Aff3 (ALF transcription elongation factor 3) - Rat Genome Database

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Gene: Aff3 (ALF transcription elongation factor 3) Rattus norvegicus
Analyze
Symbol: Aff3
Name: ALF transcription elongation factor 3
RGD ID: 1308527
Description: Predicted to enable DNA-binding transcription factor activity and double-stranded DNA binding activity. Predicted to be involved in embryonic hindlimb morphogenesis; regulation of DNA-templated transcription; and response to tumor necrosis factor. Predicted to be located in nucleus. Predicted to be part of super elongation complex. Human ortholog(s) of this gene implicated in KINSSHIP syndrome. Orthologous to human AFF3 (ALF transcription elongation factor 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AF4/FMR2 family member 3; AF4/FMR2 family, member 3; Laf4; LOC363220; lymphoid nuclear protein related to AF4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8947,894,903 - 48,352,380 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl947,894,903 - 48,353,000 (-)EnsemblGRCr8
mRatBN7.2940,399,099 - 40,856,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl940,404,375 - 40,857,247 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx948,899,305 - 49,265,012 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0954,022,065 - 54,387,766 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0952,305,093 - 52,671,188 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0944,837,979 - 45,291,964 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl944,839,960 - 45,292,047 (-)Ensemblrn6Rnor6.0
Rnor_5.0944,533,605 - 44,986,525 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4937,121,330 - 37,516,836 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera938,156,616 - 38,521,867 (-)NCBICelera
RGSC_v3.1937,122,871 - 37,648,080 (-)NCBI
Cytogenetic Map9q21-q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
crocidolite asbestos  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
Heliotrine  (ISO)
maneb  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triticonazole  (EXP)
tungsten  (ISO)
valproic acid  (EXP,ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
super elongation complex  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8555498   PMID:18616733   PMID:20444755   PMID:25162227  


Genomics

Comparative Map Data
Aff3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8947,894,903 - 48,352,380 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl947,894,903 - 48,353,000 (-)EnsemblGRCr8
mRatBN7.2940,399,099 - 40,856,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl940,404,375 - 40,857,247 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx948,899,305 - 49,265,012 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0954,022,065 - 54,387,766 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0952,305,093 - 52,671,188 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0944,837,979 - 45,291,964 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl944,839,960 - 45,292,047 (-)Ensemblrn6Rnor6.0
Rnor_5.0944,533,605 - 44,986,525 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4937,121,330 - 37,516,836 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera938,156,616 - 38,521,867 (-)NCBICelera
RGSC_v3.1937,122,871 - 37,648,080 (-)NCBI
Cytogenetic Map9q21-q22NCBI
AFF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38299,545,419 - 100,142,590 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl299,545,419 - 100,192,428 (-)Ensemblhg38GRCh38
GRCh372100,161,881 - 100,759,052 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36299,530,147 - 100,125,469 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34299,626,333 - 100,179,486NCBI
Celera294,368,402 - 94,963,584 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef293,928,916 - 94,523,831 (-)NCBIHuRef
CHM1_12100,168,034 - 100,763,379 (-)NCBICHM1_1
T2T-CHM13v2.02100,004,081 - 100,601,540 (-)NCBIT2T-CHM13v2.0
Aff3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39138,212,936 - 38,704,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl138,216,407 - 38,704,036 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38138,175,393 - 38,630,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl138,177,326 - 38,664,955 (-)Ensemblmm10GRCm38
MGSCv37138,234,172 - 38,721,800 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36138,123,789 - 38,572,845 (-)NCBIMGSCv36mm8
MGSCv36138,685,934 - 39,133,869 (-)NCBIMGSCv36mm8
Celera137,969,239 - 38,454,986 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map116.58NCBI
Aff3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554705,804,117 - 6,183,222 (-)Ensembl
ChiLan1.0NW_0049554705,800,152 - 6,183,761 (-)NCBIChiLan1.0ChiLan1.0
AFF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21228,083,022 - 28,680,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A28,120,669 - 28,683,384 (+)NCBINHGRI_mPanPan1
PanPan1.12A100,531,658 - 101,088,928 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A100,535,363 - 100,993,626 (-)EnsemblpanPan2panpan1.1
AFF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11042,587,173 - 43,111,739 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1042,586,394 - 43,247,328 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1042,510,236 - 43,038,653 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01043,455,381 - 43,984,215 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1043,415,081 - 43,983,969 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11043,175,847 - 43,697,657 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01043,449,400 - 43,980,218 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01043,639,835 - 44,162,265 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aff3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629285,304,979 - 85,798,241 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936661771,265 - 1,262,166 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936661771,265 - 1,264,456 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl354,135,532 - 54,727,885 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1354,135,476 - 54,730,201 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2356,762,725 - 57,316,245 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1143,268,751 - 3,880,415 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl143,270,636 - 3,573,300 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041170,866,487 - 171,459,229 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aff3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247494,498,621 - 4,773,900 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247494,494,740 - 5,015,118 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Aff3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14114,366,660 - 114,830,891 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aff3
3467 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:52
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000042227
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
D9Mgh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8948,269,680 - 48,269,828 (+)Marker Load Pipeline
mRatBN7.2940,773,905 - 40,774,051 (+)MAPPERmRatBN7.2
Rnor_6.0945,209,898 - 45,210,045NCBIRnor6.0
Rnor_5.0944,904,572 - 44,904,719UniSTSRnor5.0
RGSC_v3.4937,520,306 - 37,520,454RGDRGSC3.4
RGSC_v3.4937,520,307 - 37,520,454UniSTSRGSC3.4
Celera938,526,001 - 38,526,148UniSTS
RGSC_v3.1937,521,721 - 37,521,868RGD
RH 3.4 Map9378.7UniSTS
RH 3.4 Map9378.7RGD
RH 2.0 Map9395.3RGD
SHRSP x BN Map935.4398RGD
FHH x ACI Map929.65RGD
Cytogenetic Map9q21UniSTS
D9Rat26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2940,593,944 - 40,594,091 (+)MAPPERmRatBN7.2
Rnor_6.0945,029,648 - 45,029,794NCBIRnor6.0
Rnor_5.0944,725,058 - 44,725,204UniSTSRnor5.0
RGSC_v3.4937,313,134 - 37,313,280UniSTSRGSC3.4
RGSC_v3.4937,313,103 - 37,313,370RGDRGSC3.4
Celera938,346,802 - 38,346,948UniSTS
RGSC_v3.1937,314,548 - 37,314,694RGD
RH 3.4 Map9371.7RGD
RH 3.4 Map9371.7UniSTS
RH 2.0 Map9379.8RGD
SHRSP x BN Map935.4698RGD
FHH x ACI Map926.86RGD
Cytogenetic Map9q21UniSTS
BE119815  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2940,847,641 - 40,847,791 (+)MAPPERmRatBN7.2
Rnor_6.0945,283,223 - 45,283,372NCBIRnor6.0
Rnor_5.0944,977,820 - 44,977,969UniSTSRnor5.0
RGSC_v3.4937,594,563 - 37,594,712UniSTSRGSC3.4
Celera938,599,537 - 38,599,686UniSTS
RH 3.4 Map9381.5UniSTS
Cytogenetic Map9q21UniSTS
RH143740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2940,555,236 - 40,555,370 (+)MAPPERmRatBN7.2
Rnor_6.0944,990,906 - 44,991,039NCBIRnor6.0
Rnor_5.0944,686,316 - 44,686,449UniSTSRnor5.0
RGSC_v3.4937,274,387 - 37,274,520UniSTSRGSC3.4
Celera938,308,095 - 38,308,228UniSTS
RH 3.4 Map9378.3UniSTS
Cytogenetic Map9q21UniSTS
BE096992  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8948,033,611 - 48,033,777 (+)Marker Load Pipeline
mRatBN7.2940,537,817 - 40,537,983 (+)MAPPERmRatBN7.2
Rnor_6.0944,973,488 - 44,973,653NCBIRnor6.0
Rnor_5.0944,668,898 - 44,669,063UniSTSRnor5.0
RGSC_v3.4937,256,969 - 37,257,134UniSTSRGSC3.4
Celera938,290,679 - 38,290,844UniSTS
RH 3.4 Map9371.8UniSTS
Cytogenetic Map9q21UniSTS
BI286984  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2940,541,836 - 40,541,966 (+)MAPPERmRatBN7.2
Rnor_6.0944,977,507 - 44,977,636NCBIRnor6.0
Rnor_5.0944,672,917 - 44,673,046UniSTSRnor5.0
RGSC_v3.4937,260,988 - 37,261,117UniSTSRGSC3.4
Celera938,294,698 - 38,294,827UniSTS
RH 3.4 Map9363.89UniSTS
Cytogenetic Map9q21UniSTS
AW532340  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2940,519,641 - 40,519,794 (+)MAPPERmRatBN7.2
Rnor_6.0944,955,514 - 44,955,666NCBIRnor6.0
Rnor_5.0944,650,924 - 44,651,076UniSTSRnor5.0
RGSC_v3.4937,237,438 - 37,237,590UniSTSRGSC3.4
Celera938,272,555 - 38,272,707UniSTS
RH 3.4 Map9376.5UniSTS
Cytogenetic Map9q21UniSTS
BF388174  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2940,540,365 - 40,540,537 (+)MAPPERmRatBN7.2
Rnor_6.0944,976,036 - 44,976,207NCBIRnor6.0
Rnor_5.0944,671,446 - 44,671,617UniSTSRnor5.0
RGSC_v3.4937,259,517 - 37,259,688UniSTSRGSC3.4
Celera938,293,227 - 38,293,398UniSTS
RH 3.4 Map9373.8UniSTS
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 163 91 90 59 92 59 6 355 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000042227   ⟹   ENSRNOP00000047638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl947,894,903 - 48,276,829 (-)Ensembl
mRatBN7.2 Ensembl940,404,375 - 40,770,435 (-)Ensembl
Rnor_6.0 Ensembl944,840,031 - 45,206,427 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083256   ⟹   ENSRNOP00000072037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl947,894,903 - 48,352,980 (-)Ensembl
mRatBN7.2 Ensembl940,404,375 - 40,857,247 (-)Ensembl
Rnor_6.0 Ensembl944,839,960 - 45,292,047 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099335   ⟹   ENSRNOP00000084992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl947,894,903 - 48,353,000 (-)Ensembl
mRatBN7.2 Ensembl940,404,375 - 40,857,247 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130248   ⟹   ENSRNOP00000106658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl947,894,903 - 48,352,517 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152743   ⟹   ENSRNOP00000101600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl947,894,903 - 48,352,289 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165116   ⟹   ENSRNOP00000102021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl947,894,903 - 48,352,423 (-)Ensembl
RefSeq Acc Id: NM_001413892   ⟹   NP_001400821
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8947,894,903 - 48,352,380 (-)NCBI
mRatBN7.2940,399,099 - 40,856,607 (-)NCBI
RefSeq Acc Id: XM_039083844   ⟹   XP_038939772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8947,896,411 - 48,352,167 (-)NCBI
mRatBN7.2940,399,109 - 40,856,716 (-)NCBI
RefSeq Acc Id: XM_039083846   ⟹   XP_038939774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8947,896,411 - 48,352,174 (-)NCBI
mRatBN7.2940,399,109 - 40,856,406 (-)NCBI
RefSeq Acc Id: XM_063267369   ⟹   XP_063123439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8947,896,411 - 48,352,167 (-)NCBI
RefSeq Acc Id: XM_063267370   ⟹   XP_063123440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8947,896,411 - 48,352,167 (-)NCBI
RefSeq Acc Id: XM_063267371   ⟹   XP_063123441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8947,896,411 - 48,352,167 (-)NCBI
Ensembl Acc Id: ENSRNOP00000047638   ⟸   ENSRNOT00000042227
Ensembl Acc Id: ENSRNOP00000072037   ⟸   ENSRNOT00000083256
RefSeq Acc Id: XP_038939772   ⟸   XM_039083844
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K1Y7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939774   ⟸   XM_039083846
- Peptide Label: isoform X5
- UniProtKB: F1M681 (UniProtKB/TrEMBL),   A0A0G2K1Y7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084992   ⟸   ENSRNOT00000099335
RefSeq Acc Id: NP_001400821   ⟸   NM_001413892
- UniProtKB: A0A0G2K1Y7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123440   ⟸   XM_063267370
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K1Y7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123441   ⟸   XM_063267371
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K1Y7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123439   ⟸   XM_063267369
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1Y7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101600   ⟸   ENSRNOT00000152743
Ensembl Acc Id: ENSRNOP00000102021   ⟸   ENSRNOT00000165116
Ensembl Acc Id: ENSRNOP00000106658   ⟸   ENSRNOT00000130248
Protein Domains
AF4/FMR2 C-terminal homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K1Y7-F1-model_v2 AlphaFold A0A0G2K1Y7 1-1281 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308527 AgrOrtholog
BioCyc Gene G2FUF-27770 BioCyc
Ensembl Genes ENSRNOG00000018830 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042227.6 UniProtKB/TrEMBL
  ENSRNOT00000083256 ENTREZGENE
  ENSRNOT00000083256.3 UniProtKB/TrEMBL
  ENSRNOT00000099335.2 UniProtKB/TrEMBL
  ENSRNOT00000130248 ENTREZGENE
  ENSRNOT00000130248.1 UniProtKB/TrEMBL
  ENSRNOT00000152743.1 UniProtKB/TrEMBL
  ENSRNOT00000165116.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.2670 UniProtKB/TrEMBL
InterPro AF4/FMR2_C UniProtKB/TrEMBL
  AF4_int UniProtKB/TrEMBL
  TF_AF4/FMR2 UniProtKB/TrEMBL
NCBI Gene 363220 ENTREZGENE
PANTHER AF-4 UniProtKB/TrEMBL
  AF4/FMR2 FAMILY MEMBER 3 UniProtKB/TrEMBL
Pfam AF-4 UniProtKB/TrEMBL
  AF-4_C UniProtKB/TrEMBL
  AF4_int UniProtKB/TrEMBL
PhenoGen Aff3 PhenoGen
RatGTEx ENSRNOG00000018830 RatGTEx
UniProt A0A0G2K1Y7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBB7_RAT UniProtKB/TrEMBL
  A0ABK0L154_RAT UniProtKB/TrEMBL
  A0ABK0L9N1_RAT UniProtKB/TrEMBL
  A0ABK0LLK3_RAT UniProtKB/TrEMBL
  F1M681 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-05 Aff3  ALF transcription elongation factor 3  Aff3  AF4/FMR2 family, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Aff3  AF4/FMR2 family, member 3   Aff3_predicted  AF4/FMR2 family, member 3 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Aff3_predicted  AF4/FMR2 family, member 3 (predicted)  Laf4_predicted  lymphoid nuclear protein related to AF4 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Laf4_predicted  lymphoid nuclear protein related to AF4 (predicted)      Symbol and Name status set to approved 70820 APPROVED