Mob3a (MOB kinase activator 3A) - Rat Genome Database

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Gene: Mob3a (MOB kinase activator 3A) Rattus norvegicus
Analyze
Symbol: Mob3a
Name: MOB kinase activator 3A
RGD ID: 1308187
Description: Predicted to enable protein kinase activator activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB3A (MOB kinase activator 3A); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362833; MOB1, Mps One Binder kinase activator-like 2A; MOB1, Mps One Binder kinase activator-like 2A (yeast); MOB1, Mps One Binder kinase activator-like 2B; MOB1, Mps One Binder kinase activator-like 2B (yeast); Mobkl2a; Mobkl2b; mps one binder kinase activator-like 2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,661,185 - 9,678,584 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,661,288 - 9,678,581 (+)EnsemblGRCr8
mRatBN7.279,010,490 - 9,027,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,010,587 - 9,027,879 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,889,045 - 11,906,220 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,764,554 - 13,781,731 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,631,004 - 11,648,177 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,878,943 - 11,896,226 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,878,943 - 11,896,223 (+)Ensemblrn6Rnor6.0
Rnor_5.0712,045,883 - 12,063,528 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,521,114 - 10,538,158 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,193,314 - 7,210,560 (+)NCBICelera
RGSC_v3.1710,521,107 - 10,538,158 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Mob3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,661,185 - 9,678,584 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,661,288 - 9,678,581 (+)EnsemblGRCr8
mRatBN7.279,010,490 - 9,027,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,010,587 - 9,027,879 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,889,045 - 11,906,220 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,764,554 - 13,781,731 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,631,004 - 11,648,177 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,878,943 - 11,896,226 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,878,943 - 11,896,223 (+)Ensemblrn6Rnor6.0
Rnor_5.0712,045,883 - 12,063,528 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,521,114 - 10,538,158 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,193,314 - 7,210,560 (+)NCBICelera
RGSC_v3.1710,521,107 - 10,538,158 (+)NCBI
Cytogenetic Map7q11NCBI
MOB3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,071,036 - 2,096,515 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,071,032 - 2,096,679 (-)Ensemblhg38GRCh38
GRCh37192,071,035 - 2,096,325 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,022,035 - 2,047,269 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34192,022,036 - 2,047,269NCBI
Celera192,005,787 - 2,031,022 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,842,906 - 1,868,553 (-)NCBIHuRef
CHM1_1192,070,917 - 2,096,139 (-)NCBICHM1_1
T2T-CHM13v2.0192,044,090 - 2,069,735 (-)NCBIT2T-CHM13v2.0
Mob3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,521,087 - 80,537,845 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,521,087 - 80,537,811 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381080,685,253 - 80,701,820 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,685,253 - 80,701,977 (-)Ensemblmm10GRCm38
MGSCv371080,147,998 - 80,164,565 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361080,086,666 - 80,105,000 (-)NCBIMGSCv36mm8
Celera1081,703,634 - 81,720,201 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Mob3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,018,368 - 6,035,489 (+)Ensembl
ChiLan1.0NW_0049554956,018,368 - 6,033,399 (+)NCBIChiLan1.0ChiLan1.0
MOB3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,452,858 - 6,478,358 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,683,633 - 5,709,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,080,455 - 1,106,215 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,053,856 - 2,068,807 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,053,856 - 2,068,807 (-)EnsemblpanPan2panpan1.1
MOB3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,940,743 - 56,951,906 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,940,618 - 56,950,841 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2056,731,514 - 56,746,741 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02057,669,361 - 57,684,362 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,669,128 - 57,684,358 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,721,285 - 56,741,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,206,461 - 57,221,392 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,406,902 - 57,421,899 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mob3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,615,842 - 216,632,764 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,202,005 - 1,212,144 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,202,019 - 1,212,064 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOB3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,475,530 - 76,496,060 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1276,475,397 - 76,495,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MOB3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,872,426 - 1,897,476 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,870,701 - 1,885,300 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660816,843,353 - 6,867,235 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mob3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,755,059 - 6,771,961 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248286,755,018 - 6,771,614 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mob3a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11154,191,240 - 154,198,607 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mob3a
159 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:158
Interacting mature miRNAs:190
Transcripts:ENSRNOT00000025634
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH134504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,027,679 - 9,027,866 (+)MAPPERmRatBN7.2
Rnor_6.0711,896,018 - 11,896,204NCBIRnor6.0
Rnor_5.0712,063,320 - 12,063,506UniSTSRnor5.0
RGSC_v3.4710,537,952 - 10,538,138UniSTSRGSC3.4
Celera77,210,354 - 7,210,540UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025634   ⟹   ENSRNOP00000025634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,661,288 - 9,678,581 (+)Ensembl
mRatBN7.2 Ensembl79,010,587 - 9,027,879 (+)Ensembl
Rnor_6.0 Ensembl711,878,943 - 11,896,223 (+)Ensembl
RefSeq Acc Id: NM_001108734   ⟹   NP_001102204
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,661,301 - 9,678,582 (+)NCBI
mRatBN7.279,010,602 - 9,027,886 (+)NCBI
Rnor_6.0711,878,943 - 11,896,224 (+)NCBI
Rnor_5.0712,045,883 - 12,063,528 (+)NCBI
RGSC_v3.4710,521,114 - 10,538,158 (+)RGD
Celera77,193,314 - 7,210,560 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240963   ⟹   XP_006241025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,668,564 - 9,678,584 (+)NCBI
mRatBN7.279,017,899 - 9,027,888 (+)NCBI
Rnor_6.0711,885,199 - 11,896,226 (+)NCBI
Rnor_5.0712,045,883 - 12,063,528 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079395   ⟹   XP_038935323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,661,189 - 9,678,584 (+)NCBI
mRatBN7.279,010,490 - 9,027,888 (+)NCBI
RefSeq Acc Id: XM_063263743   ⟹   XP_063119813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,661,185 - 9,678,584 (+)NCBI
RefSeq Acc Id: NP_001102204   ⟸   NM_001108734
- UniProtKB: B5DEX8 (UniProtKB/TrEMBL),   F7F4P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241025   ⟸   XM_006240963
- Peptide Label: isoform X2
- UniProtKB: B5DEX8 (UniProtKB/TrEMBL),   F7F4P5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025634   ⟸   ENSRNOT00000025634
RefSeq Acc Id: XP_038935323   ⟸   XM_039079395
- Peptide Label: isoform X2
- UniProtKB: B5DEX8 (UniProtKB/TrEMBL),   F7F4P5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119813   ⟸   XM_063263743
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEX8-F1-model_v2 AlphaFold B5DEX8 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695009
Promoter ID:EPDNEW_R5534
Type:multiple initiation site
Name:Mob3a_1
Description:MOB kinase activator 3A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,878,930 - 11,878,990EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308187 AgrOrtholog
BioCyc Gene G2FUF-34962 BioCyc
Ensembl Genes ENSRNOG00000018971 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025634 ENTREZGENE
  ENSRNOT00000025634.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.30 UniProtKB/TrEMBL
InterPro Mob1_phocein UniProtKB/TrEMBL
  MOB_kinase_act_sf UniProtKB/TrEMBL
KEGG Report rno:362833 UniProtKB/TrEMBL
NCBI Gene 362833 ENTREZGENE
PANTHER Mob1_phocein UniProtKB/TrEMBL
Pfam Mob1_phocein UniProtKB/TrEMBL
PhenoGen Mob3a PhenoGen
RatGTEx ENSRNOG00000018971 RatGTEx
SMART Mob1_phocein UniProtKB/TrEMBL
Superfamily-SCOP Mob1_phocein UniProtKB/TrEMBL
UniProt B5DEX8 ENTREZGENE, UniProtKB/TrEMBL
  F7F4P5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Mob3a  MOB kinase activator 3A  Mobkl2a  MOB1, Mps One Binder kinase activator-like 2A (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Mobkl2a  MOB1, Mps One Binder kinase activator-like 2A (yeast)  Mobkl2b_predicted  MOB1, Mps One Binder kinase activator-like 2B (yeast) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Mobkl2b_predicted  MOB1, Mps One Binder kinase activator-like 2B (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED