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Gene: Ing5 (inhibitor of growth family, member 5) Rattus norvegicus

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Symbol:

Ing5

Name:

inhibitor of growth family, member 5

RGD ID:

1307908

Description:

Predicted to enable chromatin binding activity and histone H3K4me3 reader activity. Predicted to be involved in several processes, including DNA replication-dependent chromatin disassembly; positive regulation of apoptotic signaling pathway; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within negative regulation of fibroblast proliferation and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Orthologous to human ING5 (inhibitor of growth family member 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; cadmium atom; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

inhibitor of growth protein 5; LOC363292

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ING5 (inhibitor of growth family member 5)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ing5 (inhibitor of growth family, member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ing5 (inhibitor of growth family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ING5 (inhibitor of growth family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ING5 (inhibitor of growth family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ing5 (inhibitor of growth family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ING5 (inhibitor of growth family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ING5 (inhibitor of growth family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ing5 (inhibitor of growth family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ing5 (inhibitor of growth family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ING4 (inhibitor of growth family member 4)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	ING5 (inhibitor of growth family member 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ING5 (inhibitor of growth family member 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ing5 (inhibitor of growth family, member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ing5a (inhibitor of growth family, member 5a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	ing5a (inhibitor of growth family, member 5a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ing5b (inhibitor of growth family, member 5b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ing5b (inhibitor of growth family, member 5b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	PHO23	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	PHO23	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Ing5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lsy-13	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YNG2	Alliance	DIOPT (InParanoid\|OMA\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ing5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ing5	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	101,772,845 - 101,793,734 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	101,773,724 - 101,793,728 (+)	Ensembl				GRCr8
mRatBN7.2	9	94,326,549 - 94,343,392 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	94,326,548 - 94,344,220 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	102,762,026 - 102,778,869 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	107,897,415 - 107,914,334 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	106,253,524 - 106,270,444 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	100,932,932 - 100,950,233 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	100,932,545 - 100,952,416 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	100,586,087 - 100,603,189 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	93,076,701 - 93,094,002 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	91,861,169 - 91,878,610 (+)	NCBI		Celera
RGSC_v3.1	9	93,281,098 - 93,298,207 (+)	NCBI
Cytogenetic Map	9	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

dexamethasone (ISO)

Di-n-octyl phthalate (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

diisononyl phthalate (ISO)

dimethyl sulfoxide (ISO)

dorsomorphin (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

methyl methanesulfonate (ISO)

ozone (ISO)

paracetamol (ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin organization (IEA)

DNA replication-dependent chromatin disassembly (IEA,ISO)

negative regulation of cell population proliferation (IEA,ISO)

negative regulation of growth (IEA,ISO)

positive regulation of apoptotic process (ISO)

positive regulation of apoptotic signaling pathway (IBA,ISO)

protein acetylation (ISO)

regulation of cell cycle (IEA,ISO)

regulation of cell growth (IEA,ISO)

regulation of DNA biosynthetic process (IEA,ISO)

regulation of DNA replication (IEA,ISO)

regulation of DNA-templated transcription (IBA,IEA,ISO)

Cellular Component

histone acetyltransferase complex (IEA,ISO)

MOZ/MORF histone acetyltransferase complex (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

chromatin binding (IBA,IEA,ISO)

histone H3K4me3 reader activity (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12750254	PMID:16387653	PMID:16728974	PMID:18794358	PMID:21750715	PMID:22921202	PMID:24065767	PMID:31844418

Genomics

Comparative Map Data

Ing5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	101,772,845 - 101,793,734 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	101,773,724 - 101,793,728 (+)	Ensembl				GRCr8
mRatBN7.2	9	94,326,549 - 94,343,392 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	94,326,548 - 94,344,220 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	102,762,026 - 102,778,869 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	107,897,415 - 107,914,334 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	106,253,524 - 106,270,444 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	100,932,932 - 100,950,233 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	100,932,545 - 100,952,416 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	100,586,087 - 100,603,189 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	93,076,701 - 93,094,002 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	91,861,169 - 91,878,610 (+)	NCBI		Celera
RGSC_v3.1	9	93,281,098 - 93,298,207 (+)	NCBI
Cytogenetic Map	9	q36	NCBI

ING5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	241,687,020 - 241,729,478 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	241,687,085 - 241,729,481 (+)	Ensembl			hg38	GRCh38
GRCh37	2	242,626,435 - 242,668,893 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	242,290,129 - 242,317,569 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	242,361,445 - 242,388,884	NCBI
Celera	2	236,316,253 - 236,341,094 (+)	NCBI		Celera
Cytogenetic Map	2	q37.3	NCBI
HuRef	2	234,396,720 - 234,424,015 (+)	NCBI		HuRef
CHM1_1	2	242,647,558 - 242,674,989 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	242,190,352 - 242,233,501 (+)	NCBI		T2T-CHM13v2.0

Ing5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	93,731,648 - 93,749,823 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	93,731,687 - 93,749,823 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	93,803,926 - 93,822,101 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	93,803,965 - 93,822,101 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	95,700,542 - 95,718,678 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	95,634,371 - 95,652,507 (+)	NCBI		MGSCv36	mm8
Celera	1	96,750,076 - 96,766,171 (+)	NCBI		Celera
Cytogenetic Map	1	D	NCBI
cM Map	1	47.34	NCBI

Ing5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955542	132,560 - 148,138 (-)	Ensembl
ChiLan1.0	NW_004955542	135,634 - 160,991 (-)	NCBI	ChiLan1.0	ChiLan1.0

ING5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	144,396,425 - 144,439,598 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	144,426,265 - 144,451,842 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	128,979,282 - 129,007,476 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	247,769,128 - 247,793,902 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	247,755,552 - 247,793,893 (+)	Ensembl			panPan2	panpan1.1

ING5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	51,535,521 - 51,556,264 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	51,534,753 - 51,554,644 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	51,754,641 - 51,775,295 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	51,734,300 - 51,754,948 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	51,734,356 - 51,756,582 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	51,584,130 - 51,604,831 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	51,323,352 - 51,344,051 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	51,600,060 - 51,621,179 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ing5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	192,946,863 - 192,962,731 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936745	261,450 - 271,943 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936745	261,371 - 271,447 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ING5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	140,264,766 - 140,279,010 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	140,264,708 - 140,279,020 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ING5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	127,733,768 - 127,770,794 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	127,746,546 - 127,774,244 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	71,550,856 - 71,575,851 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ing5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624847	5,648,233 - 5,662,044 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624847	5,648,199 - 5,659,038 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ing5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	165,717,255 - 165,732,043 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ing5
131 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	433
Count of miRNA genes:	166
Interacting mature miRNAs:	187
Transcripts:	ENSRNOT00000025683, ENSRNOT00000065058
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
724547	Cm21	Cardiac mass QTL 21	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	86720043	110356905	Rat
2303178	Bp334	Blood pressure QTL 334	3.7	0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	86720043	121768150	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	83161999	118999486	Rat
4889852	Pur26	Proteinuria QTL 26	15	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	85262459	109044727	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	85262459	118999486	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001394332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC167048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025683 ⟹ ENSRNOP00000025683

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	100,932,545 - 100,952,416 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000065058 ⟹ ENSRNOP00000062509

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	101,773,895 - 101,793,728 (+)	Ensembl
mRatBN7.2 Ensembl	9	94,326,919 - 94,344,220 (+)	Ensembl
Rnor_6.0 Ensembl	9	100,932,932 - 100,950,233 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098886 ⟹ ENSRNOP00000087374

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	94,326,570 - 94,343,391 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104628 ⟹ ENSRNOP00000094027

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	101,773,895 - 101,791,075 (+)	Ensembl
mRatBN7.2 Ensembl	9	94,326,548 - 94,344,034 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111711 ⟹ ENSRNOP00000087453

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	94,327,933 - 94,341,367 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133252 ⟹ ENSRNOP00000107811

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	101,773,724 - 101,793,728 (+)	Ensembl

RefSeq Acc Id:

NM_001394332 ⟹ NP_001381261

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	101,773,896 - 101,790,739 (+)	NCBI
mRatBN7.2	9	94,326,549 - 94,343,392 (+)	NCBI

RefSeq Acc Id:

XM_063267473 ⟹ XP_063123543

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	101,772,845 - 101,793,734 (+)	NCBI

RefSeq Acc Id:

XM_063267474 ⟹ XP_063123544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	101,774,406 - 101,793,734 (+)	NCBI

RefSeq Acc Id:

XM_063267475 ⟹ XP_063123545

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	101,774,097 - 101,793,734 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001381261	(Get FASTA)	NCBI Sequence Viewer
	XP_063123543	(Get FASTA)	NCBI Sequence Viewer
	XP_063123544	(Get FASTA)	NCBI Sequence Viewer
	XP_063123545	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67048	(Get FASTA)	NCBI Sequence Viewer
	EDL91898	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000062509
	ENSRNOP00000062509.4
	ENSRNOP00000094027.2
	ENSRNOP00000107811
	ENSRNOP00000107811.1

Ensembl Acc Id:

ENSRNOP00000062509 ⟸ ENSRNOT00000065058

Ensembl Acc Id:

ENSRNOP00000025683 ⟸ ENSRNOT00000025683

Ensembl Acc Id:

ENSRNOP00000087453 ⟸ ENSRNOT00000111711

Ensembl Acc Id:

ENSRNOP00000087374 ⟸ ENSRNOT00000098886

Ensembl Acc Id:

ENSRNOP00000094027 ⟸ ENSRNOT00000104628

RefSeq Acc Id:	NP_001381261 ⟸ NM_001394332
- UniProtKB:	F7F3G6 (UniProtKB/TrEMBL), B2RZ71 (UniProtKB/TrEMBL), A0A8I6A7T0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063123543 ⟸ XM_063267473
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A7T0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063123545 ⟸ XM_063267475
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A7T0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063123544 ⟸ XM_063267474
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A7T0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000107811 ⟸ ENSRNOT00000133252

Protein Domains

PHD-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2RZ71-F1-model_v2	AlphaFold	B2RZ71	1-240	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696890

Promoter ID:

EPDNEW_R7408

Type:

multiple initiation site

Name:

Ing5_1

Description:

inhibitor of growth family, member 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	100,932,561 - 100,932,621	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307908	AgrOrtholog
BioCyc Gene	G2FUF-26629	BioCyc
Ensembl Genes	ENSRNOG00000018988	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000065058	ENTREZGENE
	ENSRNOT00000065058.5	UniProtKB/TrEMBL
	ENSRNOT00000104628.2	UniProtKB/TrEMBL
	ENSRNOT00000133252	ENTREZGENE
	ENSRNOT00000133252.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
	6.10.140.1740	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9100546	IMAGE-MGC_LOAD
InterPro	ING_fam	UniProtKB/TrEMBL
	ING_N	UniProtKB/TrEMBL
	Zinc_finger_PHD-type_CS	UniProtKB/TrEMBL
	Znf_FYVE_PHD	UniProtKB/TrEMBL
	Znf_PHD	UniProtKB/TrEMBL
	Znf_PHD-finger	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
MGC_CLONE	MGC:189335	IMAGE-MGC_LOAD
NCBI Gene	363292	ENTREZGENE
PANTHER	PTHR10333	UniProtKB/TrEMBL
	PTHR10333:SF41	UniProtKB/TrEMBL
Pfam	ING	UniProtKB/TrEMBL
PhenoGen	Ing5	PhenoGen
PROSITE	ZF_PHD_1	UniProtKB/TrEMBL
	ZF_PHD_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018988	RatGTEx
SMART	ING	UniProtKB/TrEMBL
	PHD	UniProtKB/TrEMBL
Superfamily-SCOP	FYVE_PHD_ZnF	UniProtKB/TrEMBL
UniProt	A0A8I6A7T0	ENTREZGENE
	A0A8I6GKJ6_RAT	UniProtKB/TrEMBL
	A0ABK0LPI4_RAT	UniProtKB/TrEMBL
	B2RZ71	ENTREZGENE, UniProtKB/TrEMBL
	F7F3G6	ENTREZGENE
UniProt Secondary	D3ZDZ0	UniProtKB/TrEMBL
	F7F3G6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Ing5	inhibitor of growth family, member 5	Ing5_predicted	inhibitor of growth family, member 5 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ing5_predicted	inhibitor of growth family, member 5 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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