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Gene: Twnk (twinkle mtDNA helicase) Rattus norvegicus

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Symbol:

Twnk

Name:

twinkle mtDNA helicase

RGD ID:

1307884

Description:

Predicted to enable several functions, including 5'-3' DNA helicase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in cellular response to glucose stimulus. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial chromosome. Human ortholog(s) of this gene implicated in Perrault syndrome; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3; chronic progressive external ophthalmoplegia; and mitochondrial DNA depletion syndrome 7. Orthologous to human TWNK (twinkle mtDNA helicase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC309441; Peo1; progressive external ophthalmoplegia 1; progressive external ophthalmoplegia 1 (human); progressive external ophthalmoplegia 1 homolog; progressive external ophthalmoplegia 1 homolog (human); twinkle protein, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TWNK (twinkle mtDNA helicase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Twnk (twinkle mtDNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Twnk (twinkle mtDNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TWNK (twinkle mtDNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TWNK (twinkle mtDNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Twnk (twinkle mtDNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TWNK (twinkle mtDNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TWNK (twinkle mtDNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Twnk (twinkle mtDNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Twnk (twinkle mtDNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TWNK (twinkle mtDNA helicase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Twnk (twinkle mtDNA helicase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F46G11.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	mtDNA-helicase	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	twnk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	twnk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	253,817,074 - 253,823,958 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	253,817,564 - 253,824,162 (+)	Ensembl				GRCr8
mRatBN7.2	1	243,867,568 - 243,874,802 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	243,868,330 - 243,874,802 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	252,016,077 - 252,022,455 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	258,713,962 - 258,720,340 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	251,366,104 - 251,372,498 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	264,756,060 - 264,762,892 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	264,756,499 - 264,762,892 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	272,198,895 - 272,205,288 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	250,073,350 - 250,079,743 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	239,679,537 - 239,685,930 (+)	NCBI		Celera
RGSC_v3.1	1	250,334,625 - 250,339,475 (+)	NCBI
Cytogenetic Map	1	q54	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Auditory Neuropathy (ISO)

autosomal dominant progressive external ophthalmoplegia 1 (ISO)

autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3 (ISO,ISS)

autosomal recessive cerebellar ataxia (ISO)

chronic progressive external ophthalmoplegia (ISO)

Experimental Diabetes Mellitus (IEP,ISO)

genetic disease (ISO)

hereditary spastic paraplegia (ISO)

mitochondrial DNA depletion syndrome (ISO,ISS)

mitochondrial DNA depletion syndrome 7 (ISO,ISS)

mitochondrial metabolism disease (ISO)

Parkinson's disease (ISS)

Perrault syndrome (ISO)

Perrault Syndrome 5 (ISO)

Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Recessive (ISO)

progressive myoclonus epilepsy 5 (ISO)

sensory ataxic neuropathy, dysarthria, and ophthalmoparesis (ISO)

Spinocerebellar Ataxias (ISO)

third-degree atrioventricular block (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

CGP 52608 (ISO)

cisplatin (ISO)

cylindrospermopsin (ISO)

DDE (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dimethyl fumarate (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

finasteride (EXP)

flutamide (EXP)

genistein (ISO)

glafenine (EXP)

hydrogen peroxide (ISO)

lamivudine (ISO)

melphalan (ISO)

methyl methanesulfonate (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

thiram (ISO)

titanium dioxide (ISO)

toluene (EXP)

triphenyl phosphate (ISO)

vinclozolin (EXP)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to glucose stimulus (IEP)

DNA replication (IEA,ISO)

DNA-templated DNA replication (ISO)

mitochondrial DNA replication (IBA,ISO)

mitochondrial transcription (ISO)

protein hexamerization (ISO)

Cellular Component

mitochondrial chromosome (ISO)

mitochondrial inner membrane (IEA)

mitochondrial nucleoid (IEA,ISO)

mitochondrion (IBA,ISO)

Molecular Function

5'-3' DNA helicase activity (IEA,ISO)

ATP binding (IEA)

ATP hydrolysis activity (ISO)

DNA helicase activity (IBA,IEA,ISO)

helicase activity (IEA)

hydrolase activity (IEA)

identical protein binding (ISO)

isomerase activity (IEA)

lipid binding (IEA,ISO)

nucleotide binding (IEA)

protease binding (ISO)

protein binding (ISO)

single-stranded DNA binding (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.	Spelbrink JN, etal., Nat Genet. 2001 Jul;28(3):223-31.
8.	Damaged mitochondrial DNA replication system and the development of diabetic retinopathy.	Tewari S, etal., Antioxid Redox Signal. 2012 Aug 1;17(3):492-504. doi: 10.1089/ars.2011.4333. Epub 2012 Feb 17.
9.	Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy.	Tewari S, etal., Invest Ophthalmol Vis Sci. 2012 Jul 24;53(8):4881-8. doi: 10.1167/iovs.12-9732.

Additional References at PubMed

PMID:12975372	PMID:14739292	PMID:15167897	PMID:18063578	PMID:18614015	PMID:18971204	PMID:19705478

Genomics

Comparative Map Data

Twnk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	253,817,074 - 253,823,958 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	253,817,564 - 253,824,162 (+)	Ensembl				GRCr8
mRatBN7.2	1	243,867,568 - 243,874,802 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	243,868,330 - 243,874,802 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	252,016,077 - 252,022,455 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	258,713,962 - 258,720,340 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	251,366,104 - 251,372,498 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	264,756,060 - 264,762,892 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	264,756,499 - 264,762,892 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	272,198,895 - 272,205,288 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	250,073,350 - 250,079,743 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	239,679,537 - 239,685,930 (+)	NCBI		Celera
RGSC_v3.1	1	250,334,625 - 250,339,475 (+)	NCBI
Cytogenetic Map	1	q54	NCBI

TWNK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	100,987,543 - 100,994,403 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	100,987,367 - 100,994,403 (+)	Ensembl			hg38	GRCh38
GRCh37	10	102,747,300 - 102,754,160 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	102,737,302 - 102,744,148 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	102,737,301 - 102,744,148	NCBI
Celera	10	96,485,015 - 96,491,881 (+)	NCBI		Celera
Cytogenetic Map	10	q24.31	NCBI
HuRef	10	96,376,620 - 96,383,636 (+)	NCBI		HuRef
CHM1_1	10	103,031,503 - 103,038,362 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	101,870,918 - 101,877,778 (+)	NCBI		T2T-CHM13v2.0

Twnk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	44,994,102 - 45,001,203 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	44,994,102 - 45,001,201 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	45,005,663 - 45,012,764 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	45,005,663 - 45,012,762 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	45,081,048 - 45,087,252 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	45,059,869 - 45,066,073 (+)	NCBI		MGSCv36	mm8
Celera	19	45,777,203 - 45,783,454 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	38.19	NCBI

Twnk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955485	9,191,919 - 9,198,697 (-)	Ensembl
ChiLan1.0	NW_004955485	9,193,838 - 9,198,697 (-)	NCBI	ChiLan1.0	ChiLan1.0

TWNK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	112,872,588 - 112,879,440 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	112,877,910 - 112,884,761 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	97,588,811 - 97,595,663 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	101,065,082 - 101,071,407 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	101,065,096 - 101,071,407 (+)	Ensembl			panPan2	panpan1.1

TWNK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	13,672,772 - 13,680,732 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	13,676,304 - 13,680,044 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	13,843,334 - 13,850,235 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	14,141,934 - 14,148,835 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	14,143,799 - 14,148,972 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	13,687,679 - 13,694,581 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	13,728,970 - 13,735,872 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	13,860,940 - 13,867,842 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Twnk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	33,087,879 - 33,093,324 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936600	4,691,104 - 4,696,507 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936600	4,691,112 - 4,696,523 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TWNK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	112,069,925 - 112,075,792 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	112,068,463 - 112,076,169 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	121,754,919 - 121,760,796 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TWNK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	94,006,183 - 94,012,783 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	94,006,188 - 94,013,164 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	55,057,779 - 55,064,501 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Twnk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624831	592,475 - 597,388 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Twnk
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	44,513,327 - 44,539,810 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Twnk
14 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	441
Count of miRNA genes:	230
Interacting mature miRNAs:	269
Transcripts:	ENSRNOT00000031018
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1578775	Iddm21	Insulin dependent diabetes mellitus QTL 21	4.13		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	245782829	270518180	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
631837	Niddm35	Non-insulin dependent diabetes mellitus QTL 35		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	248619887	269633915	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	5e-06	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	247133834	270518180	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	237995023	269633915	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2314011	Gluco56	Glucose level QTL 56			blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	209203273	254203273	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	228180370	266453608	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	238398865	255849249	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228180243	255849249	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	241569529	269633915	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	243953669	270518180	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Markers in Region

RH139435

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	243,867,062 - 243,867,251 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	264,755,119 - 264,755,307	NCBI	Rnor6.0
Rnor_5.0	1	272,197,507 - 272,197,695	UniSTS	Rnor5.0
RGSC_v3.4	1	250,070,712 - 250,070,900	UniSTS	RGSC3.4
RH 3.4 Map	1	1620.42	UniSTS
Cytogenetic Map	1	q54	UniSTS

RH129974

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	243,867,024 - 243,867,199 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	264,755,081 - 264,755,255	NCBI	Rnor6.0
Rnor_5.0	1	272,197,469 - 272,197,643	UniSTS	Rnor5.0
RGSC_v3.4	1	250,070,674 - 250,070,848	UniSTS	RGSC3.4
RH 3.4 Map	1	1616.92	UniSTS
Cytogenetic Map	1	q54	UniSTS

BF417612

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	243,867,496 - 243,867,608 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	264,755,588 - 264,755,699	NCBI	Rnor6.0
Rnor_5.0	1	272,197,984 - 272,198,095	UniSTS	Rnor5.0
RGSC_v3.4	1	250,072,439 - 250,072,550	UniSTS	RGSC3.4
Celera	1	239,678,626 - 239,678,737	UniSTS
RH 3.4 Map	1	1620.48	UniSTS
Cytogenetic Map	1	q54	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031018 ⟹ ENSRNOP00000034807

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	253,817,564 - 253,823,958 (+)	Ensembl
mRatBN7.2 Ensembl	1	243,868,330 - 243,874,802 (+)	Ensembl
Rnor_6.0 Ensembl	1	264,756,499 - 264,762,892 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000129580 ⟹ ENSRNOP00000103462

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	253,817,564 - 253,824,162 (+)	Ensembl

RefSeq Acc Id:

NM_001107599 ⟹ NP_001101069

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	253,817,564 - 253,823,958 (+)	NCBI
mRatBN7.2	1	243,868,408 - 243,874,802 (+)	NCBI
Rnor_6.0	1	264,756,499 - 264,762,892 (+)	NCBI
Rnor_5.0	1	272,198,895 - 272,205,288 (+)	NCBI
RGSC_v3.4	1	250,073,350 - 250,079,743 (+)	RGD
Celera	1	239,679,537 - 239,685,930 (+)	RGD

Sequence:

show sequence

AGGAGAGTGGTGACGCGAAGCTGGGGGCGGGAGCGTGGAGCTTCTGAAGCCGAGGGTAGAGCCC
TGGAGCCTGTAAGGGAGCCGGGTAGGAGCGCGTGACCTCCAGCTGTGTGGAGGGTCCCTGTGAC
TGCTAAGAGCTAAGAGCGCCTGGAGTTGGGGTTCAGACAGGATGCAGAGAGCTATAGAGATGAG
GTTGGCGAGAAGAGTCCGTAGAGGGGTAGTAGACGTGAAGAGATGATACAGAGAAGCCTTTTAG
ATTGAGGGGCCGTAGAAGGCTTTAGAAGTGAGCTGGTGGAGAGAAATCGTAAAGGACCTACAAG
TATGAGAGTCTTCAGAGAGGGGCGTAGACGCGAAAGGGTAGTATAGGTGTGTGGGGTTGAAGTA
ACAATATACAGGCAACCAAGGGGATTAAGAATTGTGTTCGTGGGGCTGGGGATTTAGCTCAGTG
GTAGAGCGCTTACCTAGGAAGCGCAAGGCCCTGGGTTCGGTCCCCAGCTCCGAAAAAAAAAAAG
AACAAAAAAAAAAAAAAAAAAACAAAAAAAACCCAAAAAACAAGAATTGTGTTCGTAAAGAAAT
TTGAGGAGAAATAGAGAAAAGGTAGCAATAGTGAGTTCTGTGAGTTCTTGTGAAGGGCTCCTAG
GGTCTGGCCTATTAAAGGTACAAAACCAGACACCAAAAGTTTTTGCAGTAGTGGCATCCCACTC
CATTAGGAATGTGGCTCCTTCTCCGGCGTGCTTATCCCCTCCGGATCTTGCTGCCACTGCGTGG
GGAGTGGATGGGTAGGAGAGGCCTGCCCCGAAGCTTGGCTCCAGGCCCTCCCCGAAGAAGGTAC
AGAAAAGAAGCGCTTCCAGCCTTAGAGGTACCAGTATCACCTGTGACTACAACTGAAATCCGCC
AATATTTACGAGCACATGGGATCCCCTTCCAGGATGGCCACAGCTGCCTTCGAGCACCAAGTCC
CTTTGTGGCACCCTCAGACATCAAAAATCAGAAGAAGGATGCTACCACTTCCTTCTGCCTCTTC
ATCGACAAGACCACAGGACACTTTCTCTGCATGACCAGCCTAGCAGAAGGGAGCTGGGAAGACC
TCCAGGCCAGTGTGGAGGGACGAGGCGATGGGGCCAAAGAGGGAATCCTACTTGGGGAGGGCCC
AGAAGCTGAGGACAGGGAGGAGGTCTTGAGAATCTGGAACCGAGCCATACCTCTTTGGGAGCTG
CCTGATCCCCAGGAAACCCAGCTAGCTCGTGTGATGTTTGGCCTTACCAAGGTGACAGATGACA
CACTCAGGAGATTCAATGTCCGCTATCTTCGATCTACTCGAAGTCTGGTCTTCCCTTGGTTCAC
CCCTGGGAGCTCAGGATTACGTGGCCTGAAGCTACTAGGGGTTGAGGGTCAGGAAAATGGAGTA
CAGTATGTAGAGACCACCATTCCCCGGCCTGGTGTCTATCACAACCTATTTGGATTACCCCTGA
TCGGCCGTAGAGACACTGAGGTGGTCCTGACAAGTCGAGAGCTGGACAGCCTGGCCTTGAGCCA
