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Gene: Upp2 (uridine phosphorylase 2) Rattus norvegicus

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Symbol:

Upp2

Name:

uridine phosphorylase 2

RGD ID:

1308188

Description:

Predicted to enable deoxyuridine phosphorylase activity; identical protein binding activity; and uridine phosphorylase activity. Predicted to be involved in pyrimidine nucleoside monophosphate catabolic process and uridine catabolic process. Predicted to be located in type III intermediate filament. Predicted to be active in cytosol. Orthologous to human UPP2 (uridine phosphorylase 2); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC295620

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UPP2 (uridine phosphorylase 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Upp2 (uridine phosphorylase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Upp2 (uridine phosphorylase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100995749 (uridine phosphorylase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Upp2 (uridine phosphorylase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UPP2 (uridine phosphorylase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UPP2 (uridine phosphorylase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Upp2 (uridine phosphorylase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Upp2 (uridine phosphorylase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	UPP2 (uridine phosphorylase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Upp2 (uridine phosphorylase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	upp2 (uridine phosphorylase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG17224	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Caenorhabditis elegans (roundworm):	upp-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	upp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3788	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3788	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6330	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6330	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	upp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	63,681,671 - 63,726,194 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	63,681,826 - 63,726,191 (+)	Ensembl				GRCr8
mRatBN7.2	3	43,273,048 - 43,317,417 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	43,273,048 - 43,317,417 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	46,619,808 - 46,664,017 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	55,200,614 - 55,244,977 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	52,986,266 - 53,030,541 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	44,806,106 - 44,846,464 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	44,806,106 - 44,846,464 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	49,922,719 - 49,961,766 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	40,492,002 - 40,536,956 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	41,338,432 - 41,381,638 (+)	NCBI		Celera
RGSC_v3.1	3	40,380,721 - 40,432,184 (+)	NCBI
Cytogenetic Map	3	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (EXP,ISO)

1H-pyrazole (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-D (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

D-glucose (ISO)

dextran sulfate (ISO)

dibenz[a,h]anthracene (ISO)

diclofenac (ISO)

epoxiconazole (ISO)

etoposide (ISO)

fentin chloride (EXP)

folic acid (ISO)

fructose (ISO)

furan (EXP)

glucose (ISO)

gold atom (ISO)

gold(0) (ISO)

hydrazine (ISO)

indole-3-methanol (EXP)

inulin (ISO)

melatonin (ISO)

microcystin-LR (ISO)

O-methyleugenol (ISO)

obeticholic acid (ISO)

okadaic acid (ISO)

orphenadrine (EXP)

Ortho-topolin riboside (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (ISO)

phenformin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

ritodrine (ISO)

rotenone (EXP,ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

trichloroethene (ISO)

Triptolide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

CMP catabolic process (IEA,ISO)

dCMP catabolic process (IEA,ISO)

dTMP catabolic process (IEA,ISO)

dUMP catabolic process (IEA,ISO)

nucleoside metabolic process (IEA)

nucleotide catabolic process (IEA)

UMP catabolic process (IEA,ISO)

UMP salvage (IEA)

uridine catabolic process (IBA,IEA,ISO)

xenobiotic catabolic process (IEA,ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IBA,IEA,ISO)

type III intermediate filament (IEA,ISO)

Molecular Function

catalytic activity (IEA)

deoxyuridine phosphorylase activity (IEA,ISO)

glycosyltransferase activity (IEA)

identical protein binding (IEA,ISO)

pentosyltransferase activity (IEA)

protein binding (ISO)

pyrimidine-nucleoside phosphorylase activity (IEA,ISO)

thymidine phosphorylase activity (IEA,ISO)

transferase activity (IEA)

uridine phosphorylase activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-ureidopropionase deficiency pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

orotic aciduria 1 pathway (ISO)

pyrimidine metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7488099	PMID:11278417	PMID:12849978	PMID:14715930	PMID:21855639	PMID:25416956	PMID:26871637	PMID:29892012	PMID:31515488

Genomics

Comparative Map Data

Upp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	63,681,671 - 63,726,194 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	63,681,826 - 63,726,191 (+)	Ensembl				GRCr8
mRatBN7.2	3	43,273,048 - 43,317,417 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	43,273,048 - 43,317,417 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	46,619,808 - 46,664,017 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	55,200,614 - 55,244,977 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	52,986,266 - 53,030,541 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	44,806,106 - 44,846,464 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	44,806,106 - 44,846,464 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	49,922,719 - 49,961,766 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	40,492,002 - 40,536,956 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	41,338,432 - 41,381,638 (+)	NCBI		Celera
RGSC_v3.1	3	40,380,721 - 40,432,184 (+)	NCBI
Cytogenetic Map	3	q21	NCBI

UPP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	157,995,179 - 158,136,154 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	157,876,557 - 158,136,154 (+)	Ensembl			hg38	GRCh38
GRCh37	2	158,851,691 - 158,992,666 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	158,559,937 - 158,700,724 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	158,677,198 - 158,817,985	NCBI
Celera	2	152,468,457 - 152,609,424 (+)	NCBI		Celera
Cytogenetic Map	2	q24.1	NCBI
HuRef	2	150,739,887 - 150,880,962 (+)	NCBI		HuRef
CHM1_1	2	158,857,583 - 158,998,565 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	158,452,010 - 158,592,948 (+)	NCBI		T2T-CHM13v2.0

Upp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	58,456,329 - 58,685,858 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	58,457,310 - 58,682,983 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	58,566,317 - 58,795,846 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	58,567,298 - 58,792,971 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	58,607,596 - 58,643,079 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	58,570,571 - 58,606,054 (+)	NCBI		MGSCv36	mm8
Celera	2	60,510,835 - 60,545,982 (+)	NCBI		Celera
Cytogenetic Map	2	C1.1	NCBI
cM Map	2	33.16	NCBI

Upp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	15,365,106 - 15,405,235 (-)	Ensembl
ChiLan1.0	NW_004955449	15,355,592 - 15,405,997 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100995749
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	60,768,775 - 60,805,910 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	60,783,749 - 60,820,884 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	45,363,103 - 45,400,281 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	162,603,164 - 162,636,231 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	162,496,507 - 162,636,231 (+)	Ensembl			panPan2	panpan1.1

Upp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	121,104,636 - 121,152,019 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	20,465,767 - 20,513,075 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	20,465,767 - 20,513,084 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UPP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	65,088,795 - 65,131,788 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	65,088,652 - 65,131,739 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	72,235,731 - 72,280,652 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UPP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	43,510,752 - 43,545,133 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	156,036,611 - 156,069,106 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Upp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	7,597,782 - 7,644,423 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624732	7,574,609 - 7,641,345 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Upp2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	36,518,187 - 36,556,034 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Upp2
236 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	512
Count of miRNA genes:	271
Interacting mature miRNAs:	329
Transcripts:	ENSRNOT00000035158
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	28625339	67641995	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	35403199	97383526	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
631832	Sach1	Saccharin preference QTL 1	2.7	0.02	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	3	47904172	92904172	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	48657744	93657744	Rat
10450816	Scl75	Serum cholesterol level QTL 75	4.4	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	58601291	71157804	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	37796919	82796919	Rat
2313093	Bmd77	Bone mineral density QTL 77	2.2	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	3	47904172	70710963	Rat
12879852	Cm93	Cardiac mass QTL 93		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	38708931	67641995	Rat
12879853	Am5	Aortic mass QTL 5		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	38708931	67641995	Rat
12879854	Kidm63	Kidney mass QTL 63		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	38708931	67641995	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	51092561	96092561	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	36721849	110333156	Rat
12879849	Bw180	Body weight QTL 180		0.037	body mass (VT:0001259)	body weight (CMO:0000012)	3	38708931	67641995	Rat
2313101	Bmd76	Bone mineral density QTL 76	3.6	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	3	47904172	70710963	Rat
12879850	Cm91	Cardiac mass QTL 91		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	38708931	67641995	Rat
731172	Bp151	Blood pressure QTL 151		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	38708931	67641995	Rat
12879851	Cm92	Cardiac mass QTL 92		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	38708931	67641995	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	48657744	93657744	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	36101403	81101403	Rat
10450852	Stl33	Serum triglyceride level QTL 33	3.4	0.05	blood LDL triglyceride amount (VT:0010699)	blood lipoprotein triglyceride level (CMO:0002685)	3	58601291	71157804	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
4889975	Bmd81	Bone mineral density QTL 81	4.3		tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	3	59119402	70710963	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	51490129	111359995	Rat
634317	Bw117	Body weight QTL 117	3.58		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	59863663	73704481	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	59863663	87321459	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	53651826	98651826	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	48876619	93876619	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	48876619	93876619	Rat
2313079	Bss73	Bone structure and strength QTL 73	1.5		tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	3	47904172	70710963	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	59863663	87321459	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	51092561	96092561	Rat
2313076	Bss74	Bone structure and strength QTL 74	2	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	3	47904172	70710963	Rat
1300169	Bp177	Blood pressure QTL 177	2.96		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	3	36425116	81425116	Rat
10450813	Scl74	Serum cholesterol level QTL 74	5.8	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	58601291	71157804	Rat
2302276	Bw82	Body weight QTL 82	4.32		body mass (VT:0001259)	body weight (CMO:0000012)	3	59863663	83358329	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	58925062	103925062	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	48657744	93657744	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	50766145	95766145	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	50766145	95766145	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	42158111	124558371	Rat
2325840	Bp345	Blood pressure QTL 345		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	38708931	83708931	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	48657744	93657744	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	37363734	82363734	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	48657744	93657744	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	42158111	124558371	Rat
2313049	Bss72	Bone structure and strength QTL 72	2.6	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	3	47904172	70710963	Rat

Markers in Region

D3Got245

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	43,280,796 - 43,280,989 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	44,813,854 - 44,814,046	NCBI	Rnor6.0
Rnor_5.0	3	49,930,467 - 49,930,659	UniSTS	Rnor5.0
RGSC_v3.4	3	40,499,755 - 40,499,947	UniSTS	RGSC3.4
Celera	3	41,346,180 - 41,346,372	UniSTS
Cytogenetic Map	3	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
14	9	13	52	71	69	39	25	39	6	192	58	32	73	32	30

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000035158 ⟹ ENSRNOP00000038248

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	63,681,826 - 63,726,191 (+)	Ensembl
mRatBN7.2 Ensembl	3	43,273,048 - 43,317,417 (+)	Ensembl
Rnor_6.0 Ensembl	3	44,806,106 - 44,846,464 (+)	Ensembl

RefSeq Acc Id:

NM_001106481 ⟹ NP_001099951

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	63,681,826 - 63,726,191 (+)	NCBI
mRatBN7.2	3	43,273,048 - 43,317,417 (+)	NCBI
Rnor_6.0	3	44,806,106 - 44,846,464 (+)	NCBI
Rnor_5.0	3	49,922,719 - 49,961,766 (+)	NCBI
RGSC_v3.4	3	40,492,002 - 40,536,956 (+)	RGD
Celera	3	41,338,432 - 41,381,638 (+)	RGD

Sequence:

show sequence

GACTGAAAGTGGAATTGCATCCGTGTACAGTTGTCTCAAAGCAAATAAGTCTGGGTGTCACACC
AGCCTGATGCTGGGACCAAGGTCACGTGCCACGGACGGGTGCTGGGATCAAAGTTAACAAGCTA
ACAAACCTGCTCAAAGAGAAAGGATACCACACCTTCCAAGGGAGCCTAACTCCCTGGGGGATGA
TTCTCTGAGAGCAGGGCTGAGTATAAAAGGCTATCCAGGGATGGTGTTTTGACTTTGTCAGAGG
GGTTCAAAATACTCACGGAAGATTTTAGAGAAAATTTCAGGAGGAAACCTCAGTTTGAAGGGGA
GGTGGTATTCTGACTTGAGGCTGCATCACTGTGATTAGCTCTGTAATTTAACAGCAGGCTTTCA
CACTGCTTTTTCCTGCTATCTGCCCAGTGCAGAGTATGGCTTCCATTTTGCCTGCTTCTAATAG
AACCATGAGACCTGACAAGAATCCGTATGAGAGAGAACGGTCTGTGTATGTTAGGAATCCACAC
TTGGATGCCATGGACGAAGGCATTCTCTACCACTTGGATTTAGGGACCAAAACACACAACCTAC
CAGCCATGTTTGGGGATTTTGTCTGCGTTGGTGGGAGCTCGAACAGAATGAAAGCGTTTGCACT
GTTTATGCACAAGGAACTCGGGTTGGAGGGAGATGGAGACGACATCGAGGACATCTGTGCGGGG
ACAGACAGATACTGCATGTTCAAAACAGGCCCTGTGCTCTCCCTCAGTCACGGGATGGGCATCC
CCTCCATTTCCATTATGCTCCACGAACTCATCAAATTACTCCACCATGCACGCTGCTGCGATGT
TACCATCATCAGAATTGGAACATCGGGGGGAATTGGGATTGCTCCGGGGTCTGTTGTAATAACA
GATACAGCTGTAGACTCCTTCTTCAAGCCTCGGTTTGAACAGGTCATCTTGGATAACGTGGTCA
CCCGAAGCACCGAGCTTGACAAAGAACTGGCTACTGATTTGTTCAACTGTAGCAGAGAGATCCC
CAACTTTCTAACCCTCATCGGACACACGATGTGTACCTATGACTTTTACGAAGGCCGCTTAGAT
GGAGCGCTATGTTGTTTCTCGAGAGAGAAAAAGCTGGACTATTTGAAGAGAGCGTACAAAGCTG
GAGTCAGGAACATTGAAATGGAATCGACGGTGTTCGCCGCCATGTGTGGACTATGTGGCTTGAG
AGCTGCTGTGGTCTGTGTGACACTTCTCGACAGACTCGAGAGTGACCAAATCAATCTGTCCCAT
GATGTCCTGGTGGAGTACCAGCAACGGCCACAACTCCTAATCTCAAATTTCATCAAAAAACAGC
TTGGACTTTGTGACCAGATGTCATAGCTCCGAATCCCGCCCCTCTCCTGAGAGTTGGTACATGG
ATCTGCAACGATGATGCCATGTGTTGTTTATAATATTTTTATGTAATTCTCATCCTTGGGCTAA
AAAAAATCATAAAAGATTTTATGAAATCTTTTATCTTGAAGTTCAATTTATTGCAAGAGAATTT
AATACCCATGTGAAATTAAGTTCAAATTCCATTTTAGAACGAGTTAACTAAAGCAGTCTAATAA
TTAATATTTTAAACTCATGAAATGTGACATTTGGAGTTTCACATGTAGCATTAATTAAGCTTAT
ATCAAAATAGATCAGCCATTTGTAGATGCTTACCAGTTGCTTGCTGAAGCAGATCCAGCAGTGT
ATGCTAGGATGTTGTCAGCACTTCTAGGTGTTGGACAAGTGACAAAATTTGATCATGCACATTC
AAAATATTTACAAAAATGTGTCAGTGTAATATAGGCCGGTATGGAAGAATTCTCCTTGGGGAAA
TATGGCCATCCCTTTTCTCCGGTCCCCGTACAATTTCAGTGCACAAAAATGGAATTAGAACCTT
ATGAGTGTATGTGAGAATCACAGAACATCACAGCTTGAGGTCACACTTCTGGGTTTTTCCCCCC
CCCTCTTCAAATGAAAACCCTCAGTAACACAGACCTCCACCCACCCACCCACCTCCCCAGCTGG
AAATCAGAAGTGACTCAGTTGCCTTCTCAAGATCTTTTTATTCCTACAAGGAAATATGTCACAC
ACACACACACACACACACACACACACACACACACACACAAACCTGTATTTGTCGTTGTCTCGAT
AAGAACTGAATAAGCTGCAGAATTAGTTAATAACCAAATTTAAACTTGAAATCAAGATAGTAAC
TGAATCCATCTCAGGAACTTTGAGGCGGGTCTCGTTCAGAGCCTGCACTTAATAAGCCTCCCCT
GGTTGACCTTGAGAGGATTCAAGCAGCAGAGGCTCCAGGAATTGACCCCGCCTTCCACGTTCTT
TTGAACATTTAGAAACTGGAGTGTCTGGTTGGGGTAAGAGTGGAGGAGGTCTTGCAAACTTGTA
TAGTATGTAATGTTGCATGTATGTATATATGTATGTATATAGTTGTTGAATGAATAAAATATAT
CTTTCATCACGCTG

hide sequence

RefSeq Acc Id:

XM_039104478 ⟹ XP_038960406

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	63,681,671 - 63,726,194 (+)	NCBI
mRatBN7.2	3	43,273,395 - 43,317,417 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099951	(Get FASTA)	NCBI Sequence Viewer
	XP_038960406	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM00400	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038248
	ENSRNOP00000038248.3

RefSeq Acc Id:

NP_001099951 ⟸ NM_001106481

- UniProtKB:

D4A9N9 (UniProtKB/TrEMBL), A6JF60 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASILPASNRTMRPDKNPYERERSVYVRNPHLDAMDEGILYHLDLGTKTHNLPAMFGDFVCVGG
SSNRMKAFALFMHKELGLEGDGDDIEDICAGTDRYCMFKTGPVLSLSHGMGIPSISIMLHELIK
LLHHARCCDVTIIRIGTSGGIGIAPGSVVITDTAVDSFFKPRFEQVILDNVVTRSTELDKELAT
DLFNCSREIPNFLTLIGHTMCTYDFYEGRLDGALCCFSREKKLDYLKRAYKAGVRNIEMESTVF
AAMCGLCGLRAAVVCVTLLDRLESDQINLSHDVLVEYQQRPQLLISNFIKKQLGLCDQMS

hide sequence

Ensembl Acc Id:

ENSRNOP00000038248 ⟸ ENSRNOT00000035158

RefSeq Acc Id:	XP_038960406 ⟸ XM_039104478
- Peptide Label:	isoform X1

Protein Domains

Nucleoside phosphorylase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A9N9-F1-model_v2	AlphaFold	D4A9N9	1-316	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692085

Promoter ID:

EPDNEW_R2610

Type:

initiation region

Name:

Upp2_1

Description:

uridine phosphorylase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	44,806,262 - 44,806,322	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308188	AgrOrtholog
BioCyc Gene	G2FUF-49648	BioCyc
BioCyc Pathway	PWY-7181 [pyrimidine deoxyribonucleosides degradation]	BioCyc
	PWY0-1295 [pyrimidine ribonucleosides degradation]	BioCyc
BioCyc Pathway Image	PWY-7181	BioCyc
	PWY0-1295	BioCyc
Ensembl Genes	ENSRNOG00000005341	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000035158	ENTREZGENE
	ENSRNOT00000035158.5	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1580	UniProtKB/TrEMBL
InterPro	Nucleoside_phosphorylase_CS	UniProtKB/TrEMBL
	Nucleoside_phosphorylase_d	UniProtKB/TrEMBL
	Nucleoside_phosphorylase_sf	UniProtKB/TrEMBL
	Uridine_phosphorylase_euk	UniProtKB/TrEMBL
KEGG Report	rno:295620	UniProtKB/TrEMBL
NCBI Gene	295620	ENTREZGENE
PANTHER	URIDINE PHOSPHORYLASE	UniProtKB/TrEMBL
	URIDINE PHOSPHORYLASE 2	UniProtKB/TrEMBL
Pfam	PNP_UDP_1	UniProtKB/TrEMBL
PharmGKB	UPP2	RGD
PhenoGen	Upp2	PhenoGen
PROSITE	PNP_UDP_1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005341	RatGTEx
Superfamily-SCOP	SSF53167	UniProtKB/TrEMBL
UniProt	A6JF60	ENTREZGENE, UniProtKB/TrEMBL
	D4A9N9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Upp2	uridine phosphorylase 2	Upp2_predicted	uridine phosphorylase 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Upp2_predicted	uridine phosphorylase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways