Tom1 (target of myb1 membrane trafficking protein) - Rat Genome Database

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Gene: Tom1 (target of myb1 membrane trafficking protein) Rattus norvegicus
Analyze
Symbol: Tom1
Name: target of myb1 membrane trafficking protein
RGD ID: 1308024
Description: Predicted to enable several functions, including clathrin heavy chain binding activity; phosphatidylinositol-5-phosphate binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including endosomal transport; macroautophagy; and regulation of organelle organization. Predicted to be located in cytosol; early endosome; and endosome membrane. Predicted to be active in endosome and membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TOM1 (target of myb1 membrane trafficking protein); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361370; MGC95142; target of Myb protein 1; target of myb1 (chicken); target of myb1 homolog; target of myb1 homolog (chicken)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81913,411,227 - 13,446,129 (+)NCBIGRCr8
mRatBN7.21913,405,482 - 13,440,384 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,405,501 - 13,440,384 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1913,379,786 - 13,413,732 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01914,145,055 - 14,179,001 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01913,425,894 - 13,459,953 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01914,392,405 - 14,426,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,392,423 - 14,426,491 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,504,964 - 25,539,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41913,890,549 - 13,925,393 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11913,895,374 - 13,930,219 (+)NCBI
Celera1913,274,916 - 13,309,316 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
early endosome  (ISO)
endosome  (IBA,ISO)
endosome membrane  (ISO)
membrane  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14613930   PMID:16412388   PMID:16903783   PMID:19056867   PMID:19198660   PMID:23533145  


Genomics

Comparative Map Data
Tom1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81913,411,227 - 13,446,129 (+)NCBIGRCr8
mRatBN7.21913,405,482 - 13,440,384 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,405,501 - 13,440,384 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1913,379,786 - 13,413,732 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01914,145,055 - 14,179,001 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01913,425,894 - 13,459,953 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01914,392,405 - 14,426,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,392,423 - 14,426,491 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,504,964 - 25,539,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41913,890,549 - 13,925,393 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11913,895,374 - 13,930,219 (+)NCBI
Celera1913,274,916 - 13,309,316 (+)NCBICelera
Cytogenetic Map19p11NCBI
TOM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,299,275 - 35,347,973 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2235,299,275 - 35,347,992 (+)EnsemblGRCh38hg38GRCh38
GRCh372235,695,268 - 35,743,966 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,025,861 - 34,073,973 (+)NCBINCBI36Build 36hg18NCBI36
Build 342234,020,414 - 34,068,527NCBI
Celera2219,497,943 - 19,546,669 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2218,656,369 - 18,704,501 (+)NCBIHuRef
CHM1_12235,653,446 - 35,702,167 (+)NCBICHM1_1
T2T-CHM13v2.02235,757,154 - 35,805,980 (+)NCBIT2T-CHM13v2.0
Tom1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,760,326 - 75,796,749 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl875,760,333 - 75,796,749 (+)EnsemblGRCm39 Ensembl
GRCm38875,033,642 - 75,070,121 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl875,033,705 - 75,070,121 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,557,585 - 77,594,020 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36877,929,781 - 77,966,183 (+)NCBIMGSCv36mm8
Celera879,333,738 - 79,377,348 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map835.57NCBI
Tom1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,091,633 - 43,115,016 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540543,091,632 - 43,115,016 (+)NCBIChiLan1.0ChiLan1.0
TOM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22345,240,374 - 45,289,422 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12247,937,030 - 47,986,070 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02216,306,575 - 16,355,442 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12234,150,256 - 34,198,939 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,150,256 - 34,198,939 (+)Ensemblpanpan1.1panPan2
TOM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,782,910 - 28,822,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,775,300 - 28,822,570 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,719,265 - 28,758,930 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01029,569,574 - 29,609,250 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,562,184 - 29,609,208 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,293,163 - 29,332,825 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,601,983 - 29,641,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,781,678 - 29,821,336 (-)NCBIUU_Cfam_GSD_1.0
Tom1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494512,062,860 - 12,093,325 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364925,073,191 - 5,103,739 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364925,073,274 - 5,103,733 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOM1
(Sus scrofa - pig)
No map positions available.
TOM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,062,890 - 18,110,306 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,062,948 - 18,111,585 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045107,839,944 - 107,886,455 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tom1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750357,222 - 379,356 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624750359,130 - 379,454 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tom1
215 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:75
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000018880
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat

