Nuf2 (NUF2 component of NDC80 kinetochore complex) - Rat Genome Database

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Gene: Nuf2 (NUF2 component of NDC80 kinetochore complex) Rattus norvegicus
Analyze
Symbol: Nuf2
Name: NUF2 component of NDC80 kinetochore complex
RGD ID: 1307952
Description: Predicted to enable microtubule binding activity. Predicted to be involved in kinetochore organization; mitotic spindle organization; and nuclear chromosome segregation. Predicted to be located in cytosol; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cdca1; cell division cycle associated 1; cell division cycle-associated protein 1; kinetochore protein Nuf2; LOC304951; NDC80 kinetochore complex component NUF2; NUF2, NDC80 kinetochore complex component; NUF2, NDC80 kinetochore complex component, homolog; NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,226,448 - 84,290,957 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1384,226,509 - 84,255,598 (-)EnsemblGRCr8
mRatBN7.21381,693,675 - 81,722,765 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1381,693,598 - 81,722,766 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1384,320,699 - 84,350,601 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01385,614,283 - 85,643,373 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01382,845,943 - 82,875,848 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01387,818,456 - 87,847,223 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1387,818,391 - 87,847,263 (-)Ensemblrn6Rnor6.0
Rnor_5.01392,450,022 - 92,478,789 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41385,286,634 - 85,315,366 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1381,360,832 - 81,390,131 (-)NCBICelera
RGSC_v3.11385,300,821 - 85,329,554 (-)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
diallyl trisulfide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (EXP)
glucose  (ISO)
glyphosate  (ISO)
heptanal  (ISO)
hexanal  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP,ISO)
lidocaine  (EXP)
lucanthone  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nonanal  (ISO)
ochratoxin A  (EXP)
octanal  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
vincristine  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
kinetochore  (IEA,ISO)
Ndc80 complex  (IBA,IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)
outer kinetochore  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Nuclear division cycle 80 complex is associated with malignancy and predicts poor survival of hepatocellular carcinoma. Chen X, etal., Int J Clin Exp Pathol. 2019 Apr 1;12(4):1233-1247. eCollection 2019.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis. Hayama S, etal., Cancer Res. 2006 Nov 1;66(21):10339-48. doi: 10.1158/0008-5472.CAN-06-2137.
4. siRNA-mediated knockdown against NUF2 suppresses pancreatic cancer proliferation in vitro and in vivo. Hu P, etal., Biosci Rep. 2015 Jan 14;35(1). pii: BSR20140124. doi: 10.1042/BSR20140124.
5. Downregulation of NUF2 inhibits tumor growth and induces apoptosis by regulating lncRNA AF339813. Hu P, etal., Int J Clin Exp Pathol. 2015 Mar 1;8(3):2638-48. eCollection 2015.
6. siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis. Kaneko N, etal., Biochem Biophys Res Commun. 2009 Dec 25;390(4):1235-40. doi: 10.1016/j.bbrc.2009.10.127. Epub 2009 Oct 28.
7. Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers. Kobayashi Y, etal., Int J Oncol. 2014 Jan;44(1):69-77. doi: 10.3892/ijo.2013.2177. Epub 2013 Nov 15.
8. Phase I clinical trial of cell division associated 1 (CDCA1) peptide vaccination for castration resistant prostate cancer. Obara W, etal., Cancer Sci. 2017 Jul;108(7):1452-1457. doi: 10.1111/cas.13278. Epub 2017 Jun 23.
9. Cancer-associated splicing variants of the CDCA1 and MSMB genes expressed in cancer cell lines and surgically resected gastric cancer tissues. Ohnuma S, etal., Surgery. 2009 Jan;145(1):57-68. doi: 10.1016/j.surg.2008.08.010. Epub 2008 Oct 8.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. [Expression of NUF2 in breast cancer and its clinical significance]. Sun J, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2019 May 30;39(5):591-597. doi: 10.12122/j.issn.1673-4254.2019.05.15.
14. Potential therapeutic targets of the nuclear division cycle 80 (NDC80) complexes genes in lung adenocarcinoma. Sun ZY, etal., J Cancer. 2020 Mar 4;11(10):2921-2934. doi: 10.7150/jca.41834. eCollection 2020.
15. Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer. Thang PM, etal., Int J Oncol. 2016 Oct;49(4):1385-93. doi: 10.3892/ijo.2016.3649. Epub 2016 Aug 5.
16. Cell division cycle-associated protein 1 as a new melanoma-associated antigen. Tokuzumi A, etal., J Dermatol. 2016 Dec;43(12):1399-1405. doi: 10.1111/1346-8138.13436. Epub 2016 May 30.
17. NUF2 is a valuable prognostic biomarker to predict early recurrence of hepatocellular carcinoma after surgical resection. Wang Y, etal., Int J Cancer. 2019 Aug 1;145(3):662-670. doi: 10.1002/ijc.32134. Epub 2019 Feb 4.
18. Screening of differentially expressed genes and identification of NUF2 as a prognostic marker in breast cancer. Xu W, etal., Int J Mol Med. 2019 Aug;44(2):390-404. doi: 10.3892/ijmm.2019.4239. Epub 2019 Jun 11.
Additional References at PubMed
PMID:12477932   PMID:14699129   PMID:15489334   PMID:19946888  


Genomics

Comparative Map Data
Nuf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,226,448 - 84,290,957 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1384,226,509 - 84,255,598 (-)EnsemblGRCr8
mRatBN7.21381,693,675 - 81,722,765 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1381,693,598 - 81,722,766 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1384,320,699 - 84,350,601 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01385,614,283 - 85,643,373 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01382,845,943 - 82,875,848 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01387,818,456 - 87,847,223 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1387,818,391 - 87,847,263 (-)Ensemblrn6Rnor6.0
Rnor_5.01392,450,022 - 92,478,789 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41385,286,634 - 85,315,366 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1381,360,832 - 81,390,131 (-)NCBICelera
RGSC_v3.11385,300,821 - 85,329,554 (-)NCBI
Cytogenetic Map13q24NCBI
NUF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,321,954 - 163,355,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,266,576 - 163,355,766 (+)Ensemblhg38GRCh38
GRCh371163,291,744 - 163,325,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,558,347 - 161,592,177 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341160,023,382 - 160,057,205NCBI
Celera1136,396,004 - 136,429,820 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1134,537,062 - 134,570,886 (+)NCBIHuRef
CHM1_11164,714,625 - 164,748,448 (+)NCBICHM1_1
T2T-CHM13v2.01162,666,885 - 162,701,025 (+)NCBIT2T-CHM13v2.0
Nuf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,325,503 - 169,359,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,325,503 - 169,359,033 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381169,497,934 - 169,531,464 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,497,934 - 169,531,464 (-)Ensemblmm10GRCm38
MGSCv371171,428,065 - 171,461,595 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361171,334,986 - 171,368,103 (-)NCBIMGSCv36mm8
Celera1171,916,559 - 171,956,575 (-)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map176.84NCBI
Nuf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546213,082,047 - 13,142,944 (-)Ensembl
ChiLan1.0NW_00495546213,082,874 - 13,142,709 (-)NCBIChiLan1.0ChiLan1.0
NUF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2186,420,744 - 86,454,724 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1186,089,305 - 86,123,334 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01138,743,251 - 138,777,201 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11142,538,420 - 142,572,364 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1142,538,420 - 142,572,364 (+)EnsemblpanPan2panpan1.1
NUF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13819,574,122 - 19,599,821 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3819,574,125 - 19,599,064 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3819,631,382 - 19,659,692 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03819,658,875 - 19,687,209 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3819,658,875 - 19,687,186 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13819,627,147 - 19,652,037 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03819,985,502 - 20,013,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03820,277,530 - 20,302,431 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nuf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,495,918 - 103,524,586 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648121,342,786 - 21,371,328 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648121,342,667 - 21,371,311 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl487,162,818 - 87,194,170 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1487,162,873 - 87,194,193 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2494,875,757 - 94,907,078 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12565,462,608 - 65,493,242 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2565,462,603 - 65,493,246 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605567,252,523 - 67,283,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nuf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248261,798,737 - 1,831,112 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248261,794,084 - 1,831,009 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nuf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11048,709,253 - 48,737,766 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nuf2
439 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:32
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000003650
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH139396  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,693,830 - 81,693,913 (+)MAPPERmRatBN7.2
Rnor_6.01387,818,612 - 87,818,694NCBIRnor6.0
Rnor_5.01392,450,178 - 92,450,260UniSTSRnor5.0
RGSC_v3.41385,286,790 - 85,286,872UniSTSRGSC3.4
Celera1381,360,988 - 81,361,070UniSTS
RH 3.4 Map13512.4UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 353 190 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003650   ⟹   ENSRNOP00000003650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1384,226,509 - 84,255,598 (-)Ensembl
mRatBN7.2 Ensembl1381,693,614 - 81,722,766 (-)Ensembl
Rnor_6.0 Ensembl1387,818,391 - 87,847,263 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112498   ⟹   ENSRNOP00000095694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1384,237,072 - 84,255,598 (-)Ensembl
mRatBN7.2 Ensembl1381,704,239 - 81,722,766 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113324   ⟹   ENSRNOP00000090818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1381,693,598 - 81,722,766 (-)Ensembl
RefSeq Acc Id: NM_001012028   ⟹   NP_001012028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,226,509 - 84,255,598 (-)NCBI
mRatBN7.21381,693,675 - 81,722,765 (-)NCBI
Rnor_6.01387,818,456 - 87,847,223 (-)NCBI
Rnor_5.01392,450,022 - 92,478,789 (-)NCBI
RGSC_v3.41385,286,634 - 85,315,366 (-)RGD
Celera1381,360,832 - 81,390,131 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272366   ⟹   XP_063128436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,226,448 - 84,290,957 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001012028 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128436 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78993 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003650
  ENSRNOP00000003650.5
GenBank Protein Q6AYL9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012028   ⟸   NM_001012028
- UniProtKB: Q6AYL9 (UniProtKB/Swiss-Prot),   A0A8I6ACM4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003650   ⟸   ENSRNOT00000003650
Ensembl Acc Id: ENSRNOP00000090818   ⟸   ENSRNOT00000113324
Ensembl Acc Id: ENSRNOP00000095694   ⟸   ENSRNOT00000112498
RefSeq Acc Id: XP_063128436   ⟸   XM_063272366
- Peptide Label: isoform X1
- UniProtKB: Q6AYL9 (UniProtKB/Swiss-Prot),   A0A8I6ACM4 (UniProtKB/TrEMBL)
Protein Domains
Kinetochore protein Nuf2 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYL9-F1-model_v2 AlphaFold Q6AYL9 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698978
Promoter ID:EPDNEW_R9503
Type:initiation region
Name:Nuf2_1
Description:NUF2, NDC80 kinetochore complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01387,847,210 - 87,847,270EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307952 AgrOrtholog
BioCyc Gene G2FUF-17494 BioCyc
Ensembl Genes ENSRNOG00000002711 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003650 ENTREZGENE
  ENSRNOT00000003650.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112621 IMAGE-MGC_LOAD
InterPro Kinetochore_Nuf2 UniProtKB/Swiss-Prot
  Nuf2_N_sf UniProtKB/Swiss-Prot
KEGG Report rno:304951 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93892 IMAGE-MGC_LOAD
NCBI Gene 304951 ENTREZGENE
PANTHER KINETOCHORE PROTEIN NUF2 UniProtKB/Swiss-Prot
  MEMBRALIN/KINETOCHORE PROTEIN NUF2 UniProtKB/Swiss-Prot
Pfam Nuf2 UniProtKB/Swiss-Prot
PhenoGen Nuf2 PhenoGen
RatGTEx ENSRNOG00000002711 RatGTEx
UniProt A0A8I6ACM4 ENTREZGENE
  A0A8I6B362_RAT UniProtKB/TrEMBL
  NUF2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Nuf2  NUF2 component of NDC80 kinetochore complex  Nuf2  NDC80 kinetochore complex component NUF2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-08-24 Nuf2  NDC80 kinetochore complex component NUF2  Nuf2  NUF2, NDC80 kinetochore complex component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Nuf2  NUF2, NDC80 kinetochore complex component  Nuf2  NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Nuf2  NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)  Cdca1  cell division cycle associated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Cdca1  cell division cycle associated 1  Cdca1_predicted  cell division cycle associated 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cdca1_predicted  cell division cycle associated 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED