results in decreased expression of HDHD2 mRNA CTD PMID:25123088 Hdhd2 Rat tauroursodeoxycholic acid decreases expression EXP 6480464 ursodoxicoltaurine results in decreased expression of HDHD2 mRNA CTD PMID:15885361 Hdhd2 Rat thiram decreases expression ISO HDHD2 (Homo sapiens) 6480464 Thiram results in decreased expression of HDHD2 mRNA CTD PMID:38568856 Hdhd2 Rat titanium dioxide decreases methylation ISO Hdhd2 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of HDHD2 promoter CTD PMID:35295148 Hdhd2 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of HDHD2 mRNA CTD PMID:33387578 Hdhd2 Rat triphenyl phosphate affects expression ISO HDHD2 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of HDHD2 mRNA CTD PMID:37042841 Hdhd2 Rat urethane decreases expression ISO HDHD2 (Homo sapiens) 6480464 Urethane results in decreased expression of HDHD2 mRNA CTD PMID:28818685 Hdhd2 Rat ursodeoxycholic acid decreases expression EXP 6480464 Ursodeoxycholic Acid results in decreased expression of HDHD2 mRNA CTD PMID:15885361 Hdhd2 Rat valproic acid affects expression ISO HDHD2 (Homo sapiens) 6480464 Valproic Acid affects the expression of HDHD2 mRNA CTD PMID:25979313 Hdhd2 Rat valproic acid decreases expression ISO HDHD2 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of HDHD2 mRNA CTD PMID:23179753|PMID:24935251|PMID:26272509 Hdhd2 Rat valproic acid multiple interactions ISO HDHD2 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386