Fosb (FosB proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fosb (FosB proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
Analyze
Symbol: Fosb
Name: FosB proto-oncogene, AP-1 transcription factor subunit
RGD ID: 1308198
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including behavioral response to cocaine; response to corticosterone; and response to progesterone. Located in cytosol and nucleus. Used to study heroin dependence and morphine dependence. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; amphetamine abuse; cocaine abuse; and drug dependence (multiple). Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit); INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FBJ osteosarcoma oncogene B; FBJ osteosarcoma viral oncogene isoform deltaFosb-2; fra-2; LOC100360880; transcription factor AP-1 subunit FosB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,082,324 - 88,089,506 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,082,127 - 88,089,477 (-)EnsemblGRCr8
mRatBN7.2178,954,312 - 78,961,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,954,115 - 78,961,465 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,343,248 - 84,350,106 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,900,923 - 92,907,784 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,098,337 - 86,105,195 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,214,691 - 80,221,417 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,214,494 - 80,221,710 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,480,955 - 81,510,687 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,668,497 - 78,673,330 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,416,543 - 73,423,390 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP)
8-OH-DPAT  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
agmatine  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
amphetamine  (EXP,ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
DDT  (EXP)
Delta(9)-tetrahydrocannabinolic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
disulfiram  (ISO)
dizocilpine maleate  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ferric oxide  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
haloperidol  (EXP,ISO)
heroin  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
ibuprofen  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
kenpaullone  (EXP)
L-methionine  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
mechlorethamine  (ISO)
melphalan  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
naloxone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (EXP)
okadaic acid  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
phencyclidine  (EXP)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pifithrin-alpha hydrobromide  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
rimonabant  (EXP)
SCH 23390  (EXP,ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium hypochlorite  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
tramadol  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Stress-Induced Locomotor Sensitization to Amphetamine in Adult, but not in Adolescent Rats, Is Associated with Increased Expression of ΔFosB in the Nucleus Accumbens. Carneiro de Oliveira PE, etal., Front Behav Neurosci. 2016 Sep 12;10:173. doi: 10.3389/fnbeh.2016.00173. eCollection 2016.
2. H3K4 dimethylation at FosB promoter in the striatum of chronic stressed rats promotes morphine-induced conditioned place preference. Chen M, etal., PLoS One. 2019 Aug 23;14(8):e0221506. doi: 10.1371/journal.pone.0221506. eCollection 2019.
3. Comparison of c-jun, junB, and junD mRNA expression and protein in the rat dorsal root ganglia following sciatic nerve transection. De León M, etal., J Neurosci Res. 1995 Oct 15;42(3):391-401. doi: 10.1002/jnr.490420314.
4. Withdrawal induces distinct patterns of FosB/∆FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization. De Pauli RF, etal., Pharmacol Biochem Behav. 2014 Feb;117:70-8. doi: 10.1016/j.pbb.2013.12.007. Epub 2013 Dec 16.
5. Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas. El Rawas R, etal., Front Behav Neurosci. 2012 Mar 2;6:8. doi: 10.3389/fnbeh.2012.00008. eCollection 2012.
6. Primary gene response to mechanical loading in healing rat Achilles tendons. Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
7. Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients. Gajewski PA, etal., PLoS One. 2016 Aug 5;11(8):e0160355. doi: 10.1371/journal.pone.0160355. eCollection 2016.
8. Increased alcohol consumption in sleep-restricted rats is mediated by delta FosB induction. García-García F, etal., Alcohol. 2021 Jun;93:63-70. doi: 10.1016/j.alcohol.2021.02.004. Epub 2021 Mar 1.
9. Glucocorticoids regulation of FosB/ΔFosB expression induced by chronic opiate exposure in the brain stress system. García-Pérez D, etal., PLoS One. 2012;7(11):e50264. doi: 10.1371/journal.pone.0050264. Epub 2012 Nov 21.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats. Guo L, etal., Drug Alcohol Depend. 2013 Apr 1;129(1-2):70-81. doi: 10.1016/j.drugalcdep.2012.09.012. Epub 2012 Oct 11.
13. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
14. Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge. Hansson AC and Fuxe K, Brain Res. 2008 Jun 18;1215:1-10. Epub 2008 Apr 10.
15. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Hiroi N, etal., Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10397-402. doi: 10.1073/pnas.94.19.10397.
16. The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect. Huang M, etal., Behav Brain Res. 2018 Jan 30;337:280-286. doi: 10.1016/j.bbr.2017.07.047. Epub 2017 Aug 4.
17. Differences in basal and morphine-induced FosB/DeltaFosB and pCREB immunoreactivities in dopaminergic brain regions of alcohol-preferring AA and alcohol-avoiding ANA rats. Kaste K, etal., Pharmacol Biochem Behav. 2009 Jun;92(4):655-62. doi: 10.1016/j.pbb.2009.03.004. Epub 2009 Mar 24.
18. Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex. Kontkanen O, etal., Neuropsychopharmacology. 2002 Aug;27(2):152-62.
19. Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal. Larson EB, etal., J Neurochem. 2010 Oct;115(1):112-22. doi: 10.1111/j.1471-4159.2010.06907.x. Epub 2010 Aug 3.
20. Region-specific induction of FosB/ΔFosB by voluntary alcohol intake: effects of naltrexone. Li J, etal., Alcohol Clin Exp Res. 2010 Oct;34(10):1742-50. doi: 10.1111/j.1530-0277.2010.01261.x. Epub 2010 Jul 9.
21. Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB/ΔFosB levels in reward-related brain regions. Li J, etal., PLoS One. 2012;7(7):e40347. doi: 10.1371/journal.pone.0040347. Epub 2012 Jul 9.
22. Vagus nerve stimulation inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in rats. Liu H, etal., Neurosci Lett. 2011 Apr 20;494(1):70-4. doi: 10.1016/j.neulet.2011.02.059. Epub 2011 Mar 6.
23. Accumbal FosB/DeltaFosB immunoreactivity and conditioned place preference in alcohol-preferring AA rats and alcohol-avoiding ANA rats treated repeatedly with cocaine. Marttila K, etal., Brain Res. 2007 Jul 30;1160:82-90. doi: 10.1016/j.brainres.2007.05.036. Epub 2007 May 31.
24. Early activation of transcription factor expression in Schwann cells by progesterone. Mercier G, etal., Brain Res Mol Brain Res. 2001 Dec 30;97(2):137-48.
25. Rapid effects of triiodothyronine on immediate-early gene expression in Schwann cells. Mercier G, etal., Glia. 2001 Aug;35(2):81-9.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Differential expression of activator protein-1 transcription factors in pregnant rat myometrium. Mitchell JA and Lye SJ, Biol Reprod. 2002 Jul;67(1):240-6.
28. Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells. Mitchell JA, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E439-45. Epub 2004 May 4.
29. Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats. Moon S, etal., Neurochem Res. 2019 Apr;44(4):874-883. doi: 10.1007/s11064-019-02720-9. Epub 2019 Jan 10.
30. D1 dopamine receptors modulate deltaFosB induction in rat striatum after intermittent morphine administration. Muller DL and Unterwald EM, J Pharmacol Exp Ther. 2005 Jul;314(1):148-54. Epub 2005 Mar 16.
31. NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior. Nygard SK, etal., Behav Brain Res. 2017 Jan 15;317:218-225. doi: 10.1016/j.bbr.2016.09.047. Epub 2016 Sep 21.
32. Sexually dimorphic intracellular responses after cocaine-induced conditioned place preference expression. Nygard SK, etal., Brain Res. 2013 Jul 3;1520:121-33. doi: 10.1016/j.brainres.2013.04.060. Epub 2013 May 9.
33. Region and context-specific intracellular responses associated with cocaine-induced conditioned place preference expression. Nygard SK, etal., Neuroscience. 2015 Feb 26;287:1-8. doi: 10.1016/j.neuroscience.2014.12.010. Epub 2014 Dec 15.
34. Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. Núñez C, etal., J Neurochem. 2010 Jul;114(2):475-87. doi: 10.1111/j.1471-4159.2010.06765.x. Epub 2010 Apr 23.
35. GOA pipeline RGD automated data pipeline
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Unique Behavioral and Neurochemical Effects Induced by Repeated Adolescent Consumption of Caffeine-Mixed Alcohol in C57BL/6 Mice. Robins MT, etal., PLoS One. 2016 Jul 5;11(7):e0158189. doi: 10.1371/journal.pone.0158189. eCollection 2016.
38. Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice. Ryabinin AE and Wang YM, Alcohol Clin Exp Res. 1998 Nov;22(8):1646-54.
39. Tramadol induces changes in Δ-FosB, µ-opioid receptor, and p-CREB level in the nucleus accumbens and prefrontal cortex of male Wistar rat. Sadat-Shirazi MS, etal., Am J Drug Alcohol Abuse. 2019;45(1):84-89. doi: 10.1080/00952990.2018.1529182. Epub 2019 Jan 11.
40. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. Sharma SC and Richards JS, J Biol Chem. 2000 Oct 27;275(43):33718-28.
41. Nicotine increases FosB expression within a subset of reward- and memory-related brain regions during both peri- and post-adolescence. Soderstrom K, etal., Psychopharmacology (Berl). 2007 May;191(4):891-7. doi: 10.1007/s00213-007-0744-9. Epub 2007 Feb 27.
42. [Effects of electroacupuncture of low frequency on heroin-seeking behavior and FosB protein expression in relative brain regions]. Sun LM, etal., Zhongguo Zhen Jiu. 2006 Nov;26(11):833-7.
43. Expression pattern of JunD after acute or chronic L-DOPA treatment: comparison with deltaFosB. Valastro B, etal., Neuroscience. 2007 Jan 5;144(1):198-207. doi: 10.1016/j.neuroscience.2006.09.001. Epub 2006 Oct 19.
44. Regional changes in ∆FosB expression in rat brain following MDMA self-administration predict increased sensitivity to effects of locally infused MDMA. van de Wetering R and Schenk S, Addict Biol. 2020 Sep;25(5):e12814. doi: 10.1111/adb.12814. Epub 2019 Aug 1.
45. Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Varghese S, etal., Endocrinology. 2000 Jun;141(6):2185-91.
46. Effects of enriched environment on morphine-induced reward in mice. Xu Z, etal., Exp Neurol. 2007 Apr;204(2):714-9. doi: 10.1016/j.expneurol.2006.12.027. Epub 2007 Jan 27.
47. Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: The possible role of μ-opioid receptors and ΔFosB in the brain reward pathway. Yazdanfar N, etal., Brain Res Bull. 2021 May;170:98-105. doi: 10.1016/j.brainresbull.2021.02.005. Epub 2021 Feb 13.
48. Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice. Zhu H, etal., Hum Mol Genet. 2007 Apr 1;16(7):820-36. doi: 10.1093/hmg/ddm027.
Additional References at PubMed
PMID:7790908   PMID:12220541   PMID:12371906   PMID:12525489   PMID:15081600   PMID:15458969   PMID:15564575   PMID:15632090   PMID:15802201   PMID:15828020   PMID:15926929   PMID:16303124  
PMID:16373449   PMID:16633904   PMID:16687504   PMID:17561814   PMID:17640529   PMID:17898221   PMID:17936518   PMID:18280640   PMID:18320311   PMID:18377962   PMID:18842886   PMID:19135469  
PMID:19303854   PMID:19560520   PMID:20513656   PMID:20618447   PMID:21507338   PMID:21820506   PMID:22286499   PMID:22387553   PMID:22521816   PMID:22621966   PMID:22689746   PMID:23022956  
PMID:23426671   PMID:23585124   PMID:23895375   PMID:24026072   PMID:24090157   PMID:24246425   PMID:25721540   PMID:26164345   PMID:27530066   PMID:27542594   PMID:28003214   PMID:29101166  
PMID:30503921   PMID:33677486   PMID:34699790   PMID:37642495  


Genomics

Comparative Map Data
Fosb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,082,324 - 88,089,506 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,082,127 - 88,089,477 (-)EnsemblGRCr8
mRatBN7.2178,954,312 - 78,961,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,954,115 - 78,961,465 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,343,248 - 84,350,106 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,900,923 - 92,907,784 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,098,337 - 86,105,195 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,214,691 - 80,221,417 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,214,494 - 80,221,710 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,480,955 - 81,510,687 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,668,497 - 78,673,330 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,416,543 - 73,423,390 (-)NCBICelera
Cytogenetic Map1q21NCBI
FOSB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,467,996 - 45,475,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,467,995 - 45,475,179 (+)Ensemblhg38GRCh38
GRCh371945,971,254 - 45,978,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,663,093 - 50,670,276 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341950,663,092 - 50,670,276NCBI
Celera1942,777,353 - 42,784,537 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,400,874 - 42,408,060 (+)NCBIHuRef
CHM1_11945,974,496 - 45,981,682 (+)NCBICHM1_1
T2T-CHM13v2.01948,295,244 - 48,302,427 (+)NCBIT2T-CHM13v2.0
Fosb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,036,621 - 19,043,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,036,621 - 19,043,976 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,302,696 - 19,310,118 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,302,696 - 19,310,051 (-)Ensemblmm10GRCm38
MGSCv37719,888,045 - 19,895,394 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36718,461,436 - 18,468,273 (-)NCBIMGSCv36mm8
Celera716,719,831 - 16,727,180 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.56NCBI
Fosb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,438,864 - 2,445,846 (+)Ensembl
ChiLan1.0NW_0049555552,438,864 - 2,445,846 (+)NCBIChiLan1.0ChiLan1.0
FOSB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,628,596 - 51,636,058 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,500,106 - 53,507,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,416,781 - 42,424,003 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,013,350 - 51,020,570 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,013,350 - 51,020,570 (+)EnsemblpanPan2panpan1.1
FOSB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,088,686 - 110,092,818 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,087,036 - 110,092,818 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1109,572,939 - 109,577,071 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01110,619,054 - 110,625,469 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,619,068 - 110,625,971 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,297,099 - 110,301,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,931,231 - 109,935,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,800,596 - 110,804,728 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fosb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,553,572 - 17,560,226 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,900,931 - 1,906,772 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,900,954 - 1,907,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOSB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,837,719 - 51,844,529 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1651,836,780 - 51,844,531 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FOSB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,916,039 - 38,924,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607318,534,366 - 18,539,824 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fosb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249072,328,691 - 2,339,099 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249072,332,746 - 2,338,825 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fosb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12171,311,080 - 171,318,457 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fosb
76 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:217
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000072149
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
RH135266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,954,237 - 78,954,423 (+)MAPPERmRatBN7.2
Rnor_6.0180,214,617 - 80,214,802NCBIRnor6.0
Rnor_5.0181,481,100 - 81,481,285UniSTSRnor5.0
RGSC_v3.4178,666,557 - 78,666,742UniSTSRGSC3.4
Celera173,416,469 - 73,416,654UniSTS
RH 3.4 Map1787.5UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 160 71 70 39 92 39 6 335 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000072149   ⟹   ENSRNOP00000065427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,082,324 - 88,089,184 (-)Ensembl
mRatBN7.2 Ensembl178,954,312 - 78,961,172 (-)Ensembl
Rnor_6.0 Ensembl180,214,691 - 80,221,417 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091687   ⟹   ENSRNOP00000073814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,082,127 - 88,089,477 (-)Ensembl
mRatBN7.2 Ensembl178,954,115 - 78,961,465 (-)Ensembl
Rnor_6.0 Ensembl180,214,494 - 80,221,710 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109325   ⟹   ENSRNOP00000091996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,083,396 - 88,089,477 (-)Ensembl
mRatBN7.2 Ensembl178,955,918 - 78,961,465 (-)Ensembl
RefSeq Acc Id: NM_001256509   ⟹   NP_001243438
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,082,324 - 88,089,184 (-)NCBI
mRatBN7.2178,954,312 - 78,961,172 (-)NCBI
Rnor_6.0180,214,691 - 80,221,417 (-)NCBI
Rnor_5.0181,480,955 - 81,510,687 (-)NCBI
Celera173,416,543 - 73,423,390 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101873   ⟹   XP_038957801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,083,291 - 88,089,506 (-)NCBI
mRatBN7.2178,956,246 - 78,961,492 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001243438 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957801 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AGR67147 (Get FASTA)   NCBI Sequence Viewer  
  D3ZLB7 (Get FASTA)   NCBI Sequence Viewer  
  EDM08212 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065427
  ENSRNOP00000065427.1
  ENSRNOP00000091996
RefSeq Acc Id: NP_001243438   ⟸   NM_001256509
- UniProtKB: D3ZLB7 (UniProtKB/Swiss-Prot),   S5NB67 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065427   ⟸   ENSRNOT00000072149
Ensembl Acc Id: ENSRNOP00000073814   ⟸   ENSRNOT00000091687
RefSeq Acc Id: XP_038957801   ⟸   XM_039101873
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AEQ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091996   ⟸   ENSRNOT00000109325
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLB7-F1-model_v2 AlphaFold D3ZLB7 1-338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689774
Promoter ID:EPDNEW_R291
Type:initiation region
Name:Fosb_1
Description:FosB proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,221,674 - 80,221,734EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308198 AgrOrtholog
BioCyc Gene G2FUF-60514 BioCyc
Ensembl Genes ENSRNOG00000046667 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072149 ENTREZGENE
  ENSRNOT00000072149.2 UniProtKB/Swiss-Prot
  ENSRNOT00000109325 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
InterPro AP-1 UniProtKB/Swiss-Prot
  bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
KEGG Report rno:100360880 UniProtKB/Swiss-Prot
NCBI Gene Fosb ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot
  PTHR23351:SF3 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
PhenoGen Fosb PhenoGen
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046667 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt A0A8I6AEQ0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLB7 ENTREZGENE, UniProtKB/Swiss-Prot
  S5NB67 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-11 Fosb  FosB proto-oncogene, AP-1 transcription factor subunit  Fosb  FBJ osteosarcoma oncogene B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-19 Fosb  FBJ osteosarcoma oncogene B  LOC100360880  FBJ osteosarcoma oncogene B  Data merged from RGD:2321278 737654 APPROVED
2010-05-05 LOC100360880  FBJ osteosarcoma oncogene B      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Fosb  FBJ osteosarcoma oncogene B  Fosb_predicted  FBJ osteosarcoma oncogene B (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fosb_predicted  FBJ osteosarcoma oncogene B (predicted)      Symbol and Name status set to approved 70820 APPROVED