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Gene: Cd180 (CD180 molecule) Rattus norvegicus

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Symbol:

Cd180

Name:

CD180 molecule

RGD ID:

1308170

Description:

Predicted to enable lipopolysaccharide immune receptor activity. Predicted to be involved in B cell proliferation involved in immune response; cellular response to lipopolysaccharide; and positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human CD180 (CD180 molecule); INTERACTS WITH 4,4'-diaminodiphenylmethane; acetamide; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CD180 antigen; LOC294706; Ly78; lymphocyte antigen 78; RP105

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD180 (CD180 molecule)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cd180 (CD180 antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cd180 (CD180 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CD180 (CD180 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD180 (CD180 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd180 (CD180 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD180 (CD180 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CD180 (CD180 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cd180 (CD180 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cd180 (CD180 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CD180 (CD180 molecule)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cd180 (CD180 antigen)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cd180 (CD180 molecule)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	rdo	Alliance	DIOPT (Ensembl Compara\|OMA)
Drosophila melanogaster (fruit fly):	Fili	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	ltl	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	cd180	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	35,589,889 - 35,602,837 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	35,589,451 - 35,603,982 (+)	Ensembl				GRCr8
mRatBN7.2	2	33,855,940 - 33,870,046 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	33,855,991 - 33,899,936 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	40,975,821 - 40,988,664 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	39,034,515 - 39,047,362 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	33,882,318 - 33,895,184 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	32,820,275 - 32,833,223 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	32,820,322 - 32,833,125 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	51,958,928 - 51,971,865 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	33,609,034 - 33,621,585 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	29,841,151 - 29,853,945 (+)	NCBI		Celera
RGSC_v3.1	2	33,529,523 - 33,541,542 (+)	NCBI
Cytogenetic Map	2	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

atrazine (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

choline (ISO)

cocaine (EXP)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

dimethylarsinic acid (ISO)

diquat (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

fluorescein 5-isothiocyanate (ISO)

folic acid (ISO)

furan (EXP)

L-methionine (ISO)

lipopolysaccharide (ISO)

methylarsonic acid (ISO)

nevirapine (ISO)

nickel atom (ISO)

nitrates (ISO)

ozone (EXP)

paracetamol (ISO)

progesterone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell proliferation (ISO)

B cell proliferation involved in immune response (IBA,ISO)

cellular response to lipopolysaccharide (IBA,ISO)

immune system process (IEA)

inflammatory response (IEA)

innate immune response (IEA)

lipopolysaccharide-mediated signaling pathway (IEA)

positive regulation of lipopolysaccharide-mediated signaling pathway (IBA,ISO)

Cellular Component

plasma membrane (IBA,IEA,ISO)

Molecular Function

lipopolysaccharide immune receptor activity (ISO)

protein binding (ISO)

signaling receptor activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10880523	PMID:26742900	PMID:27431018	PMID:29436577	PMID:29693119	PMID:31532760	PMID:32626996

Genomics

Comparative Map Data

Cd180
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	35,589,889 - 35,602,837 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	35,589,451 - 35,603,982 (+)	Ensembl				GRCr8
mRatBN7.2	2	33,855,940 - 33,870,046 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	33,855,991 - 33,899,936 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	40,975,821 - 40,988,664 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	39,034,515 - 39,047,362 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	33,882,318 - 33,895,184 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	32,820,275 - 32,833,223 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	32,820,322 - 32,833,125 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	51,958,928 - 51,971,865 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	33,609,034 - 33,621,585 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	29,841,151 - 29,853,945 (+)	NCBI		Celera
RGSC_v3.1	2	33,529,523 - 33,541,542 (+)	NCBI
Cytogenetic Map	2	q13	NCBI

CD180
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	67,179,613 - 67,196,799 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	67,179,613 - 67,196,799 (-)	Ensembl			hg38	GRCh38
GRCh37	5	66,475,441 - 66,492,627 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	66,513,872 - 66,528,368 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	66,513,871 - 66,528,368	NCBI
Celera	5	63,476,512 - 63,491,026 (-)	NCBI		Celera
Cytogenetic Map	5	q12.3	NCBI
HuRef	5	63,436,781 - 63,451,299 (-)	NCBI		HuRef
CHM1_1	5	66,478,494 - 66,493,008 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	68,001,761 - 68,018,951 (-)	NCBI		T2T-CHM13v2.0

Cd180
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	102,830,055 - 102,843,139 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	102,830,066 - 102,876,137 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	102,693,547 - 102,706,631 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	102,693,558 - 102,739,629 (+)	Ensembl			mm10	GRCm38
MGSCv37	13	103,483,638 - 103,496,711 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	103,813,970 - 103,827,337 (+)	NCBI		MGSCv36	mm8
Celera	13	106,283,432 - 106,296,502 (+)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	54.92	NCBI

Cd180
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	1,940,496 - 1,961,287 (+)	Ensembl
ChiLan1.0	NW_004955446	1,940,498 - 1,959,804 (+)	NCBI	ChiLan1.0	ChiLan1.0

CD180
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	46,719,183 - 46,734,718 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	44,872,809 - 44,888,345 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	46,799,607 - 46,815,214 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	48,364,874 - 48,381,700 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	48,364,874 - 48,381,694 (+)	Ensembl			panPan2	panpan1.1

CD180
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	52,644,357 - 52,660,830 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	52,645,766 - 52,660,790 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	49,605,279 - 49,621,785 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	53,143,232 - 53,159,719 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	53,144,431 - 53,159,652 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	50,207,853 - 50,224,342 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	50,990,473 - 51,006,742 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	51,878,479 - 51,894,980 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cd180
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	193,168,668 - 193,183,146 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	2,105,084 - 2,119,739 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	2,105,179 - 2,119,137 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD180
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	45,571,173 - 45,588,066 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	45,571,252 - 45,588,032 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	49,212,355 - 49,229,137 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	16	q14	NCBI

CD180
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	63,361,277 - 63,377,492 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	63,359,844 - 63,377,459 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666049	12,018,496 - 12,039,973 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cd180
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624815	2,511,552 - 2,529,891 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624815	2,511,506 - 2,528,396 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cd180
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	194,577,609 - 194,589,645 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cd180
69 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	60
Count of miRNA genes:	44
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000013768
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	13325041	58325041	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	24117813	69117813	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	42977529	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
9590080	Insglur4	Insulin/glucose ratio QTL 4	28.7	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	2	6152767	51152767	Rat
1579916	Bp270	Blood pressure QTL 270		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	16051883	61051883	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
731166	Mamtr2	Mammary tumor resistance QTL 2		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	54623581	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	14368707	59368707	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	44538110	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	5736325	50736325	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	33269996	78269996	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Markers in Region

RH137386

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	33,868,603 - 33,868,757 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	32,832,939 - 32,833,092	NCBI	Rnor6.0
Rnor_5.0	2	51,971,581 - 51,971,734	UniSTS	Rnor5.0
RGSC_v3.4	2	33,621,399 - 33,621,552	UniSTS	RGSC3.4
Celera	2	29,853,759 - 29,853,912	UniSTS
RH 3.4 Map	2	129.4	UniSTS
Cytogenetic Map	2	q12	UniSTS

G46465

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	33,858,783 - 33,859,079 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	32,823,115 - 32,823,410	NCBI	Rnor6.0
Rnor_5.0	2	51,961,757 - 51,962,052	UniSTS	Rnor5.0
RGSC_v3.4	2	33,611,827 - 33,612,122	UniSTS	RGSC3.4
Celera	2	29,843,944 - 29,844,239	UniSTS
Cytogenetic Map	2	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	67	157	91	90	59	92	59	6	352	191	11	135	78	92	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013768 ⟹ ENSRNOP00000013768

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	35,589,451 - 35,603,246 (+)	Ensembl
mRatBN7.2 Ensembl	2	33,855,991 - 33,868,790 (+)	Ensembl
Rnor_6.0 Ensembl	2	32,820,322 - 32,833,125 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099385 ⟹ ENSRNOP00000082320

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	33,855,991 - 33,899,936 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000160951 ⟹ ENSRNOP00000100934

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	35,589,926 - 35,603,982 (+)	Ensembl

RefSeq Acc Id:

NM_001106405 ⟹ NP_001099875

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	35,589,930 - 35,602,837 (+)	NCBI
mRatBN7.2	2	33,855,985 - 33,868,888 (+)	NCBI
Rnor_6.0	2	32,820,322 - 32,833,125 (+)	NCBI
Rnor_5.0	2	51,958,928 - 51,971,865 (+)	NCBI
RGSC_v3.4	2	33,609,034 - 33,621,585 (+)	RGD
Celera	2	29,841,151 - 29,853,945 (+)	RGD

Sequence:

show sequence

AAGACCGACCTTCTGAACACCTCACTGCCTGCCAAATTGCCAGAGCTATTAGAGTGTGATTAGA
TTGCTTGGCTCTGAGCGTTAGCTAATCCTATGCAGCTGGGCTTGCTCTGGACCTGAGATGGCTC
TGGACATCAGCTGCTTCCTTTTAGTGGCTCTCTTCTCAGCCAGCTGCCAAGCCATCGGATCCTC
AGATCAGAGGTGCACTGAGAAAGAAGTCAACAAAACATACAACTGTGAACATTTAGGTCTCAGT
GAAATTCCTGGCACTCTACCAAACTCAACAGAATCTTTGGAGTTCAGCTTTAATGCCTTGCCTA
CGATTCAAAAGACGACTTTCAGCAGACTCGTAAATCTCACCTTCCTGGATTTAACCAGGTGCCA
GATTTACTGGATACATGAAGATACTTTCCAAAGCCAACATCGGTTAGAGACACTTGTGCTAACT
GCAAATCCCCTGATATTTATGGCAGAGACAGCACTTACTGGGCCTAAGGCACTGAAGCATCTGT
TCTTCATCCAAACAGGAATATCCAGTATTGAGTTTATCCCAGTGCATAGTCAAAAAGCCTTGGA
AAGCCTCTATCTTGGAAGCAACCATATTTCCTCCATTAGACTCCCCAAAGATTTCCCAACAGAG
AAGCTGAAGGTCCTGGATTTTCAGAATAATGCTATCCATCACCTGTCGAAAGAAGACGTGAGCT
CTCTACAGCAAGCCACTAATCTGAGCCTGAACTTAAATGGAAACGACATTACAGGAATAGAGCC
CGGGGCTTTCAAGTCAACTGTCTTCCAAAGTTTGAACTTCGGAGGGACTCAAAGCTTGCTTGTT
ATCTTCAAGGGTCTGCAGAACTCTACTATCCAGTCTCTCTGGCTGGGGACATTTGAGGACATTG
ATGACGACGAAGATATTAGTTCTTCCATGTTTGAGGGCCTCTGTGAAATGTCTGTTGAGAGAAT
CAACCTACAGAAGCATCACTTCTTCAACATCACTTCCAACACATTCTACTGCTTCAGCGGTCTC
CAGGAGCTGGACCTAACAGCCACCCACCTGACAGAATTACCGTCTGGGATTGTGGGACTAAGCA
AGCTCAAGAAATTAGTTCTTAGTGCAAATAAGTTTGAGAATTTGTGCCAAATCAGTGCTTCCAA
TTTCCCCTCCCTTACACACCTTTACATCAAAGGCAACACAAAGAGACTTGAACTTGGTTCGGGC
TGTTTAGAAACCCTAGAACACCTTCGTGAGCTTGACCTAAGCCATGATGACATTGAAACTTCTG
ATTGCTGCAACCTGCAACTCAGAAACCTGTCTCACCTACAGAGCCTGAACCTGAGCTACAATGA
ACCCCTGGGCCTCAGGACTGAGGCCTTCAAAGAATGTCCTCAGCTAGAACTGCTAGACTTGGCA
TTTACCCGACTCCATGTTAAAGATGCACAAAGTCCTTTCCAGAACCTCCATCTCTTGAAGGTGC
TAAATCTCTCCCACTGCCTCCTTGGCTCCAGCAATCAGCATCTCCTTGATGGCCTGCCAGCACT
CCGGCATCTGAATTTACAGGGAAATCGCTTTCCAAATGGGAATATCCAAAAGACCAACCCACTT
CAAGCACTGGGAAGCCTAGAAATCCTGATTTTATCGTTTTGTGATCTCTCCTCCATTGACCATC
AAGCCTTCATCAATCTGAAGATAATGAATCATGTAGACCTTAGTCACAACAGGCTGACATCCAG
TAGTATTGAGGCCCTTAGTCATCTTAAGGGGATCTACCTCAATCTAGCTTCCAATCGCATTAGC
ATCATCCCGCCCAGTCTCCTCCCCGTGTTGTCCCAGCAGAGGACCATTAATTTAAGACAAAATC
CCCTTGACTGCACTTGCTCAAACATTTACTTTTTAGAATGGTACAAAGAAAACATGCAAAAACT
CGAAGACATAGAGGACACTTTTTGCGCAAATCCCCCATTGTTGAGGGGAGTCAAGGTCTCTGAC
GTCATGCTGTCCTGTAGTATGGCAGCTGTAGGCATTTTCTTTCTCATTGTATTCTTGCTCTTGT
TTGCTGTTTTGTTGATTTTTGCAGTGAAACGTTTTCTCAGGTGGAAATACCAACACATTTAGCA
CAAGGTTTCCAGAGGAGGCAGATGAACGTGTTGAGCAGAATTGTCCTAAGTGAAGAAACTGTCA
TTCTCGAGTGACCAGACTTTTCTATTGGTCCCCTAGGCTGGGGGTTCACTGAACATATGTCTTA
CTCACATGAGTCTCCCACGGTGCTGTGGCTGGAGGACCAGACATGGCTGAGACACAGGGCCAAT
TCCTCCAGTGAGAAGTGACCCACATTCATAGAATACCCAATAGCAGCCCCACCCATCTGAGAAA
GAAGAGCATTGTATCACAACCATCATCATCTCCCCCACCCCTACCCTTCTGTCTCACCCACCCA
CCCTAGCCCCAACCCTAGCTCCCACCCCCGAGCCCACCATCTACTCTATCTCTCTCACACTTTT
GACATTTTGCTTGAGGCTGAGCTCATTGTAATTGAGCCATTTTGGAAAGTTAGGCCCCAGCAAA
ATCTAA

hide sequence

RefSeq Acc Id:

XM_039101928 ⟹ XP_038957856

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	35,589,889 - 35,602,837 (+)	NCBI
mRatBN7.2	2	33,855,940 - 33,870,046 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099875	(Get FASTA)	NCBI Sequence Viewer
	XP_038957856	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM10243	(Get FASTA)	NCBI Sequence Viewer
	EDM10244	(Get FASTA)	NCBI Sequence Viewer
	EDM10245	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013768.5
	ENSRNOP00000100934
	ENSRNOP00000100934.1

RefSeq Acc Id:	NP_001099875 ⟸ NM_001106405
- Peptide Label:	precursor
- UniProtKB:	D3ZIP2 (UniProtKB/TrEMBL), A6I5D7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALDISCFLLVALFSASCQAIGSSDQRCTEKEVNKTYNCEHLGLSEIPGTLPNSTESLEFSFNA LPTIQKTTFSRLVNLTFLDLTRCQIYWIHEDTFQSQHRLETLVLTANPLIFMAETALTGPKALK HLFFIQTGISSIEFIPVHSQKALESLYLGSNHISSIRLPKDFPTEKLKVLDFQNNAIHHLSKED VSSLQQATNLSLNLNGNDITGIEPGAFKSTVFQSLNFGGTQSLLVIFKGLQNSTIQSLWLGTFE DIDDDEDISSSMFEGLCEMSVERINLQKHHFFNITSNTFYCFSGLQELDLTATHLTELPSGIVG LSKLKKLVLSANKFENLCQISASNFPSLTHLYIKGNTKRLELGSGCLETLEHLRELDLSHDDIE TSDCCNLQLRNLSHLQSLNLSYNEPLGLRTEAFKECPQLELLDLAFTRLHVKDAQSPFQNLHLL KVLNLSHCLLGSSNQHLLDGLPALRHLNLQGNRFPNGNIQKTNPLQALGSLEILILSFCDLSSI DHQAFINLKIMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIPPSLLPVLSQQRTINLR QNPLDCTCSNIYFLEWYKENMQKLEDIEDTFCANPPLLRGVKVSDVMLSCSMAAVGIFFLIVFL LLFAVLLIFAVKRFLRWKYQHI hide sequence

Ensembl Acc Id:

ENSRNOP00000013768 ⟸ ENSRNOT00000013768

RefSeq Acc Id:	XP_038957856 ⟸ XM_039101928
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000082320 ⟸ ENSRNOT00000099385

Ensembl Acc Id:

ENSRNOP00000100934 ⟸ ENSRNOT00000160951

Protein Domains

LRRCT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZIP2-F1-model_v2	AlphaFold	D3ZIP2	1-662	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691116

Promoter ID:

EPDNEW_R1641

Type:

initiation region

Name:

Cd180_1

Description:

CD180 molecule

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	32,820,316 - 32,820,376	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308170	AgrOrtholog
BioCyc Gene	G2FUF-54581	BioCyc
Ensembl Genes	ENSRNOG00000010266	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013768.7	UniProtKB/TrEMBL
	ENSRNOT00000160951	ENTREZGENE
	ENSRNOT00000160951.1	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
InterPro	Cys-rich_flank_reg_C	UniProtKB/TrEMBL
	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRR_11	UniProtKB/TrEMBL
KEGG Report	rno:294706	UniProtKB/TrEMBL
NCBI Gene	294706	ENTREZGENE
PANTHER	TOLL-LIKE RECEPTOR	UniProtKB/TrEMBL
	TOLL-LIKE RECEPTOR 4	UniProtKB/TrEMBL
Pfam	LRR_11	UniProtKB/TrEMBL
	LRR_6	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
PhenoGen	Cd180	PhenoGen
RatGTEx	ENSRNOG00000010266	RatGTEx
SMART	LRR_TYP	UniProtKB/TrEMBL
	LRRCT	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
UniProt	A0ABK0LDN3_RAT	UniProtKB/TrEMBL
	A6I5D7	ENTREZGENE, UniProtKB/TrEMBL
	D3ZIP2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-06-27	Cd180	CD180 molecule	Cd180	Cd180 molecule	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-06-27	Cd180	Cd180 molecule	Cd180	CD180 antigen	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Cd180	CD180 antigen	Cd180_predicted	CD180 antigen (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Cd180_predicted	CD180 antigen (predicted)	Ly78_predicted	lymphocyte antigen 78 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Ly78_predicted	lymphocyte antigen 78 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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