Markers in Region
RH133352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,440,110 - 13,440,328 (+)MAPPERmRatBN7.2
Rnor_6.01914,426,209 - 14,426,426NCBIRnor6.0
Rnor_5.01925,538,740 - 25,538,957UniSTSRnor5.0
RGSC_v3.41913,925,121 - 13,925,338UniSTSRGSC3.4
Celera1913,309,044 - 13,309,261UniSTS
RH 3.4 Map19134.78UniSTS
Cytogenetic Map19p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 41 18 41 8 11 74 35 41 11 8
Low 1 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000018880   ⟹   ENSRNOP00000018880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,405,501 - 13,440,384 (+)Ensembl
Rnor_6.0 Ensembl1914,392,423 - 14,426,491 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108363   ⟹   ENSRNOP00000089787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,405,520 - 13,440,381 (+)Ensembl
RefSeq Acc Id: NM_001008365   ⟹   NP_001008366
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,411,244 - 13,446,129 (+)NCBI
mRatBN7.21913,405,501 - 13,440,384 (+)NCBI
Rnor_6.01914,392,477 - 14,426,481 (+)NCBI
Rnor_5.01925,504,964 - 25,539,013 (+)NCBI
RGSC_v3.41913,890,549 - 13,925,393 (+)RGD
Celera1913,274,916 - 13,309,316 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255145   ⟹   XP_006255207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,411,227 - 13,446,129 (+)NCBI
mRatBN7.21913,405,482 - 13,440,384 (+)NCBI
Rnor_6.01914,392,405 - 14,426,482 (+)NCBI
Rnor_5.01925,504,964 - 25,539,013 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601310   ⟹   XP_017456799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,411,229 - 13,446,129 (+)NCBI
mRatBN7.21913,405,486 - 13,440,384 (+)NCBI
Rnor_6.01914,392,466 - 14,426,482 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097811   ⟹   XP_038953739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,411,328 - 13,446,129 (+)NCBI
mRatBN7.21913,405,566 - 13,440,384 (+)NCBI
RefSeq Acc Id: NP_001008366   ⟸   NM_001008365
- UniProtKB: Q5XI21 (UniProtKB/TrEMBL),   F7EYC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255207   ⟸   XM_006255145
- Peptide Label: isoform X1
- UniProtKB: F7EYC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456799   ⟸   XM_017601310
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ACG3 (UniProtKB/TrEMBL),   F7EYC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018880   ⟸   ENSRNOT00000018880
RefSeq Acc Id: XP_038953739   ⟸   XM_039097811
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000089787   ⟸   ENSRNOT00000108363
Protein Domains
GAT   VHS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI21-F1-model_v2 AlphaFold Q5XI21 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700959
Promoter ID:EPDNEW_R11483
Type:initiation region
Name:Tom1_1
Description:target of myb1 membrane trafficking protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01914,392,459 - 14,392,519EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308024 AgrOrtholog
BioCyc Gene G2FUF-6424 BioCyc
Ensembl Genes ENSRNOG00000014093 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018880 ENTREZGENE
  ENSRNOT00000018880.5 UniProtKB/TrEMBL
  ENSRNOT00000108363.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.160 UniProtKB/TrEMBL
  1.25.40.90 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128979 IMAGE-MGC_LOAD
InterPro ENTH_VHS UniProtKB/TrEMBL
  GAT UniProtKB/TrEMBL
  GAT_sf UniProtKB/TrEMBL
  TOM1 UniProtKB/TrEMBL
  VHS UniProtKB/TrEMBL
KEGG Report rno:361370 UniProtKB/TrEMBL
MGC_CLONE MGC:95142 IMAGE-MGC_LOAD
NCBI Gene 361370 ENTREZGENE
PANTHER TARGET OF MYB PROTEIN 1 UniProtKB/TrEMBL
  VHS DOMAIN CONTAINING PROTEIN FAMILY UniProtKB/TrEMBL
Pfam GAT UniProtKB/TrEMBL
  VHS UniProtKB/TrEMBL
PhenoGen Tom1 PhenoGen
PIRSF TOM1 UniProtKB/TrEMBL
PROSITE GAT UniProtKB/TrEMBL
  VHS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014093 RatGTEx
SMART VHS UniProtKB/TrEMBL
Superfamily-SCOP ENTH_VHS UniProtKB/TrEMBL
  GAT-like domain UniProtKB/TrEMBL
UniProt A0A8I6ACG3 ENTREZGENE, UniProtKB/TrEMBL
  A6JY94_RAT UniProtKB/TrEMBL
  A6JY95_RAT UniProtKB/TrEMBL
  A6JY96_RAT UniProtKB/TrEMBL
  F7EYC4 ENTREZGENE, UniProtKB/TrEMBL
  Q5XI21 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-26 Tom1  target of myb1 membrane trafficking protein  Tom1  target of myb1 (chicken)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-04 Tom1  target of myb1 (chicken)  Tom1  target of myb1 homolog (chicken)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Tom1  target of myb1 homolog (chicken)  Tom1_predicted  target of myb1 homolog (chicken) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tom1_predicted  target of myb1 homolog (chicken) (predicted)      Symbol and Name status set to approved 70820 APPROVED