GTCCACGGGGCTGCCAACCCTTTCCCTACCCCGAGGAACGGTCTGCTTACCCCCAGCCCTACTC
CCTTACCTCGAACAGTTCCGGAGGATTGTGTTCTGGCTAGGGGATGACCTTCGATCGTGGGAAG
CTGCCAAACTGTTTGCCCGAAAACTGAACCCCAAGCGATGCTCTTTGGTGAGGCCTGGGAACCA
ACAACCTCGTCCCCTGGAGGCCTTAAACCAAGGCTTAAGTCTTCCCCGTATTCTCCGTACTGCC
CTCCCTGCCTGGCACAAGTCTATTGTGTCTTTTCGCCAGCTCCGAGAAGAGGTTTTAGGAGAGC
TATCAAATGTGGACCAAGCAGCCGGTGTCCGTTGGAGCCGATTCCCAGACCTTAATCGGCTGCT
GAAGGGTCATCGGAAGGGCGAGCTGACGGTCTTTACAGGGCCAACAGGCAGTGGCAAGACAACA
TTCATCAGTGAGTATGCCCTGGACTTGTGTACCCAGGGAGTGAACACACTGTGGGGTAGCTTTG
AGATCAGCAATGTGAGACTAGCCCGGGTCATGCTGACTCAGTTTGCTGTGACACGGCTAGAAGA
ACAACTGGACAAGTATGAAGAGTGGGCAGACCGTTTTGAGGACCTGCCTCTCTATTTCATGACT
TTCCACGGACAACAGAGCATCAGGTCTGTCATAGACACAATGCAACATGCTGTCTACGTCTATG
ACGTTTGTCATGTAGTCATCGACAACTTGCAGTTCATGATGGGTCATGAGCAGCTCTCTACTGA
CAGGATCGCAGCTCAAGACTACATTGTTGGAGCCTTTCGGAAGTTTGCCACAGACAATAGCTGC
CACGTGACTCTGGTTATTCACCCACGGAAAGAAGATGACGACAAGGAACTACAGACAGCATCCA
TTTTTGGCTCAGCCAAAGCCAGCCAAGAAGCAGACAATGTTCTGATCTTGCAGGACAGGAAGCT
GGTGACTGGGCCTGGGAAACGGTATCTGCAGGTGTCCAAAAATCGCTTTGATGGAGACGTAGGC
GTCTTCCCACTTGAGTTCAACAAGAGTTCCCTTACCTTCTCCATCCCACCTAAGAGCAAAGCCC
GACTCAAGAAGATTAAGGATGACAATGGACTAGTGGCCAAGAAGTCCTCCTCTGGAAAAAAAGG
GTCTGCGCACCAGAACTCTGAGACTTGCATAGGCCAGGACCCCTGCCAGCCAGATACCTCCCCG
TCCTCAAGGTGAATGCAGTCAGAGCTGCTTGCTGAAGTGACCCTGGTGAACCAGGCTGACACAG
ACTCTTGGCCTTCTGCTGGGGCTCGTCCCGAGTGAGCCTTTCCCAGCCCAGGGCTCGGTTCCAT
GGTGAAAAGTTTAATTCAGCAGCTACTAAGGCTCTCCTATATGCTGGTTCAGGTTTTTTCCCCA
TAGGTTTTCATGTATAGCACTGAAAAGACAAAGTCTGTTTCCAAAGAACCAGCATCTTGGGGTT
GGGGATTTAGCTCAGTGGTAGAGCGCTTGCCTAGGAAGCGCAAGGCCCTGGGTTCAATCCCCAG
CTCCGAAAAAAAAGAACCAAAAAAAAAAAAAAAAAAAGAACCAGCATCTTGGTGAAAGGAACAA
AGCTAAGTGGGACTGCTCAGCTAGTTTTGATCAGTCACCCTAAAAAGATGGCTGATCAGAGTGC
ATGTGAGAACCATGGTCTGGTGAACCTCTGGAGAAAGGGATCCAGGTGGAGAAACACCAAAATC
ACAGGGGGGAATGAGCAAGTCAGATAAAGAGGGCGGACCCTGAACCTGCCACGAAACAGGAGGC
TTGCTGGGACTCCAGCATGTTGGCATTCGGAGCGGAAGAGTAATGCAGTGGGCACCTCTCTGCT
CTGCTTTGTCGAGCCAGGCATAAGAATTGATCTGAGGTGCTTATCCTGTGCTGTCAGAGCCTCA
AAGCTGGACCATGGAGAGAAGCTGTGAGCCTGCAGTGCCTGCCCCCTTGATGCCGATTCCACTG
TGTGCTGCTGCCTTGGACAGCGGGAGCTAGGACTCTTGGTGGAGCCTTTTCCAGTTGAATGAAG
CATTTCTATGGCCTCTG

hide sequence

RefSeq Acc Id:

XM_008760429 ⟹ XP_008758651

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	253,817,474 - 253,823,958 (+)	NCBI
mRatBN7.2	1	243,868,324 - 243,874,802 (+)	NCBI
Rnor_6.0	1	264,756,443 - 264,762,892 (+)	NCBI

Sequence:

show sequence

GGAGTCACAGCGAGCGGCGCGTGCGGGCAACCCACGTTTTGGACAGAACACTAGAGAGGAGAGT
GGTGACGCGAAGCTGGGGGCGGGAGCGTGGAGCTTCTGAAGCCGAGGGTAGAGCCCTGGAGCCT
GTAAGGGAGCCGGGTAGGAGCGCGTGACCTCCAGCTGTGTGGAGGGTCCCTGTGACTGCTAAGA
GCTAAGAGCGCCTGGAGTTGGGGTTCAGACAGGATGCAGAGAGCTATAGAGATGAGGTTGGCGA
GAAGAGTCCGTAGAGGGGTAGTAGACGTGAAGAGATGATACAGAGAAGCCTTTTAGATTGAGGG
GCCGTAGAAGGCTTTAGAAGTGAGCTGGTGGAGAGAAATCGTAAAGGACCTACAAGTATGAGAG
TCTTCAGAGAGGGGCGTAGACGCGAAAGGGTAGTATAGGTGTGTGGGGTTGAAGTAACAATATA
CAGGCAACCAAGGGGATTAAGAATTGTGTTCGTGGGGCTGGGGATTTAGCTCAGTGGTAGAGCG
CTTACCTAGGAAGCGCAAGGCCCTGGGTTCGGTCCCCAGCTCCGAAAAAAAAAAAGAACAAAAA
AAAAAAAAAAAAAACAAAAAAAACCCAAAAAACAAGAATTGTGTTCGTAAAGAAATTTGAGGAG
AAATAGAGAAAAGGTAGCAATAGTGAGTTCTGTGAGTTCTTGTGAAGGGCTCCTAGGGTCTGGC
CTATTAAAGGTACAAAACCAGACACCAAAAGTTTTTGCAGTAGTGGCATCCCACTCCATTAGGA
ATGTGGCTCCTTCTCCGGCGTGCTTATCCCCTCCGGATCTTGCTGCCACTGCGTGGGGAGTGGA
TGGGTAGGAGAGGCCTGCCCCGAAGCTTGGCTCCAGGCCCTCCCCGAAGAAGGTACAGAAAAGA
AGCGCTTCCAGCCTTAGAGGTACCAGTATCACCTGTGACTACAACTGAAATCCGCCAATATTTA
CGAGCACATGGGATCCCCTTCCAGGATGGCCACAGCTGCCTTCGAGCACCAAGTCCCTTTGTGG
CACCCTCAGACATCAAAAATCAGAAGAAGGATGCTACCACTTCCTTCTGCCTCTTCATCGACAA
GACCACAGGACACTTTCTCTGCATGACCAGCCTAGCAGAAGGGAGCTGGGAAGACCTCCAGGCC
AGTGTGGAGGGACGAGGCGATGGGGCCAAAGAGGGAATCCTACTTGGGGAGGGCCCAGAAGCTG
AGGACAGGGAGGAGGTCTTGAGAATCTGGAACCGAGCCATACCTCTTTGGGAGCTGCCTGATCC
CCAGGAAACCCAGCTAGCTCGTGTGATGTTTGGCCTTACCAAGGTGACAGATGACACACTCAGG
AGATTCAATGTCCGCTATCTTCGATCTACTCGAAGTCTGGTCTTCCCTTGGTTCACCCCTGGGA
GCTCAGGATTACGTGGCCTGAAGCTACTAGGGGTTGAGGGTCAGGAAAATGGAGTACAGTATGT
AGAGACCACCATTCCCCGGCCTGGTGTCTATCACAACCTATTTGGATTACCCCTGATCGGCCGT
AGAGACACTGAGGTGGTCCTGACAAGTCGAGAGCTGGACAGCCTGGCCTTGAGCCAGTCCACGG
GGCTGCCAACCCTTTCCCTACCCCGAGGAACGGTCTGCTTACCCCCAGCCCTACTCCCTTACCT
CGAACAGTTCCGGAGGATTGTGTTCTGGCTAGGGGATGACCTTCGATCGTGGGAAGCTGCCAAA
CTGTTTGCCCGAAAACTGAACCCCAAGCGATGCTCTTTGGTGAGGCCTGGGAACCAACAACCTC
GTCCCCTGGAGGCCTTAAACCAAGGCTTAAGTCTTCCCCGTATTCTCCGTACTGCCCTCCCTGC
CTGGCACAAGTCTATTGTGTCTTTTCGCCAGCTCCGAGAAGAGGTTTTAGGAGAGCTATCAAAT
GTGGACCAAGCAGCCGGTGTCCGTTGGAGCCGATTCCCAGACCTTAATCGGCTGCTGAAGGGTC
ATCGGAAGGGCGAGCTGACGGTCTTTACAGGGCCAACAGGCAGTGGCAAGACAACATTCATCAG
TGAGTATGCCCTGGACTTGTGTACCCAGGGAGTGAACACACTGTGGGGTAGCTTTGAGATCAGC
AATGTGAGACTAGCCCGGGTCATGCTGACTCAGTTTGCTGTGACACGGCTAGAAGAACAACTGG
ACAAGTATGAAGAGTGGGCAGACCGTTTTGAGGACCTGCCTCTCTATTTCATGACTTTCCACGG
ACAACAGAGCATCAGGTCTGTCATAGACACAATGCAACATGCTGTCTACGTCTATGACGTTTGT
CATGTAGTCATCGACAACTTGCAGTTCATGATGGGTCATGAGCAGCTCTCTACTGACAGGATCG
CAGCTCAAGACTACATTGTTGGAGCCTTTCGGAAGTTTGCCACAGACAATAGCTGCCACGTGAC
TCTGGTTATTCACCCACGGAAAGAAGATGACGACAAGGAACTACAGACAGCATCCATTTTTGGC
TCAGCCAAAGCCAGCCAAGAAGCAGACAATGTTCTGATCTTGCAGGACAGGAAGCTGGTGACTG
GGCCTGGGAAACGGTATCTGCAGGTGTCCAAAAATCGCTTTGATGGAGACGTAGGCGTCTTCCC
ACTTGAGTTCAACAAGAGTTCCCTTACCTTCTCCATCCCACCTAAGAGCAAAGCCCGACTCAAG
AAGATTAAGGATGACAATGGACTAGTGGCCAAGAAGTCCTCCTCTGGAAAAAAAGGGTCTGCGC
ACCAGAACTCTGAGACTTGCATAGGCCAGGACCCCTGCCAGCCAGATACCTCCCCGTCCTCAAG
GCATAAGAATTGATCTGAGGTGCTTATCCTGTGCTGTCAGAGCCTCAAAGCTGGACCATGGAGA
GAAGCTGTGAGCCTGCAGTGCCTGCCCCCTTGATGCCGATTCCACTGTGTGCTGCTGCCTTGGA
CAGCGGGAGCTAGGACTCTTGGTGGAGCCTTTTCCAGTTGAATGAAGCATTTCTATGGCCTCTG

hide sequence

RefSeq Acc Id:

XM_008760430 ⟹ XP_008758652

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	253,817,074 - 253,823,958 (+)	NCBI
mRatBN7.2	1	243,867,568 - 243,874,802 (+)	NCBI
Rnor_6.0	1	264,756,060 - 264,762,892 (+)	NCBI

Sequence:

show sequence

TTCAAGTATATTACGACTCCTGGGTTCCGTCGGGCGAAGTCCGTCACTTCGCGTTCCACGAACT
CCCTGGGGACCCAACGAAGGGCCAACAGGCAGTGGCAAGACAACATTCATCAGTGAGTATGCCC
TGGACTTGTGTACCCAGGGAGTGAACACACTGTGGGGTAGCTTTGAGATCAGCAATGTGAGACT
AGCCCGGGTCATGCTGACTCAGTTTGCTGTGACACGGCTAGAAGAACAACTGGACAAGTATGAA
GAGTGGGCAGACCGTTTTGAGGACCTGCCTCTCTATTTCATGACTTTCCACGGACAACAGAGCA
TCAGGTCTGTCATAGACACAATGCAACATGCTGTCTACGTCTATGACGTTTGTCATGTAGTCAT
CGACAACTTGCAGTTCATGATGGGTCATGAGCAGCTCTCTACTGACAGGATCGCAGCTCAAGAC
TACATTGTTGGAGCCTTTCGGAAGTTTGCCACAGACAATAGCTGCCACGTGACTCTGGTTATTC
ACCCACGGAAAGAAGATGACGACAAGGAACTACAGACAGCATCCATTTTTGGCTCAGCCAAAGC
CAGCCAAGAAGCAGACAATGTTCTGATCTTGCAGGACAGGAAGCTGGTGACTGGGCCTGGGAAA
CGGTATCTGCAGGTGTCCAAAAATCGCTTTGATGGAGACGTAGGCGTCTTCCCACTTGAGTTCA
ACAAGAGTTCCCTTACCTTCTCCATCCCACCTAAGAGCAAAGCCCGACTCAAGAAGATTAAGGA
TGACAATGGACTAGTGGCCAAGAAGTCCTCCTCTGGAAAAAAAGGGTCTGCGCACCAGAACTCT
GAGACTTGCATAGGCCAGGACCCCTGCCAGCCAGATACCTCCCCGTCCTCAAGGCATAAGAATT
GATCTGAGGTGCTTATCCTGTGCTGTCAGAGCCTCAAAGCTGGACCATGGAGAGAAGCTGTGAG
CCTGCAGTGCCTGCCCCCTTGATGCCGATTCCACTGTGTGCTGCTGCCTTGGACAGCGGGAGCT
AGGACTCTTGGTGGAGCCTTTTCCAGTTGAATGAAGCATTTCTATGGCCTCTG

hide sequence

RefSeq Acc Id:

XM_008760431 ⟹ XP_008758653

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	253,817,497 - 253,823,958 (+)	NCBI
mRatBN7.2	1	243,868,361 - 243,874,802 (+)	NCBI
Rnor_6.0	1	264,756,453 - 264,762,892 (+)	NCBI

Sequence:

show sequence

CGAGCGGCGCGTGCGGGCAACCCACGTTTTGGACAGAACACTAGAGAGGAGAGTGGTGACGCGA
AGCTGGGGGCGGGAGCGTGGAGCTTCTGAAGCCGAGGGTAGAGCCCTGGAGCCTGTAAGGGAGC
CGGGGCCAACAGGCAGTGGCAAGACAACATTCATCAGTGAGTATGCCCTGGACTTGTGTACCCA
GGGAGTGAACACACTGTGGGGTAGCTTTGAGATCAGCAATGTGAGACTAGCCCGGGTCATGCTG
ACTCAGTTTGCTGTGACACGGCTAGAAGAACAACTGGACAAGTATGAAGAGTGGGCAGACCGTT
TTGAGGACCTGCCTCTCTATTTCATGACTTTCCACGGACAACAGAGCATCAGGTCTGTCATAGA
CACAATGCAACATGCTGTCTACGTCTATGACGTTTGTCATGTAGTCATCGACAACTTGCAGTTC
ATGATGGGTCATGAGCAGCTCTCTACTGACAGGATCGCAGCTCAAGACTACATTGTTGGAGCCT
TTCGGAAGTTTGCCACAGACAATAGCTGCCACGTGACTCTGGTTATTCACCCACGGAAAGAAGA
TGACGACAAGGAACTACAGACAGCATCCATTTTTGGCTCAGCCAAAGCCAGCCAAGAAGCAGAC
AATGTTCTGATCTTGCAGGACAGGAAGCTGGTGACTGGGCCTGGGAAACGGTATCTGCAGGTGT
CCAAAAATCGCTTTGATGGAGACGTAGGCGTCTTCCCACTTGAGTTCAACAAGAGTTCCCTTAC
CTTCTCCATCCCACCTAAGAGCAAAGCCCGACTCAAGAAGATTAAGGATGACAATGGACTAGTG
GCCAAGAAGTCCTCCTCTGGAAAAAAAGGGTCTGCGCACCAGAACTCTGAGACTTGCATAGGCC
AGGACCCCTGCCAGCCAGATACCTCCCCGTCCTCAAGGCATAAGAATTGATCTGAGGTGCTTAT
CCTGTGCTGTCAGAGCCTCAAAGCTGGACCATGGAGAGAAGCTGTGAGCCTGCAGTGCCTGCCC
CCTTGATGCCGATTCCACTGTGTGCTGCTGCCTTGGACAGCGGGAGCTAGGACTCTTGGTGGAG
CCTTTTCCAGTTGAATGAAGCATTTCTATGGCCTCTG

hide sequence

RefSeq Acc Id:

XM_017589287 ⟹ XP_017444776

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	253,817,515 - 253,823,958 (+)	NCBI
mRatBN7.2	1	243,868,351 - 243,874,802 (+)	NCBI
Rnor_6.0	1	264,756,453 - 264,762,892 (+)	NCBI

Sequence:

show sequence

CGAGCGGCGCGTGCGGGCAACCCACGTTTTGGACAGAACACTAGAGAGGAGAGTGGTGACGCGA
AGCTGGGGGCGGGAGCGTGGAGCTTCTGAAGCCGAGGGTAGAGCCCTGGAGCCTGGCCAACAGG
CAGTGGCAAGACAACATTCATCAGTGAGTATGCCCTGGACTTGTGTACCCAGGGAGTGAACACA
CTGTGGGGTAGCTTTGAGATCAGCAATGTGAGACTAGCCCGGGTCATGCTGACTCAGTTTGCTG
TGACACGGCTAGAAGAACAACTGGACAAGTATGAAGAGTGGGCAGACCGTTTTGAGGACCTGCC
TCTCTATTTCATGACTTTCCACGGACAACAGAGCATCAGGTCTGTCATAGACACAATGCAACAT
GCTGTCTACGTCTATGACGTTTGTCATGTAGTCATCGACAACTTGCAGTTCATGATGGGTCATG
AGCAGCTCTCTACTGACAGGATCGCAGCTCAAGACTACATTGTTGGAGCCTTTCGGAAGTTTGC
CACAGACAATAGCTGCCACGTGACTCTGGTTATTCACCCACGGAAAGAAGATGACGACAAGGAA
CTACAGACAGCATCCATTTTTGGCTCAGCCAAAGCCAGCCAAGAAGCAGACAATGTTCTGATCT
TGCAGGACAGGAAGCTGGTGACTGGGCCTGGGAAACGGTATCTGCAGGTGTCCAAAAATCGCTT
TGATGGAGACGTAGGCGTCTTCCCACTTGAGTTCAACAAGAGTTCCCTTACCTTCTCCATCCCA
CCTAAGAGCAAAGCCCGACTCAAGAAGATTAAGGATGACAATGGACTAGTGGCCAAGAAGTCCT
CCTCTGGAAAAAAAGGGTCTGCGCACCAGAACTCTGAGACTTGCATAGGCCAGGACCCCTGCCA
GCCAGATACCTCCCCGTCCTCAAGGCATAAGAATTGATCTGAGGTGCTTATCCTGTGCTGTCAG
AGCCTCAAAGCTGGACCATGGAGAGAAGCTGTGAGCCTGCAGTGCCTGCCCCCTTGATGCCGAT
TCCACTGTGTGCTGCTGCCTTGGACAGCGGGAGCTAGGACTCTTGGTGGAGCCTTTTCCAGTTG
AATGAAGCATTTCTATGGCCTCTG

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Protein Sequences


Protein RefSeqs	NP_001101069	(Get FASTA)	NCBI Sequence Viewer
	XP_008758651	(Get FASTA)	NCBI Sequence Viewer
	XP_008758652	(Get FASTA)	NCBI Sequence Viewer
	XP_008758653	(Get FASTA)	NCBI Sequence Viewer
	XP_017444776	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL94298	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000034807
	ENSRNOP00000034807.6
	ENSRNOP00000103462
	ENSRNOP00000103462.1

RefSeq Acc Id:

NP_001101069 ⟸ NM_001107599

- UniProtKB:

D3ZA68 (UniProtKB/TrEMBL), A6JHH4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWLLLRRAYPLRILLPLRGEWMGRRGLPRSLAPGPPRRRYRKEALPALEVPVSPVTTTEIRQYL
RAHGIPFQDGHSCLRAPSPFVAPSDIKNQKKDATTSFCLFIDKTTGHFLCMTSLAEGSWEDLQA
SVEGRGDGAKEGILLGEGPEAEDREEVLRIWNRAIPLWELPDPQETQLARVMFGLTKVTDDTLR
RFNVRYLRSTRSLVFPWFTPGSSGLRGLKLLGVEGQENGVQYVETTIPRPGVYHNLFGLPLIGR
RDTEVVLTSRELDSLALSQSTGLPTLSLPRGTVCLPPALLPYLEQFRRIVFWLGDDLRSWEAAK
LFARKLNPKRCSLVRPGNQQPRPLEALNQGLSLPRILRTALPAWHKSIVSFRQLREEVLGELSN
VDQAAGVRWSRFPDLNRLLKGHRKGELTVFTGPTGSGKTTFISEYALDLCTQGVNTLWGSFEIS
NVRLARVMLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVC
HVVIDNLQFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFG
SAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLK
KIKDDNGLVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSR

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RefSeq Acc Id:

XP_008758652 ⟸ XM_008760430

- Peptide Label:

isoform X2

- Sequence:

show sequence

MLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNL
QFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQE
ADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLKKIKDDNG
LVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSRHKN

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RefSeq Acc Id:	XP_008758651 ⟸ XM_008760429
- Peptide Label:	isoform X1
- UniProtKB:	D3ZA68 (UniProtKB/TrEMBL)
- Sequence:	show sequence MWLLLRRAYPLRILLPLRGEWMGRRGLPRSLAPGPPRRRYRKEALPALEVPVSPVTTTEIRQYL RAHGIPFQDGHSCLRAPSPFVAPSDIKNQKKDATTSFCLFIDKTTGHFLCMTSLAEGSWEDLQA SVEGRGDGAKEGILLGEGPEAEDREEVLRIWNRAIPLWELPDPQETQLARVMFGLTKVTDDTLR RFNVRYLRSTRSLVFPWFTPGSSGLRGLKLLGVEGQENGVQYVETTIPRPGVYHNLFGLPLIGR RDTEVVLTSRELDSLALSQSTGLPTLSLPRGTVCLPPALLPYLEQFRRIVFWLGDDLRSWEAAK LFARKLNPKRCSLVRPGNQQPRPLEALNQGLSLPRILRTALPAWHKSIVSFRQLREEVLGELSN VDQAAGVRWSRFPDLNRLLKGHRKGELTVFTGPTGSGKTTFISEYALDLCTQGVNTLWGSFEIS NVRLARVMLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVC HVVIDNLQFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFG SAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLK KIKDDNGLVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSRHKN hide sequence

RefSeq Acc Id:

XP_008758653 ⟸ XM_008760431

- Peptide Label:

isoform X2

- Sequence:

show sequence

MLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNL
QFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQE
ADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLKKIKDDNG
LVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSRHKN

hide sequence

RefSeq Acc Id:

XP_017444776 ⟸ XM_017589287

- Peptide Label:

isoform X2

- Sequence:

show sequence

MLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNL
QFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQE
ADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLKKIKDDNG
LVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSRHKN

hide sequence

Ensembl Acc Id:

ENSRNOP00000034807 ⟸ ENSRNOT00000031018

Ensembl Acc Id:

ENSRNOP00000103462 ⟸ ENSRNOT00000129580

Protein Domains

SF4 helicase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZA68-F1-model_v2	AlphaFold	D3ZA68	1-683	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690945

Promoter ID:

EPDNEW_R1470

Type:

initiation region

Name:

Twnk_1

Description:

twinkle mtDNA helicase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	264,756,445 - 264,756,505	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307884	AgrOrtholog
BioCyc Gene	G2FUF-55570	BioCyc
Ensembl Genes	ENSRNOG00000014935	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000031018	ENTREZGENE
	ENSRNOT00000031018.6	UniProtKB/TrEMBL
	ENSRNOT00000129580	ENTREZGENE
	ENSRNOT00000129580.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1360.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	DNA_helicase_DnaB-like_C	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	TOPRIM_DnaG/twinkle	UniProtKB/TrEMBL
	Twinkle-like	UniProtKB/TrEMBL
KEGG Report	rno:309441	UniProtKB/TrEMBL
NCBI Gene	309441	ENTREZGENE
PANTHER	PTHR12873	UniProtKB/TrEMBL
	TWINKLE PROTEIN, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	AAA_25	UniProtKB/TrEMBL
PhenoGen	Twnk	PhenoGen
PROSITE	SF4_HELICASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014935	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0ABK0LFN5_RAT	UniProtKB/TrEMBL
	A6JHH4	ENTREZGENE, UniProtKB/TrEMBL
	D3ZA68	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-28	Twnk	twinkle mtDNA helicase	Peo1	progressive external ophthalmoplegia 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-04-23	Peo1	progressive external ophthalmoplegia 1	Peo1	progressive external ophthalmoplegia 1 (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Peo1	progressive external ophthalmoplegia 1 (human)	Peo1_predicted	progressive external ophthalmoplegia 1 homolog (human) (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Peo1_predicted	progressive external ophthalmoplegia 1 homolog (human) (predicted)		progressive external ophthalmoplegia 1 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Peo1_predicted	progressive external ophthalmoplegia 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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