Prxl2b (peroxiredoxin like 2B) - Rat Genome Database

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Gene: Prxl2b (peroxiredoxin like 2B) Rattus norvegicus
Analyze
Symbol: Prxl2b
Name: peroxiredoxin like 2B
RGD ID: 1308251
Description: Predicted to enable prostaglandin-F synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Located in myelin sheath. Orthologous to human PRXL2B (peroxiredoxin like 2B); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fam213b; family with sequence similarity 213, member B; hypothetical protein LOC362676; LOC362676; prostamide/PG F synthase; prostamide/PGF synthase; prostamide/prostaglandin F synthase; RGD1308251; similar to RIKEN cDNA 2810405K02
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,744,953 - 170,747,556 (-)NCBIGRCr8
mRatBN7.25165,462,610 - 165,465,213 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx5168,167,749 - 168,170,352 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,989,159 - 169,991,762 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,951,697 - 169,954,300 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,304,799 - 172,307,402 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,304,758 - 172,307,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,760,762 - 175,763,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,704,247 - 171,706,850 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,714,741 - 171,717,325 (-)NCBI
Celera5163,669,128 - 163,671,731 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (ISO)
endoplasmic reticulum  (ISO,ISS)
myelin sheath  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily. Moriuchi H, etal., J Biol Chem. 2008 Jan 11;283(2):792-801. Epub 2007 Nov 15.
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. Yoshikawa K, etal., Brain Res. 2011 Jan 7;1367:22-32. doi: 10.1016/j.brainres.2010.10.019. Epub 2010 Oct 13.
Additional References at PubMed
PMID:19056867   PMID:23376485  


Genomics

Comparative Map Data
Prxl2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,744,953 - 170,747,556 (-)NCBIGRCr8
mRatBN7.25165,462,610 - 165,465,213 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx5168,167,749 - 168,170,352 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,989,159 - 169,991,762 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,951,697 - 169,954,300 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,304,799 - 172,307,402 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,304,758 - 172,307,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,760,762 - 175,763,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,704,247 - 171,706,850 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,714,741 - 171,717,325 (-)NCBI
Celera5163,669,128 - 163,671,731 (-)NCBICelera
Cytogenetic Map5q36NCBI
PRXL2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,586,523 - 2,591,468 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,586,491 - 2,591,469 (+)EnsemblGRCh38hg38GRCh38
GRCh3712,517,962 - 2,522,907 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,508,109 - 2,512,762 (+)NCBINCBI36Build 36hg18NCBI36
Celera163,098 - 67,751 (-)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef11,797,135 - 1,802,144 (+)NCBIHuRef
CHM1_112,504,978 - 2,509,987 (+)NCBICHM1_1
T2T-CHM13v2.012,028,168 - 2,033,113 (+)NCBIT2T-CHM13v2.0
Prxl2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,980,884 - 154,983,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,979,961 - 154,983,592 (-)EnsemblGRCm39 Ensembl
GRCm384154,896,430 - 154,899,043 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,895,504 - 154,899,135 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,270,539 - 154,273,152 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,740,230 - 153,742,843 (-)NCBIMGSCv36mm8
Celera4157,167,936 - 157,170,549 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map485.67NCBI
Prxl2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,663,595 - 8,666,469 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,663,708 - 8,666,369 (-)NCBIChiLan1.0ChiLan1.0
PRXL2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,656,040 - 225,660,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,316,576 - 224,321,263 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,319,718 - 1,324,409 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,457,130 - 2,463,858 (+)NCBIpanpan1.1PanPan1.1panPan2
PRXL2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,429,973 - 57,434,371 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,429,212 - 57,434,210 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,443,767 - 57,448,116 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,634,086 - 57,638,435 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1557,625,412 - 57,629,761 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,517,700 - 57,522,050 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,907,472 - 57,911,821 (+)NCBIUU_Cfam_GSD_1.0
Prxl2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,465,190 - 28,467,637 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936737998,186 - 1,000,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936737998,313 - 1,000,757 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRXL2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,432,148 - 64,435,320 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,432,187 - 64,435,328 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,856,668 - 58,859,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRXL2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120128,964,750 - 128,969,469 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20128,964,987 - 128,967,620 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605433,307,985 - 33,311,032 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prxl2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,483,001 - 7,485,431 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,478,680 - 7,485,431 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prxl2b
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000018453
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
AI836168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,462,654 - 165,462,778 (+)MAPPERmRatBN7.2
Rnor_6.05172,304,844 - 172,304,967NCBIRnor6.0
Rnor_5.05175,760,807 - 175,760,930UniSTSRnor5.0
RGSC_v3.45171,704,292 - 171,704,415UniSTSRGSC3.4
Celera5163,669,173 - 163,669,296UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 11 28 20 10 20 8 11 70 33 13 8
Low 1 32 29 21 9 21 4 2 27 11
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018453   ⟹   ENSRNOP00000018453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5172,304,758 - 172,307,431 (-)Ensembl
RefSeq Acc Id: NM_001108697   ⟹   NP_001102167
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,744,953 - 170,747,556 (-)NCBI
mRatBN7.25165,462,610 - 165,465,213 (-)NCBI
Rnor_6.05172,304,799 - 172,307,402 (-)NCBI
Rnor_5.05175,760,762 - 175,763,365 (-)NCBI
RGSC_v3.45171,704,247 - 171,706,850 (-)RGD
Celera5163,669,128 - 163,671,731 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102167 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZVR7 (Get FASTA)   NCBI Sequence Viewer  
  EDL81278 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00065013651
Reference Protein Sequences
RefSeq Acc Id: NP_001102167   ⟸   NM_001108697
- UniProtKB: D3ZVR7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018453   ⟸   ENSRNOT00000018453

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVR7-F1-model_v2 AlphaFold D3ZVR7 1-201 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694313
Promoter ID:EPDNEW_R4838
Type:multiple initiation site
Name:Fam213b_1
Description:family with sequence similarity 213, member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05172,307,381 - 172,307,441EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308251 AgrOrtholog
BioCyc Gene G2FUF-38945 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000013468 Ensembl
  ENSRNOG00065011030 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00065017856 UniProtKB/Swiss-Prot
InterPro PXL2A/B/C UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:362676 UniProtKB/Swiss-Prot
NCBI Gene 362676 ENTREZGENE
PANTHER PROSTAMIDE/PROSTAGLANDIN F SYNTHASE UniProtKB/Swiss-Prot
  PTHR28630 UniProtKB/Swiss-Prot
Pfam AhpC-TSA_2 UniProtKB/Swiss-Prot
PhenoGen Prxl2b PhenoGen
RatGTEx ENSRNOG00000013468 RatGTEx
  ENSRNOG00065011030 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt D3ZVR7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-26 Prxl2b  peroxiredoxin like 2B  Fam213b  family with sequence similarity 213, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-06 Fam213b  family with sequence similarity 213, member B  RGD1308251  similar to RIKEN cDNA 2810405K02  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308251  similar to RIKEN cDNA 2810405K02   RGD1308251_predicted  similar to RIKEN cDNA 2810405K02 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308251_predicted  similar to RIKEN cDNA 2810405K02 (predicted)  LOC362676_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362676_predicted  similar to RIKEN cDNA 2810405K02 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL