Nkiras1 (NFKB inhibitor interacting Ras-like 1)

Gene: Nkiras1 (NFKB inhibitor interacting Ras-like 1) Rattus norvegicus

Analyze

Symbol:

Nkiras1

Name:

NFKB inhibitor interacting Ras-like 1

RGD ID:

1308560

Description:

Predicted to enable GTPase activating protein binding activity. Predicted to be involved in Ral protein signal transduction. Predicted to act upstream of or within lung alveolus development; regulation of tumor necrosis factor-mediated signaling pathway; and surfactant homeostasis. Predicted to be located in cytosol and endoplasmic reticulum. Orthologous to human NKIRAS1 (NFKB inhibitor interacting Ras like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC305751; NF-kappa-B inhibitor-interacting Ras-like protein 1; NFKB inhibitor interacting Ras-like protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nkiras1 (NFKB inhibitor interacting Ras like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nkiras1 (NFKB inhibitor interacting Ras like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nkiras1 (NFKB inhibitor interacting Ras like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nkiras1 (NFKB inhibitor interacting Ras-like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	kbrl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	kappaB-Ras	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nkiras1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	9,924,316 - 9,934,538 (-)	NCBI		GRCr8
mRatBN7.2	15	7,493,531 - 7,503,758 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	7,493,531 - 7,503,854 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	9,639,240 - 9,649,428 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	10,552,037 - 10,562,225 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	8,852,455 - 8,862,643 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	8,179,090 - 8,188,656 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	8,179,102 - 8,183,682 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	12,240,637 - 12,250,727 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	9,072,535 - 9,082,065 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	9,072,669 - 9,082,112 (-)	NCBI
Celera	15	7,547,539 - 7,557,053 (-)	NCBI		Celera
Cytogenetic Map	15	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Diamond-Blackfan anemia 12 (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (EXP)

4-hydroxynon-2-enal (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

carbon nanotube (ISO)

copper(II) sulfate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

ketamine (EXP)

lead(0) (ISO)

methyl methanesulfonate (ISO)

o-anisidine (ISO)

paracetamol (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

quercetin (ISO)

SB 431542 (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zalcitabine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical NF-kappaB signal transduction (IEA)

lung alveolus development (ISO)

negative regulation of canonical NF-kappaB signal transduction (IEA)

Ral protein signal transduction (IBA,ISO)

regulation of tumor necrosis factor-mediated signaling pathway (ISO)

surfactant homeostasis (ISO)

Cellular Component

cytosol (ISO)

endoplasmic reticulum (ISO)

Molecular Function

GTP binding (IEA)

GTPase activating protein binding (IBA,ISO)

GTPase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Nkiras1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	9,924,316 - 9,934,538 (-)	NCBI		GRCr8
mRatBN7.2	15	7,493,531 - 7,503,758 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	7,493,531 - 7,503,854 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	9,639,240 - 9,649,428 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	10,552,037 - 10,562,225 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	8,852,455 - 8,862,643 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	8,179,090 - 8,188,656 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	8,179,102 - 8,183,682 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	12,240,637 - 12,250,727 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	9,072,535 - 9,082,065 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	9,072,669 - 9,082,112 (-)	NCBI
Celera	15	7,547,539 - 7,557,053 (-)	NCBI		Celera
Cytogenetic Map	15	p16	NCBI

NKIRAS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	23,889,951 - 23,946,562 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	23,889,951 - 23,946,591 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	23,931,442 - 23,988,053 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	23,908,576 - 23,933,541 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	23,908,575 - 23,933,541	NCBI
Celera	3	23,869,757 - 23,894,727 (-)	NCBI		Celera
Cytogenetic Map	3	p24.2	NCBI
HuRef	3	23,879,660 - 23,904,631 (-)	NCBI		HuRef
CHM1_1	3	23,885,392 - 23,910,352 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	23,894,728 - 23,951,314 (-)	NCBI		T2T-CHM13v2.0

Nkiras1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	4,185,693 - 4,198,560 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	4,185,693 - 4,198,560 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	18,271,136 - 18,284,003 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	18,271,136 - 18,284,003 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	19,103,656 - 19,116,517 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	17,064,260 - 17,077,121 (+)	NCBI		MGSCv36	mm8
Celera	14	13,963,372 - 13,975,560 (+)	NCBI		Celera
Cytogenetic Map	14	A1	NCBI
cM Map	14	7.08	NCBI

Nkiras1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	15,736,341 - 15,758,870 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	15,736,060 - 15,766,362 (-)	NCBI	ChiLan1.0	ChiLan1.0

NKIRAS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	23,852,802 - 23,877,793 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	23,857,568 - 23,882,559 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	23,804,054 - 23,829,071 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	24,128,587 - 24,152,731 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	24,128,587 - 24,146,611 (-)	Ensembl	panpan1.1		panPan2

NKIRAS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	19,829,764 - 19,861,462 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	19,830,124 - 19,861,424 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	19,827,022 - 19,859,564 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	20,141,926 - 20,174,508 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	20,142,715 - 20,177,656 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	19,951,249 - 19,983,814 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	20,060,471 - 20,093,032 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	20,169,590 - 20,202,160 (+)	NCBI		UU_Cfam_GSD_1.0

Nkiras1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	182,420,600 - 182,433,203 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	15,559,159 - 15,571,819 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	15,559,243 - 15,571,780 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NKIRAS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	10,686,488 - 10,716,099 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	10,686,480 - 10,716,162 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	12,134,526 - 12,255,285 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NKIRAS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	68,567,392 - 68,596,810 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	68,568,411 - 68,587,591 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	41,690,495 - 41,720,512 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nkiras1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624788	1,608,247 - 1,639,083 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624788	1,590,441 - 1,639,059 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nkiras1
42 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	332
Count of miRNA genes:	196
Interacting mature miRNAs:	250
Transcripts:	ENSRNOT00000011438
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
5684946	Bss98	Bone structure and strength QTL 98	3.9	0.0026	tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	15	1058250	14481294	Rat
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	colorectal tumor number (CMO:0001794)	15	2266368	22711984	Rat
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2266368	22711984	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat

Markers in Region

RH132821

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	7,495,710 - 7,495,894 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	8,180,554 - 8,180,737	NCBI	Rnor6.0
Rnor_5.0	15	12,242,595 - 12,242,778	UniSTS	Rnor5.0
RGSC_v3.4	15	9,073,999 - 9,074,182	UniSTS	RGSC3.4
Celera	15	7,549,003 - 7,549,186	UniSTS
RH 3.4 Map	15	92.13	UniSTS
Cytogenetic Map	15	p16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium					2		8	11	40		7		8
Low	3	43	57	41	17	41			34	35	34	11
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001400975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001400976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770514	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC169080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000011438 ⟹ ENSRNOP00000011438

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	7,493,531 - 7,503,854 (-)	Ensembl
Rnor_6.0 Ensembl	15	8,179,102 - 8,183,682 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116929 ⟹ ENSRNOP00000095926

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	7,493,531 - 7,503,854 (-)	Ensembl

RefSeq Acc Id:

NM_001107252 ⟹ NP_001100722

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	9,924,316 - 9,934,538 (-)	NCBI
mRatBN7.2	15	7,493,531 - 7,503,758 (-)	NCBI
Rnor_6.0	15	8,179,090 - 8,188,592 (-)	NCBI
Rnor_5.0	15	12,240,637 - 12,250,727 (-)	NCBI
RGSC_v3.4	15	9,072,535 - 9,082,065 (-)	RGD
Celera	15	7,547,539 - 7,557,053 (-)	RGD

Sequence:

show sequence

GCTAGCTCTCAGCAGCGCTCCTGAGCCGCTGAGGCTGCGAAAAGTGAGAGGCGGTGAGCTCGCG
TGTGCCATCGGCGCGGGACCGGAGGAAGCAGATCGGGGACGGGCTCCAGAGGGGCGTCTTCGGA
CCGCGCTGACCCGCGTGCCACTATCTCACTACCCTGCTGTGTCAGCTCATCTGTTGGAGTCCAG
CTCATGCAGAAGACCAGGTGAAACACCCCCCCTCGTGGAACTAAGTAACTACCGGATTCTTGCC
CACTGTTGGGTTAGTTGGACTGCAGACTTGCTGTCCCAGGAGAAGATGGGAAAAGGTTGCAAGG
TTGTCGTTTGTGGGCTGTTGTCCGTTGGGAAAACTGCAATTTTGGAGCAACTCCTTTATGGGAA
TCACACTATTGGCATGGAAGACTGTGAAACGCTGGAAGACGTGTACATGGCATCTGTGGAGACA
GACCGTGGGGTGAAGGAGCAGCTGCACTTGTACGACACCCGAGGCCTGCAGGAAGGCGTGGAGC
TGCCTAAGCACTATTTCTCATTTGCCGACGGCTTCGTTCTCGTGTACAGCGTGAATAACCTCGA
GTCCTTCCAGAGAGTGGAGCTTCTGAAGAAAGAGATTGATAAGTTCAAAGACAAAAAGGAGGTG
GCAATCGTTGTGTTAGGAAACAAACTGGACCTTTCTGAGCAGAGGCAAGTGGACGCTGACGCAG
CACAACAGTGGGCTAGAAGTGAGAAGGTGAAGCTCTGGGAGGTGACGGTGACGGACCGCAGGAC
GCTGATTGAGCCCTTCACACTACTGGCCAGCAAGCTTTCCCAGCCCCAGAGCAAATCTAGCTTC
CCTCTGCCAGGGAGGAAAAACAAAGGGAACTCCAATTCCGAAAACTGAGTCAAGCCTTGAAATG
TCTCTAGCATGACACAGGGTTCCGATTTAATGTGGCTCTTCACAAACCTCCTCTGGGCCTTAGG
GAACCCCTAAGTGGTAACTTAATGCACTTTAATGCAAGCTACTGGTTTGCTGCTGTTGGACATT
ATTTTGTCTTTATTTGAAACCTGCTCTTAAAATCGAGTTTTGTTATTCTGCACCTGTCAGTAAT
AATAAACGTTAGAGTATGCAGTGTACCATGGGAAGGAACCCTTCCAGCTTGTCAGGGACTCTCA
TACTCATTGTAGTTTTATGCACATGCCTTGGCGTGACCATAAGTCATTACTGTGTGTGTGGAGT
TGGCTTTCTCCTTCCATCTACGCATGAATTTCAGGGCTGTAACTCAGGTGGCCTGGCTCGCCTG
GCAAAGCACCTTCTCCACTGAGTCATCTTAACAGGCCCAGAATTCCGTTTTAAAAACGTTGACT
ACTCAGGGCTGGGGAGATTGCTCAGTAGCTAAGATTGAAGCTCTCACAGAAGAGCCAGGTCCAG
TTTATAGCACCTACATGGTGGCTCATAACCACCTATAAGAGAGTCCAAAGGATTCAGTGTCTTC
CCTTGGTTTCTTCAGACATTGCATGCAGTTAGTGCTCATGTACAGATGCAGGGAAAACCATACA
CACGTAGAATGATAGCTAAACTTTTTTAAAGGTTAATTATCTAATATCTCAGATTATAAAGCTT
GGCAGTGGCTTTCTTTGTGCAGCTAAATTGTGCCAATGACGACAATCTGGACCTCTGAGTTAAA
CTCTCATTTCACGGAGGCTTTGCTGACAGACCACATGTGGTTTTGCGTCGCTCGCTCTGTTAAG
TATAATCGATCGTAGGTTAGCATGAGTAGCTTCTGTATTCAGAGCCCTGTCTTTATAAGCTAGG
CCTGTGCTGACGATAAAGTGAAATACTAGAGGGTCTTCAGAAAACGGTTAGGCTGAAGAATGAG
GAAGCATCCCTTTCTTCTAATAACCTCATCGTATACAATAAAATGTCAGAAATACAGAGTTACC
ACTAGTTTTACATATTAATCTGAGTTTGTAATTTAGTTTATGGAAAATCTTACCAAGATCCGAG
CAGTTTTGGTCACTGTATTGAACAAGATTGCCAGACCTATGCAAAGAACTAGGAAATGAACTGC
CTGGTGGTTCCAACTGTAAATCAACTTTAGCCATTTACCTGAAAAGCAAAGTGTGAAACAAGGT
GTAGTAAACACAGGAAGGCAAGTAAAGTATGGACTCTTCAGTGCAATGCTTTCAACTGTGGCTG
GCTCAGTCCAGTGAGTTCAAGCCAAGGACCGCCGTGTATAATGTAAACCATTAGCACTATTGCC
ACTTGCTTTTCTGTTGGTGGCACTGCAGTCTGAACCCAAGGGTTCACACACATGCATCATTAAC
CGTTTTACTTTGTGAGAAAGGGTCTTAATAAACAACCCAAGCTTTGAAGTTGGAATCCTTGTGC
CCTGAATACTGGGGTTATAGCCACCAGGCTTGTCCCTCATCCCCCTAAAGACAAGGTTACTGTA
TAACCCTGGCTGGTTGGAATTATGTAGACTAGGCTAGCCTTGACCTCCAAGTCCTGCTCAGCTG
GGATTAGAAGTGTGTACCACCATGCTGTCTTGGCCAATTCTTTAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001400975 ⟹ NP_001387904

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	9,924,316 - 9,934,538 (-)	NCBI
mRatBN7.2	15	7,493,531 - 7,503,758 (-)	NCBI

RefSeq Acc Id:

NM_001400976 ⟹ NP_001387905

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	9,924,316 - 9,934,538 (-)	NCBI
mRatBN7.2	15	7,493,531 - 7,503,758 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100722	(Get FASTA)	NCBI Sequence Viewer
	NP_001387904	(Get FASTA)	NCBI Sequence Viewer
	NP_001387905	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI69080	(Get FASTA)	NCBI Sequence Viewer
	EDL94081	(Get FASTA)	NCBI Sequence Viewer
	EDL94082	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011438.3
	ENSRNOP00000095926.1

RefSeq Acc Id:	NP_001100722 ⟸ NM_001107252
- UniProtKB:	B5DFJ1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETLEDVYMASVETDRGVKEQLHLYDTRG LQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKLDLSEQR QVDADAAQQWARSEKVKLWEVTVTDRRTLIEPFTLLASKLSQPQSKSSFPLPGRKNKGNSNSEN hide sequence

RefSeq Acc Id:

ENSRNOP00000011438 ⟸ ENSRNOT00000011438

RefSeq Acc Id:

ENSRNOP00000095926 ⟸ ENSRNOT00000116929

RefSeq Acc Id:	NP_001387905 ⟸ NM_001400976
- UniProtKB:	B5DFJ1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001387904 ⟸ NM_001400975
- UniProtKB:	B5DFJ1 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DFJ1-F1-model_v2	AlphaFold	B5DFJ1	1-192	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308560	AgrOrtholog
BioCyc Gene	G2FUF-14460	BioCyc
Ensembl Genes	ENSRNOG00000008565	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011438.6	UniProtKB/TrEMBL
	ENSRNOT00000116929.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	KBRS	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Ras_GTPase	UniProtKB/TrEMBL
	Small_GTP_bd	UniProtKB/TrEMBL
KEGG Report	rno:305751	UniProtKB/TrEMBL
NCBI Gene	305751	ENTREZGENE
PANTHER	NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN 1	UniProtKB/TrEMBL
	PTHR46152	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PhenoGen	Nkiras1	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008565	RatGTEx
SMART	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I6APQ3_RAT	UniProtKB/TrEMBL
	B5DFJ1	ENTREZGENE, UniProtKB/TrEMBL
	F7FHT8_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-20	Nkiras1	NFKB inhibitor interacting Ras-like 1	Nkiras1	NFKB inhibitor interacting Ras-like protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Nkiras1	NFKB inhibitor interacting Ras-like protein 1	Nkiras1_predicted	NFKB inhibitor interacting Ras-like protein 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Nkiras1_predicted	NFKB inhibitor interacting Ras-like protein 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar