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Gene: Cldn8 (claudin 8) Rattus norvegicus

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Symbol:

Cldn8

Name:

claudin 8

RGD ID:

1308575

Description:

Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be located in apicolateral plasma membrane and basolateral plasma membrane. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN8 (claudin 8); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH 17beta-estradiol; 3,3',5,5'-tetrabromobisphenol A; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

claudin-8; LOC304124; MGC124857

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CLDN8 (claudin 8)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cldn8 (claudin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cldn8 (claudin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CLDN8 (claudin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CLDN8 (claudin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cldn8 (claudin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CLDN8 (claudin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CLDN8 (claudin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cldn8 (claudin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cldn8 (claudin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CLDN17 (claudin 17)	HGNC	OrthoDB
Homo sapiens (human):	ROBO2 (roundabout guidance receptor 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CLDN8 (claudin 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cldn8 (claudin 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cldn8 (claudin 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:110333	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cldn17 (claudin 17)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cldn8.4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cldn8.4	Alliance	DIOPT (OMA\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	cldn8.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cldn8.1	Alliance	DIOPT (OMA\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	cldn8.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cldn17.3	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cldn8.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cldn17	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	41,362,081 - 41,364,330 (-)	NCBI	GRCr8	GRCr8		GRCr8
mRatBN7.2	11	27,875,857 - 27,878,106 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	27,875,692 - 27,878,513 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	36,569,725 - 36,571,974 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	29,269,957 - 29,272,206 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	28,434,450 - 28,436,699 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	28,525,641 - 28,527,890 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	28,525,643 - 28,527,890 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	32,145,321 - 32,147,570 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	28,419,612 - 28,421,861 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	27,591,523 - 27,593,772 (-)	NCBI		Celera
RGSC_v3.1	11	28,420,518 - 28,421,859 (-)	NCBI
Cytogenetic Map	11	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

malignant mesothelioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

5-azacytidine (ISO)

acetohydrazide (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbon nanotube (ISO)

copper atom (EXP)

copper(0) (EXP)

dibenzo[a,l]pyrene (ISO)

diethyl phthalate (EXP)

dimethyl sulfoxide (ISO)

dioxygen (ISO)

diquat (ISO)

formaldehyde (ISO)

genistein (ISO)

hydrogen peroxide (ISO)

hydroquinone (ISO)

inulin (ISO)

leuprolide (ISO)

nickel atom (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

progesterone (ISO)

quercitrin (ISO)

rac-lactic acid (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

testosterone (EXP,ISO)

tetracycline (ISO)

trichostatin A (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

apicolateral plasma membrane (ISO)

basolateral plasma membrane (ISO)

bicellular tight junction (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hepatitis C pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9892664	PMID:12477932	PMID:16520537	PMID:16651389	PMID:16780588	PMID:18036336	PMID:28493961

Genomics

Comparative Map Data

Cldn8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	41,362,081 - 41,364,330 (-)	NCBI	GRCr8	GRCr8		GRCr8
mRatBN7.2	11	27,875,857 - 27,878,106 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	27,875,692 - 27,878,513 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	36,569,725 - 36,571,974 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	29,269,957 - 29,272,206 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	28,434,450 - 28,436,699 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	28,525,641 - 28,527,890 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	28,525,643 - 28,527,890 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	32,145,321 - 32,147,570 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	28,419,612 - 28,421,861 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	27,591,523 - 27,593,772 (-)	NCBI		Celera
RGSC_v3.1	11	28,420,518 - 28,421,859 (-)	NCBI
Cytogenetic Map	11	q11	NCBI

CLDN8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	30,214,006 - 30,216,097 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	30,214,006 - 30,216,097 (-)	Ensembl			hg38	GRCh38
GRCh37	21	31,586,324 - 31,588,415 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	30,508,201 - 30,510,189 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	30,508,200 - 30,510,189	NCBI
Celera	21	16,769,465 - 16,771,610 (-)	NCBI		Celera
Cytogenetic Map	21	q22.11	NCBI
HuRef	21	16,995,205 - 16,997,350 (-)	NCBI		HuRef
CHM1_1	21	31,147,901 - 31,150,046 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	21	28,579,873 - 28,581,964 (-)	NCBI		T2T-CHM13v2.0

