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Gene: Asb6 (ankyrin repeat and SOCS box-containing 6) Rattus norvegicus

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Symbol:

Asb6

Name:

ankyrin repeat and SOCS box-containing 6

RGD ID:

1308445

Description:

Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB6 (ankyrin repeat and SOCS box containing 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ankyrin repeat and SOCS box protein 6; ankyrin repeat and SOCS box-containing protein 6; LOC296627

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	34,508,390 - 34,513,033 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	34,508,140 - 34,513,033 (-)	Ensembl				GRCr8
mRatBN7.2	3	14,110,628 - 14,115,274 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	14,110,628 - 14,115,242 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	17,183,011 - 17,187,627 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	25,768,001 - 25,772,617 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	24,015,358 - 24,019,986 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	9,659,707 - 9,664,445 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	9,659,710 - 9,664,318 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	15,019,070 - 15,023,731 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	9,877,183 - 9,881,794 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	8,870,957 - 8,875,568 (-)	NCBI		Celera
RGSC_v3.1	3	9,772,553 - 9,777,162 (-)	NCBI
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

C60 fullerene (EXP)

diazinon (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

fenofibrate (ISO)

lead diacetate (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methotrexate (ISO)

okadaic acid (ISO)

paracetamol (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

quercitrin (ISO)

sodium arsenite (ISO)

T-2 toxin (EXP)

tamoxifen (ISO)

titanium dioxide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IEA)

protein ubiquitination (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Asb6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	34,508,390 - 34,513,033 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	34,508,140 - 34,513,033 (-)	Ensembl				GRCr8
mRatBN7.2	3	14,110,628 - 14,115,274 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	14,110,628 - 14,115,242 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	17,183,011 - 17,187,627 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	25,768,001 - 25,772,617 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	24,015,358 - 24,019,986 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	9,659,707 - 9,664,445 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	9,659,710 - 9,664,318 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	15,019,070 - 15,023,731 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	9,877,183 - 9,881,794 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	8,870,957 - 8,875,568 (-)	NCBI		Celera
RGSC_v3.1	3	9,772,553 - 9,777,162 (-)	NCBI
Cytogenetic Map	3	p12	NCBI

ASB6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	129,634,605 - 129,642,151 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	129,634,602 - 129,642,169 (-)	Ensembl			hg38	GRCh38
GRCh37	9	132,396,884 - 132,404,430 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	131,436,704 - 131,444,265 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	9	103,047,698 - 103,055,260 (-)	NCBI		Celera
Cytogenetic Map	9	q34.11	NCBI
HuRef	9	101,995,954 - 102,003,527 (-)	NCBI		HuRef
CHM1_1	9	132,545,620 - 132,553,185 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	141,839,213 - 141,846,767 (-)	NCBI		T2T-CHM13v2.0

Asb6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	30,713,109 - 30,718,312 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	30,713,109 - 30,720,345 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	30,823,097 - 30,828,300 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	30,823,097 - 30,830,333 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	30,678,617 - 30,683,820 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	30,626,160 - 30,652,340 (-)	NCBI		MGSCv36	mm8
Celera	2	30,527,264 - 30,532,517 (-)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	21.74	NCBI

Asb6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955570	1,748,568 - 1,752,572 (-)	Ensembl
ChiLan1.0	NW_004955570	1,747,965 - 1,752,728 (-)	NCBI	ChiLan1.0	ChiLan1.0

ASB6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	9,707,386 - 9,715,601 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	9,709,726 - 9,717,946 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	100,761,165 - 100,768,725 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	129,418,472 - 129,426,018 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	129,421,661 - 129,425,868 (-)	Ensembl			panPan2	panpan1.1

ASB6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	54,157,945 - 54,163,557 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	54,158,052 - 54,163,372 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	53,353,908 - 53,359,477 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	55,053,477 - 55,059,046 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	55,035,032 - 55,060,800 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	53,831,991 - 53,837,559 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	54,152,043 - 54,157,611 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	54,245,449 - 54,251,019 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Asb6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	197,127,781 - 197,131,746 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	16,896,326 - 16,900,277 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	16,896,308 - 16,900,294 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASB6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	269,828,985 - 269,834,271 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	269,828,978 - 269,834,283 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	303,696,571 - 303,701,834 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ASB6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	8,503,235 - 8,510,752 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	8,503,321 - 8,507,602 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666079	6,927,931 - 6,935,745 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Asb6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	5,699,433 - 5,703,672 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624760	5,699,522 - 5,704,172 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Asb6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	4,793,332 - 4,797,970 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Asb6
26 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	123
Count of miRNA genes:	90
Interacting mature miRNAs:	106
Transcripts:	ENSRNOT00000034927
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	29056275	47904329	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10450811	Scl73	Serum cholesterol level QTL 73	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat
10450808	Scl72	Serum cholesterol level QTL 72	4.4	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
10450806	Scl71	Serum cholesterol level QTL 71	5.8	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	28625339	67641995	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	6125437	51125437	Rat
8693641	Alc30	Alcohol consumption QTL 30	2	0.739	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	3	30832384	44921701	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	36721849	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	6556347	51556347	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	3e-08	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	15272348	60272348	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	29056275	47904329	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat

Markers in Region

BI277553

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	14,110,343 - 14,110,494 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	9,659,423 - 9,659,573	NCBI	Rnor6.0
Rnor_5.0	3	15,018,786 - 15,018,936	UniSTS	Rnor5.0
RGSC_v3.4	3	9,876,899 - 9,877,049	UniSTS	RGSC3.4
Celera	3	8,870,673 - 8,870,823	UniSTS
RH 3.4 Map	3	49.6	UniSTS
Cytogenetic Map	3	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399347	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC125306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000034927 ⟹ ENSRNOP00000031019

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	34,508,390 - 34,513,033 (-)	Ensembl
mRatBN7.2 Ensembl	3	14,110,631 - 14,115,242 (-)	Ensembl
Rnor_6.0 Ensembl	3	9,659,710 - 9,664,318 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105180 ⟹ ENSRNOP00000097464

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	34,508,140 - 34,513,033 (-)	Ensembl
mRatBN7.2 Ensembl	3	14,110,628 - 14,114,662 (-)	Ensembl

RefSeq Acc Id:

NM_001011963 ⟹ NP_001011963

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	34,508,390 - 34,513,033 (-)	NCBI
mRatBN7.2	3	14,110,628 - 14,115,274 (-)	NCBI
Rnor_6.0	3	9,659,707 - 9,664,318 (-)	NCBI
Rnor_5.0	3	15,019,070 - 15,023,731 (-)	NCBI
RGSC_v3.4	3	9,877,183 - 9,881,794 (-)	RGD
Celera	3	8,870,957 - 8,875,568 (-)	RGD

Sequence:

show sequence

CGACTGCTCCCGGCGCGGGGTCTGAACCGGTAGATCGGGAGGTGGTGGCGAGTGGGTATCCGGA
CGCGCGGCCGACGCCATGCCGTTCCTGCACGGCTTCCGCAGGATCATCTTCGAGTACCAGCCCC
TGGTGGACGCCATCCTGGGTGCCCTGGGCATCCAGGATCTGGAGCGGCAGGAGCCTCTGGATGA
GTGAGTCGCTGCGGTCCCCTGTGGTTGTCGCGGCGGGAGCGGGAGCTGCGTGGCTGCGAGCTCG
AGCGCCAGCCTGAGTTACGCTTCCAGTGAGGAGAGCCGGATCCTGGTCCTTACGGAGCTGCTGG
AGCAGAAGGCCCACTCTCCTTTCTACCAGGAAGGTGTGAGCAATGCTCTGCTGAAGATGGCCGA
GCTGGGCCTGACCCGGGCAGCTGCGGTCCTCCTGCAGAGTGGGGCCAACCTCAACTTTGAAGAC
CCTGTCACCTACTACACAGCCCTGCACATTGCTGTCCTGAGAAACCAGCCTGACATGGTGGAGC
TGCTGGTGCGCCACGGGGCTGATATCAACAGGAGGGACCGGATCCACGAGAGCAGCCCCTTGGA
TCTGGCCAGTGAGGAACCTGAACGCCTGCCCTGCCTGCAGCGCCTCTTGGATCTTGGAGCAGAT
GTCAACGCAGCAGACAAGAATGGGAAGACAGCGCTGTTGCATGCTCTGGCCAGCAGTGATGGGG
TGCAGATCCACAACACAGACAACATCCGGCTCCTCCTGGAGGGAGGGGCAGACGTCAAGGCTAC
CACCAAAGATGGGGACACTGTATTCACATGCATCATCTTCCTGCTCGGTGAGACCGTCTGTGGG
GACAAGGAGGAGGCCCCAATGATCAACCGCTTCTGCTTCCAAGTCACGCAGCTTTTGTTGGCCC
ATGGTGCCGACCCCAGTGAGTGCCCAGCCCACGAGTCCCTCACGCACATCTGCCTCAAGAGCTT
CAAGTTGCACTTCCCACTCCTGCGCTTCCTGCTGGAGTCAGGGGCAGCCTACAACTGCTCCCTG
CATGGTGCGTCCTGCTGGTCTGGCTTCAACCTCATTTTTGAGAGGCTCTGCTCGCACCCGGGCT
GCGCCGAGGATGATAGCCATGTTGAGCTTCTGCATAAGGCTGAGACCGTGCTGGACCTCATGGT
GACTAGCTCCCAGAGGCTGCAGCTGCCTGAGAACTTCAACATCCACCCAGTGGGTGGCTTGGCA
GGGAAGATCCAGGCCCTTCATGCCTCCCTGAGGCAGCTCGAGAGCTACCCACCACCTCTCAAAC
ACCTGTGCCGGGTGTCCATCCGGCTGTGCCTGCGACCGTGGCCTGTGGACACCAAGGTCAAAGC
GCTGCCCTTGCCGGACAGGCTCAAGTGGTACCTGCTCAGTGCACACAGTAGCCCAGAAGACACT
TGCTGAGGGATCCCAGGATAGAATGATCTGGGGTAGCCAAAGCCAGCCTGAGGGTAGGCCTGGC
ACCTGTAATCGCCTTCAGAAGGTCCTTTATCTGGGCAAGGTTTGCCCTTTTCTGCTATGAAACC
ACTAGGGGGTGCCCTGGAGGCCAAAGGCATGGCTGCCTCCAGGGAGATTCCCACCCCCTCCCTC
TTAGTATTTCACAACTGAGGGGCCAGGGCAGGCAGGATGCAGCCACCCTCTGTATTAGGAGCTG
ACTGGACCATTTGCAGGGAACTAGGGGCCAGGCCCCTCAGAACTCTGGCAACTATGGTTGGTCC
GATGGGGGAGGCACATGCCTGGGTCTTTCCAGGGGCAGTGCCAAAATTCCTGGGCCATCCAGTT
AGGCCCTACCTATTCCTGCCACCTCGGACCTCAGGATGCCTTGGAGGAGCTGGGGACAGAACTG
AGGCCAGCACAGGCTGGCCGGTCTGGGTTAGAGGCCTGCCTGGTCTTGTGGTCTTCAGGGCTCT
GGCACCATGGTTGGTGGTCCTTCTGTTCATGCCTCACCCAGGTCTCAAGGATGGTGCCTTGTTT
AAGGGCATCTCGGGAACAGCAGGACTTTGTGAGGGGTCCTTCAGAATACAGTGCTGAGGCCAGA
AGCCAGCCCTACTCCAGTGCCAAGCCCTCACAAGGTCTTCCCAGTAGGTTTGGCTTTCGGTTGT
ATAAATGCCTCTGGGAATGAGCAGAGATGATTAAATATATTTATAAGATTAAAAAAAAAAAAAA
AAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001399347 ⟹ NP_001386276

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	34,508,390 - 34,513,033 (-)	NCBI
mRatBN7.2	3	14,110,628 - 14,115,274 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001011963	(Get FASTA)	NCBI Sequence Viewer
	NP_001386276	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79099	(Get FASTA)	NCBI Sequence Viewer
	EDL93291	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000031019
	ENSRNOP00000031019.3
	ENSRNOP00000097464
	ENSRNOP00000097464.2

RefSeq Acc Id:	NP_001011963 ⟸ NM_001011963
- Peptide Label:	isoform 2
- UniProtKB:	Q6AYC9 (UniProtKB/TrEMBL), A0A8I6ANG1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAELGLTRAAAVLLQSGANLNFEDPVTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIHESS PLDLASEEPERLPCLQRLLDLGADVNAADKNGKTALLHALASSDGVQIHNTDNIRLLLEGGADV KATTKDGDTVFTCIIFLLGETVCGDKEEAPMINRFCFQVTQLLLAHGADPSECPAHESLTHICL KSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFNLIFERLCSHPGCAEDDSHVELLHKAETVLD LMVTSSQRLQLPENFNIHPVGGLAGKIQALHASLRQLESYPPPLKHLCRVSIRLCLRPWPVDTK VKALPLPDRLKWYLLSAHSSPEDTC hide sequence

Ensembl Acc Id:

ENSRNOP00000031019 ⟸ ENSRNOT00000034927

Ensembl Acc Id:

ENSRNOP00000097464 ⟸ ENSRNOT00000105180

RefSeq Acc Id:	NP_001386276 ⟸ NM_001399347
- Peptide Label:	isoform 1
- UniProtKB:	A6JU06 (UniProtKB/TrEMBL), A6JU05 (UniProtKB/TrEMBL)

Protein Domains

SOCS box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYC9-F1-model_v2	AlphaFold	Q6AYC9	1-345	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691966

Promoter ID:

EPDNEW_R2491

Type:

initiation region

Name:

Asb6_1

Description:

ankyrin repeat and SOCS box-containing 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	9,664,323 - 9,664,383	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308445	AgrOrtholog
BioCyc Gene	G2FUF-50194	BioCyc
Ensembl Genes	ENSRNOG00000024786	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000034927	ENTREZGENE
	ENSRNOT00000034927.5	UniProtKB/TrEMBL
	ENSRNOT00000105180	ENTREZGENE
	ENSRNOT00000105180.2	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
	SOCS box	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7124433	IMAGE-MGC_LOAD
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	ASB6_SOCS	UniProtKB/TrEMBL
	SOCS_box_dom_like	UniProtKB/TrEMBL
	SOCS_C	UniProtKB/TrEMBL
KEGG Report	rno:296627	UniProtKB/TrEMBL
MGC_CLONE	MGC:94078	IMAGE-MGC_LOAD
NCBI Gene	296627	ENTREZGENE
PANTHER	ANKYRIN REPEAT AND SOCS BOX PROTEIN 6	UniProtKB/TrEMBL
	ANKYRIN REPEAT AND SOCS BOX PROTEIN 6	UniProtKB/TrEMBL
Pfam	Ank_2	UniProtKB/TrEMBL
	Ank_4	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
PhenoGen	Asb6	PhenoGen
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000024786	RatGTEx
SMART	ANK	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
Superfamily-SCOP	ANK	UniProtKB/TrEMBL
	SSF158235	UniProtKB/TrEMBL
UniProt	A0A8I6ANG1	ENTREZGENE, UniProtKB/TrEMBL
	A6JU05	ENTREZGENE, UniProtKB/TrEMBL
	A6JU06	ENTREZGENE, UniProtKB/TrEMBL
	Q6AYC9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-25	Asb6	ankyrin repeat and SOCS box-containing 6	Asb6	ankyrin repeat and SOCS box-containing protein 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Asb6	ankyrin repeat and SOCS box-containing protein 6	Asb6_predicted	ankyrin repeat and SOCS box-containing protein 6 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Asb6_predicted	ankyrin repeat and SOCS box-containing protein 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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