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Gene: Plcxd3 (phosphatidylinositol-specific phospholipase C, X domain containing 3) Rattus norvegicus

Analyze

Symbol:

Plcxd3

Name:

phosphatidylinositol-specific phospholipase C, X domain containing 3

RGD ID:

1308448

Description:

Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid catabolic process and signal transduction. Predicted to be active in glutamatergic synapse. Orthologous to human PLCXD3 (phosphatidylinositol specific phospholipase C X domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hypothetical protein LOC310358; LOC310358; PI-PLC X domain-containing protein 3; RGD1308448; similar to RIKEN cDNA B130016O10 gene

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	55,294,597 - 55,473,968 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	55,294,613 - 55,474,220 (+)	Ensembl				GRCr8
mRatBN7.2	2	53,567,022 - 53,746,384 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	53,567,022 - 53,746,384 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	60,693,680 - 60,858,116 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	58,752,412 - 58,916,834 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	53,745,239 - 53,922,397 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	54,191,538 - 54,360,780 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	54,191,538 - 54,360,780 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	73,220,198 - 73,389,440 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	53,401,083 - 53,584,697 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	49,231,797 - 49,405,738 (+)	NCBI		Celera
RGSC_v3.1	2	53,329,468 - 53,512,933 (+)	NCBI
Cytogenetic Map	2	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,4-methylenedioxymethamphetamine (EXP)

6-propyl-2-thiouracil (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium dichloride (EXP)

carbamazepine (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

DDE (ISO)

diiodine (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

fenofibrate (ISO)

fenvalerate (EXP)

furan (EXP)

ketamine (EXP)

medroxyprogesterone acetate (ISO)

methimazole (EXP)

nickel atom (ISO)

paracetamol (ISO)

PCB138 (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

trametinib (ISO)

trichostatin A (ISO)

triclosan (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipid catabolic process (IEA)

lipid metabolic process (IEA)

signal transduction (IEA)

Cellular Component

glutamatergic synapse (ISO)

synapse (IBA,ISO)

Molecular Function

hydrolase activity (IEA)

phosphoric diester hydrolase activity (IBA,IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:24413018

Genomics

Comparative Map Data

Plcxd3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	55,294,597 - 55,473,968 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	55,294,613 - 55,474,220 (+)	Ensembl				GRCr8
mRatBN7.2	2	53,567,022 - 53,746,384 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	53,567,022 - 53,746,384 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	60,693,680 - 60,858,116 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	58,752,412 - 58,916,834 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	53,745,239 - 53,922,397 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	54,191,538 - 54,360,780 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	54,191,538 - 54,360,780 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	73,220,198 - 73,389,440 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	53,401,083 - 53,584,697 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	49,231,797 - 49,405,738 (+)	NCBI		Celera
RGSC_v3.1	2	53,329,468 - 53,512,933 (+)	NCBI
Cytogenetic Map	2	q16	NCBI

PLCXD3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	41,306,952 - 41,510,601 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	41,306,952 - 41,510,601 (-)	Ensembl			hg38	GRCh38
GRCh37	5	41,307,054 - 41,510,703 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	41,342,805 - 41,546,487 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	5	41,195,619 - 41,399,134 (-)	NCBI		Celera
Cytogenetic Map	5	p13.1	NCBI
HuRef	5	41,259,522 - 41,463,634 (-)	NCBI		HuRef
CHM1_1	5	41,309,079 - 41,512,527 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	41,563,425 - 41,766,981 (-)	NCBI		T2T-CHM13v2.0

Plcxd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	4,404,973 - 4,605,067 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	4,404,973 - 4,605,035 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	4,375,491 - 4,575,585 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	4,375,491 - 4,575,553 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	4,325,491 - 4,525,585 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	4,325,491 - 4,470,414 (+)	NCBI		MGSCv36	mm8
Celera	15	4,236,436 - 4,428,991 (+)	NCBI		Celera
Cytogenetic Map	15	A1	NCBI
cM Map	15	1.96	NCBI

Plcxd3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	25,569,468 - 25,719,952 (-)	Ensembl
ChiLan1.0	NW_004955426	25,563,222 - 25,719,939 (-)	NCBI	ChiLan1.0	ChiLan1.0

PLCXD3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	68,837,058 - 69,037,309 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	66,990,680 - 67,190,940 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	68,885,917 - 69,079,834 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	73,928,078 - 74,123,570 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	73,928,317 - 74,121,546 (+)	Ensembl			panPan2	panpan1.1

PLCXD3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	68,013,905 - 68,198,316 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	68,014,162 - 68,198,283 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	67,697,069 - 67,881,481 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	68,526,001 - 68,710,417 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	68,526,233 - 68,692,125 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	68,287,206 - 68,471,449 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	68,397,959 - 68,583,013 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	68,937,855 - 69,122,456 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Plcxd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	229,988,119 - 230,133,463 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	1,238,783 - 1,378,008 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936518	1,238,283 - 1,379,318 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLCXD3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	26,165,588 - 26,347,135 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	26,144,798 - 26,348,578 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	27,361,652 - 27,534,255 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLCXD3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	40,082,622 - 40,268,861 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	40,082,871 - 40,269,080 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666071	30,514,436 - 30,704,591 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Plcxd3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	13,473,653 - 13,671,795 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624759	13,473,863 - 13,678,067 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Plcxd3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	175,643,564 - 175,811,753 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Plcxd3
667 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	499
Count of miRNA genes:	255
Interacting mature miRNAs:	303
Transcripts:	ENSRNOT00000019524
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	13325041	58325041	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	24117813	69117813	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	36750344	81750344	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1579916	Bp270	Blood pressure QTL 270		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	16051883	61051883	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	14368707	59368707	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	44904355	85286097	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	51266859	96266859	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	36868643	81868643	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	44904355	89904355	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	33269996	78269996	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Markers in Region

AU029108

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	53,702,748 - 53,702,919 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	54,317,484 - 54,317,652	NCBI	Rnor6.0
Rnor_5.0	2	73,346,144 - 73,346,312	UniSTS	Rnor5.0
RGSC_v3.4	2	53,539,801 - 53,539,969	UniSTS	RGSC3.4
Celera	2	49,362,555 - 49,362,705	UniSTS
Cytogenetic Map	2	q16	UniSTS

RH140707

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	55,418,459 - 55,418,682 (+)	Marker Load Pipeline
mRatBN7.2	2	53,690,891 - 53,691,094 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	54,305,615 - 54,305,829	NCBI	Rnor6.0
Rnor_5.0	2	73,334,275 - 73,334,489	UniSTS	Rnor5.0
RGSC_v3.4	2	53,527,932 - 53,528,146	UniSTS	RGSC3.4
Celera	2	49,350,676 - 49,350,900	UniSTS
Cytogenetic Map	2	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	9	62	133	48	44	16	23	16	6	189	106	3	112	48	79	28	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019524 ⟹ ENSRNOP00000019524

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	55,294,613 - 55,474,220 (+)	Ensembl
mRatBN7.2 Ensembl	2	53,567,022 - 53,746,384 (+)	Ensembl
Rnor_6.0 Ensembl	2	54,191,538 - 54,360,780 (+)	Ensembl

RefSeq Acc Id:

NM_001107671 ⟹ NP_001101141

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	55,294,597 - 55,473,968 (+)	NCBI
mRatBN7.2	2	53,567,022 - 53,746,384 (+)	NCBI
Rnor_6.0	2	54,191,538 - 54,360,780 (+)	NCBI
Rnor_5.0	2	73,220,198 - 73,389,440 (+)	NCBI
RGSC_v3.4	2	53,401,083 - 53,584,697 (+)	RGD
Celera	2	49,231,797 - 49,405,738 (+)	RGD

Sequence:

show sequence

GAACAAAAGCCCCGGCAGTGGAGTCTGGCAAGGCAAGGAGGGAGCATGGGGTGTTTTTGAATAA
TTATTAAAATGAGCATGTGTCTGCGCCATCCTGTGGGTGTGGCGCAGAGCAGAGTGTAAACTCT
AGCCGGGCGAAGCAAACATTGGCTTAGCGGCAGCAGCTGCCAGCCTGTGCCTAGGAGTGTGGGG
ACTAGCGTGGCGGCAAGCAGACCGGCACCATGGCTTCGTCTCAGGGGAAAAACGAGCTGAAATT
CGCCGACTGGATGGCAACTCTGCCTGAGAGCATCCACAGCATCCCCCTCACCAATTTAGCCATC
CCAGGGTCCCATGATTCCTTCAGCTTCTACATTGATGAAGCTTCTCCAGTAGGCCCTGAGCAGC
CAGAAACTGTCCAAAACTTTGTCTCTGTGTTCGGAACTGTAGCCAAGAAGCTGATGCGGAAATG
GTTAGCCACTCAAACAATGAGCTTCACTGGTCAGCTGGGAGCTGGAATCCGTTACTTTGATCTT
CGAATTTCCACCAAGCCCAGAGACCCAGACAATGAACTGTATTTTGCTCATGGCTTATTCAGTG
CCAAAGTCAATGAGGGTCTTGAAGAGATCAATGCATTTCTCACAGACCACCACAAAGAGGTAGT
ATTCTTGGACTTCAATCATTTCTATGGGATGCAGAAATATCACCATGAAAAATTGGTCCAAATG
CTGAAAGACATCTATGGAAACAAAATGTGCCCAGCCATTTTTGCCCAGGAAGTGAGTTTAAAGT
ACCTATGGGAGAAGAGCTATCAAGTATTGGTCTTCTACCACAGCCCAGTGGCACTGGAAGTGCC
CTTCCTCTGGCCTGGGCAGATGATGCCAGCACCTTGGGCAAACACGACAGACCCTGAGAAATTG
ATCCAGTTTCTTCAGGCATCCATCACTGAGAGAAGAAAGAAGGGCTCGTTTTTTATATCTCAGG
TGGTGCTGACACCCAAAGCAAGCACAGTGGTCAAGGGTGTGGCAAGTGGCCTCAGAGAAACAAT
CACAGAAAGAGCTCTCCCTGCCATGATGCAGTGGATCCGCACCCAGAAGCCAGGAGAGAGCGGC
ATCAATATTGTCACTGCTGATTTTGTAGAACTTGGTGACTTTATCAGCACTGTCATAAAACTCA
ACTATGTCTTTGATGAAGGAGAAGCCAATACTTGATATTACTCTTCTGAGTGTCCTTAAGGAAG
ATAGAGAAGCCTCATTGTATTAGACATATTATCAATAAGCCCTCTGATTTTCCTGTTCCACTGA
GTCTCTGAAGGAATTAAGGTTTAGCAGTGGGCAGAAAATGAGGGTAAATCATGTCTTCAGTGAT
TGTAACCATATTCTGCATTGCTATAAATATGTCATTTCCAATTTGGTGACCAAAATCTACTTCT
AGTGTTAGGAATAGAAAAGAACAGTGAATTTCATTTTTCAGAATTAATGTTTGTGCTGTGTAAC
TCATGAGTGTTTACTAGATTGCATTTTCTAATTTCAACCTCGGGGCCCTGTATTATTCATAGCC
TCAACCCTTTCCACTCCCTCTCTCTTGCTCGCTCTTCCTAATTAGATGCTATATGGGTCTCAAA
ACAATTGAATGCCCAACATAATGTGCATTGCATTGTTGTGTTGAAATGTGTTTGTTTCGTGAGA
CTTGGTAAAATATCCCATAGTCATCTGCAATTGGGCAATCATAGCTAATTCTTGGTCGTAGAAA
ATATGCATCAAATCAGTCTCCCTGCATCTGTAATATTGTCAGTCAGGAGTGATTTTGTGTTTTA
GGAAAACAACAGCATTTCACAGCAGCTCTGTGCGAAGCAGCTAGGACTACCATGCAAACAGACT
TTTGGAAAGACAAGTGTCAACTTCAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101141	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL75737	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019524
	ENSRNOP00000019524.5

RefSeq Acc Id:

NP_001101141 ⟸ NM_001107671

- UniProtKB:

D4A1H2 (UniProtKB/TrEMBL), A6KGC8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASSQGKNELKFADWMATLPESIHSIPLTNLAIPGSHDSFSFYIDEASPVGPEQPETVQNFVSV
FGTVAKKLMRKWLATQTMSFTGQLGAGIRYFDLRISTKPRDPDNELYFAHGLFSAKVNEGLEEI
NAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMCPAIFAQEVSLKYLWEKSYQVL
VFYHSPVALEVPFLWPGQMMPAPWANTTDPEKLIQFLQASITERRKKGSFFISQVVLTPKASTV
VKGVASGLRETITERALPAMMQWIRTQKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEAN
T

hide sequence

Ensembl Acc Id:

ENSRNOP00000019524 ⟸ ENSRNOT00000019524

Protein Domains

Phosphatidylinositol-specific phospholipase C X

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A1H2-F1-model_v2	AlphaFold	D4A1H2	1-321	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308448	AgrOrtholog
BioCyc Gene	G2FUF-54190	BioCyc
BioCyc Pathway	PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis]	BioCyc
	PWY-6367 [D-myo-inositol-5-phosphate metabolism]	BioCyc
	PWY-8052 [2-arachidonoylglycerol biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-6351	BioCyc
	PWY-6367	BioCyc
	PWY-8052	BioCyc
Ensembl Genes	ENSRNOG00000014550	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019524	ENTREZGENE
	ENSRNOT00000019524.7	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.190	UniProtKB/TrEMBL
InterPro	PI-PLC_domain	UniProtKB/TrEMBL
	PLC-like_Pdiesterase_TIM-brl	UniProtKB/TrEMBL
	PLCXD1/2/3	UniProtKB/TrEMBL
	PLipase_C_PInositol-sp_X_dom	UniProtKB/TrEMBL
KEGG Report	rno:310358	UniProtKB/TrEMBL
NCBI Gene	310358	ENTREZGENE
PANTHER	PI-PLC X DOMAIN-CONTAINING PROTEIN 3	UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/TrEMBL
Pfam	PI-PLC-X	UniProtKB/TrEMBL
PhenoGen	Plcxd3	PhenoGen
PROSITE	PIPLC_X_DOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014550	RatGTEx
SMART	PLCXc	UniProtKB/TrEMBL
Superfamily-SCOP	PLC-like_Pdiesterase_TIM-brl	UniProtKB/TrEMBL
UniProt	A6KGC8	ENTREZGENE, UniProtKB/TrEMBL
	D4A1H2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-05-25	Plcxd3	phosphatidylinositol-specific phospholipase C, X domain containing 3	RGD1308448	similar to RIKEN cDNA B130016O10 gene	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1308448	similar to RIKEN cDNA B130016O10 gene	RGD1308448_predicted	similar to RIKEN cDNA B130016O10 gene (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1308448_predicted	similar to RIKEN cDNA B130016O10 gene (predicted)	LOC310358_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC310358_predicted	similar to RIKEN cDNA B130016O10 gene (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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