Arl11 (ARF like GTPase 11) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Arl11 (ARF like GTPase 11) Rattus norvegicus
Analyze
Symbol: Arl11
Name: ARF like GTPase 11 (Ensembl:ADP-ribosylation factor like GTPase 11)
RGD ID: 1308083
Description: Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARL11 (ARF like GTPase 11); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADP-ribosylation factor like GTPase 11; ADP-ribosylation factor-like 11; ADP-ribosylation factor-like protein 11; LOC364396; MGC108833
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,659,404 - 39,661,651 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1539,656,050 - 39,664,105 (+)EnsemblGRCr8
mRatBN7.21535,483,330 - 35,485,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1535,480,018 - 35,496,596 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1537,348,246 - 37,350,384 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01538,498,890 - 38,501,028 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01536,944,125 - 36,946,271 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,639,985 - 41,645,685 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,643,541 - 41,645,685 (+)Ensemblrn6Rnor6.0
Rnor_5.01545,448,923 - 45,451,069 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41540,458,780 - 40,460,926 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1535,180,893 - 35,182,952 (+)NCBICelera
RGSC_v3.11540,474,479 - 40,476,626 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:24029230  


Genomics

Comparative Map Data
Arl11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,659,404 - 39,661,651 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1539,656,050 - 39,664,105 (+)EnsemblGRCr8
mRatBN7.21535,483,330 - 35,485,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1535,480,018 - 35,496,596 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1537,348,246 - 37,350,384 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01538,498,890 - 38,501,028 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01536,944,125 - 36,946,271 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,639,985 - 41,645,685 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,643,541 - 41,645,685 (+)Ensemblrn6Rnor6.0
Rnor_5.01545,448,923 - 45,451,069 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41540,458,780 - 40,460,926 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1535,180,893 - 35,182,952 (+)NCBICelera
RGSC_v3.11540,474,479 - 40,476,626 (+)NCBI
Cytogenetic Map15p12NCBI
ARL11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381349,628,507 - 49,633,872 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1349,628,464 - 49,634,842 (+)Ensemblhg38GRCh38
GRCh371350,202,643 - 50,208,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361349,100,625 - 49,105,732 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341349,100,435 - 49,106,009NCBI
Celera1331,257,372 - 31,262,945 (+)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1330,995,906 - 31,001,479 (+)NCBIHuRef
CHM1_11350,169,956 - 50,175,529 (+)NCBICHM1_1
T2T-CHM13v2.01348,847,427 - 48,852,792 (+)NCBIT2T-CHM13v2.0
Arl11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391461,543,740 - 61,549,386 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1461,547,202 - 61,549,385 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl1461,542,858 - 61,551,618 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381461,306,290 - 61,311,937 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1461,309,753 - 61,311,936 (+)Ensemblmm10GRCm38
MGSCv371461,928,590 - 61,930,773 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361460,263,863 - 60,266,046 (+)NCBIMGSCv36mm8
Celera1459,078,077 - 59,080,081 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1432.66NCBI
Arl11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554313,086,983 - 3,090,423 (+)Ensembl
ChiLan1.0NW_0049554313,086,983 - 3,090,423 (+)NCBIChiLan1.0ChiLan1.0
ARL11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21451,067,071 - 51,071,028 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11349,718,749 - 49,722,670 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01330,767,431 - 30,770,962 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11349,516,084 - 49,519,462 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1349,518,030 - 49,518,620 (+)EnsemblpanPan2panpan1.1
Arl11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945159,201,892 - 159,204,115 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365652,686,783 - 2,687,377 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARL11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1118,095,974 - 18,099,819 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11118,097,723 - 18,100,425 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21118,412,359 - 18,414,343 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARL11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1327,544,990 - 27,550,306 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl327,547,359 - 27,547,949 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605716,333,716 - 16,338,843 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arl11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247485,023,391 - 5,025,131 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247485,023,391 - 5,025,389 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arl11
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11263,101,725 - 63,102,715 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arl11
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:357
Count of miRNA genes:200
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000019646
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH133399  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21535,485,394 - 35,485,544 (+)MAPPERmRatBN7.2
Rnor_6.01541,645,501 - 41,645,650NCBIRnor6.0
Rnor_5.01545,450,885 - 45,451,034UniSTSRnor5.0
RGSC_v3.41540,460,742 - 40,460,891UniSTSRGSC3.4
Celera1535,182,768 - 35,182,917UniSTS
RH 3.4 Map15227.6UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 89 59 6 351 189 11 139 79 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000019646   ⟹   ENSRNOP00000019646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1539,656,050 - 39,661,647 (+)Ensembl
mRatBN7.2 Ensembl1535,480,966 - 35,485,646 (+)Ensembl
Rnor_6.0 Ensembl1541,643,541 - 41,645,685 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118171   ⟹   ENSRNOP00000096153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1539,656,070 - 39,661,647 (+)Ensembl
mRatBN7.2 Ensembl1535,480,018 - 35,496,596 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000146172   ⟹   ENSRNOP00000101260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1539,658,992 - 39,664,105 (+)Ensembl
RefSeq Acc Id: NM_001013433   ⟹   NP_001013451
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,659,505 - 39,661,651 (+)NCBI
mRatBN7.21535,483,433 - 35,485,579 (+)NCBI
Rnor_6.01541,643,541 - 41,645,685 (+)NCBI
Rnor_5.01545,448,923 - 45,451,069 (+)NCBI
RGSC_v3.41540,458,780 - 40,460,926 (+)RGD
Celera1535,180,893 - 35,182,952 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599762   ⟹   XP_017455251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,659,404 - 39,661,647 (+)NCBI
mRatBN7.21535,483,330 - 35,485,575 (+)NCBI
Rnor_6.01541,643,037 - 41,645,681 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001013451 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418519 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455251 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91183 (Get FASTA)   NCBI Sequence Viewer  
  EDL85275 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019646.2
  ENSRNOP00000096153
  ENSRNOP00000096153.1
GenBank Protein Q5BK71 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013451   ⟸   NM_001013433
- UniProtKB: Q5BK71 (UniProtKB/Swiss-Prot),   A6K6B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455251   ⟸   XM_017599762
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000019646   ⟸   ENSRNOT00000019646
Ensembl Acc Id: ENSRNOP00000096153   ⟸   ENSRNOT00000118171
Ensembl Acc Id: ENSRNOP00000101260   ⟸   ENSRNOT00000146172

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK71-F1-model_v2 AlphaFold Q5BK71 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699742
Promoter ID:EPDNEW_R10265
Type:initiation region
Name:Arl11_1
Description:ADP-ribosylation factor like GTPase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01541,643,514 - 41,643,574EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308083 AgrOrtholog
BioCyc Gene G2FUF-13506 BioCyc
Ensembl Genes ENSRNOG00000014653 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019646.4 UniProtKB/Swiss-Prot
  ENSRNOT00000118171 ENTREZGENE
  ENSRNOT00000118171.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7365828 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase_ARF UniProtKB/Swiss-Prot
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot
KEGG Report rno:364396 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108833 IMAGE-MGC_LOAD
NCBI Gene 364396 ENTREZGENE
PANTHER PTHR11711 UniProtKB/Swiss-Prot
Pfam Arf UniProtKB/Swiss-Prot
PhenoGen Arl11 PhenoGen
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot
PROSITE ARF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014653 RatGTEx
SMART ARF UniProtKB/Swiss-Prot
  SAR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A6K6B5 ENTREZGENE, UniProtKB/TrEMBL
  ARL11_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-11-07 Arl11  ARF like GTPase 11  Arl11  ADP-ribosylation factor like GTPase 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-09 Arl11  ADP-ribosylation factor like GTPase 11  Arl11  ADP-ribosylation factor-like 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Arl11  ADP-ribosylation factor-like 11  Arl11_predicted  ADP-ribosylation factor-like 11 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Arl11_predicted  ADP-ribosylation factor-like 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED