Fam209 (family with sequence similarity 209) - Rat Genome Database

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Gene: Fam209 (family with sequence similarity 209) Rattus norvegicus
Analyze
Symbol: Fam209
Name: family with sequence similarity 209
RGD ID: 1307805
Description: Predicted to be involved in acrosome assembly. Predicted to be located in acrosomal vesicle and nuclear inner membrane. Orthologous to several human genes including FAM209B (family with sequence similarity 209 member B); INTERACTS WITH bisphenol A; cadmium dichloride; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fam209a; family with sequence similarity 209 member B; family with sequence similarity 209, member A; hypothetical LOC296411; hypothetical protein LOC296411; LOC296411; RGD1307805; uncharacterized protein LOC296411
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83181,658,479 - 181,660,164 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3181,658,461 - 181,660,164 (+)EnsemblGRCr8
mRatBN7.23161,240,062 - 161,241,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,240,034 - 161,241,755 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3165,049,976 - 165,051,661 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03173,548,998 - 173,550,683 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,290,817 - 171,292,502 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,475,831 - 170,477,516 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,475,831 - 170,477,516 (+)Ensemblrn6Rnor6.0
Rnor_5.03176,551,257 - 176,552,942 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43163,382,104 - 163,383,789 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3160,439,543 - 160,441,228 (+)NCBICelera
RGSC_v3.13163,288,186 - 163,289,828 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21630459  


Genomics

Comparative Map Data
Fam209
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83181,658,479 - 181,660,164 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3181,658,461 - 181,660,164 (+)EnsemblGRCr8
mRatBN7.23161,240,062 - 161,241,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,240,034 - 161,241,755 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3165,049,976 - 165,051,661 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03173,548,998 - 173,550,683 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,290,817 - 171,292,502 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,475,831 - 170,477,516 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,475,831 - 170,477,516 (+)Ensemblrn6Rnor6.0
Rnor_5.03176,551,257 - 176,552,942 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43163,382,104 - 163,383,789 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3160,439,543 - 160,441,228 (+)NCBICelera
RGSC_v3.13163,288,186 - 163,289,828 (+)NCBI
Cytogenetic Map3q42NCBI
FAM209B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382056,533,246 - 56,536,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2056,533,246 - 56,536,520 (+)Ensemblhg38GRCh38
GRCh372055,108,302 - 55,111,576 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362054,541,709 - 54,544,983 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2051,848,734 - 51,852,008 (+)NCBICelera
Cytogenetic Map20q13.31NCBI
HuRef2051,892,678 - 51,895,950 (+)NCBIHuRef
CHM1_12055,009,547 - 55,012,798 (+)NCBICHM1_1
T2T-CHM13v2.02058,310,734 - 58,314,011 (+)NCBIT2T-CHM13v2.0
Fam209
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,314,474 - 172,316,236 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2172,314,440 - 172,316,251 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382172,472,554 - 172,474,316 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2172,472,520 - 172,474,331 (+)Ensemblmm10GRCm38
MGSCv372172,298,054 - 172,299,816 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362172,163,733 - 172,165,536 (+)NCBIMGSCv36mm8
Celera2178,434,213 - 178,435,975 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map294.87NCBI
FAM209B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22162,279,189 - 62,287,897 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12062,272,304 - 62,279,758 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02052,865,695 - 52,878,805 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12054,155,508 - 54,163,919 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2054,161,366 - 54,163,910 (+)EnsemblpanPan2panpan1.1
LOC611771
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12441,710,637 - 41,712,305 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2440,958,180 - 40,959,840 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02442,473,409 - 42,475,068 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12441,660,898 - 41,662,558 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02441,800,163 - 41,801,823 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02442,458,447 - 42,460,107 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
FAM209B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1757,087,126 - 57,088,944 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11757,087,126 - 57,088,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21764,198,764 - 64,200,593 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103243877
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.127,576,393 - 7,596,092 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605055,649,449 - 55,669,450 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam209b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474123,201,781 - 23,204,038 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:11
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000006949
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3181611379189428310Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
BF404558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,241,405 - 161,241,606 (+)MAPPERmRatBN7.2
Rnor_6.03170,477,175 - 170,477,375NCBIRnor6.0
Rnor_5.03176,552,601 - 176,552,801UniSTSRnor5.0
RGSC_v3.43163,383,448 - 163,383,648UniSTSRGSC3.4
Celera3160,440,887 - 160,441,087UniSTS
RH 3.4 Map31496.8UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 7 20 81 49 50 27 42 27 3 134 74 71 26 44 23 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000006949   ⟹   ENSRNOP00000006949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3181,658,461 - 181,660,164 (+)Ensembl
mRatBN7.2 Ensembl3161,240,062 - 161,241,747 (+)Ensembl
Rnor_6.0 Ensembl3170,475,831 - 170,477,516 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113984   ⟹   ENSRNOP00000077031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,240,034 - 161,241,755 (+)Ensembl
RefSeq Acc Id: NM_001106548   ⟹   NP_001100018
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83181,658,479 - 181,660,164 (+)NCBI
mRatBN7.23161,240,062 - 161,241,747 (+)NCBI
Rnor_6.03170,475,831 - 170,477,516 (+)NCBI
Rnor_5.03176,551,257 - 176,552,942 (+)NCBI
RGSC_v3.43163,382,104 - 163,383,789 (+)RGD
Celera3160,439,543 - 160,441,228 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100018 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85140 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006949
  ENSRNOP00000006949.4
RefSeq Acc Id: NP_001100018   ⟸   NM_001106548
- Peptide Label: precursor
- UniProtKB: D3ZKD8 (UniProtKB/TrEMBL),   A6KKX6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006949   ⟸   ENSRNOT00000006949
Ensembl Acc Id: ENSRNOP00000077031   ⟸   ENSRNOT00000113984

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKD8-F1-model_v2 AlphaFold D3ZKD8 1-170 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692708
Promoter ID:EPDNEW_R3232
Type:initiation region
Name:Fam209a_1
Description:family with sequence similarity 209, member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03170,475,813 - 170,475,873EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307805 AgrOrtholog
BioCyc Gene G2FUF-46536 BioCyc
Ensembl Genes ENSRNOG00000005235 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006949 ENTREZGENE
  ENSRNOT00000006949.7 UniProtKB/TrEMBL
InterPro FAM209 UniProtKB/TrEMBL
KEGG Report rno:296411 UniProtKB/TrEMBL
NCBI Gene 296411 ENTREZGENE
PANTHER PROTEIN FAM209A UniProtKB/TrEMBL
  PTHR35157 UniProtKB/TrEMBL
Pfam FAM209 UniProtKB/TrEMBL
PhenoGen Fam209 PhenoGen
RatGTEx ENSRNOG00000005235 RatGTEx
UniProt A6KKX6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKD8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-17 Fam209  family with sequence similarity 209  Fam209  family with sequence similarity 209 member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-16 Fam209  family with sequence similarity 209 member B  Fam209a  family with sequence similarity 209, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-06 Fam209a  family with sequence similarity 209, member A  RGD1307805  hypothetical LOC296411  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1307805  hypothetical LOC296411   RGD1307805_predicted  hypothetical LOC296411 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1307805_predicted  hypothetical LOC296411 (predicted)  LOC296411_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296411_predicted  hypothetical LOC296411 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL