Rnf149 (ring finger protein 149) - Rat Genome Database

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Gene: Rnf149 (ring finger protein 149) Rattus norvegicus
Analyze
Symbol: Rnf149
Name: ring finger protein 149
RGD ID: 1308460
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Predicted to be located in membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and late endosome. Orthologous to human RNF149 (ring finger protein 149); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase RNF149; LOC108351917; LOC363222; uncharacterized LOC108351917
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,322,524 - 49,350,361 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl949,323,857 - 49,350,042 (-)EnsemblGRCr8
mRatBN7.2941,826,825 - 41,854,381 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,830,233 - 41,854,279 (-)EnsemblmRatBN7.2
Rnor_6.0946,285,546 - 46,309,692 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,286,657 - 46,309,451 (-)Ensemblrn6Rnor6.0
Rnor_5.0945,970,740 - 45,998,478 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4938,623,812 - 38,647,344 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera939,579,130 - 39,603,686 (-)NCBICelera
RGSC_v3.1938,624,617 - 38,666,917 (-)NCBI
Cytogenetic Map9q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19946888   PMID:22628551   PMID:23376485   PMID:35634494  


Genomics

Comparative Map Data
Rnf149
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,322,524 - 49,350,361 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl949,323,857 - 49,350,042 (-)EnsemblGRCr8
mRatBN7.2941,826,825 - 41,854,381 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,830,233 - 41,854,279 (-)EnsemblmRatBN7.2
Rnor_6.0946,285,546 - 46,309,692 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,286,657 - 46,309,451 (-)Ensemblrn6Rnor6.0
Rnor_5.0945,970,740 - 45,998,478 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4938,623,812 - 38,647,344 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera939,579,130 - 39,603,686 (-)NCBICelera
RGSC_v3.1938,624,617 - 38,666,917 (-)NCBI
Cytogenetic Map9q22NCBI
RNF149
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382101,271,219 - 101,308,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2101,271,219 - 101,308,724 (-)Ensemblhg38GRCh38
GRCh372101,892,063 - 101,925,163 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362101,258,985 - 101,291,584 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342101,351,070 - 101,383,670NCBI
Celera296,096,053 - 96,129,169 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef295,656,251 - 95,689,364 (-)NCBIHuRef
CHM1_12101,896,449 - 101,929,560 (-)NCBICHM1_1
T2T-CHM13v2.02101,729,922 - 101,767,398 (-)NCBIT2T-CHM13v2.0
Rnf149
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39139,590,375 - 39,616,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl139,590,377 - 39,616,486 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38139,551,294 - 39,577,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl139,551,296 - 39,577,405 (-)Ensemblmm10GRCm38
MGSCv37139,608,141 - 39,634,192 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36139,495,847 - 39,521,951 (-)NCBIMGSCv36mm8
Celera139,345,843 - 39,371,852 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map118.33NCBI
Rnf149
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554707,051,552 - 7,073,466 (-)Ensembl
ChiLan1.0NW_0049554707,051,552 - 7,074,187 (-)NCBIChiLan1.0ChiLan1.0
RNF149
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,916,627 - 26,954,887 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A26,919,758 - 26,957,643 (+)NCBINHGRI_mPanPan1
PanPan1.12A102,246,631 - 102,282,593 (-)NCBIPanPan1.1PanPan1.1panPan2
RNF149
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11041,621,529 - 41,648,263 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1041,547,575 - 41,573,564 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01042,490,082 - 42,521,877 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1042,489,915 - 42,522,414 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11042,202,899 - 42,228,856 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01042,485,639 - 42,511,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01042,677,027 - 42,703,016 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rnf149
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629291,030,865 - 91,060,241 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493671374,462 - 101,954 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493671374,126 - 102,051 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF149
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl353,032,631 - 53,060,333 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1353,032,432 - 53,067,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2355,578,363 - 55,613,065 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNF149
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1144,978,429 - 5,011,117 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl144,979,126 - 5,011,083 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041172,644,948 - 172,677,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf149
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247495,982,313 - 6,002,221 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247495,975,844 - 6,002,422 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rnf149
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14115,792,775 - 115,819,453 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rnf149
79 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:105
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000018684
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
RH143394  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2941,843,948 - 41,844,081 (+)MAPPERmRatBN7.2
Rnor_6.0946,299,254 - 46,299,386NCBIRnor6.0
Rnor_5.0945,987,860 - 45,987,992UniSTSRnor5.0
RGSC_v3.4938,636,910 - 38,637,042UniSTSRGSC3.4
Celera939,593,248 - 39,593,380UniSTS
RH 3.4 Map9391.2UniSTS
Cytogenetic Map9q21UniSTS
RH136998  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2941,830,665 - 41,830,835 (+)MAPPERmRatBN7.2
Rnor_6.0946,285,968 - 46,286,137NCBIRnor6.0
Rnor_5.0945,974,574 - 45,974,743UniSTSRnor5.0
RGSC_v3.4938,623,624 - 38,623,793UniSTSRGSC3.4
Celera939,579,552 - 39,579,721UniSTS
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 83 217 91 90 59 159 59 6 490 285 22 195 115 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000018684   ⟹   ENSRNOP00000018684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl949,325,945 - 49,350,042 (-)Ensembl
mRatBN7.2 Ensembl941,830,233 - 41,854,279 (-)Ensembl
Rnor_6.0 Ensembl946,286,657 - 46,309,451 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109723   ⟹   ENSRNOP00000091517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl949,323,857 - 49,349,991 (-)Ensembl
mRatBN7.2 Ensembl941,830,246 - 41,853,831 (-)Ensembl
RefSeq Acc Id: XM_063267894   ⟹   XP_063123964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,322,524 - 49,350,361 (-)NCBI
RefSeq Acc Id: XR_010054760
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,322,524 - 49,350,361 (-)NCBI
RefSeq Acc Id: XR_010054761
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,322,524 - 49,350,361 (-)NCBI
RefSeq Acc Id: XR_010054762
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,326,986 - 49,350,361 (-)NCBI
RefSeq Acc Id: XR_010054763
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,322,524 - 49,349,851 (-)NCBI
RefSeq Acc Id: XR_010054764
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,334,991 - 49,350,361 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001418215 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123964 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018684
  ENSRNOP00000018684.6
  ENSRNOP00000091517.2
Ensembl Acc Id: ENSRNOP00000018684   ⟸   ENSRNOT00000018684
Ensembl Acc Id: ENSRNOP00000091517   ⟸   ENSRNOT00000109723
RefSeq Acc Id: XP_063123964   ⟸   XM_063267894

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZI66-F1-model_v2 AlphaFold D3ZI66 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696630
Promoter ID:EPDNEW_R7151
Type:initiation region
Name:Rnf149_1
Description:ring finger protein 149
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0946,309,524 - 46,309,584EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308460 AgrOrtholog
BioCyc Gene G2FUF-27747 BioCyc
Ensembl Genes ENSRNOG00000013946 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018684 ENTREZGENE
  ENSRNOT00000018684.8 UniProtKB/TrEMBL
  ENSRNOT00000109723.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  3.50.30.30 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7301405 IMAGE-MGC_LOAD
InterPro IPR003137 UniProtKB/TrEMBL
  PA_dom_sf UniProtKB/TrEMBL
  RNF149_RING-H2 UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
MGC_CLONE MGC:105927 IMAGE-MGC_LOAD
NCBI Gene 363222 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE ATL42 UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE RNF149 UniProtKB/TrEMBL
Pfam PF02225 UniProtKB/TrEMBL
  zf-RING_2 UniProtKB/TrEMBL
PhenoGen Rnf149 PhenoGen
PROSITE ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013946 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP PA domain UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
UniProt A0A8I6AS25_RAT UniProtKB/TrEMBL
  D3ZI66 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Rnf149  ring finger protein 149  LOC108351917  uncharacterized LOC108351917  Data merged from RGD:11363175 737654 PROVISIONAL
2016-08-02 LOC108351917  uncharacterized LOC108351917      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Rnf149  ring finger protein 149  Rnf149_predicted  ring finger protein 149 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rnf149_predicted  ring finger protein 149 (predicted)      Symbol and Name status set to approved 70820 APPROVED