Cnrip1 (cannabinoid receptor interacting protein 1) - Rat Genome Database

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Pathways
Gene: Cnrip1 (cannabinoid receptor interacting protein 1) Rattus norvegicus
Analyze
Symbol: Cnrip1
Name: cannabinoid receptor interacting protein 1
RGD ID: 1308373
Description: Enables type 1 cannabinoid receptor binding activity. Predicted to be involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynapse. Orthologous to human CNRIP1 (cannabinoid receptor interacting protein 1); INTERACTS WITH all-trans-retinoic acid; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CB1 cannabinoid receptor interacting; CB1 cannabinoid receptor-interacting protein 1; CRIP-1; Crip1a; LOC364208; RGD1308373; similar to DKFZP566K1924 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,664,435 - 95,707,062 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1495,664,774 - 95,694,371 (+)EnsemblGRCr8
mRatBN7.21491,462,877 - 91,492,739 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,462,647 - 91,492,735 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1495,775,359 - 95,802,450 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,019,686 - 97,046,778 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,484,748 - 93,511,843 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,217,547 - 100,247,235 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,217,289 - 100,247,235 (+)Ensemblrn6Rnor6.0
Rnor_5.014100,291,061 - 100,320,330 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41497,908,407 - 97,937,729 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1490,510,990 - 90,539,802 (+)NCBICelera
RGSC_v3.11497,927,551 - 97,956,872 (+)NCBI
Cytogenetic Map14q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
GABA-ergic synapse  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
presynapse  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Niehaus JL, etal., Mol Pharmacol. 2007 Dec;72(6):1557-66. Epub 2007 Sep 25.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:17634366   PMID:18308297   PMID:18782338   PMID:22079489   PMID:22871113   PMID:23286559   PMID:25657338   PMID:27895162   PMID:29476059  


Genomics

Comparative Map Data
Cnrip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,664,435 - 95,707,062 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1495,664,774 - 95,694,371 (+)EnsemblGRCr8
mRatBN7.21491,462,877 - 91,492,739 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,462,647 - 91,492,735 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1495,775,359 - 95,802,450 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,019,686 - 97,046,778 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,484,748 - 93,511,843 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,217,547 - 100,247,235 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,217,289 - 100,247,235 (+)Ensemblrn6Rnor6.0
Rnor_5.014100,291,061 - 100,320,330 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41497,908,407 - 97,937,729 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1490,510,990 - 90,539,802 (+)NCBICelera
RGSC_v3.11497,927,551 - 97,956,872 (+)NCBI
Cytogenetic Map14q22NCBI
CNRIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,284,171 - 68,319,949 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,284,171 - 68,320,051 (-)Ensemblhg38GRCh38
GRCh37268,511,303 - 68,547,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,373,646 - 68,400,347 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34268,431,793 - 68,458,494NCBI
Celera268,360,897 - 68,396,770 (-)NCBICelera
Cytogenetic Map2p14NCBI
HuRef268,248,683 - 68,284,582 (-)NCBIHuRef
CHM1_1268,442,098 - 68,477,947 (-)NCBICHM1_1
T2T-CHM13v2.0268,294,742 - 68,330,519 (-)NCBIT2T-CHM13v2.0
Cnrip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,001,859 - 17,029,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,001,586 - 17,029,371 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381117,051,859 - 17,079,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,051,586 - 17,079,371 (+)Ensemblmm10GRCm38
MGSCv371116,951,937 - 16,979,375 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361116,951,937 - 16,979,375 (+)NCBIMGSCv36mm8
Celera1117,425,098 - 17,450,009 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.5NCBI
Cnrip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,563,499 - 16,588,711 (+)Ensembl
ChiLan1.0NW_00495542416,563,499 - 16,588,711 (+)NCBIChiLan1.0ChiLan1.0
CNRIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21258,085,538 - 58,134,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A58,092,645 - 58,128,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A68,332,179 - 68,368,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A69,465,496 - 69,492,148 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A69,456,924 - 69,492,716 (-)EnsemblpanPan2panpan1.1
CNRIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,340,452 - 67,358,927 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,340,604 - 67,357,360 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1067,230,395 - 67,246,774 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01068,360,141 - 68,376,535 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,360,293 - 68,376,514 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,043,382 - 68,059,580 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,341,262 - 68,357,739 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,636,647 - 68,653,120 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CNRIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,939,481 - 73,943,131 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1373,939,486 - 73,963,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,470,781 - 77,495,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNRIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,768,496 - 38,792,368 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,769,105 - 38,792,412 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604573,174,652 - 73,207,864 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnrip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247625,029,753 - 5,054,197 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247625,030,278 - 5,051,504 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cnrip1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11185,541,719 - 85,564,603 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cnrip1
326 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:97
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000007104
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)1486271332100078267Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat

Markers in Region
RH129001  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,492,384 - 91,492,593 (+)MAPPERmRatBN7.2
Rnor_6.014100,246,884 - 100,247,092NCBIRnor6.0
Rnor_5.014100,291,204 - 100,291,412UniSTSRnor5.0
RGSC_v3.41497,937,378 - 97,937,586UniSTSRGSC3.4
Celera1490,539,451 - 90,539,659UniSTS
RH 3.4 Map14675.1UniSTS
Cytogenetic Map14q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 352 192 11 142 77 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007104   ⟹   ENSRNOP00000007104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1495,664,774 - 95,694,371 (+)Ensembl
mRatBN7.2 Ensembl1491,463,046 - 91,492,735 (+)Ensembl
Rnor_6.0 Ensembl14100,217,393 - 100,247,235 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077171   ⟹   ENSRNOP00000071855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,462,647 - 91,492,735 (+)Ensembl
Rnor_6.0 Ensembl14100,217,289 - 100,246,555 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118949   ⟹   ENSRNOP00000095876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,463,421 - 91,492,735 (+)Ensembl
RefSeq Acc Id: NM_001014232   ⟹   NP_001014254
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,664,512 - 95,694,372 (+)NCBI
mRatBN7.21491,462,877 - 91,492,739 (+)NCBI
Rnor_6.014100,217,547 - 100,247,235 (+)NCBI
Rnor_5.014100,291,061 - 100,320,330 (-)NCBI
RGSC_v3.41497,908,407 - 97,937,729 (+)RGD
Celera1490,510,990 - 90,539,802 (+)RGD
Sequence:
RefSeq Acc Id: XM_063273439   ⟹   XP_063129509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,664,435 - 95,707,062 (+)NCBI
RefSeq Acc Id: NP_001014254   ⟸   NM_001014232
- UniProtKB: A2RQR5 (UniProtKB/Swiss-Prot),   Q5M7A7 (UniProtKB/Swiss-Prot),   A6JPY5 (UniProtKB/TrEMBL),   A0A0G2K1I5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071855   ⟸   ENSRNOT00000077171
Ensembl Acc Id: ENSRNOP00000007104   ⟸   ENSRNOT00000007104
Ensembl Acc Id: ENSRNOP00000095876   ⟸   ENSRNOT00000118949
RefSeq Acc Id: XP_063129509   ⟸   XM_063273439
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7A7-F1-model_v2 AlphaFold Q5M7A7 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699509
Promoter ID:EPDNEW_R10024
Type:initiation region
Name:Cnrip1_1
Description:cannabinoid receptor interacting protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014100,217,314 - 100,217,374EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308373 AgrOrtholog
BioCyc Gene G2FUF-14936 BioCyc
Ensembl Genes ENSRNOG00000005326 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007104 ENTREZGENE
  ENSRNOT00000007104.7 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7319918 IMAGE-MGC_LOAD
InterPro CNRIP1 UniProtKB/Swiss-Prot
KEGG Report rno:364208 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105778 IMAGE-MGC_LOAD
NCBI Gene 364208 ENTREZGENE
PANTHER CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR31952 UniProtKB/Swiss-Prot
Pfam CNRIP1 UniProtKB/Swiss-Prot
PhenoGen Cnrip1 PhenoGen
RatGTEx ENSRNOG00000005326 RatGTEx
UniProt A0A0G2K1I5 ENTREZGENE
  A2RQR5 ENTREZGENE
  A6JPY5 ENTREZGENE, UniProtKB/TrEMBL
  CNRP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2RQR5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-31 Cnrip1  cannabinoid receptor interacting protein 1  RGD1308373  similar to DKFZP566K1924 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1308373  similar to DKFZP566K1924 protein  RGD1308373_predicted  similar to DKFZP566K1924 protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308373_predicted  similar to DKFZP566K1924 protein (predicted)  LOC364208_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC364208_predicted  similar to DKFZP566K1924 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL