Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hapln4 | Rat | 17beta-estradiol | increases expression | ISO | Hapln4 (Mus musculus) | 6480464 | Estradiol results in increased expression of HAPLN4 mRNA | CTD | PMID:39298647 | Hapln4 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HAPLN4 mRNA | CTD | PMID:27291303 | Hapln4 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Hapln4 (Mus musculus) | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether affects the expression of HAPLN4 mRNA | CTD | PMID:30294300 | Hapln4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Hapln4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HAPLN4 promoter] | CTD | PMID:19654925 | Hapln4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hapln4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HAPLN4 mRNA | CTD | PMID:26377647 | Hapln4 | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Hapln4 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of HAPLN4 exon; bisphenol S results in decreased methylation more ... | CTD | PMID:31683443|PMID:33297965 | Hapln4 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of HAPLN4 mRNA | CTD | PMID:24780913|PMID:30047161 | Hapln4 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of HAPLN4 mRNA | CTD | PMID:30047161|PMID:38685447 | Hapln4 | Rat | atrazine | decreases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of HAPLN4 mRNA | CTD | PMID:22378314 | Hapln4 | Rat | belinostat | decreases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | belinostat results in decreased expression of HAPLN4 mRNA | CTD | PMID:27188386 | Hapln4 | Rat | benzo[a]pyrene | decreases methylation | ISO | HAPLN4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of HAPLN4 3' UTR; Benzo(a)pyrene results in decreased methylation of more ... | CTD | PMID:27901495 | Hapln4 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HAPLN4 mRNA | CTD | PMID:25181051 | Hapln4 | Rat | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of HAPLN4 mRNA | CTD | PMID:19167457 | Hapln4 | Rat | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of HAPLN4 promoter | CTD | PMID:22457795 | Hapln4 | Rat | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of HAPLN4 mRNA | CTD | PMID:33453195 | Hapln4 | Rat | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes, Carbon results in increased expression of HAPLN4 mRNA | CTD | PMID:19836432 | Hapln4 | Rat | chlorpyrifos | increases expression | ISO | Hapln4 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of HAPLN4 mRNA | CTD | PMID:32715474|PMID:37019170 | Hapln4 | Rat | choline | multiple interactions | ISO | Hapln4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Hapln4 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of HAPLN4 mRNA | CTD | PMID:26577399 | Hapln4 | Rat | cyclosporin A | decreases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of HAPLN4 mRNA | CTD | PMID:20106945 | Hapln4 | Rat | cyclosporin A | increases expression | ISO | Hapln4 (Mus musculus) | 6480464 | Cyclosporine results in increased expression of HAPLN4 mRNA | CTD | PMID:19770486 | Hapln4 | Rat | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of HAPLN4 mRNA | CTD | PMID:23640034|PMID:23914054 | Hapln4 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of HAPLN4 mRNA | CTD | PMID:21551480 | Hapln4 | Rat | dorsomorphin | multiple interactions | ISO | HAPLN4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Hapln4 | Rat | entinostat | increases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | entinostat results in increased expression of HAPLN4 mRNA | CTD | PMID:27188386 | Hapln4 | Rat | ethanol | affects splicing | ISO | Hapln4 (Mus musculus) | 6480464 | Ethanol affects the splicing of HAPLN4 mRNA | CTD | PMID:30319688 | Hapln4 | Rat | fenthion | decreases expression | ISO | Hapln4 (Mus musculus) | 6480464 | Fenthion results in decreased expression of HAPLN4 mRNA | CTD | PMID:34813904 | Hapln4 | Rat | folic acid | multiple interactions | ISO | Hapln4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Hapln4 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of HAPLN4 mRNA | CTD | PMID:22061828|PMID:33387578 | Hapln4 | Rat | inulin | multiple interactions | ISO | Hapln4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of HAPLN4 mRNA | CTD | PMID:36331819 | Hapln4 | Rat | L-methionine | multiple interactions | ISO | Hapln4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Hapln4 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of HAPLN4 mRNA | CTD | PMID:30047161 | Hapln4 | Rat | N-nitrosodiethylamine | increases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | Diethylnitrosamine results in increased expression of HAPLN4 mRNA | CTD | PMID:21527772 | Hapln4 | Rat | okadaic acid | decreases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of HAPLN4 mRNA | CTD | PMID:38832940 | Hapln4 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Hapln4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of HAPLN4 mRNA; [perfluorooctane sulfonic more ... | CTD | PMID:36331819 | Hapln4 | Rat | phenylmercury acetate | decreases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of HAPLN4 mRNA | CTD | PMID:26272509 | Hapln4 | Rat | phenylmercury acetate | multiple interactions | ISO | HAPLN4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Hapln4 | Rat | propanal | decreases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of HAPLN4 mRNA | CTD | PMID:26079696 | Hapln4 | Rat | quartz | affects expression | EXP | | 6480464 | Quartz affects the expression of HAPLN4 mRNA | CTD | PMID:19836432 | Hapln4 | Rat | resveratrol | multiple interactions | ISO | HAPLN4 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of HAPLN4 mRNA | CTD | PMID:23557933 | Hapln4 | Rat | SB 431542 | multiple interactions | ISO | HAPLN4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Hapln4 | Rat | sodium arsenite | decreases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of HAPLN4 mRNA | CTD | PMID:29301061 | Hapln4 | Rat | sodium arsenite | increases expression | ISO | Hapln4 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of HAPLN4 mRNA | CTD | PMID:37682722 | Hapln4 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of HAPLN4 mRNA | CTD | PMID:30047161 | Hapln4 | Rat | sunitinib | decreases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of HAPLN4 mRNA | CTD | PMID:31533062 | Hapln4 | Rat | tetrachloroethene | decreases expression | ISO | Hapln4 (Mus musculus) | 6480464 | Tetrachloroethylene results in decreased expression of HAPLN4 mRNA | CTD | PMID:28973375 | Hapln4 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of HAPLN4 mRNA | CTD | PMID:34492290 | Hapln4 | Rat | titanium dioxide | increases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | titanium dioxide results in increased expression of HAPLN4 mRNA | CTD | PMID:19695317 | Hapln4 | Rat | titanium dioxide | decreases methylation | ISO | Hapln4 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of HAPLN4 gene | CTD | PMID:35295148 | Hapln4 | Rat | trichloroethene | decreases expression | ISO | Hapln4 (Mus musculus) | 6480464 | Trichloroethylene results in decreased expression of HAPLN4 mRNA | CTD | PMID:28973375 | Hapln4 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of HAPLN4 mRNA | CTD | PMID:33387578 | Hapln4 | Rat | triclosan | decreases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of HAPLN4 mRNA | CTD | PMID:30510588 | Hapln4 | Rat | valproic acid | increases expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of HAPLN4 mRNA | CTD | PMID:23179753|PMID:29154799 | Hapln4 | Rat | valproic acid | affects expression | ISO | HAPLN4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HAPLN4 mRNA | CTD | PMID:25979313 | Hapln4 | Rat | valproic acid | increases methylation | ISO | HAPLN4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of HAPLN4 gene | CTD | PMID:29154799 | | 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