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Gene: Mlec (malectin) Rattus norvegicus

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Symbol:

Mlec

Name:

malectin

RGD ID:

1307736

Description:

Predicted to enable carbohydrate binding activity and enzyme binding activity. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Predicted to be active in membrane. Orthologous to human MLEC (malectin); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC304543; MGC108831; RGD1307736; similar to Hypothetical protein KIAA0152

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MLEC (malectin)	RGD	RGD
Mus musculus (house mouse):	Mlec (malectin)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Mlec (malectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MLEC (malectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MLEC (malectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mlec (malectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MLEC (malectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MLEC (malectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mlec (malectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mlec (malectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Mlec (malectin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MLEC (malectin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mlec (malectin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F44E2.10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9257	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mlec	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mlec	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	47,118,918 - 47,133,598 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	47,118,855 - 47,130,064 (+)	Ensembl				GRCr8
mRatBN7.2	12	41,458,234 - 41,468,710 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,458,231 - 41,468,708 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,625,752 - 42,636,202 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	43,239,406 - 43,249,859 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	42,299,973 - 42,310,424 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	47,219,071 - 47,233,769 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	47,218,969 - 47,252,286 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	49,014,186 - 49,024,662 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,729,870 - 42,740,346 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	43,076,917 - 43,087,411 (+)	NCBI		Celera
RGSC_v3.1	12	42,593,257 - 42,603,733 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

allethrin (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

captan (ISO)

carbon nanotube (ISO)

chlorpyrifos (EXP)

choline (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibric acid (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

cyproconazole (ISO)

dexamethasone (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

diuron (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenvalerate (EXP)

finasteride (EXP)

flutamide (EXP)

furan (EXP)

gentamycin (EXP)

glafenine (EXP)

glyphosate (ISO)

indometacin (ISO)

inulin (ISO)

ivermectin (ISO)

lead diacetate (ISO)

leflunomide (ISO)

methyl methanesulfonate (ISO)

miconazole (ISO)

mitomycin C (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

nitrates (ISO)

Nutlin-3 (ISO)

paclitaxel (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

piperonyl butoxide (EXP)

pirinixic acid (ISO)

propiconazole (ISO)

pyrethrins (EXP)

rac-lactic acid (ISO)

rotenone (EXP,ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium fluoride (ISO)

Soman (EXP)

testosterone (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP,ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

endoplasmic reticulum (IEA,ISS)

endoplasmic reticulum membrane (IEA)

membrane (IBA)

Molecular Function

carbohydrate binding (IEA,ISS)

enzyme binding (IEA,ISO)

protein binding (ISO)

protein-folding chaperone binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:19946888	PMID:22988243	PMID:25002582

Genomics

Comparative Map Data

Mlec
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	47,118,918 - 47,133,598 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	47,118,855 - 47,130,064 (+)	Ensembl				GRCr8
mRatBN7.2	12	41,458,234 - 41,468,710 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,458,231 - 41,468,708 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,625,752 - 42,636,202 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	43,239,406 - 43,249,859 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	42,299,973 - 42,310,424 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	47,219,071 - 47,233,769 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	47,218,969 - 47,252,286 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	49,014,186 - 49,024,662 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,729,870 - 42,740,346 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	43,076,917 - 43,087,411 (+)	NCBI		Celera
RGSC_v3.1	12	42,593,257 - 42,603,733 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

MLEC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	120,687,149 - 120,701,859 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	120,687,125 - 120,704,282 (+)	Ensembl			hg38	GRCh38
GRCh37	12	121,124,952 - 121,139,662 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	119,609,332 - 119,624,050 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	119,587,668 - 119,602,387	NCBI
Celera	12	120,759,216 - 120,773,932 (+)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	118,134,230 - 118,148,946 (+)	NCBI		HuRef
CHM1_1	12	121,093,737 - 121,108,453 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	120,676,305 - 120,691,013 (+)	NCBI		T2T-CHM13v2.0

Mlec
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	115,281,040 - 115,296,235 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	115,281,040 - 115,296,238 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	115,142,981 - 115,158,176 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	115,142,981 - 115,158,179 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	115,592,990 - 115,608,185 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	115,406,090 - 115,419,145 (-)	NCBI		MGSCv36	mm8
Celera	5	112,239,386 - 112,254,583 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	55.99	NCBI

Mlec
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	10,974,968 - 10,983,965 (-)	Ensembl
ChiLan1.0	NW_004955455	10,969,859 - 10,983,977 (-)	NCBI	ChiLan1.0	ChiLan1.0

MLEC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	128,756,840 - 128,772,048 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	128,753,637 - 128,768,421 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	118,270,574 - 118,285,314 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	121,643,823 - 121,658,825 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	121,644,247 - 121,653,514 (+)	Ensembl			panPan2	panpan1.1

MLEC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	16,536,545 - 16,551,891 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	16,537,016 - 16,546,514 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	16,539,273 - 16,553,193 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	16,802,656 - 16,816,591 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	16,802,901 - 16,816,540 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	16,763,251 - 16,777,154 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	16,838,978 - 16,854,245 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	16,881,299 - 16,895,214 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mlec
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	145,797,684 - 145,812,544 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	301,710 - 311,713 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	293,997 - 311,441 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MLEC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	40,601,990 - 40,617,295 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	40,601,982 - 40,617,382 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	43,069,346 - 43,084,744 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MLEC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	116,043,591 - 116,058,578 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	116,043,522 - 116,053,342 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	129,038,771 - 129,054,067 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mlec
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	13,000,403 - 13,009,818 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	12,995,246 - 13,009,827 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mlec
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	38,669,500 - 38,681,018 (+)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	225
Count of miRNA genes:	168
Interacting mature miRNAs:	187
Transcripts:	ENSRNOT00000038395
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	44139558	52308831	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	12	61	132	57	60	41	86	41	298	168	11	123	71	73	19	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121426	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000038395 ⟹ ENSRNOP00000035497

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	47,118,869 - 47,129,393 (+)	Ensembl
mRatBN7.2 Ensembl	12	41,458,231 - 41,468,708 (+)	Ensembl
Rnor_6.0 Ensembl	12	47,219,089 - 47,229,564 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077871 ⟹ ENSRNOP00000072503

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	41,478,808 - 41,491,432 (+)	Ensembl
Rnor_6.0 Ensembl	12	47,239,663 - 47,252,286 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081343 ⟹ ENSRNOP00000071670

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	12	47,218,969 - 47,244,005 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000149206 ⟹ ENSRNOP00000108117

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	47,118,855 - 47,130,064 (+)	Ensembl

RefSeq Acc Id:

NM_001013983 ⟹ NP_001014005

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	47,118,918 - 47,129,394 (+)	NCBI
mRatBN7.2	12	41,458,234 - 41,468,710 (+)	NCBI
Rnor_6.0	12	47,219,089 - 47,229,565 (+)	NCBI
Rnor_5.0	12	49,014,186 - 49,024,662 (+)	NCBI
RGSC_v3.4	12	42,729,870 - 42,740,346 (+)	RGD
Celera	12	43,076,917 - 43,087,411 (+)	RGD

Sequence:

show sequence

GGAGGCCCGAGAGCGACATGTCCCGGGTTGCTGAGGCAGAACGGTCCGTGGCGCTGTTTTACTG
AGTCGGGGGCGGCCTGGCGGCCGGCCGAGGACGAGGGTCGGCAGGGGCTGCCCCCGCAGTGGTG
GCCGCCATGCTGAAGCCCCGGGCAGCCGAGGGAGCCGCTGTGGCGCTTCTCCGGCTGCTGCTGC
TGCTGCTGCTGTTGCCGCCGGAGCTCCGGGATCGGGGGCTCGGCGTGGCCGGCGCCGCTGGGGC
CGGACTGCCCGAGAGCGTCATTTGGGCAGTGAACGCAGGCGGCGAGGCGCATGTGGACGTGCAC
GGGATCCACTTCCGCAAGGACCCTCTGGAAGGCCGGGTGGGCCGAGCCTCAGACTATGGCATGA
AACTGCCAATCCTGCGCTCCACCCCAGAGGACCAGATCCTCTATCAGACAGAGCGGTACAATGA
AGAGACTTTTGGCTACGAAGTACCTGTCAAGGAGGAGGGGGACTATGTGCTGGTGTTGAAGTTT
GCTGAGGTTTACTTCGCACAGTCTCAGCAGAAGGTATTTGATGTCCGATTAAATGGCCATGTTG
TGGTGAAAGACTTAGACATCTTTGACCGTGTTGGCCACAGCACGGCTCATGATGAAATCATCCC
CATGAGCATCAGAAAGGGGAAGCTGAGTGTCCAGGGGGAGGTGTCTACCTTCACTGGGAAGCTC
TACATCGAGTTCGTCAAGGGGTACTATGACAATCCCAAAGTCTGTGCACTCTACATAATGGCTG
GGACAGTAGACGATGTGCCAAAGCTGCAGCCTCATCCAGGATTGGAGAAGAAAGAAGAGGAGGA
GGAAGAGGAAGAATATGATGAGGGGTCTAATCTCAAAAGACAGACCAACAAGAACAGGGTGCAG
TCAGGCCCCCGCACACCTAACCCCTACGCCTCGGACAACAGCAGCCTCATGTTTCCTATTCTGG
TGGCCTTCGGAGTGTTCATTCCAACCCTCTTCTGCCTCTGCCGCTTGTGAGAACAAATGACCAT
CCTCAGCAGGGTGGATGGGAGGGGAAAGAAACCAGCCATGTTGGTTTCTGTATTCTTCACAGTG
TTTTGCAAAAGAGAAACCAAGTCAAACAGCACACACACACGCGCACGCGTGCGCGCGCGCACAC
ACACACACACACACACACACACACACACACACACACACACACACGAAAAGAGATAAGAGAAGCA
GTGTGAGTGGGGTCGACCCACCAACATTGGCCGCAGAGCTGCTCAGTCCTACTCTGCCTAGCTG
GCCCCCAGCGCTCTTTTCCTATGGGGTACTTAGGTGAGTGGATCCTTTTTCTCCAAGGATCCTC
ACTATATATATACCTAGTAGAGAGGACTCTGAACTCGGAGCAGTCACAGCTCCTGGTTTTTTAG
GTTAGACATTAACAAACAGCGGGAAAATGTCACCTAGCCTGGAAAGACCTCAGTGGGAGTTGGG
TGTGTTCTGAGTTTATGTCCAAATGTGGTTTCAGAATTCATGGTATTCCAAGTATGTGCGTGGA
GGTAAGGACAGGAAAAAGCAAAGGATTGGAAAAGAGTCAGTGTGTCCTTCCTGGGAAGCCTTCC
TAGGTTGATCTGTGGACGGCTCCGCCTCACGCCCCTTCATTGTCATCCCATCTTGGTGTGGCCA
GTTAGAGGGCCATCTGGTGCCCAGGACGACTAGTGTGTGTCGATCCTCAGATCACCTACAGCTC
GTTACTCAACAAATGGTTTTGATTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063271352 ⟹ XP_063127422

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	47,118,991 - 47,133,598 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001014005	(Get FASTA)	NCBI Sequence Viewer
	XP_063127422	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89839	(Get FASTA)	NCBI Sequence Viewer
	EDM13905	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000035497
	ENSRNOP00000035497.4
GenBank Protein	Q5FVQ4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001014005 ⟸ NM_001013983
- Peptide Label:	precursor
- UniProtKB:	Q5FVQ4 (UniProtKB/Swiss-Prot), A6J1W6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLKPRAAEGAAVALLRLLLLLLLLPPELRDRGLGVAGAAGAGLPESVIWAVNAGGEAHVDVHGI HFRKDPLEGRVGRASDYGMKLPILRSTPEDQILYQTERYNEETFGYEVPVKEEGDYVLVLKFAE VYFAQSQQKVFDVRLNGHVVVKDLDIFDRVGHSTAHDEIIPMSIRKGKLSVQGEVSTFTGKLYI EFVKGYYDNPKVCALYIMAGTVDDVPKLQPHPGLEKKEEEEEEEEYDEGSNLKRQTNKNRVQSG PRTPNPYASDNSSLMFPILVAFGVFIPTLFCLCRL hide sequence

Ensembl Acc Id:

ENSRNOP00000035497 ⟸ ENSRNOT00000038395

Ensembl Acc Id:

ENSRNOP00000072503 ⟸ ENSRNOT00000077871

Ensembl Acc Id:

ENSRNOP00000071670 ⟸ ENSRNOT00000081343

RefSeq Acc Id:	XP_063127422 ⟸ XM_063271352
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000108117 ⟸ ENSRNOT00000149206

Protein Domains

Malectin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5FVQ4-F1-model_v2	AlphaFold	Q5FVQ4	1-291	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698701

Promoter ID:

EPDNEW_R9224

Type:

initiation region

Name:

Mlec_2

Description:

malectin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9225

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	47,219,074 - 47,219,134	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307736	AgrOrtholog
BioCyc Gene	G2FUF-18974	BioCyc
Ensembl Genes	ENSRNOG00000021725	Ensembl
	ENSRNOG00000064601	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000038395	ENTREZGENE
	ENSRNOT00000038395.5	UniProtKB/Swiss-Prot
Gene3D-CATH	Galactose-binding lectin	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7365814	IMAGE-MGC_LOAD
InterPro	Malectin_dom	UniProtKB/Swiss-Prot
	MLEC	UniProtKB/Swiss-Prot
KEGG Report	rno:304543	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108831	IMAGE-MGC_LOAD
NCBI Gene	304543	ENTREZGENE
PANTHER	MALECTIN	UniProtKB/Swiss-Prot
	PTHR13460	UniProtKB/Swiss-Prot
Pfam	Malectin	UniProtKB/Swiss-Prot
PhenoGen	Mlec	PhenoGen
RatGTEx	ENSRNOG00000021725	RatGTEx
	ENSRNOG00000064601	RatGTEx
UniProt	A0ABK0LSL2_RAT	UniProtKB/TrEMBL
	A6J1W6	ENTREZGENE, UniProtKB/TrEMBL
	MLEC_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-06-12	Mlec	malectin	RGD1307736	similar to Hypothetical protein KIAA0152	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1307736	similar to Hypothetical protein KIAA0152	RGD1307736_predicted	similar to Hypothetical protein KIAA0152 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1307736_predicted	similar to Hypothetical protein KIAA0152 (predicted)	LOC304543_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC304543_predicted	similar to Hypothetical protein KIAA0152 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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