Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Plekhh1 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of PLEKHH1 mRNA | CTD | PMID:22206623 | Plekhh1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Plekhh1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of PLEKHH1 mRNA] | CTD | PMID:22206623 | Plekhh1 | Rat | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of PLEKHH1 mRNA | CTD | PMID:25380136 | Plekhh1 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of PLEKHH1 mRNA | CTD | PMID:26496021 | Plekhh1 | Rat | 17beta-estradiol | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of PLEKHH1 mRNA | CTD | PMID:31614463 | Plekhh1 | Rat | 17beta-estradiol | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Estradiol results in increased expression of PLEKHH1 mRNA | CTD | PMID:19484750|PMID:39298647 | Plekhh1 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Plekhh1 (Mus musculus) | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether affects the expression of PLEKHH1 mRNA | CTD | PMID:24680724 | Plekhh1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLEKHH1 mRNA | CTD | PMID:26377647 | Plekhh1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLEKHH1 mRNA | CTD | PMID:33387578 | Plekhh1 | Rat | 2-methoxyethanol | increases expression | EXP | | 6480464 | methyl cellosolve results in increased expression of PLEKHH1 mRNA | CTD | PMID:21061450 | Plekhh1 | Rat | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of PLEKHH1 mRNA | CTD | PMID:25380136 | Plekhh1 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of PLEKHH1 mRNA | CTD | PMID:28973697 | Plekhh1 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PLEKHH1 mRNA | CTD | PMID:24780913 | Plekhh1 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of PLEKHH1 mRNA | CTD | PMID:28959563 | Plekhh1 | Rat | acrylamide | decreases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of PLEKHH1 mRNA | CTD | PMID:32763439 | Plekhh1 | Rat | aflatoxin B1 | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of PLEKHH1 mRNA | CTD | PMID:19770486 | Plekhh1 | Rat | all-trans-retinoic acid | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PLEKHH1 mRNA | CTD | PMID:21934132 | Plekhh1 | Rat | all-trans-retinoic acid | decreases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PLEKHH1 mRNA | CTD | PMID:33167477 | Plekhh1 | Rat | aristolochic acid A | decreases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PLEKHH1 mRNA | CTD | PMID:33212167 | Plekhh1 | Rat | arsane | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Plekhh1 | Rat | arsenic atom | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Plekhh1 | Rat | benzo[a]pyrene | decreases methylation | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PLEKHH1 5' UTR; Benzo(a)pyrene results in decreased methylation of more ... | CTD | PMID:27901495 | Plekhh1 | Rat | benzo[a]pyrene | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PLEKHH1 mRNA | CTD | PMID:19770486 | Plekhh1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of PLEKHH1 mRNA | CTD | PMID:26496021 | Plekhh1 | Rat | bisphenol A | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PLEKHH1 gene | CTD | PMID:31601247 | Plekhh1 | Rat | bisphenol A | decreases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PLEKHH1 mRNA | CTD | PMID:33670352 | Plekhh1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PLEKHH1 mRNA | CTD | PMID:34947998 | Plekhh1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PLEKHH1 mRNA | CTD | PMID:30816183|PMID:32528016 | Plekhh1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PLEKHH1 mRNA | CTD | PMID:25181051 | Plekhh1 | Rat | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of PLEKHH1 mRNA | CTD | PMID:19167457 | Plekhh1 | Rat | carbon nanotube | decreases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of PLEKHH1 mRNA | CTD | PMID:25554681 | Plekhh1 | Rat | CGP 52608 | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PLEKHH1 gene] | CTD | PMID:28238834 | Plekhh1 | Rat | choline | multiple interactions | ISO | Plekhh1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Plekhh1 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of PLEKHH1 mRNA | CTD | PMID:27523638 | Plekhh1 | Rat | dicrotophos | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of PLEKHH1 mRNA | CTD | PMID:28302478 | Plekhh1 | Rat | dorsomorphin | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Plekhh1 | Rat | doxorubicin | decreases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of PLEKHH1 mRNA | CTD | PMID:39631538 | Plekhh1 | Rat | folic acid | multiple interactions | ISO | Plekhh1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992|PMID:22206623 | Plekhh1 | Rat | FR900359 | affects phosphorylation | ISO | PLEKHH1 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PLEKHH1 protein | CTD | PMID:37730182 | Plekhh1 | Rat | fulvestrant | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PLEKHH1 gene | CTD | PMID:31601247 | Plekhh1 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PLEKHH1 mRNA | CTD | PMID:33387578 | Plekhh1 | Rat | glyphosate | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Glyphosate results in increased expression of PLEKHH1 mRNA | CTD | PMID:35897073 | Plekhh1 | Rat | L-methionine | multiple interactions | ISO | Plekhh1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Plekhh1 | Rat | manganese atom | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Plekhh1 | Rat | manganese(0) | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Plekhh1 | Rat | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of PLEKHH1 mRNA | CTD | PMID:28801915 | Plekhh1 | Rat | manganese(II) chloride | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Plekhh1 | Rat | methylmercury chloride | decreases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PLEKHH1 mRNA | CTD | PMID:28001369 | Plekhh1 | Rat | monosodium L-glutamate | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Sodium Glutamate results in increased expression of PLEKHH1 mRNA | CTD | PMID:22078008 | Plekhh1 | Rat | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PLEKHH1 mRNA | CTD | PMID:28801915 | Plekhh1 | Rat | nickel atom | decreases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Nickel results in decreased expression of PLEKHH1 mRNA | CTD | PMID:24768652|PMID:25583101 | Plekhh1 | Rat | okadaic acid | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Okadaic Acid results in increased expression of PLEKHH1 mRNA | CTD | PMID:38832940 | Plekhh1 | Rat | orphenadrine | affects expression | EXP | | 6480464 | Orphenadrine affects the expression of PLEKHH1 mRNA | CTD | PMID:23665939 | Plekhh1 | Rat | ozone | multiple interactions | ISO | Plekhh1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in increased expression of PLEKHH1 more ... | CTD | PMID:27106289 | Plekhh1 | Rat | p-chloromercuribenzoic acid | decreases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of PLEKHH1 mRNA | CTD | PMID:26272509 | Plekhh1 | Rat | p-chloromercuribenzoic acid | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Plekhh1 | Rat | paracetamol | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PLEKHH1 mRNA | CTD | PMID:22230336|PMID:29067470 | Plekhh1 | Rat | paracetamol | affects expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PLEKHH1 mRNA | CTD | PMID:17562736 | Plekhh1 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PLEKHH1 mRNA | CTD | PMID:33387578 | Plekhh1 | Rat | pentachlorophenol | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of PLEKHH1 mRNA | CTD | PMID:23892564 | Plekhh1 | Rat | perfluorohexanesulfonic acid | decreases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of PLEKHH1 mRNA | CTD | PMID:37995155 | Plekhh1 | Rat | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of PLEKHH1 mRNA | CTD | PMID:30047161 | Plekhh1 | Rat | phenobarbital | affects expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Phenobarbital affects the expression of PLEKHH1 mRNA | CTD | PMID:23091169 | Plekhh1 | Rat | pirinixic acid | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PLEKHH1 mRNA | CTD | PMID:17426115|PMID:20813756 | Plekhh1 | Rat | pirinixic acid | multiple interactions | ISO | Plekhh1 (Mus musculus) | 6480464 | [pirinixic acid co-treated with PPARA] results in increased expression of PLEKHH1 mRNA | CTD | PMID:20813756 | Plekhh1 | Rat | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of PLEKHH1 mRNA | CTD | PMID:22698814 | Plekhh1 | Rat | propiconazole | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | propiconazole results in increased expression of PLEKHH1 mRNA | CTD | PMID:21278054 | Plekhh1 | Rat | quercetin | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Quercetin results in increased expression of PLEKHH1 mRNA | CTD | PMID:21632981 | Plekhh1 | Rat | SB 431542 | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Plekhh1 | Rat | silicon dioxide | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of PLEKHH1 mRNA | CTD | PMID:25895662 | Plekhh1 | Rat | sodium arsenite | multiple interactions | ISO | PLEKHH1 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Plekhh1 | Rat | sunitinib | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PLEKHH1 mRNA | CTD | PMID:31533062 | Plekhh1 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PLEKHH1 mRNA | CTD | PMID:23411599|PMID:34492290 | Plekhh1 | Rat | titanium dioxide | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | titanium dioxide results in increased expression of PLEKHH1 mRNA | CTD | PMID:34973136 | Plekhh1 | Rat | tributylstannane | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | tributyltin results in increased expression of PLEKHH1 mRNA | CTD | PMID:31939706 | Plekhh1 | Rat | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of PLEKHH1 mRNA | CTD | PMID:30589522 | Plekhh1 | Rat | Triptolide | increases expression | ISO | Plekhh1 (Mus musculus) | 6480464 | triptolide results in increased expression of PLEKHH1 mRNA | CTD | PMID:32835833 | Plekhh1 | Rat | valproic acid | increases expression | ISO | PLEKHH1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PLEKHH1 mRNA | CTD | PMID:23179753 | Plekhh1 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PLEKHH1 mRNA | CTD | PMID:19015723 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















