Trio (trio Rho guanine nucleotide exchange factor) - Rat Genome Database

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Gene: Trio (trio Rho guanine nucleotide exchange factor) Rattus norvegicus
Analyze
Symbol: Trio
Name: trio Rho guanine nucleotide exchange factor
RGD ID: 1308360
Description: Enables enzyme binding activity. Involved in modulation of chemical synaptic transmission. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal dominant intellectual developmental disorder 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC310192; triple functional domain (PTPRF interacting); triple functional domain protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8280,235,485 - 80,531,824 (-)NCBIGRCr8
mRatBN7.2278,505,069 - 78,801,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl278,505,070 - 78,803,135 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx285,573,060 - 85,868,316 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0283,694,791 - 83,990,060 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0278,761,319 - 79,056,786 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0280,471,398 - 80,769,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl280,473,202 - 80,667,481 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02100,137,355 - 100,437,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4279,634,843 - 79,832,549 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1279,581,604 - 79,878,530 (-)NCBI
Celera274,141,588 - 74,436,556 (-)NCBICelera
Cytogenetic Map2q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel dichloride  (EXP,ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP. Herring BE and Nicoll RA, Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2264-9. doi: 10.1073/pnas.1600179113. Epub 2016 Feb 8.
4. Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action. Paskus JD, etal., Cell Rep. 2019 Dec 3;29(10):2944-2952.e5. doi: 10.1016/j.celrep.2019.10.115.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon. Terry-Lorenzo RT, etal., PLoS One. 2016 Dec 1;11(12):e0167535. doi: 10.1371/journal.pone.0167535. eCollection 2016.
9. Cdk5 and Trio modulate endocrine cell exocytosis. Xin X, etal., J Cell Sci. 2004 Sep 15;117(Pt 20):4739-48. Epub 2004 Aug 25.
Additional References at PubMed
PMID:8889548   PMID:15669055   PMID:15715966   PMID:20519585   PMID:22666460   PMID:23230270   PMID:24859002   PMID:26323693   PMID:26721934   PMID:28928363  


Genomics

Comparative Map Data
Trio
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8280,235,485 - 80,531,824 (-)NCBIGRCr8
mRatBN7.2278,505,069 - 78,801,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl278,505,070 - 78,803,135 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx285,573,060 - 85,868,316 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0283,694,791 - 83,990,060 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0278,761,319 - 79,056,786 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0280,471,398 - 80,769,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl280,473,202 - 80,667,481 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02100,137,355 - 100,437,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4279,634,843 - 79,832,549 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1279,581,604 - 79,878,530 (-)NCBI
Celera274,141,588 - 74,436,556 (-)NCBICelera
Cytogenetic Map2q22NCBI
TRIO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38514,143,342 - 14,510,204 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl514,143,342 - 14,532,128 (+)EnsemblGRCh38hg38GRCh38
GRCh37514,143,451 - 14,510,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36514,196,829 - 14,562,458 (+)NCBINCBI36Build 36hg18NCBI36
Build 34514,196,828 - 14,562,457NCBI
Celera514,168,142 - 14,532,209 (+)NCBICelera
Cytogenetic Map5p15.2NCBI
HuRef514,242,473 - 14,481,695 (+)NCBIHuRef
CHM1_1514,143,936 - 14,509,323 (+)NCBICHM1_1
T2T-CHM13v2.0514,080,499 - 14,449,245 (+)NCBIT2T-CHM13v2.0
Trio
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391527,730,735 - 28,025,954 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1527,730,737 - 28,025,934 (-)EnsemblGRCm39 Ensembl
GRCm381527,730,649 - 28,025,848 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1527,730,651 - 28,025,848 (-)EnsemblGRCm38mm10GRCm38
MGSCv371527,660,404 - 27,955,603 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361527,675,376 - 27,970,437 (-)NCBIMGSCv36mm8
Celera1528,478,779 - 28,774,257 (-)NCBICelera
Cytogenetic Map15B1NCBI
cM Map1510.4NCBI
Trio
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554263,646,728 - 3,846,988 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554263,647,273 - 3,846,916 (+)NCBIChiLan1.0ChiLan1.0
TRIO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2414,378,176 - 14,744,826 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1512,531,783 - 12,898,436 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0514,448,259 - 14,814,875 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1514,417,910 - 14,655,906 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl514,423,780 - 14,654,124 (+)Ensemblpanpan1.1panPan2
TRIO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.134271,572 - 505,656 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl34272,290 - 505,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha344,764,923 - 5,120,561 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.034182,486 - 534,192 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl34220,773 - 415,767 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.134194,569 - 548,163 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.034194,407 - 546,539 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.034437,086 - 788,757 (-)NCBIUU_Cfam_GSD_1.0
Trio
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213233,228,026 - 233,436,351 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366651,821,583 - 2,030,371 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366651,821,580 - 2,029,839 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl163,564,171 - 3,921,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1163,690,831 - 3,921,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2164,216,390 - 4,261,443 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRIO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1413,846,753 - 14,214,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl413,847,936 - 14,215,164 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606414,316,908 - 14,686,030 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trio
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475111,362,844 - 11,565,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475111,252,934 - 11,566,190 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trio
1673 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000016784, ENSRNOT00000049793
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
D2Rat75  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,665,616 - 78,665,758 (+)MAPPERmRatBN7.2
Rnor_6.0280,631,950 - 80,632,091NCBIRnor6.0
Rnor_5.02100,298,393 - 100,298,534UniSTSRnor5.0
RGSC_v3.4279,796,790 - 79,797,113RGDRGSC3.4
RGSC_v3.4279,796,831 - 79,796,972UniSTSRGSC3.4
RGSC_v3.1279,741,793 - 79,741,934RGD
Celera274,301,000 - 74,301,141UniSTS
RH 3.4 Map2396.9RGD
RH 3.4 Map2396.9UniSTS
RH 2.0 Map2399.9RGD
SHRSP x BN Map230.8998RGD
FHH x ACI Map236.4899RGD
Cytogenetic Map2q22UniSTS
D2Mco18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,665,619 - 78,665,763 (+)MAPPERmRatBN7.2
Rnor_6.0280,631,953 - 80,632,096NCBIRnor6.0
Rnor_5.02100,298,396 - 100,298,539UniSTSRnor5.0
RGSC_v3.4279,796,834 - 79,796,977UniSTSRGSC3.4
RGSC_v3.4279,796,833 - 79,796,977RGDRGSC3.4
RGSC_v3.1279,741,795 - 79,741,939RGD
Celera274,301,003 - 74,301,146UniSTS
Cytogenetic Map2q22UniSTS
D2Chm172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,794,334 - 78,794,584 (+)MAPPERmRatBN7.2
Rnor_6.0280,762,019 - 80,762,268NCBIRnor6.0
Rnor_5.02100,429,269 - 100,429,518UniSTSRnor5.0
RGSC_v3.4279,927,091 - 79,927,340UniSTSRGSC3.4
Celera274,429,947 - 74,430,196UniSTS
Cytogenetic Map2q22UniSTS
D2Got381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,580,439 - 78,580,561 (+)MAPPERmRatBN7.2
Rnor_6.0280,546,796 - 80,546,915NCBIRnor6.0
Rnor_5.02100,213,239 - 100,213,358UniSTSRnor5.0
RGSC_v3.4279,711,313 - 79,711,432UniSTSRGSC3.4
Celera274,215,838 - 74,215,957UniSTS
Cytogenetic Map2q22UniSTS
RH144049  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,532,627 - 78,532,748 (+)MAPPERmRatBN7.2
Rnor_6.0280,498,950 - 80,499,070NCBIRnor6.0
Rnor_5.02100,165,624 - 100,165,744UniSTSRnor5.0
RGSC_v3.4279,662,694 - 79,662,814UniSTSRGSC3.4
Celera274,169,077 - 74,169,197UniSTS
RH 3.4 Map2395.5UniSTS
Cytogenetic Map2q22UniSTS
RH140371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,505,210 - 78,505,373 (+)MAPPERmRatBN7.2
Rnor_6.0280,471,540 - 80,471,702NCBIRnor6.0
Rnor_5.02100,137,497 - 100,137,659UniSTSRnor5.0
RGSC_v3.4279,634,981 - 79,635,143UniSTSRGSC3.4
Celera274,141,730 - 74,141,892UniSTS
Cytogenetic Map2q22UniSTS
RH128153  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,505,672 - 78,505,853 (+)MAPPERmRatBN7.2
Rnor_6.0280,472,002 - 80,472,182NCBIRnor6.0
Rnor_5.02100,137,959 - 100,138,139UniSTSRnor5.0
RGSC_v3.4279,635,443 - 79,635,623UniSTSRGSC3.4
Celera274,142,192 - 74,142,372UniSTS
Cytogenetic Map2q22UniSTS
RH142794  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,506,240 - 78,506,359 (+)MAPPERmRatBN7.2
Rnor_6.0280,472,570 - 80,472,688NCBIRnor6.0
Rnor_5.02100,138,527 - 100,138,645UniSTSRnor5.0
RGSC_v3.4279,636,011 - 79,636,129UniSTSRGSC3.4
Celera274,142,760 - 74,142,878UniSTS
RH 3.4 Map2394.0UniSTS
Cytogenetic Map2q22UniSTS
RH143590  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,618,167 - 78,618,294 (+)MAPPERmRatBN7.2
Rnor_6.0280,584,500 - 80,584,626NCBIRnor6.0
Rnor_5.02100,250,943 - 100,251,069UniSTSRnor5.0
RGSC_v3.4279,749,381 - 79,749,507UniSTSRGSC3.4
Celera274,253,556 - 74,253,682UniSTS
RH 3.4 Map2396.5UniSTS
Cytogenetic Map2q22UniSTS
RH143835  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,774,446 - 78,774,724 (+)MAPPERmRatBN7.2
Rnor_6.0280,742,132 - 80,742,409NCBIRnor6.0
Rnor_5.02100,409,382 - 100,409,659UniSTSRnor5.0
RGSC_v3.4279,907,204 - 79,907,481UniSTSRGSC3.4
Celera274,410,032 - 74,410,309UniSTS
RH 3.4 Map2397.8UniSTS
Cytogenetic Map2q22UniSTS
BE106322  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,698,221 - 78,698,372 (+)MAPPERmRatBN7.2
Rnor_6.0280,665,909 - 80,666,059NCBIRnor6.0
Rnor_5.02100,333,159 - 100,333,309UniSTSRnor5.0
RGSC_v3.4279,830,981 - 79,831,131UniSTSRGSC3.4
Celera274,333,391 - 74,333,541UniSTS
RH 3.4 Map2396.0UniSTS
Cytogenetic Map2q22UniSTS
BE115314  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,544,060 - 78,544,226 (+)MAPPERmRatBN7.2
Rnor_6.0280,510,380 - 80,510,545NCBIRnor6.0
Rnor_5.02100,177,054 - 100,177,219UniSTSRnor5.0
RGSC_v3.4279,674,062 - 79,674,227UniSTSRGSC3.4
Celera274,179,449 - 74,179,614UniSTS
RH 3.4 Map2397.0UniSTS
Cytogenetic Map2q22UniSTS
RH138486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,513,320 - 78,513,484 (+)MAPPERmRatBN7.2
Rnor_6.0280,479,650 - 80,479,813NCBIRnor6.0
Rnor_5.02100,145,607 - 100,145,770UniSTSRnor5.0
RGSC_v3.4279,643,091 - 79,643,254UniSTSRGSC3.4
Celera274,149,840 - 74,150,003UniSTS
RH 3.4 Map2385.8UniSTS
Cytogenetic Map2q22UniSTS
RH139536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,505,210 - 78,505,390 (+)MAPPERmRatBN7.2
Rnor_6.0280,471,540 - 80,471,719NCBIRnor6.0
Rnor_5.02100,137,497 - 100,137,676UniSTSRnor5.0
RGSC_v3.4279,634,981 - 79,635,160UniSTSRGSC3.4
Celera274,141,730 - 74,141,909UniSTS
RH 3.4 Map2394.1UniSTS
Cytogenetic Map2q22UniSTS
BE119929  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,611,740 - 78,611,910 (+)MAPPERmRatBN7.2
Rnor_6.0280,578,073 - 80,578,242NCBIRnor6.0
Rnor_5.02100,244,516 - 100,244,685UniSTSRnor5.0
RGSC_v3.4279,742,954 - 79,743,123UniSTSRGSC3.4
Celera274,247,129 - 74,247,298UniSTS
RH 3.4 Map2394.5UniSTS
Cytogenetic Map2q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003749226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003753540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BF522721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ211464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB546429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016784   ⟹   ENSRNOP00000016784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl278,505,070 - 78,699,794 (-)Ensembl
Rnor_6.0 Ensembl280,473,202 - 80,667,481 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093833   ⟹   ENSRNOP00000091530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl278,505,070 - 78,803,135 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099604   ⟹   ENSRNOP00000081265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl278,545,095 - 78,803,135 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107418   ⟹   ENSRNOP00000076435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl278,505,070 - 78,803,135 (-)Ensembl
RefSeq Acc Id: NM_001107658   ⟹   NP_001101128
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8280,235,485 - 80,531,612 (-)NCBI
mRatBN7.2278,505,069 - 78,801,207 (-)NCBI
RefSeq Acc Id: XM_006232090   ⟹   XP_006232152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8280,235,485 - 80,531,824 (-)NCBI
mRatBN7.2278,505,069 - 78,801,384 (-)NCBI
Rnor_6.0280,471,398 - 80,769,313 (-)NCBI
Rnor_5.02100,137,355 - 100,437,964 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232091   ⟹   XP_006232153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8280,235,485 - 80,531,127 (-)NCBI
mRatBN7.2278,505,069 - 78,800,738 (-)NCBI
Rnor_6.0280,473,202 - 80,767,997 (-)NCBI
Rnor_5.02100,137,355 - 100,437,964 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591212   ⟹   XP_017446701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8280,247,534 - 80,531,824 (-)NCBI
mRatBN7.2278,517,118 - 78,801,384 (-)NCBI
Rnor_6.0280,483,497 - 80,769,312 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102226   ⟹   XP_038958154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8280,235,485 - 80,380,061 (-)NCBI
mRatBN7.2278,505,069 - 78,649,651 (-)NCBI
RefSeq Acc Id: XP_006232152   ⟸   XM_006232090
- Peptide Label: isoform X1
- UniProtKB: F1M0Z1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232153   ⟸   XM_006232091
- Peptide Label: isoform X2
- UniProtKB: A0A1P0PBZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446701   ⟸   XM_017591212
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000016784   ⟸   ENSRNOT00000016784
RefSeq Acc Id: NP_001101128   ⟸   NM_001107658
- UniProtKB: F1M0Z1 (UniProtKB/Swiss-Prot),   A0A8I6AS57 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958154   ⟸   XM_039102226
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000091530   ⟸   ENSRNOT00000093833
Ensembl Acc Id: ENSRNOP00000081265   ⟸   ENSRNOT00000099604
Ensembl Acc Id: ENSRNOP00000076435   ⟸   ENSRNOT00000107418
Protein Domains
CRAL-TRIO   DH   Ig-like   Ig-like C2-type   PH   Protein kinase   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308360 AgrOrtholog
BioCyc Gene G2FUF-53911 BioCyc
Ensembl Genes ENSRNOG00000012148 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016784.8 UniProtKB/TrEMBL
  ENSRNOT00000093833.1 UniProtKB/TrEMBL
  ENSRNOT00000099604.1 UniProtKB/TrEMBL
  ENSRNOT00000107418.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.525.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kalirin_TRIO_PH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kalirin_TRIO_SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF_Guanine_NuclExch_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 310192 ENTREZGENE
PANTHER DH DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED UniProtKB/TrEMBL
  RHO GUANINE EXCHANGE FACTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIPLE FUNCTIONAL DOMAIN PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CRAL_TRIO_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-RhoG_link UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trio PhenoGen
PROSITE CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012148 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEC14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1P0PBZ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5XUX3_RAT UniProtKB/TrEMBL
  A0A8I5ZS58_RAT UniProtKB/TrEMBL
  A0A8I6AS57 ENTREZGENE, UniProtKB/TrEMBL
  A6JMY2_RAT UniProtKB/TrEMBL
  F1M0Z1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-02 Trio  trio Rho guanine nucleotide exchange factor  Trio  triple functional domain (PTPRF interacting)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Trio  triple functional domain (PTPRF interacting)  Trio_predicted  triple functional domain (PTPRF interacting) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Trio_predicted  triple functional domain (PTPRF interacting) (predicted)      Symbol and Name status set to approved 70820 APPROVED