Cldn8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	88,357,714 - 88,360,071 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	88,357,716 - 88,360,071 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	88,560,826 - 88,563,183 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	88,560,828 - 88,563,183 (-)	Ensembl			mm10	GRCm38
MGSCv37	16	88,561,071 - 88,563,428 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	88,449,685 - 88,451,994 (-)	NCBI		MGSCv36	mm8
Celera	16	88,764,283 - 88,766,640 (-)	NCBI		Celera
Cytogenetic Map	16	C3.3	NCBI
cM Map	16	51.22	NCBI

Cldn8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	29,563,982 - 29,568,728 (-)	Ensembl
ChiLan1.0	NW_004955407	29,563,982 - 29,568,728 (-)	NCBI	ChiLan1.0	ChiLan1.0

CLDN8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	26,385,128 - 26,387,221 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	21,240,806 - 21,242,921 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	16,634,733 - 16,636,809 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	30,019,035 - 30,021,171 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	30,020,274 - 30,020,951 (-)	Ensembl			panPan2	panpan1.1

CLDN8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	25,088,451 - 25,090,719 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	25,067,825 - 25,090,388 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	25,081,031 - 25,083,309 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	25,202,944 - 25,205,222 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	31	25,152,567 - 25,154,844 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	25,162,068 - 25,164,343 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	25,626,351 - 25,628,630 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cldn8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	25,560,223 - 25,562,291 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	11,905,678 - 11,906,355 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	11,905,635 - 11,907,141 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLDN8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	193,562,074 - 193,564,168 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	193,563,314 - 193,564,090 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	204,165,854 - 204,166,630 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLDN8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	62,012,738 - 62,017,840 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	62,016,228 - 62,016,905 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666071	4,587,555 - 4,589,699 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cldn8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	18,282,293 - 18,282,970 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	18,281,038 - 18,283,442 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cldn8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	55,287,514 - 55,289,989 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cldn8
5 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	38
Count of miRNA genes:	38
Interacting mature miRNAs:	38
Transcripts:	ENSRNOT00000002138
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	22524746	82951192	Rat
1598841	Memor7	Memory QTL 7			exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	11	33306008	78306008	Rat
1598842	Glom10	Glomerulus QTL 10	3.4		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	3818154	48818154	Rat
1598811	Bp291	Blood pressure QTL 291	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	33306008	78306008	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	10806125	55806125	Rat
634341	Bw121	Body weight QTL 121	3.56		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	11	35323199	55805892	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	32943067	89836615	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	29958996	57754989	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	31915469	76915469	Rat
2290451	Scl58	Serum cholesterol level QTL 58	3.48		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	11	26318031	55806125	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	36428416	81428416	Rat
1600394	Edcs1	Endometrial carcinoma susceptibility QTL1	2.9	0.04	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	11	12823152	57823152	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	34618760	79618760	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	36749459	81749459	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	36749459	81749459	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
631510	Spl2	Serum phospholipid level QTL 2	4.1		blood phospholipid amount (VT:0006084)	serum phospholipid level (CMO:0001171)	11	27556685	72556685	Rat

Markers in Region

PMC99911P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	27,877,557 - 27,878,024 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	28,527,342 - 28,527,808	NCBI	Rnor6.0
Rnor_5.0	11	32,147,022 - 32,147,488	UniSTS	Rnor5.0
RGSC_v3.4	11	28,421,313 - 28,421,779	UniSTS	RGSC3.4
Celera	11	27,593,224 - 27,593,690	UniSTS
Cytogenetic Map	11	q11	UniSTS

BI292090

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	27,876,007 - 27,876,126 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	28,525,792 - 28,525,910	NCBI	Rnor6.0
Rnor_5.0	11	32,145,472 - 32,145,590	UniSTS	Rnor5.0
RGSC_v3.4	11	28,419,763 - 28,419,881	UniSTS	RGSC3.4
Celera	11	27,591,674 - 27,591,792	UniSTS
RH 3.4 Map	11	146.7	UniSTS
Cytogenetic Map	11	q11	UniSTS

Cldn8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	27,877,782 - 27,878,028 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	28,527,567 - 28,527,812	NCBI	Rnor6.0
Rnor_5.0	11	32,147,247 - 32,147,492	UniSTS	Rnor5.0
RGSC_v3.4	11	28,421,538 - 28,421,783	UniSTS	RGSC3.4
Celera	11	27,593,449 - 27,593,694	UniSTS
Cytogenetic Map	11	q11	UniSTS

Cldn8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	27,877,495 - 27,878,092 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	28,527,280 - 28,527,876	NCBI	Rnor6.0
Rnor_5.0	11	32,146,960 - 32,147,556	UniSTS	Rnor5.0
RGSC_v3.4	11	28,421,251 - 28,421,847	UniSTS	RGSC3.4
Celera	11	27,593,162 - 27,593,758	UniSTS
Cytogenetic Map	11	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	4	6	42	57	69	38	18	38	6	164	25	35	81	82	31	2	2

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037774	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC099804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002138 ⟹ ENSRNOP00000002138

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	27,875,692 - 27,878,513 (-)	Ensembl
Rnor_6.0 Ensembl	11	28,525,643 - 28,527,890 (-)	Ensembl

RefSeq Acc Id:

NM_001037774 ⟹ NP_001032863

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	41,362,081 - 41,364,330 (-)	NCBI
mRatBN7.2	11	27,875,857 - 27,878,106 (-)	NCBI
Rnor_6.0	11	28,525,641 - 28,527,890 (-)	NCBI
Rnor_5.0	11	32,145,321 - 32,147,570 (-)	NCBI
RGSC_v3.4	11	28,419,612 - 28,421,861 (-)	RGD
Celera	11	27,591,523 - 27,593,772 (-)	RGD

Sequence:

show sequence

CCATGGCAACCTACGCTCTTCAAATGGCTGCCCTGGTGCTTGGTGGTGTTGGCATGGTGGGCAC
AGTGGCTGTGACGATCATGCCTCAGTGGAGAGTGTCTGCCTTCATCGAAAGTAACATTGTCGTG
TTTGAGAACCGCTGGGAAGGTTTGTGGATGAACTGCATGAGGCATGCCAACATCAGAATGCAGT
GTAAGGTCTATGACTCCCTGCTGGCTCTTAGTCCAGACCTCCAGGCATCCAGAGGACTGATGTG
TGCTGCGTCCGTCCTGTCCTTCTTGGCTTTCATGACAGCCATCCTCGGAATGAAGTGCACCAGG
TGCACCGGGGAGGACGAGAACGTGAAGAGCCGCATCTTGCTGACGGCTGGAATCATCTTCTTCA
TCACCGGCTTGGTTGTGCTCATCCCTGTCAGCTGGGTTGCCAATGCCATCATCAGAGACTTCTA
CAACCCGCTGGTGGATGTGGCCCAAAAGCGCGAGCTTGGTGAAGCCCTCTACATAGGCTGGACC
ACGGCGCTGGTGCTGATCGCTGGAGGAGCACTGTTCTGTTGCGTGTTTTGCTGTACTGAAAGGA
GTAACAGTTACAAGTACTCGGTACCATCCCATCGCACCACTCAGAGGAGTTTCCACGCCGAAAA
GAGATCCCCGAGCATATACTCCAAAAGTCAGTATGTGTAGCTGTGTGTGTATATTTTAGCTGTA
GCTATAAAGCGAAGCTTTATAAATCACTGAACCAGCCACTATTTTATAGAAATGGAACCCACAG
TGTTTCCATTTACCTTTCTTAACTGCCTCGTACTCATTACAGGAAATACGCAGCGTCTATGATT
CCATAAATGATTTTAGCAGAATGAGGTATTATGCACACTGCTTCAATTGTTCCAGAAAGCATAG
CCATTTGTTTTCTAAAATGGTTCACGCGGTTCTTCTTTTATCAGTCACTCTAAGACGACCCATC
GAAAGACTGTTGGTTTAAGCTGCGATTTCTCTGTGTCATGGCATTATACAAGTAATGCGAGTGG
CAGTTATAGCTCACACAAATAGAGACAGGCTTATGTGGTTCTATTTAAAGTGAAATGCCAATCC
ATCAGGCTGAATAAACAGAACTCAGCTATTGCATTTCAGGGGACCTGGGGATAAAAGGAAAGAA
GGCTGATATTAATTGCCTAAAAACAGCTTAAGGATTAGTGCACTCTATTTATAGCAAAGGTTAA
AATGAAGGCTTTCATCATTAGTGTAAGGGAAACTGAATGGCTTTCTGATCGCCTGCTTTGCAGC
CTCCAGGAGTTAAAAATCCTGTCACCTTTATCCTTTATCCACGTGCCTTTTTTTTTTCTGATTG
TGTTCCTTAGTATCTTTTAAAGTTTAAAGCAGATATTGTAACAAAATATTTTTTTTCTTCAGAC
TACGTTTGTAAGGCTGGGCTAACAAGAGAGATAAAGCAGTGGTCTTAGAAAAATTAACGTTTTC
AGAAAAATGACTTTACCTTAGCCTTTCTCTTTAGAGAAGAATGTATTGTTTTTAAAATGAAGTC
ACATCATATAAAAGGGGCCGTTCAAGTGCTATTTGTGCATACCTTTTTGGGAATTTTTCTGTAT
AAATAAGAGAGGAAAAAGAATATTTTGTCATTTACTTACCCCAAAGAGGTACAATCCCTCCAAA
TCCAAAAACTTGTCCTCTTTCAACTCTTGTCATTCAATCAAAGTTGTCATTTCTGTTCTGTTGG
AGGTGATTTCCTCTTTTTCTATGTCTTTGCTAAGTTTTATTAAAGTGTGGTATCACTGTGTGTT
TCCTCCTAATTTGAGACAACTATTAAGGTAATACCAAATTTCATATATATGACTTTTATATTGG
TAAATTGTATCTTTTATAACAATATAGCATTTCTTACATTTACATTCTTTTTCATTACTTTGCA
CAAGTGTTTAAAACTTGGCATTGACAATTTATGTTTGAACATAGATTTCGTGTTCATTTTTTCT
GGTGCGGTGTAGGATTTAAATCAATTTACTTTATAATGACCTGACTCATGCATTAATATTTGAT
TAATATATTAATAATACTAAGTTCTACTTAGGTCCAGTGAAATGTGTTTGCTGTAAATATTGTG
TATGTAATCATATTTTTAAAAGTTGTCCATATGTATTTCAACTTCTGAGAATTCGTTTGAATTA
AAAACAAAGCTGAATGATTTGGGAGTATGCACCATATTTATGTGAAGTATATTATTAAAACTTT
GCAATACTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001032863	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99804	(Get FASTA)	NCBI Sequence Viewer
	EDM10659	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001032863 ⟸ NM_001037774

- UniProtKB:

Q499Q7 (UniProtKB/TrEMBL), F7FAZ0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATYALQMAALVLGGVGMVGTVAVTIMPQWRVSAFIESNIVVFENRWEGLWMNCMRHANIRMQC
KVYDSLLALSPDLQASRGLMCAASVLSFLAFMTAILGMKCTRCTGEDENVKSRILLTAGIIFFI
TGLVVLIPVSWVANAIIRDFYNPLVDVAQKRELGEALYIGWTTALVLIAGGALFCCVFCCTERS
NSYKYSVPSHRTTQRSFHAEKRSPSIYSKSQYV

hide sequence

Ensembl Acc Id:

ENSRNOP00000002138 ⟸ ENSRNOT00000002138

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q499Q7-F1-model_v2	AlphaFold	Q499Q7	1-225	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308575	AgrOrtholog
BioCyc Gene	G2FUF-22028	BioCyc
Ensembl Genes	ENSRNOG00000001571	Ensembl
Gene3D-CATH	1.20.140.150	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7937572	IMAGE-MGC_LOAD
InterPro	Claudin	UniProtKB/TrEMBL
	Claudin_CS	UniProtKB/TrEMBL
	PMP22/EMP/MP20/Claudin	UniProtKB/TrEMBL
KEGG Report	rno:304124	UniProtKB/TrEMBL
MGC_CLONE	MGC:124857	IMAGE-MGC_LOAD
NCBI Gene	304124	ENTREZGENE
PANTHER	Claudin	UniProtKB/TrEMBL
Pfam	PMP22_Claudin	UniProtKB/TrEMBL
PhenoGen	Cldn8	PhenoGen
PRINTS	CLAUDIN	UniProtKB/TrEMBL
	CLAUDIN8	UniProtKB/TrEMBL
PROSITE	CLAUDIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001571	RatGTEx
UniProt	F7FAZ0	ENTREZGENE, UniProtKB/TrEMBL
	Q499Q7	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Cldn8	claudin 8	Cldn8_predicted	claudin 8 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Cldn8_predicted	claudin 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)