Ascc3 (activating signal cointegrator 1 complex subunit 3) - Rat Genome Database

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Gene: Ascc3 (activating signal cointegrator 1 complex subunit 3) Rattus norvegicus
Analyze
Symbol: Ascc3
Name: activating signal cointegrator 1 complex subunit 3
RGD ID: 1307995
Description: Predicted to enable 3'-5' DNA helicase activity and ATP hydrolysis activity. Predicted to be involved in DNA alkylation repair; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within CAT tailing; protein monoubiquitination; and protein ufmylation. Predicted to be located in cytosol. Predicted to be part of DNA repair complex and RQC-trigger complex. Predicted to be active in cytosolic ribosome and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Helic1; helicase, ATP binding 1; LOC309887; MGC189522
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82055,089,430 - 55,372,374 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2055,255,503 - 55,372,374 (+)EnsemblGRCr8
mRatBN7.22053,510,137 - 53,795,446 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2053,510,184 - 53,790,165 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2055,224,947 - 55,504,975 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02054,874,662 - 55,154,704 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02055,566,701 - 55,846,785 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02055,253,670 - 55,557,249 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2055,253,686 - 55,556,473 (+)Ensemblrn6Rnor6.0
Rnor_5.02056,856,631 - 57,157,620 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42054,581,641 - 54,869,456 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2046,374,387 - 46,653,574 (-)NCBICelera
RGSC_v3.12054,629,602 - 54,897,551 (+)NCBI
Cytogenetic Map20q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
furfural  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO,ISS)
cytosolic ribosome  (ISO)
DNA repair complex  (ISO)
endoplasmic reticulum  (IEA)
membrane  (IEA)
nuclear speck  (IEA)
nucleus  (IBA,IEA,ISO,ISS)
RQC-trigger complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12077347   PMID:12477932   PMID:19946888   PMID:22055184   PMID:22681889   PMID:30361391   PMID:31505169  


Genomics

Comparative Map Data
Ascc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82055,089,430 - 55,372,374 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2055,255,503 - 55,372,374 (+)EnsemblGRCr8
mRatBN7.22053,510,137 - 53,795,446 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2053,510,184 - 53,790,165 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2055,224,947 - 55,504,975 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02054,874,662 - 55,154,704 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02055,566,701 - 55,846,785 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02055,253,670 - 55,557,249 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2055,253,686 - 55,556,473 (+)Ensemblrn6Rnor6.0
Rnor_5.02056,856,631 - 57,157,620 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42054,581,641 - 54,869,456 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2046,374,387 - 46,653,574 (-)NCBICelera
RGSC_v3.12054,629,602 - 54,897,551 (+)NCBI
Cytogenetic Map20q13NCBI
ASCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386100,508,194 - 100,881,329 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6100,508,194 - 100,881,407 (-)Ensemblhg38GRCh38
GRCh376100,956,070 - 101,329,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366101,063,329 - 101,435,945 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346101,063,330 - 101,422,632NCBI
Celera6101,600,815 - 101,973,409 (-)NCBICelera
Cytogenetic Map6q16.3NCBI
HuRef698,395,506 - 98,771,546 (-)NCBIHuRef
CHM1_16101,218,626 - 101,591,172 (-)NCBICHM1_1
T2T-CHM13v2.06101,681,937 - 102,055,217 (-)NCBIT2T-CHM13v2.0
Ascc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391050,468,756 - 50,727,300 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1050,468,765 - 50,727,581 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381050,592,663 - 50,851,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1050,592,669 - 50,851,485 (+)Ensemblmm10GRCm38
MGSCv371050,312,475 - 50,571,008 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361050,281,084 - 50,539,617 (+)NCBIMGSCv36mm8
Celera1051,441,982 - 51,700,475 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1024.87NCBI
Ascc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541126,302,597 - 26,598,824 (-)Ensembl
ChiLan1.0NW_00495541126,305,103 - 26,599,375 (-)NCBIChiLan1.0ChiLan1.0
ASCC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25120,550,608 - 120,925,972 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16118,431,998 - 118,807,918 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0698,345,023 - 98,720,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16102,224,820 - 102,599,521 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6102,224,820 - 102,599,521 (-)EnsemblpanPan2panpan1.1
ASCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11258,590,888 - 58,932,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1258,592,025 - 58,932,615 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1258,345,682 - 58,685,818 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01259,419,550 - 59,766,286 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1259,424,275 - 59,766,260 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11258,772,232 - 59,112,625 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01258,613,343 - 58,954,346 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01258,858,694 - 59,195,100 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ascc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494693,497,171 - 93,835,719 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366511,953,240 - 2,275,756 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366511,952,594 - 2,291,143 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl167,331,948 - 67,657,085 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1167,331,939 - 67,657,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ASCC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11373,044,869 - 73,411,481 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1373,044,986 - 73,412,752 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604045,340,597 - 45,708,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ascc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248104,123,746 - 4,431,003 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248104,112,072 - 4,432,639 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ascc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11848,954,311 - 49,228,615 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:334
Count of miRNA genes:198
Interacting mature miRNAs:238
Transcripts:ENSRNOT00000057016
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
RH139501  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22053,789,714 - 53,789,919 (+)MAPPERmRatBN7.2
Rnor_6.02055,556,023 - 55,556,227NCBIRnor6.0
Rnor_5.02057,156,394 - 57,156,598UniSTSRnor5.0
RGSC_v3.42054,869,013 - 54,869,217UniSTSRGSC3.4
Celera2046,374,633 - 46,374,837UniSTS
Cytogenetic Map20q13UniSTS
MARC_10283-10284:998926151:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22053,685,953 - 53,687,143 (+)MAPPERmRatBN7.2
Rnor_6.02055,454,269 - 55,455,458NCBIRnor6.0
Rnor_5.02057,054,640 - 57,055,829UniSTSRnor5.0
RGSC_v3.42054,765,768 - 54,766,957UniSTSRGSC3.4
Celera2046,476,682 - 46,477,871UniSTS
Cytogenetic Map20q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC169103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000057016   ⟹   ENSRNOP00000053848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2053,510,184 - 53,790,165 (+)Ensembl
Rnor_6.0 Ensembl2055,253,686 - 55,556,473 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107212   ⟹   ENSRNOP00000082272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2053,510,184 - 53,790,165 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109030   ⟹   ENSRNOP00000076420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2055,255,503 - 55,372,374 (+)Ensembl
mRatBN7.2 Ensembl2053,673,309 - 53,790,165 (+)Ensembl
RefSeq Acc Id: NM_001277057   ⟹   NP_001263986
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,383 - 55,372,374 (+)NCBI
mRatBN7.22053,510,184 - 53,790,165 (+)NCBI
Rnor_6.02055,253,686 - 55,556,473 (+)NCBI
Rnor_5.02056,856,631 - 57,157,620 (+)NCBI
Celera2046,374,387 - 46,653,574 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256602   ⟹   XP_006256664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,347 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
Rnor_6.02055,253,670 - 55,557,249 (+)NCBI
Rnor_5.02056,856,631 - 57,157,620 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256603   ⟹   XP_006256665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,361 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
Rnor_6.02055,253,670 - 55,557,249 (+)NCBI
Rnor_5.02056,856,631 - 57,157,620 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772992   ⟹   XP_008771214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,359 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
Rnor_6.02055,253,670 - 55,557,249 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772993   ⟹   XP_008771215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,372 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
Rnor_6.02055,253,670 - 55,557,249 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098773   ⟹   XP_038954701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,370 - 55,372,371 (+)NCBI
mRatBN7.22053,510,139 - 53,789,556 (+)NCBI
RefSeq Acc Id: XM_063279180   ⟹   XP_063135250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,347 - 55,372,371 (+)NCBI
RefSeq Acc Id: XM_063279181   ⟹   XP_063135251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,089,430 - 55,372,371 (+)NCBI
RefSeq Acc Id: XM_063279183   ⟹   XP_063135253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,372 - 55,372,371 (+)NCBI
RefSeq Acc Id: XM_063279184   ⟹   XP_063135254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,347 - 55,372,371 (+)NCBI
RefSeq Acc Id: XR_010060704
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82055,092,347 - 55,273,560 (+)NCBI
RefSeq Acc Id: NP_001263986   ⟸   NM_001277057
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256665   ⟸   XM_006256603
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256664   ⟸   XM_006256602
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771214   ⟸   XM_008772992
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771215   ⟸   XM_008772993
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053848   ⟸   ENSRNOT00000057016
RefSeq Acc Id: XP_038954701   ⟸   XM_039098773
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082272   ⟸   ENSRNOT00000107212
Ensembl Acc Id: ENSRNOP00000076420   ⟸   ENSRNOT00000109030
RefSeq Acc Id: XP_063135251   ⟸   XM_063279181
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135250   ⟸   XM_063279180
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135254   ⟸   XM_063279184
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWJ5 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135253   ⟸   XM_063279183
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY43 (UniProtKB/TrEMBL),   A6K6T5 (UniProtKB/TrEMBL)
Protein Domains
Helicase ATP-binding   Helicase C-terminal   SEC63

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LPQ2-F1-model_v2 AlphaFold F1LPQ2 1-2197 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701686
Promoter ID:EPDNEW_R12209
Type:initiation region
Name:Ascc3_2
Description:activating signal cointegrator 1 complex subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12210  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02055,253,678 - 55,253,738EPDNEW
RGD ID:13701687
Promoter ID:EPDNEW_R12210
Type:single initiation site
Name:Ascc3_1
Description:activating signal cointegrator 1 complex subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12209  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02055,253,847 - 55,253,907EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307995 AgrOrtholog
BioCyc Gene G2FUF-3230 BioCyc
Ensembl Genes ENSRNOG00000037604 Ensembl
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/Swiss-Prot
  Sec63 N-terminal domain-like domain UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot
  Hel308/SKI2 UniProtKB/Swiss-Prot
  Helicase_ATP-bd UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Sec63-dom UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
NCBI Gene 309887 ENTREZGENE
PANTHER DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED UniProtKB/Swiss-Prot
  SEC63 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam DEAD UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
  Sec63 UniProtKB/Swiss-Prot
  SNRNP200_wHTH UniProtKB/Swiss-Prot
PhenoGen Ascc3 PhenoGen
PIRSF BRR2 UniProtKB/Swiss-Prot
PROSITE HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot
  HELICASE_CTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000037604 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
  DEXDc UniProtKB/Swiss-Prot
  HELICc UniProtKB/Swiss-Prot
  Sec63 UniProtKB/Swiss-Prot
Superfamily-SCOP Sec63 N-terminal domain-like UniProtKB/Swiss-Prot
  SSF46785 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A0A0A0MY43 ENTREZGENE
  A0A8I5ZK28_RAT UniProtKB/TrEMBL
  A0A8I5ZWJ5 ENTREZGENE
  A6K6T5 ENTREZGENE, UniProtKB/TrEMBL
  ASCC3_RAT UniProtKB/Swiss-Prot
  B5DFL2_RAT UniProtKB/TrEMBL
  F1LPQ2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ascc3  activating signal cointegrator 1 complex subunit 3   Ascc3_predicted  activating signal cointegrator 1 complex subunit 3 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ascc3_predicted  activating signal cointegrator 1 complex subunit 3 (predicted)  Helic1_predicted  helicase, ATP binding 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Helic1_predicted  helicase, ATP binding 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED