Ppp1r7 (protein phosphatase 1, regulatory subunit 7) - Rat Genome Database

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Gene: Ppp1r7 (protein phosphatase 1, regulatory subunit 7) Rattus norvegicus
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Symbol: Ppp1r7
Name: protein phosphatase 1, regulatory subunit 7
RGD ID: 1308169
Description: Predicted to enable protein phosphatase regulator activity. Predicted to act upstream of or within chromosome segregation. Predicted to be located in chromosome. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC105784; protein phosphatase 1 regulatory subunit 22; protein phosphatase 1 regulatory subunit 7; protein phosphatase 1, regulatory (inhibitor) subunit 7; Sds22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,333,472 - 101,358,589 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9101,333,497 - 101,360,959 (+)EnsemblGRCr8
mRatBN7.2993,886,068 - 93,911,198 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,886,143 - 93,914,850 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9102,321,658 - 102,346,746 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,457,461 - 107,482,640 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,813,603 - 105,838,783 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0999,556,587 - 100,504,077 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0999,226,358 - 99,235,083 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.09100,116,100 - 100,160,432 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4992,624,083 - 92,648,034 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera991,421,088 - 91,444,915 (+)NCBICelera
RGSC_v3.1992,828,851 - 92,852,802 (+)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA,ISO)
cytoplasm  (IBA)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7498485   PMID:12226088   PMID:12477932   PMID:12555814   PMID:15489334   PMID:16396499   PMID:19056867   PMID:21630459   PMID:22206666   PMID:22801782   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Ppp1r7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,333,472 - 101,358,589 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9101,333,497 - 101,360,959 (+)EnsemblGRCr8
mRatBN7.2993,886,068 - 93,911,198 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,886,143 - 93,914,850 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9102,321,658 - 102,346,746 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,457,461 - 107,482,640 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,813,603 - 105,838,783 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0999,556,587 - 100,504,077 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0999,226,358 - 99,235,083 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.09100,116,100 - 100,160,432 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4992,624,083 - 92,648,034 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera991,421,088 - 91,444,915 (+)NCBICelera
RGSC_v3.1992,828,851 - 92,852,802 (+)NCBI
Cytogenetic Map9q36NCBI
PPP1R7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,149,573 - 241,183,652 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,149,576 - 241,183,652 (+)Ensemblhg38GRCh38
GRCh372242,088,988 - 242,123,067 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,738,575 - 241,771,112 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342241,809,891 - 241,842,429NCBI
Celera2235,759,626 - 235,792,623 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2233,846,344 - 233,879,486 (+)NCBIHuRef
CHM1_12242,095,958 - 242,128,538 (+)NCBICHM1_1
T2T-CHM13v2.02241,648,673 - 241,683,461 (+)NCBIT2T-CHM13v2.0
Ppp1r7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,271,350 - 93,295,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,270,576 - 93,301,211 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38193,343,610 - 93,367,616 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,342,854 - 93,373,489 (+)Ensemblmm10GRCm38
MGSCv37195,240,222 - 95,264,195 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36195,174,051 - 95,198,024 (+)NCBIMGSCv36mm8
Celera196,288,260 - 96,312,213 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.24NCBI
Ppp1r7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542515,934 - 539,688 (-)Ensembl
ChiLan1.0NW_004955542520,605 - 539,699 (-)NCBIChiLan1.0ChiLan1.0
PPP1R7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213143,849,616 - 143,883,834 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B143,864,512 - 143,898,730 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,418,212 - 128,452,417 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,214,953 - 247,248,761 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,214,882 - 247,248,761 (+)EnsemblpanPan2panpan1.1
PPP1R7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,181,092 - 51,206,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,181,053 - 51,206,193 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2551,393,754 - 51,418,900 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02551,375,512 - 51,400,669 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,375,474 - 51,401,299 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,223,238 - 51,248,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02550,962,763 - 50,987,892 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,239,231 - 51,264,386 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp1r7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,555,414 - 192,584,880 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745639,240 - 664,799 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936745639,379 - 663,926 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15139,917,257 - 139,941,251 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115139,918,006 - 139,937,168 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215155,032,379 - 155,050,592 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,206,233 - 127,243,577 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604072,137,475 - 72,176,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,246,734 - 5,263,867 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248475,247,094 - 5,263,873 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp1r7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14165,278,910 - 165,304,744 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppp1r7
216 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:103
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000022854
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
RH130818  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,909,729 - 93,909,921 (+)MAPPERmRatBN7.2
Rnor_6.09100,503,816 - 100,504,007NCBIRnor6.0
Rnor_5.09100,160,171 - 100,160,362UniSTSRnor5.0
RGSC_v3.4992,647,773 - 92,647,964UniSTSRGSC3.4
Celera991,444,654 - 91,444,845UniSTS
RH 3.4 Map9801.0UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 51 67 138 95 11 50 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022854   ⟹   ENSRNOP00000022854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,335,705 - 101,358,589 (+)Ensembl
mRatBN7.2 Ensembl993,888,313 - 93,911,195 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095497   ⟹   ENSRNOP00000081944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,333,497 - 101,358,589 (+)Ensembl
mRatBN7.2 Ensembl993,886,149 - 93,911,195 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103695   ⟹   ENSRNOP00000095250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,333,547 - 101,360,959 (+)Ensembl
mRatBN7.2 Ensembl993,886,143 - 93,914,850 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162773   ⟹   ENSRNOP00000100917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,333,766 - 101,358,589 (+)Ensembl
RefSeq Acc Id: NM_001009825   ⟹   NP_001009825
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,333,497 - 101,358,589 (+)NCBI
mRatBN7.2993,886,104 - 93,911,198 (+)NCBI
Rnor_6.0999,557,511 - 100,504,077 (+)NCBI
Rnor_5.0999,226,358 - 99,235,083 (+)NCBI
Rnor_5.09100,116,100 - 100,160,432 (+)NCBI
RGSC_v3.4992,624,083 - 92,648,034 (+)RGD
Celera991,421,088 - 91,444,915 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767362   ⟹   XP_008765584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,333,472 - 101,350,755 (+)NCBI
mRatBN7.2993,886,068 - 93,902,220 (+)NCBI
Rnor_6.0999,556,587 - 100,496,306 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001009825 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765584 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88868 (Get FASTA)   NCBI Sequence Viewer  
  EDL91950 (Get FASTA)   NCBI Sequence Viewer  
  EDL91951 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081944
  ENSRNOP00000081944.1
GenBank Protein Q5HZV9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009825   ⟸   NM_001009825
- UniProtKB: Q5HZV9 (UniProtKB/Swiss-Prot),   A6JQY6 (UniProtKB/TrEMBL),   A0A8I6AM99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765584   ⟸   XM_008767362
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000081944   ⟸   ENSRNOT00000095497
Ensembl Acc Id: ENSRNOP00000095250   ⟸   ENSRNOT00000103695
Ensembl Acc Id: ENSRNOP00000022854   ⟸   ENSRNOT00000022854
Ensembl Acc Id: ENSRNOP00000100917   ⟸   ENSRNOT00000162773
Protein Domains
LRRCT   U2A'/phosphoprotein 32 family A C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-R9PXV7-F1-model_v2 AlphaFold R9PXV7 1-215 view protein structure
AF-Q5HZV9-F1-model_v2 AlphaFold Q5HZV9 1-360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308169 AgrOrtholog
BioCyc Gene G2FUF-26647 BioCyc
Ensembl Genes ENSRNOG00000016974 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000095497 ENTREZGENE
  ENSRNOT00000095497.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7321115 IMAGE-MGC_LOAD
InterPro Cilia_flagella_integrity UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_4 UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  U2A'_phosphoprotein32A_C UniProtKB/Swiss-Prot
KEGG Report rno:301618 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105784 IMAGE-MGC_LOAD
NCBI Gene 301618 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7 UniProtKB/Swiss-Prot
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED UniProtKB/Swiss-Prot
Pfam LRR_4 UniProtKB/Swiss-Prot
  LRR_9 UniProtKB/Swiss-Prot
PhenoGen Ppp1r7 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016974 RatGTEx
SMART LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRcap UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
UniProt A0A8I6AM99 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0KZX7_RAT UniProtKB/TrEMBL
  A6JQY6 ENTREZGENE, UniProtKB/TrEMBL
  A6JQY7_RAT UniProtKB/TrEMBL
  PP1R7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R9PXV7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Ppp1r7  protein phosphatase 1, regulatory subunit 7  Ppp1r7  protein phosphatase 1, regulatory (inhibitor) subunit 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ppp1r7  protein phosphatase 1, regulatory (inhibitor) subunit 7  Ppp1r7_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ppp1r7_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED