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Gene: Ifit2 (interferon-induced protein with tetratricopeptide repeats 2) Rattus norvegicus

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Symbol:

Ifit2

Name:

interferon-induced protein with tetratricopeptide repeats 2

RGD ID:

1307804

Description:

Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus and positive regulation of apoptotic process. Predicted to act upstream of or within antiviral innate immune response and cellular response to interferon-alpha. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human IFIT2 (interferon induced protein with tetratricopeptide repeats 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC294091

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	241,515,735 - 241,521,799 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	241,515,709 - 241,521,798 (+)	Ensembl				GRCr8
mRatBN7.2	1	232,102,570 - 232,108,638 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	232,102,570 - 232,108,635 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	240,492,458 - 240,498,552 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	247,415,346 - 247,421,410 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	240,253,552 - 240,259,616 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	252,894,663 - 252,900,727 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	252,894,663 - 252,900,726 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	260,116,148 - 260,122,212 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	238,559,729 - 238,565,793 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	229,215,652 - 229,221,701 (+)	NCBI		Celera
RGSC_v3.1	1	238,723,617 - 238,729,681 (+)	NCBI
Cytogenetic Map	1	q53	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Human Influenza (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

22-Hydroxycholesterol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

butanal (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

camptothecin (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

cordycepin (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

DDT (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dichloromethane (ISO)

dieldrin (EXP,ISO)

dimethylarsinous acid (ISO)

dioxygen (EXP)

disulfiram (ISO)

doxorubicin (ISO)

Echimidine (EXP)

endosulfan (EXP)

Enterolactone (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

ethylbenzene (ISO)

flurbiprofen (ISO)

flutamide (EXP)

formaldehyde (ISO)

fructose (ISO)

gentamycin (EXP)

glucose (ISO)

glyphosate (ISO)

GSK-J4 (ISO)

hexadecanoic acid (ISO)

indometacin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

metam (ISO)

methapyrilene (EXP)

methimazole (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-acetyl-L-cysteine (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

nimesulide (EXP)

nitrates (ISO)

Nutlin-3 (ISO)

o-xylene (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

poly(I:C) (ISO)

potassium dichromate (ISO)

raloxifene (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

senecionine (EXP)

serpentine asbestos (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

sulforaphane (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene (EXP,ISO)

topotecan (EXP)

trichloroethene (ISO)

triphenyl phosphate (ISO)

Triptolide (EXP)

trovafloxacin (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vincristine (ISO)

zidovudine (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antiviral innate immune response (IBA,IEA,ISO)

cellular response to cytokine stimulus (IBA)

cellular response to interferon-alpha (IEA,ISO)

defense response to virus (IEA)

immune system process (IEA)

innate immune response (IEA)

positive regulation of apoptotic process (IEA,ISO)

response to other organism (IEA)

response to virus (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IBA)

endoplasmic reticulum (IEA,ISO)

Molecular Function

protein binding (ISO)

RNA binding (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7896268	PMID:12477932	PMID:19416887	PMID:21085181	PMID:21190939	PMID:21642987	PMID:22658674	PMID:25428874

Genomics

Comparative Map Data

Ifit2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	241,515,735 - 241,521,799 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	241,515,709 - 241,521,798 (+)	Ensembl				GRCr8
mRatBN7.2	1	232,102,570 - 232,108,638 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	232,102,570 - 232,108,635 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	240,492,458 - 240,498,552 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	247,415,346 - 247,421,410 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	240,253,552 - 240,259,616 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	252,894,663 - 252,900,727 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	252,894,663 - 252,900,726 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	260,116,148 - 260,122,212 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	238,559,729 - 238,565,793 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	229,215,652 - 229,221,701 (+)	NCBI		Celera
RGSC_v3.1	1	238,723,617 - 238,729,681 (+)	NCBI
Cytogenetic Map	1	q53	NCBI

IFIT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	89,302,046 - 89,309,271 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	89,283,694 - 89,309,271 (+)	Ensembl			hg38	GRCh38
GRCh37	10	91,061,803 - 91,069,028 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	91,051,686 - 91,059,013 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	91,051,782 - 91,058,658	NCBI
Celera	10	84,808,536 - 84,815,863 (+)	NCBI		Celera
Cytogenetic Map	10	q23.31	NCBI
HuRef	10	84,695,886 - 84,703,213 (+)	NCBI		HuRef
CHM1_1	10	91,343,763 - 91,351,090 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	90,185,914 - 90,193,139 (+)	NCBI		T2T-CHM13v2.0

Ifit2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	34,527,961 - 34,553,934 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	34,528,094 - 34,553,819 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	34,550,550 - 34,576,534 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	34,550,694 - 34,576,419 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	34,625,184 - 34,651,024 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	34,616,943 - 34,642,520 (+)	NCBI		MGSCv36	mm8
Celera	19	35,326,712 - 35,353,360 (+)	NCBI		Celera
Cytogenetic Map	19	C1	NCBI
cM Map	19	29.73	NCBI

Ifit2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	3,682,327 - 3,692,397 (-)	Ensembl
ChiLan1.0	NW_004955425	3,685,626 - 3,692,482 (-)	NCBI	ChiLan1.0	ChiLan1.0

IFIT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	101,320,503 - 101,327,833 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	101,325,811 - 101,333,147 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	86,027,170 - 86,034,246 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	89,566,827 - 89,574,147 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	89,566,827 - 89,573,795 (+)	Ensembl			panPan2	panpan1.1

IFIT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	63,020 - 71,734 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	62,801 - 69,868 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	101,029 - 109,732 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	80,723 - 89,386 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	80,493 - 87,519 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	73,156 - 81,858 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	180,486 - 189,179 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	380,558 - 389,253 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

IFIT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	101,193,419 - 101,204,288 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	101,193,421 - 101,204,292 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	110,179,601 - 110,190,465 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IFIT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	82,711,647 - 82,718,983 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	82,711,612 - 82,718,973 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	43,387,711 - 43,395,073 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ifit2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	119,458 - 131,567 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624737	123,044 - 129,222 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ifit2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	34,195,606 - 34,201,670 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ifit2
51 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	148
Count of miRNA genes:	114
Interacting mature miRNAs:	128
Transcripts:	ENSRNOT00000054757
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8693637	Alc29	Alcohol consumption QTL 29	2.7	0.258	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	243666627	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	207243873	252243873	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	223964326	248681945	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	237995023	269633915	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	146080545	243492863	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	207243873	252243873	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2314011	Gluco56	Glucose level QTL 56			blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	209203273	254203273	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	202543537	247543537	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	228180370	266453608	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	205674651	250674651	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	207243873	252243873	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	238398865	255849249	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	188241285	250779312	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	208798288	253798288	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228180243	255849249	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	201464383	246464383	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	203675682	248675682	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	205674651	250674651	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	207099883	252099883	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Markers in Region

D1Got348

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	232,102,271 - 232,102,408 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	252,894,367 - 252,894,501	NCBI	Rnor6.0
Rnor_5.0	1	260,115,852 - 260,115,986	UniSTS	Rnor5.0
RGSC_v3.4	1	238,559,433 - 238,559,567	UniSTS	RGSC3.4
Celera	1	229,215,358 - 229,215,490	UniSTS
Cytogenetic Map	1	q52	UniSTS

AI009765

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	232,108,048 - 232,108,242 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	252,900,138 - 252,900,331	NCBI	Rnor6.0
Rnor_5.0	1	260,121,623 - 260,121,816	UniSTS	Rnor5.0
RGSC_v3.4	1	238,565,204 - 238,565,397	UniSTS	RGSC3.4
Celera	1	229,221,112 - 229,221,305	UniSTS
Cytogenetic Map	1	q52	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097384	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000054757 ⟹ ENSRNOP00000051639

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	241,516,697 - 241,520,996 (+)	Ensembl
mRatBN7.2 Ensembl	1	232,102,570 - 232,108,635 (+)	Ensembl
Rnor_6.0 Ensembl	1	252,894,663 - 252,900,726 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000172900 ⟹ ENSRNOP00000110747

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	241,515,709 - 241,521,798 (+)	Ensembl

RefSeq Acc Id:

NM_001024753 ⟹ NP_001019924

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	241,515,735 - 241,521,799 (+)	NCBI
mRatBN7.2	1	232,102,570 - 232,108,638 (+)	NCBI
Rnor_6.0	1	252,894,663 - 252,900,727 (+)	NCBI
Rnor_5.0	1	260,116,148 - 260,122,212 (+)	NCBI
RGSC_v3.4	1	238,559,729 - 238,565,793 (+)	RGD
Celera	1	229,215,652 - 229,221,701 (+)	RGD

Sequence:

show sequence

GTCAGCTGCACAGAAACAGGAAAAGAAACCAGCAGCTACTGTTATATATGGGTCTGTAGCATTT
CATTAGAAGGCAGAGGAAGAGCTTGCCTGGAGAGTGCCTGCTGCCAGCCCTGGGCTGAGTGCTT
TGACACAGCGCGCCAGTGACACAGCAGTTGAGTGTGCTTCCAGAGACACAGACACCGACACCAC
AAACAGTCACACAGCAGTCATGAGTACAGCCAGTAAGGAATCATTGGAGAGCAGTCTACAGCAG
CTCAAATGCCACTTCACCTGGAACCTGAGAGCAGAAGACGAGTCCTTGGATGAGTTTGAGGACA
GGGTGTTTAACAAAGATGAGTTTCAGAACAGTGAGTTTAAAGCCACCATGTGCAACCTACTGGC
CTATGTTAAGCATTGCAGAGGTCTAAATGAGGCAGCACTGAAATGCTTAGGGGAAGCCGAAGAC
TTCATCCGGCAACAACATCCTGATCAAATAGAAATCAAAAGTCTGGTCACCTGGGGAAACTATG
CTTGGGTTTACTATCACATGGGCCAGCTGTCCAAAGCTCAGGAGTATCTGGACAAGGTGAAACA
GGTCTGTAAGAAGTTCTCCAGTCCCTACAGGATTGAGAATCCTGTGCTTGACTGTGAGGAGGGG
TGGGCCCGACTAAAGTGTACCAAGAACCAAAATGAGAGAATGAAGGTGTGCTTCGAGAAGGCTC
TGGAAAAGGACCCAAAGAACCCAGAATCCACTTCTGGATGGGCCATTGCAAACTACCGTCTGGA
TGACTGGCCAGCATCCAATGACTATATTGACTCTCTGGAGCAAGCCATTAGCCTGTCTCCTGAC
AACACGTATGTTAAAGTCCTCTTGGCAATGAAACTTGAGGAGGTGCATGAAAACCGAGCAAAGG
AGCTAGTTGAAGAAGCCTTGAAGAAGGACCCAAGTGCAATAGATACAATGCTTGGTGCAGCCAA
GTTTTACGTCAAGGTACATGACACAGACAGAGCAATACAGTTGCTTAAAAAGGCTTTGGAATCC
ATGCCCAACAATGCTTATGTGCATTACTACCTTGGGTGCTGTTACAGGTCAAAAGTCCTTCACA
TACTGAACACCGAAGAAACCACATCTAATGGAAATAGGGAGAAGTTAGAGGCACTGATACAACC
AGCACTGAATCACTTACGGAAAGCAGAGGATATCAAGGAGATGATCGAAAATTCCTGTAGTCAC
CTCGCCGGCCTTTATGTCACAACAAAGCAGTATGAAGAAGCCGATTATTACTTCCAGAAAGAAT
TCAACAAGGACCTCCGTCCCCTCCCTAAACAGTTACTCCATCTACGGTATGGCAACTTTCAGTT
CTACGAAAGGAAGTGTGAAGACAGAGCCATCTACCACTATATGGAGGGTGTGAAAATAAATCGG
GAATCAAAGCCTAAAGGAAAGATGAGAGACAAACTTCGAAAACTTGCTCTAAGGCGGCTTTCTA
GAGATGAATCTGATCCTGAGGCCTTGCGCATCTTGGCATTCCTTAGGGAGCATAGAGAAGGTCA
GGGAGCTGATAAAGCCTCGGAGGGAGAAGAGGACCCTGGAAACCGGGTCCCTTCAGCATCTTTG
GAATGAAAACTAGTGACACAGTGGCAGGCTTACTGCTAGAAGGAAACCGCAAACCCTTACCAAG
CTGCCATTTAAAATACTTAACAACTCCATGGACCAAGCATGGTCTGTCATTCTGACTAATAGTA
TTCGTCAGAATTTTGGGGAATTCTGCTGTCAGGTTTTAGCACCTGAATTGCTGGATCATGGGGT
GTCTGAGAGAGGGACCAAACGCAGGGAGAGATGTAGGATCTTAGCAAACAGCGTAGGGTTCTAT
TTCTTTAAAATAGTTTCCACAGTAGTAATTCTTTAATCACCCCCCCCCAGCTTGCCTGGAGTTT
GATGCTGTATTTATTCAAAGCAGCCAAATTCCTCACATGGGTGAGTGTTCCACCCTTGAATTAC
TTGAGATGTTGCACAGCCCTGCTCTACAATGTCCATCAAAAGGCTGAGGAGCCAGGGACTGTGG
CTCGGGACTGTGATCCTAGCACTTGGGAACTGAGACAGGAGGATTACAGTAAGCTTGAGGTCAG
CCTGAACATGACCTGGAAGGGGTGGTGGTGGTGGGTGATGGGAATTATAAATGTAATACTTAAT
GACTACATATATTTGCCTTGCTAGTTTGAGTGTAGATATGTCTATATAACCACTATTAACACAC
ACACACACACACACACACACACACACACACACACAGAGAGAGAGAGAGAGAGAGAGAGAGAGAG
AGAGAGAGAAGGTGGTGATTTTGCTTTATTGAATAAATTTGAGACTAACAAAATAATGTCCAAT
ATTAATTGAGCTCAAAATAGAAATTCAATAGTGAGTCCCAGGTCTAAAAACAAACAAACAACAA
AAGCTGTGGGGCCAAATCATTTCTCCAGTTTACCAGCCACTCCTCAATCTATGGCGTCTCACAC
ACATGAGTTTAACTGTTCCATTAGCTCAGAGGCAGACTTCCAGAAGGCAGACAAGGAGACTTCT
TAGCCACTCTTTTCTCCTATGACTATGTTGTTATATGAAAAGAAGGGGGATTCTGTCTCCCATC
CTGACAATTCATATAAACATTTATTTCAAGTGTGTGGAAACTTCACTGGGGATGAAGGGATTGC
CGATTTATACTTGCTGATTATAAACTCCCAAGGGAAATGTTTATAGTCACTGTTAGGAAGCTTT
CCCTGTCAAATGAACACTTATTTTATTCCAAAATGCTACATTGGACCCATATTGCAGATGCCAG
GAAGGCAGCTGGCTGGAAGAATAACTTGGACTGAAGCTTAGGTGGAGAGACTTAGAAATGACAT
GGGTATTGGAGGTTGAGTTGTTTTCTTCCATTAGAAATGTGGCACATGGAGGAATATAAAAAAT
TCTCTTAACTCTGGAAAAAAAACTATAGAAACACCAAAAATTTGACAACTGCCATTTCCTAGGC
AGATCTTGAAGGGCCTAAGTATTGAGGTTGGTATGAATCAACAGAGTCAAGTGGCCCAGCCTAA
GAACTGTCAGCTACATTCCGGGATACAAAAATGTTTCTCTACTGGCATTAGCTTGTCTTTATGT
ATCCATGAACATCTTATTTAGCAATTAAAACATATATGAGTCTCAGATTGTTAAAACTAAACAT
TCCAACAGCTGTAATAATGGTCTATGATATTTTAAAAATTCAAATATTCTCTATGCATTAAGTC
CATTGATATTTGCCATTTGAATTTCTGGAAAAATAACAAATGTTGTTTATAAATAATGCATGAT
GGAACATTAAACTATGCTCTGGAACTGTACTGTACCTTCGCTTTTTTAGACTCAAGTGCAGATA
ATAAAGAGTAACATTACAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001019924	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97384	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000051639.3
	ENSRNOP00000110747
	ENSRNOP00000110747.1

RefSeq Acc Id:

NP_001019924 ⟸ NM_001024753

- UniProtKB:

Q4V8H9 (UniProtKB/TrEMBL), A6I135 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSTASKESLESSLQQLKCHFTWNLRAEDESLDEFEDRVFNKDEFQNSEFKATMCNLLAYVKHCR
GLNEAALKCLGEAEDFIRQQHPDQIEIKSLVTWGNYAWVYYHMGQLSKAQEYLDKVKQVCKKFS
SPYRIENPVLDCEEGWARLKCTKNQNERMKVCFEKALEKDPKNPESTSGWAIANYRLDDWPASN
DYIDSLEQAISLSPDNTYVKVLLAMKLEEVHENRAKELVEEALKKDPSAIDTMLGAAKFYVKVH
DTDRAIQLLKKALESMPNNAYVHYYLGCCYRSKVLHILNTEETTSNGNREKLEALIQPALNHLR
KAEDIKEMIENSCSHLAGLYVTTKQYEEADYYFQKEFNKDLRPLPKQLLHLRYGNFQFYERKCE
DRAIYHYMEGVKINRESKPKGKMRDKLRKLALRRLSRDESDPEALRILAFLREHREGQGADKAS
EGEEDPGNRVPSASLE

hide sequence

Ensembl Acc Id:

ENSRNOP00000051639 ⟸ ENSRNOT00000054757

Ensembl Acc Id:

ENSRNOP00000110747 ⟸ ENSRNOT00000172900

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V8H9-F1-model_v2	AlphaFold	Q4V8H9	1-464	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690866

Promoter ID:

EPDNEW_R1390

Type:

multiple initiation site

Name:

Ifit2_1

Description:

interferon-induced protein with tetratricopeptide repeats 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	252,894,643 - 252,894,703	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307804	AgrOrtholog
BioCyc Gene	G2FUF-55872	BioCyc
Ensembl Genes	ENSRNOG00000036604	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000054757.5	UniProtKB/TrEMBL
	ENSRNOT00000172900	ENTREZGENE
	ENSRNOT00000172900.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7446350	IMAGE-MGC_LOAD
InterPro	TPR-like_helical	UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/TrEMBL
KEGG Report	rno:294091	UniProtKB/TrEMBL
MGC_CLONE	MGC:114424	IMAGE-MGC_LOAD
NCBI Gene	294091	ENTREZGENE
PANTHER	INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS	UniProtKB/TrEMBL
	PTHR10271:SF4	UniProtKB/TrEMBL
Pfam	TPR_19	UniProtKB/TrEMBL
	TPR_8	UniProtKB/TrEMBL
PhenoGen	Ifit2	PhenoGen
PROSITE	TPR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000036604	RatGTEx
SMART	TPR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48452	UniProtKB/TrEMBL
UniProt	A6I135	ENTREZGENE, UniProtKB/TrEMBL
	F7EKC1_RAT	UniProtKB/TrEMBL
	Q4V8H9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Ifit2	interferon-induced protein with tetratricopeptide repeats 2	Ifit2_predicted	interferon-induced protein with tetratricopeptide repeats 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ifit2_predicted	interferon-induced protein with tetratricopeptide repeats 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD