Dhrs7l1 (dehydrogenase/reductase (SDR family) member 7-like 1) - Rat Genome Database

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Gene: Dhrs7l1 (dehydrogenase/reductase (SDR family) member 7-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Dhrs7l1
Name: dehydrogenase/reductase (SDR family) member 7-like 1
RGD ID: 1308036
Description: Orthologous to human DHRS7 (dehydrogenase/reductase 7); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; allopurinol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dehydrogenase/reductase (SDR family) member 7; Dhrs7; Down-regulated in nephrectomized rat kidney #3; DR-NR#3; LOC299131; MGC124901
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,025,094 - 97,047,899 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl697,025,094 - 97,047,899 (-)EnsemblGRCr8
mRatBN7.2691,289,200 - 91,312,010 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,197,292 - 91,207,959 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl691,289,200 - 91,312,010 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx691,659,134 - 91,682,060 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0691,958,601 - 91,981,529 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0691,386,539 - 91,409,469 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0695,387,709 - 95,502,845 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl695,387,718 - 95,502,845 (-)Ensemblrn6Rnor6.0
Rnor_5.06104,917,830 - 104,940,633 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4695,005,675 - 95,029,519 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera689,658,803 - 89,669,083 (-)NCBICelera
Celera689,750,172 - 89,772,981 (-)NCBICelera
RGSC_v3.1695,009,130 - 95,032,975 (-)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gene expression variance based on random sequencing in rat remnant kidney. Horiba N, etal., Kidney Int 2004 Jul;66(1):29-45.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Dhrs7l1
94 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 12 50 122 91 90 59 26 59 6 261 104 6 98 81 88 31 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000034289   ⟹   ENSRNOP00000036519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl697,025,094 - 97,047,899 (-)Ensembl
mRatBN7.2 Ensembl691,289,200 - 91,312,010 (-)Ensembl
Rnor_6.0 Ensembl695,480,042 - 95,502,845 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074990   ⟹   ENSRNOP00000064322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl696,933,356 - 96,943,520 (-)Ensembl
mRatBN7.2 Ensembl691,197,292 - 91,207,959 (-)Ensembl
Rnor_6.0 Ensembl695,387,718 - 95,502,775 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101424   ⟹   ENSRNOP00000078569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl691,197,292 - 91,207,602 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000121270   ⟹   ENSRNOP00000111559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl696,933,587 - 96,941,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122009   ⟹   ENSRNOP00000104231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl696,937,323 - 96,943,497 (-)Ensembl
RefSeq Acc Id: NM_001013098   ⟹   NP_001013116
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,025,094 - 97,047,899 (-)NCBI
mRatBN7.2691,289,200 - 91,312,010 (-)NCBI
Rnor_6.0695,480,042 - 95,502,845 (-)NCBI
Rnor_5.06104,917,830 - 104,940,633 (-)NCBI
RGSC_v3.4695,005,675 - 95,029,519 (-)RGD
Celera689,750,172 - 89,772,981 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013116 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI04714 (Get FASTA)   NCBI Sequence Viewer  
  BAD23896 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036519
  ENSRNOP00000036519.2
  ENSRNOP00000064322.3
  ENSRNOP00000104231.1
  ENSRNOP00000111559.1
RefSeq Acc Id: NP_001013116   ⟸   NM_001013098
- UniProtKB: Q6I7R1 (UniProtKB/TrEMBL),   M0R4N4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036519   ⟸   ENSRNOT00000034289
Ensembl Acc Id: ENSRNOP00000064322   ⟸   ENSRNOT00000074990
Ensembl Acc Id: ENSRNOP00000078569   ⟸   ENSRNOT00000101424
Ensembl Acc Id: ENSRNOP00000111559   ⟸   ENSRNOT00000121270
Ensembl Acc Id: ENSRNOP00000104231   ⟸   ENSRNOT00000122009

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4N4-F1-model_v2 AlphaFold M0R4N4 1-324 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694661
Promoter ID:EPDNEW_R5182
Type:multiple initiation site
Name:Dhrs7l1_1
Description:dehydrogenase/reductase member 7-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0695,502,763 - 95,502,823EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308036 AgrOrtholog
Ensembl Genes ENSRNOG00000025648 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000067058 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034289 ENTREZGENE
  ENSRNOT00000034289.4 UniProtKB/TrEMBL
  ENSRNOT00000074990.4 UniProtKB/TrEMBL
  ENSRNOT00000121270.1 UniProtKB/TrEMBL
  ENSRNOT00000122009.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7370181 IMAGE-MGC_LOAD
InterPro Glc/ribitol_DH UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/TrEMBL
  SDR_family_member_7 UniProtKB/TrEMBL
KEGG Report rno:299131 UniProtKB/TrEMBL
MGC_CLONE MGC:124901 IMAGE-MGC_LOAD
NCBI Gene 299131 ENTREZGENE
PANTHER DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED UniProtKB/TrEMBL
  GENE 4756-RELATED UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
PhenoGen Dhrs7l1 PhenoGen
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025648 RatGTEx
  ENSRNOG00000067058 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A0ABK0LQU1_RAT UniProtKB/TrEMBL
  A0ABK0M6U5_RAT UniProtKB/TrEMBL
  M0R4N4 ENTREZGENE, UniProtKB/TrEMBL
  Q6I7R1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-25 Dhrs7l1  dehydrogenase/reductase (SDR family) member 7-like 1  Dhrs7  dehydrogenase/reductase (SDR family) member 7  Name and Symbol changed 629549 APPROVED
2005-12-06 Dhrs7  dehydrogenase/reductase (SDR family) member 7  Dhrs7_predicted  dehydrogenase/reductase (SDR family) member 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dhrs7_predicted  dehydrogenase/reductase (SDR family) member 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED