Prcp (prolylcarboxypeptidase) - Rat Genome Database

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Gene: Prcp (prolylcarboxypeptidase) Rattus norvegicus
Analyze
Symbol: Prcp
Name: prolylcarboxypeptidase
RGD ID: 1307842
Description: Predicted to enable dipeptidyl-peptidase activity and metallocarboxypeptidase activity. Predicted to be involved in angiogenesis involved in wound healing; regulation of blood vessel endothelial cell migration; and regulation of systemic arterial blood pressure. Predicted to act upstream of or within several processes, including glucose homeostasis; plasma kallikrein-kinin cascade; and regulation of thyroid hormone receptor signaling pathway. Predicted to be located in basal part of cell and lysosome. Predicted to be active in extracellular region. Biomarker of brain infarction. Orthologous to human PRCP (prolylcarboxypeptidase); PARTICIPATES IN kallikrein-kinin cascade pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC293118; lysosomal Pro-X carboxypeptidase; prolylcarboxypeptidase (angiotensinase C)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bw190 Bw192 Bw194
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,343,894 - 156,396,295 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1156,343,896 - 156,396,939 (+)EnsemblGRCr8
mRatBN7.21146,931,487 - 146,983,891 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1146,930,561 - 146,984,530 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1154,881,441 - 154,933,793 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01162,061,635 - 162,113,987 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01154,935,079 - 154,987,439 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01157,701,089 - 157,750,177 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1157,701,089 - 157,750,169 (+)Ensemblrn6Rnor6.0
Rnor_5.01163,944,735 - 163,993,907 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41149,711,289 - 149,763,876 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1145,111,750 - 145,163,370 (+)NCBICelera
RGSC_v3.11149,789,694 - 149,841,461 (+)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
furan  (EXP)
ivermectin  (ISO)
linezolid  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
basal part of cell  (IEA,ISO)
extracellular region  (IEA,ISO)
lysosome  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Prolylcarboxypeptidase: a cardioprotective enzyme. Mallela J, etal., Int J Biochem Cell Biol. 2009 Mar;41(3):477-81. doi: 10.1016/j.biocel.2008.02.022. Epub 2008 Feb 29.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:19018804   PMID:19056867   PMID:19620781   PMID:21297000   PMID:22202165   PMID:22454290   PMID:23376485   PMID:23533145   PMID:23744584   PMID:24627106   PMID:25218829   PMID:26509155  
PMID:29514215  


Genomics

Comparative Map Data
Prcp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,343,894 - 156,396,295 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1156,343,896 - 156,396,939 (+)EnsemblGRCr8
mRatBN7.21146,931,487 - 146,983,891 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1146,930,561 - 146,984,530 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1154,881,441 - 154,933,793 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01162,061,635 - 162,113,987 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01154,935,079 - 154,987,439 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01157,701,089 - 157,750,177 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1157,701,089 - 157,750,169 (+)Ensemblrn6Rnor6.0
Rnor_5.01163,944,735 - 163,993,907 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41149,711,289 - 149,763,876 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1145,111,750 - 145,163,370 (+)NCBICelera
RGSC_v3.11149,789,694 - 149,841,461 (+)NCBI
Cytogenetic Map1q32NCBI
PRCP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381182,822,936 - 82,901,644 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1182,822,936 - 82,970,584 (-)Ensemblhg38GRCh38
GRCh371182,533,978 - 82,612,686 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361182,213,057 - 82,289,205 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341182,213,057 - 82,289,205NCBI
Celera1179,845,280 - 79,921,309 (-)NCBICelera
Cytogenetic Map11q14.1NCBI
HuRef1178,832,683 - 78,908,888 (-)NCBIHuRef
CHM1_11182,419,542 - 82,495,693 (-)NCBICHM1_1
T2T-CHM13v2.01182,759,396 - 82,838,151 (-)NCBIT2T-CHM13v2.0
Prcp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39792,524,461 - 92,583,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl792,523,678 - 92,583,791 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38792,875,253 - 92,934,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl792,874,470 - 92,934,583 (+)Ensemblmm10GRCm38
MGSCv377100,023,763 - 100,083,091 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36792,750,489 - 92,809,191 (+)NCBIMGSCv36mm8
Celera790,163,557 - 90,222,992 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map751.64NCBI
Prcp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554149,631,223 - 9,700,184 (+)Ensembl
ChiLan1.0NW_0049554149,631,223 - 9,700,537 (+)NCBIChiLan1.0ChiLan1.0
PRCP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2983,756,442 - 83,833,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11184,807,700 - 84,884,861 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,890,115 - 77,967,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11181,502,658 - 81,579,504 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1181,502,658 - 81,578,361 (-)EnsemblpanPan2panpan1.1
PRCP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12116,219,688 - 16,285,186 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2116,219,831 - 16,285,188 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2116,097,793 - 16,163,243 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02116,408,607 - 16,474,124 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2116,409,749 - 16,474,124 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12116,183,589 - 16,248,861 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02116,263,613 - 16,328,869 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02116,333,763 - 16,399,043 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prcp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494769,437,691 - 69,510,026 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649811,036,916 - 11,109,788 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649811,037,294 - 11,109,657 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRCP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl917,002,699 - 17,076,284 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1917,002,699 - 17,134,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2918,896,514 - 18,972,510 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRCP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1174,021,085 - 74,104,623 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl174,018,409 - 74,104,515 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604351,600,562 - 51,685,236 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prcp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248456,973,452 - 7,070,019 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248456,973,816 - 7,067,187 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Prcp
207 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000014271
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat

Markers in Region
RH131211  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21146,980,552 - 146,980,759 (+)MAPPERmRatBN7.2
Rnor_6.01157,746,838 - 157,747,044NCBIRnor6.0
Rnor_5.01163,990,568 - 163,990,774UniSTSRnor5.0
RGSC_v3.41149,760,537 - 149,760,743UniSTSRGSC3.4
Celera1145,160,031 - 145,160,237UniSTS
RH 3.4 Map11133.9UniSTS
Cytogenetic Map1q32UniSTS
AU049686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21146,948,214 - 146,948,355 (+)MAPPERmRatBN7.2
Rnor_6.01157,717,819 - 157,717,959NCBIRnor6.0
Rnor_5.01163,961,465 - 163,961,605UniSTSRnor5.0
RGSC_v3.41149,728,025 - 149,728,165UniSTSRGSC3.4
Celera1145,128,468 - 145,128,608UniSTS
Cytogenetic Map1q32UniSTS
AI451719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21146,978,153 - 146,978,253 (+)MAPPERmRatBN7.2
Rnor_6.01157,744,483 - 157,744,582NCBIRnor6.0
Rnor_5.01163,988,213 - 163,988,312UniSTSRnor5.0
RGSC_v3.41149,758,138 - 149,758,237UniSTSRGSC3.4
Celera1145,157,632 - 145,157,731UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014271   ⟹   ENSRNOP00000014271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1156,343,896 - 156,396,939 (+)Ensembl
mRatBN7.2 Ensembl1146,931,496 - 146,984,530 (+)Ensembl
Rnor_6.0 Ensembl1157,701,089 - 157,750,169 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094554   ⟹   ENSRNOP00000090435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1146,930,561 - 146,983,066 (+)Ensembl
RefSeq Acc Id: NM_001106281   ⟹   NP_001099751
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,343,894 - 156,396,295 (+)NCBI
mRatBN7.21146,931,487 - 146,983,891 (+)NCBI
Rnor_6.01157,701,089 - 157,750,177 (+)NCBI
Rnor_5.01163,944,735 - 163,993,907 (+)NCBI
RGSC_v3.41149,711,289 - 149,763,876 (+)RGD
Celera1145,111,750 - 145,163,370 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099751 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18511 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014271
  ENSRNOP00000014271.4
RefSeq Acc Id: NP_001099751   ⟸   NM_001106281
- Peptide Label: precursor
- UniProtKB: D4AA31 (UniProtKB/TrEMBL),   A0A8I6AN30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014271   ⟸   ENSRNOT00000014271
Ensembl Acc Id: ENSRNOP00000090435   ⟸   ENSRNOT00000094554

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA31-F1-model_v2 AlphaFold D4AA31 1-493 view protein structure
PRCP pdb 3n2z D4AA31 43-488 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690199
Promoter ID:EPDNEW_R724
Type:initiation region
Name:Prcp_1
Description:prolylcarboxypeptidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01157,701,109 - 157,701,169EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307842 AgrOrtholog
BioCyc Gene G2FUF-58488 BioCyc
Ensembl Genes ENSRNOG00000010630 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014271 ENTREZGENE
  ENSRNOT00000014271.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.980 UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Peptidase_S28 UniProtKB/TrEMBL
  Ser_carbopepase_S28_SKS UniProtKB/TrEMBL
KEGG Report rno:293118 UniProtKB/TrEMBL
NCBI Gene 293118 ENTREZGENE
PANTHER LYSOSOMAL PRO-X CARBOXYPEPTIDASE UniProtKB/TrEMBL
  PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED UniProtKB/TrEMBL
Pfam Peptidase_S28 UniProtKB/TrEMBL
PhenoGen Prcp PhenoGen
RatGTEx ENSRNOG00000010630 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8I6AN30 ENTREZGENE
  D4AA31 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Prcp  prolylcarboxypeptidase  Prcp  prolylcarboxypeptidase (angiotensinase C)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Prcp  prolylcarboxypeptidase (angiotensinase C)   Prcp_predicted  prolylcarboxypeptidase (angiotensinase C) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Prcp_predicted  prolylcarboxypeptidase (angiotensinase C) (predicted)      Symbol and Name status set to approved 70820 APPROVED