Nsd1 (nuclear receptor binding SET domain protein 1) - Rat Genome Database

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Pathways
Gene: Nsd1 (nuclear receptor binding SET domain protein 1) Rattus norvegicus
Analyze
Symbol: Nsd1
Name: nuclear receptor binding SET domain protein 1
RGD ID: 1307748
Description: Predicted to enable several functions, including nuclear receptor binding activity; protein-lysine N-methyltransferase activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of DNA-templated transcription. Predicted to act upstream of or within gastrulation with mouth forming second. Predicted to be located in chromosome and nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; histone-lysine N-methyltransferase, H3 lysine-36 specific; LOC306764
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,317,085 - 9,431,528 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,317,085 - 9,452,250 (-)EnsemblGRCr8
mRatBN7.2179,311,963 - 9,426,373 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,315,237 - 9,425,358 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,328,369 - 9,440,603 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,857,509 - 10,970,288 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,324,761 - 9,437,004 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,840,859 - 9,955,391 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,844,133 - 9,952,898 (-)Ensemblrn6Rnor6.0
Rnor_5.01711,950,539 - 12,065,042 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,362,482 - 15,471,961 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,393,607 - 9,502,492 (-)NCBICelera
RGSC_v3.11715,363,376 - 15,471,151 (-)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
chromosome  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Berdasco M, etal., Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21830-5. doi: 10.1073/pnas.0906831106. Epub 2009 Dec 14.
2. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3. Auxological data in patients clinically suspected of Sotos syndrome with NSD1 gene alterations. de Boer L, etal., Acta Paediatr. 2005 Aug;94(8):1142-4.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. A transposon-based analysis of gene mutations related to skin cancer development. Quintana RM, etal., J Invest Dermatol. 2013 Jan;133(1):239-48. doi: 10.1038/jid.2012.245. Epub 2012 Jul 26.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Further Evidence of Contrasting Phenotypes Caused by Reciprocal Deletions and Duplications: Duplication of NSD1 Causes Growth Retardation and Microcephaly. Rosenfeld JA, etal., Mol Syndromol. 2013 Jan;3(6):247-54. doi: 10.1159/000345578. Epub 2013 Jan 5.
15. NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia. Shiba N, etal., Genes Chromosomes Cancer. 2013 Jul;52(7):683-93. doi: 10.1002/gcc.22064. Epub 2013 Apr 30.
16. Mutations in NSD1 are responsible for Sotos syndrome, but are not a frequent finding in other overgrowth phenotypes. Turkmen S, etal., Eur J Hum Genet. 2003 Nov;11(11):858-65.
17. Familial gigantism caused by an NSD1 mutation. van Haelst MM, etal., Am J Med Genet A. 2005 Nov 15;139(1):40-4.
Additional References at PubMed
PMID:9628876   PMID:11509567   PMID:12805229   PMID:15522233   PMID:18157086   PMID:20837538   PMID:21196496  


Genomics

Comparative Map Data
Nsd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,317,085 - 9,431,528 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,317,085 - 9,452,250 (-)EnsemblGRCr8
mRatBN7.2179,311,963 - 9,426,373 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,315,237 - 9,425,358 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,328,369 - 9,440,603 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,857,509 - 10,970,288 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,324,761 - 9,437,004 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,840,859 - 9,955,391 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,844,133 - 9,952,898 (-)Ensemblrn6Rnor6.0
Rnor_5.01711,950,539 - 12,065,042 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,362,482 - 15,471,961 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,393,607 - 9,502,492 (-)NCBICelera
RGSC_v3.11715,363,376 - 15,471,151 (-)NCBI
Cytogenetic Map17p14NCBI
NSD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,131,798 - 177,300,213 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5177,131,787 - 177,300,213 (+)Ensemblhg38GRCh38
GRCh375176,558,799 - 176,727,214 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,493,532 - 176,655,369 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345176,494,690 - 176,655,367NCBI
Celera5171,774,148 - 171,941,231 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,481,615 - 171,647,948 (+)NCBIHuRef
CHM1_15175,992,834 - 176,160,257 (+)NCBICHM1_1
T2T-CHM13v2.05177,675,008 - 177,843,448 (+)NCBIT2T-CHM13v2.0
Nsd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,357,595 - 55,466,138 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,357,595 - 55,466,138 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381355,209,782 - 55,318,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,209,782 - 55,318,325 (+)Ensemblmm10GRCm38
MGSCv371355,311,143 - 55,419,686 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361355,243,517 - 55,324,503 (+)NCBIMGSCv36mm8
Celera1356,265,599 - 56,373,905 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1329.8NCBI
Nsd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,413,595 - 29,542,768 (+)Ensembl
ChiLan1.0NW_00495540829,416,393 - 29,547,444 (+)NCBIChiLan1.0ChiLan1.0
NSD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,214,174 - 172,384,745 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,353,696 - 170,524,284 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,431,968 - 172,602,174 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,499,866 - 179,666,351 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,499,865 - 179,666,351 (+)EnsemblpanPan2panpan1.1
NSD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1436,058,351 - 36,214,254 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl436,063,134 - 36,210,999 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha436,025,606 - 36,179,354 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0436,424,511 - 36,576,907 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,429,281 - 36,578,335 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,249,611 - 36,403,905 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,435,795 - 36,591,251 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,945,351 - 37,099,849 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nsd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,401,170 - 122,552,286 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,425,974 - 1,572,715 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365971,426,318 - 1,577,193 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,654,379 - 80,809,059 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1280,649,882 - 80,810,934 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2282,120,312 - 82,218,958 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NSD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,140,148 - 79,309,579 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,141,114 - 79,304,820 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607510,326,178 - 10,497,901 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,786,347 - 12,927,980 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473312,781,693 - 12,929,861 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nsd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11473,532,826 - 73,638,872 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nsd1
535 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:122
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000060928
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
D17Rat101  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8179,353,439 - 9,353,652 (+)Marker Load Pipeline
mRatBN7.2179,348,318 - 9,348,531 (+)MAPPERmRatBN7.2
Rnor_6.0179,877,214 - 9,877,426NCBIRnor6.0
Rnor_5.01711,986,894 - 11,987,106UniSTSRnor5.0
RGSC_v3.41715,396,414 - 15,396,627RGDRGSC3.4
RGSC_v3.41715,396,415 - 15,396,627UniSTSRGSC3.4
Celera179,426,695 - 9,426,903UniSTS
RGSC_v3.11715,396,415 - 15,396,627RGD
RH 3.4 Map1777.9UniSTS
RH 3.4 Map1777.9RGD
RH 2.0 Map1741.5RGD
SHRSP x BN Map178.3RGD
Cytogenetic Map17p14UniSTS
RH137723  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,332,331 - 9,332,526 (+)MAPPERmRatBN7.2
Rnor_6.0179,861,228 - 9,861,422NCBIRnor6.0
Rnor_5.01711,970,908 - 11,971,102UniSTSRnor5.0
RGSC_v3.41715,379,577 - 15,379,771UniSTSRGSC3.4
Celera179,410,703 - 9,410,897UniSTS
RH 3.4 Map1776.4UniSTS
Cytogenetic Map17p14UniSTS
RH136183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,317,647 - 9,317,847 (+)MAPPERmRatBN7.2
Rnor_6.0179,846,544 - 9,846,743NCBIRnor6.0
Rnor_5.01711,956,224 - 11,956,423UniSTSRnor5.0
RGSC_v3.41715,364,893 - 15,365,092UniSTSRGSC3.4
Celera179,396,018 - 9,396,217UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000060928   ⟹   ENSRNOP00000057648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,317,085 - 9,427,349 (-)Ensembl
mRatBN7.2 Ensembl179,315,237 - 9,423,870 (-)Ensembl
Rnor_6.0 Ensembl179,844,133 - 9,952,898 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105851   ⟹   ENSRNOP00000084557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,317,085 - 9,428,186 (-)Ensembl
mRatBN7.2 Ensembl179,315,237 - 9,423,040 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107527   ⟹   ENSRNOP00000077028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,317,085 - 9,452,250 (-)Ensembl
mRatBN7.2 Ensembl179,315,237 - 9,425,358 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113096   ⟹   ENSRNOP00000078952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,421,716 - 9,424,152 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118233   ⟹   ENSRNOP00000094644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,317,085 - 9,429,521 (-)Ensembl
mRatBN7.2 Ensembl179,315,237 - 9,424,476 (-)Ensembl
RefSeq Acc Id: NM_001401536   ⟹   NP_001388465
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,521 (-)NCBI
mRatBN7.2179,311,963 - 9,424,375 (-)NCBI
RefSeq Acc Id: XM_006253621   ⟹   XP_006253683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,430,506 (-)NCBI
mRatBN7.2179,311,963 - 9,425,180 (-)NCBI
Rnor_6.0179,840,859 - 9,954,376 (-)NCBI
Rnor_5.01711,950,539 - 12,065,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253622   ⟹   XP_006253684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,588 (-)NCBI
mRatBN7.2179,311,963 - 9,424,134 (-)NCBI
Rnor_6.0179,840,859 - 9,953,180 (-)NCBI
Rnor_5.01711,950,539 - 12,065,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253623   ⟹   XP_006253685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,634 (-)NCBI
mRatBN7.2179,311,963 - 9,424,099 (-)NCBI
Rnor_6.0179,840,859 - 9,953,134 (-)NCBI
Rnor_5.01711,950,539 - 12,065,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253624   ⟹   XP_006253686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,431,521 (-)NCBI
mRatBN7.2179,311,963 - 9,426,373 (-)NCBI
Rnor_6.0179,840,859 - 9,955,391 (-)NCBI
Rnor_5.01711,950,539 - 12,065,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253627   ⟹   XP_006253689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,323,025 - 9,429,627 (-)NCBI
mRatBN7.2179,317,899 - 9,424,455 (-)NCBI
Rnor_6.0179,846,845 - 9,953,421 (-)NCBI
Rnor_5.01711,950,539 - 12,065,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771491   ⟹   XP_008769713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,013 (-)NCBI
mRatBN7.2179,311,963 - 9,423,865 (-)NCBI
Rnor_6.0179,840,859 - 9,952,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095618   ⟹   XP_038951546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,623 (-)NCBI
mRatBN7.2179,311,963 - 9,424,450 (-)NCBI
RefSeq Acc Id: XM_039095619   ⟹   XP_038951547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,430,526 (-)NCBI
mRatBN7.2179,311,963 - 9,425,180 (-)NCBI
RefSeq Acc Id: XM_039095620   ⟹   XP_038951548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,431,528 (-)NCBI
mRatBN7.2179,311,963 - 9,426,373 (-)NCBI
RefSeq Acc Id: XM_039095621   ⟹   XP_038951549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,287 (-)NCBI
mRatBN7.2179,311,963 - 9,424,097 (-)NCBI
RefSeq Acc Id: XM_039095622   ⟹   XP_038951550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,283 (-)NCBI
mRatBN7.2179,311,963 - 9,424,135 (-)NCBI
RefSeq Acc Id: XM_039095623   ⟹   XP_038951551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,428,125 (-)NCBI
mRatBN7.2179,311,963 - 9,422,974 (-)NCBI
RefSeq Acc Id: XM_039095625   ⟹   XP_038951553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,357,208 - 9,429,627 (-)NCBI
mRatBN7.2179,352,086 - 9,424,462 (-)NCBI
RefSeq Acc Id: XM_063276337   ⟹   XP_063132407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,430,743 (-)NCBI
RefSeq Acc Id: XM_063276338   ⟹   XP_063132408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,759 (-)NCBI
RefSeq Acc Id: XM_063276339   ⟹   XP_063132409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,430,095 (-)NCBI
RefSeq Acc Id: XM_063276340   ⟹   XP_063132410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,430,867 (-)NCBI
RefSeq Acc Id: XM_063276341   ⟹   XP_063132411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,430,148 (-)NCBI
RefSeq Acc Id: XM_063276342   ⟹   XP_063132412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,008 (-)NCBI
RefSeq Acc Id: XM_063276343   ⟹   XP_063132413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,317,085 - 9,429,785 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388465 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253683 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253684 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253685 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253686 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253689 (Get FASTA)   NCBI Sequence Viewer  
  XP_008769713 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951546 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951547 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951548 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951549 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951550 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951551 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951553 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132407 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132408 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132409 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132410 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132411 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132412 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132413 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94004 (Get FASTA)   NCBI Sequence Viewer  
  EDL94005 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057648
  ENSRNOP00000057648.3
  ENSRNOP00000077028
  ENSRNOP00000077028.1
  ENSRNOP00000084557
  ENSRNOP00000084557.1
  ENSRNOP00000094644
  ENSRNOP00000094644.1
RefSeq Acc Id: XP_006253686   ⟸   XM_006253624
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMN8 (UniProtKB/TrEMBL),   A0A8I6A1J6 (UniProtKB/TrEMBL),   A6KAU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253683   ⟸   XM_006253621
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMN8 (UniProtKB/TrEMBL),   A0A8I6A1J6 (UniProtKB/TrEMBL),   A6KAU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253684   ⟸   XM_006253622
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMN8 (UniProtKB/TrEMBL),   A0A8I6A1J6 (UniProtKB/TrEMBL),   A6KAU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253685   ⟸   XM_006253623
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMN8 (UniProtKB/TrEMBL),   A0A8I6A1J6 (UniProtKB/TrEMBL),   A6KAU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253689   ⟸   XM_006253627
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008769713   ⟸   XM_008771491
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMN8 (UniProtKB/TrEMBL),   A0A8I6A1J6 (UniProtKB/TrEMBL),   A6KAU6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057648   ⟸   ENSRNOT00000060928
RefSeq Acc Id: XP_038951548   ⟸   XM_039095620
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL4 (UniProtKB/TrEMBL),   A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951547   ⟸   XM_039095619
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL4 (UniProtKB/TrEMBL),   A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951546   ⟸   XM_039095618
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL4 (UniProtKB/TrEMBL),   A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951550   ⟸   XM_039095622
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL4 (UniProtKB/TrEMBL),   A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951549   ⟸   XM_039095621
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL4 (UniProtKB/TrEMBL),   A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951551   ⟸   XM_039095623
- Peptide Label: isoform X3
- UniProtKB: A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951553   ⟸   XM_039095625
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000078952   ⟸   ENSRNOT00000113096
Ensembl Acc Id: ENSRNOP00000084557   ⟸   ENSRNOT00000105851
Ensembl Acc Id: ENSRNOP00000094644   ⟸   ENSRNOT00000118233
Ensembl Acc Id: ENSRNOP00000077028   ⟸   ENSRNOT00000107527
RefSeq Acc Id: NP_001388465   ⟸   NM_001401536
- UniProtKB: A0A8I6AMN8 (UniProtKB/TrEMBL),   A0A8I6A1J6 (UniProtKB/TrEMBL),   A6KAU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132410   ⟸   XM_063276340
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL4 (UniProtKB/TrEMBL),   A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132407   ⟸   XM_063276337
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMN8 (UniProtKB/TrEMBL),   A0A8I6A1J6 (UniProtKB/TrEMBL),   A6KAU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132411   ⟸   XM_063276341
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL4 (UniProtKB/TrEMBL),   A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132409   ⟸   XM_063276339
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMN8 (UniProtKB/TrEMBL),   A0A8I6A1J6 (UniProtKB/TrEMBL),   A6KAU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132413   ⟸   XM_063276343
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL4 (UniProtKB/TrEMBL),   A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132408   ⟸   XM_063276338
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMN8 (UniProtKB/TrEMBL),   A0A8I6A1J6 (UniProtKB/TrEMBL),   A6KAU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132412   ⟸   XM_063276342
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBL4 (UniProtKB/TrEMBL),   A6KAU7 (UniProtKB/TrEMBL),   D4AA06 (UniProtKB/TrEMBL)
Protein Domains
AWS   PHD-type   Post-SET   PWWP   RING-type   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA06-F1-model_v2 AlphaFold D4AA06 1-2381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307748 AgrOrtholog
BioCyc Gene G2FUF-10194 BioCyc
Ensembl Genes ENSRNOG00000016680 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060928 ENTREZGENE
  ENSRNOT00000060928.4 UniProtKB/TrEMBL
  ENSRNOT00000105851 ENTREZGENE
  ENSRNOT00000105851.2 UniProtKB/TrEMBL
  ENSRNOT00000107527 ENTREZGENE
  ENSRNOT00000107527.2 UniProtKB/TrEMBL
  ENSRNOT00000118233 ENTREZGENE
  ENSRNOT00000118233.2 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro AWS UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  NSD_PHD UniProtKB/TrEMBL
  PHD1_NSD1_2 UniProtKB/TrEMBL
  PHD2_NSD1 UniProtKB/TrEMBL
  PHD3_NSD1 UniProtKB/TrEMBL
  PHD4_NSD1 UniProtKB/TrEMBL
  PHD5_NSD1 UniProtKB/TrEMBL
  PHDvar_NSD UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  PWWP_NSD1_rpt2 UniProtKB/TrEMBL
  SET2_Histone-Lys_MeTrsfase UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  SET_NSD1 UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 306764 ENTREZGENE
PANTHER SET DOMAIN PROTEINS UniProtKB/TrEMBL
Pfam AWS UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  NSD_PHD UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PHD-1st_NSD UniProtKB/TrEMBL
  PHDvar_NSD UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PhenoGen Nsd1 PhenoGen
PROSITE AWS UniProtKB/TrEMBL
  POST_SET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016680 RatGTEx
SMART AWS UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PostSET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A8I5YBL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A1J6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMN8 ENTREZGENE, UniProtKB/TrEMBL
  A6KAU6 ENTREZGENE, UniProtKB/TrEMBL
  A6KAU7 ENTREZGENE, UniProtKB/TrEMBL
  D4AA06 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Nsd1  nuclear receptor binding SET domain protein 1   Nsd1_predicted  nuclear receptor binding SET domain protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nsd1_predicted  nuclear receptor binding SET domain protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED