Anxa8 (annexin A8) - Rat Genome Database

Name: Anxa8
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Anxa8 (annexin A8) Rattus norvegicus

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Symbol:

Anxa8

Name:

annexin A8

RGD ID:

1307719

Description:

Predicted to enable several functions, including actin filament binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in endosomal transport; endosome organization; and negative regulation of hydrolase activity. Predicted to be located in cytosol; late endosome membrane; and plasma membrane. Predicted to be active in cytoplasm; sarcolemma; and vesicle membrane. Orthologous to human ANXA8 (annexin A8); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

annexin VIII; annexin-8; LOC306283; MGC116246

RGD Orthologs

Human

Mouse

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ANXA8 (annexin A8)	RGD	RGD
Mus musculus (house mouse):	Anxa8 (annexin A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ANXA8L1 (annexin A8 like 1)	HGNC	Ensembl, HomoloGene, Inparanoid, Panther, PhylomeDB
Homo sapiens (human):	ANXA4 (annexin A4)	HGNC	OrthoDB
Homo sapiens (human):	PLEK (pleckstrin)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ANXA8 (annexin A8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Anxa8 (annexin A8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	AnxB10	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	nex-4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	9,403,267 - 9,418,317 (+)	NCBI		GRCr8
mRatBN7.2	16	9,397,144 - 9,412,072 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	9,397,113 - 9,412,043 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	9,416,681 - 9,431,616 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	10,561,386 - 10,576,325 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	9,411,746 - 9,426,672 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	10,417,174 - 10,432,388 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	10,417,185 - 10,432,393 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	8,737,501 - 8,752,773 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	9,715,644 - 9,730,584 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	9,715,608 - 9,730,490 (+)	NCBI
Celera	16	5,797,809 - 5,812,655 (-)	NCBI		Celera
Cytogenetic Map	16	p15	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cholangiocarcinoma (ISO)

pancreatic ductal carcinoma (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,4-diaminotoluene (ISO)

2-acetamidofluorene (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (ISO)

7,12-dimethyltetraphene (ISO)

8-Br-cAMP (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzylpenicillin (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chloropicrin (ISO)

chloroprene (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

cytarabine (ISO)

dexamethasone (ISO)

diallyl trisulfide (EXP)

dibenz[a,h]anthracene (ISO)

diclofenac (ISO)

diiodine (ISO)

dimethylarsinic acid (ISO)

dioxygen (ISO)

doxifluridine (ISO)

ethanol (ISO)

folic acid (ISO)

genistein (ISO)

ibuprofen (ISO)

isobutanol (ISO)

lipopolysaccharide (ISO)

methylarsonic acid (ISO)

N-nitrosodiethylamine (EXP)

ozone (ISO)

paclitaxel (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

potassium dichromate (ISO)

quercetin (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

serpentine asbestos (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sulforaphane (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

blood coagulation (IEA)

endosomal transport (IBA,ISO)

endosome organization (IBA,ISO)

negative regulation of phospholipase A2 activity (ISO)

negative regulation of serine-type endopeptidase activity (ISO)

Cellular Component

cytoplasm (IBA)

cytosol (ISO)

late endosome membrane (ISO)

plasma membrane (ISO)

sarcolemma (IBA)

vesicle membrane (IBA)

Molecular Function

actin filament binding (ISO)

calcium ion binding (IEA,ISO)

calcium-dependent phospholipid binding (IBA,IEA,ISO)

phosphatidylinositol-3,4,5-trisphosphate binding (ISO)

phosphatidylinositol-3,4-bisphosphate binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (ISO)

phosphatidylserine binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8.	Karanjawala ZE, etal., Am J Surg Pathol. 2008 Feb;32(2):188-96.
3.	ANXA8 down-regulation by EGF-FOXO4 signaling is involved in cell scattering and tumor metastasis of cholangiocarcinoma.	Lee MJ, etal., Gastroenterology. 2009 Sep;137(3):1138-50, 1150.e1-9. Epub 2009 Apr 16.
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:2530088	PMID:12477932	PMID:15489334	PMID:15644210	PMID:16638567	PMID:18923148

Genomics

Comparative Map Data

Anxa8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	9,403,267 - 9,418,317 (+)	NCBI		GRCr8
mRatBN7.2	16	9,397,144 - 9,412,072 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	9,397,113 - 9,412,043 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	9,416,681 - 9,431,616 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	10,561,386 - 10,576,325 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	9,411,746 - 9,426,672 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	10,417,174 - 10,432,388 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	10,417,185 - 10,432,393 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	8,737,501 - 8,752,773 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	9,715,644 - 9,730,584 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	9,715,608 - 9,730,490 (+)	NCBI
Celera	16	5,797,809 - 5,812,655 (-)	NCBI		Celera
Cytogenetic Map	16	p15	NCBI

ANXA8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	47,467,993 - 47,991,796 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	47,460,162 - 47,484,158 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	48,255,247 - 48,271,369 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	47,875,231 - 47,891,375 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	47,217,012 - 47,233,044	NCBI
Cytogenetic Map	10	q11.22	NCBI
HuRef	10	43,018,066 - 43,029,984 (+)	NCBI		HuRef
CHM1_1	10	48,417,242 - 48,433,403 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	48,359,294 - 48,840,973 (-)	NCBI		T2T-CHM13v2.0

Anxa8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	33,807,936 - 33,822,528 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	33,807,938 - 33,822,528 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	34,085,979 - 34,100,571 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	34,085,981 - 34,100,571 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	34,899,176 - 34,913,757 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	32,915,077 - 32,929,663 (+)	NCBI		MGSCv36	mm8
MGSCv36	14	29,195,890 - 29,210,476 (+)	NCBI		MGSCv36	mm8
Celera	14	30,348,562 - 30,363,455 (+)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	20.8	NCBI

Variants

Variants in Anxa8
63 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	330
Count of miRNA genes:	205
Interacting mature miRNAs:	233
Transcripts:	ENSRNOT00000027464
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	9639137	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
737825	Alc13	Alcohol consumption QTL 13	4.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	16039848	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4227730	17696785	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	2851709	15884239	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat

Markers in Region

RH141108

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	9,411,680 - 9,411,860 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	10,431,997 - 10,432,176	NCBI	Rnor6.0
Rnor_5.0	16	8,752,382 - 8,752,561	UniSTS	Rnor5.0
RGSC_v3.4	16	9,730,193 - 9,730,372	UniSTS	RGSC3.4
Celera	16	5,798,021 - 5,798,200	UniSTS
RH 3.4 Map	10	157.6	UniSTS
Cytogenetic Map	16	p16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	110	89	88	57	25	57	6	214	95	90	45	58	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001031654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252627	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275365	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC099106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000082186 ⟹ ENSRNOP00000069969

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	9,397,113 - 9,412,043 (+)	Ensembl
Rnor_6.0 Ensembl	16	10,417,185 - 10,432,393 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111644 ⟹ ENSRNOP00000087636

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	9,401,388 - 9,412,043 (+)	Ensembl

RefSeq Acc Id:

NM_001031654 ⟹ NP_001026824

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	9,403,387 - 9,418,317 (+)	NCBI
mRatBN7.2	16	9,397,144 - 9,412,072 (+)	NCBI
Rnor_6.0	16	10,417,275 - 10,432,388 (+)	NCBI
Rnor_5.0	16	8,737,501 - 8,752,773 (+)	NCBI
RGSC_v3.4	16	9,715,644 - 9,730,584 (+)	RGD
Celera	16	5,797,809 - 5,812,655 (-)	RGD

Sequence:

show sequence

CTGTGAGGCACACAGGATGGCCTGGTGGAAAGCCTGGGTTGAACAAGAGGGCGTCAGTGTGAAG
GGTAGTTCTCATTTCAACCCAGACCCTGATGCAGAGACCCTCTACAAAGCCATGAAGGGGATCG
GAACCAACGAGCAGGCCATCATAGACGTGCTCACCAAGAGGAGCAATGTGCAGAGGCAGCAGAT
TGCCAAGTCCTTCAAGGCTCAATTTGGAAAGGACCTCACTGAGACCCTAAAGTCAGAGCTGAGT
GGCAAATTCGAGAGGCTCATCGTGGCCCTCATGTACCCGCCATACAGATATGAGGCCAAGGAGC
TGCACGACGCTATGAAGGGCTTAGGAACCAAAGAAGGAGTCATCATTGAGATCCTGGCTTCTCG
GACCAAGAACCAGCTGAGAGAGATAATGAAGGCCTATGAGGAAGACTACGGATCTACCCTGGAA
GAAGACATCCAAGGAGACACGAGTGGCTATCTGGAGCGGATTCTGGTGTGTCTTCTGCAGGGCT
GCAGAGATGACGTGAGTGGTTTTGTGGACCCAGGACTGGCCCTTCAAGATGCACAGGACCTGCA
TGCAGCAGGTGAGAAGATTCTGGGGACTGATGAGATGAAGTTCATCACCATCCTGTGTACACGC
AGTGCCACTCATCTGATGAGAGTGTTCGAGGAATATGAAAAGATTGCCAACAAGAGCATTGAGG
ATAGCATCAAGAGTGAGACCCATGGTTCACTGGAGGAGGCCATGCTCACTGTGGTGAAATGCAC
CCGGAACGTCCACAGCTACTTTGCAGAGAGACTGTACTATGCCATGAAGGGAGCAGGGACACTT
GATGGGACGCTGATCAGGAACATTGTTTCCAGGAGTGAGATTGACTTAAACCTTATCAAGAGTC
AGTTTCAGAAGATGTACGGCAAGACTCTCAGCAGCATGATCATGGGCGACACCAGCGGTTACTA
CAAGACTGCCCTGCTGAACCTTGTGGGTACTGACCTCTGAAAATGTCAAAAAATCAAACAAGGG
CAAGAAGGGTCAGCACAGCCCCTGTGGCTTCAGCCCTGACCCCATGGGTGAGGTGGGGGTAAGG
GACACCTCATGTGGCTTTTAATCTTCTGTCTCCCGGTTTCTGATGCTTCTCATCCAATGCTTCT
GACCCAGAAGGTGAGACCAGCCTGGGTTTCCCTTCCACCTCTCCCCTGAGTCATTTCTAATGCC
CACCCTAGCATTACCTCTGAGCAAACAGAAACAACATGAAGAAGCTTGCAGGAACCTGTGGGCC
ATTCCTTCCCTGCACAAAAGCTCCTGGGTACAGGTCACACTCTGCCTTGGCTCTGAGTCATCCA
CTGAATCAGGGTCTTTGGAGGAGGAACCAACCATGGATTTCTAGCAGTCGTCTTAGCTGATAAG
CATCATTATCAGGCAGCCAGTGAGCAAGTGGGAGAGCACGGCTATGAGAGAACACAGCCGTGGG
AACTGAGAAAGGGTCACAGAGCTGTGCCAAGTGGGATGTCTGTGACACTCATTTAACAGAAATT
GTTAGGCTGTAGGTGGAGGAAGATTCTTACGCCATCCTAATAGCAAGAATTAGATTGGATTGCA
AATCCCTGTCCTGACCCAAGTACACCATGGCCCGAGAGCGTCAGGCTTGTCCAGCCATTGGCCA
AATCAGATGTTCGTTCCCTCCATGCTGAAGCTTGCAGACTAGGAAGCCCCCCAACCCTGAGCAT
GAATCCTAACCTCCGATCGTGGTCTCCAAGCCTGAAGAACATGACAGAACTCTCCCTAATATTC
ATTGGGCTTTCAGAATCATAAACGTTTGTACTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039094474 ⟹ XP_038950402

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	9,403,332 - 9,417,846 (+)	NCBI
mRatBN7.2	16	9,397,616 - 9,412,072 (+)	NCBI

RefSeq Acc Id:

XM_063275365 ⟹ XP_063131435

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	9,403,267 - 9,417,846 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001026824	(Get FASTA)	NCBI Sequence Viewer
	XP_038950402	(Get FASTA)	NCBI Sequence Viewer
	XP_063131435	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99106	(Get FASTA)	NCBI Sequence Viewer
	EDL88890	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069969.1
	ENSRNOP00000087636.1
	ENSRNOP00055014179
	ENSRNOP00060017802
	ENSRNOP00065018036
GenBank Protein	Q4FZU6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001026824 ⟸ NM_001031654

- UniProtKB:

Q4FZU6 (UniProtKB/Swiss-Prot), A0A8I6A7L2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAWWKAWVEQEGVSVKGSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNVQRQQIAKSFK
AQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQL
REIMKAYEEDYGSTLEEDIQGDTSGYLERILVCLLQGCRDDVSGFVDPGLALQDAQDLHAAGEK
ILGTDEMKFITILCTRSATHLMRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNVHS
YFAERLYYAMKGAGTLDGTLIRNIVSRSEIDLNLIKSQFQKMYGKTLSSMIMGDTSGYYKTALL
NLVGTDL

hide sequence

Ensembl Acc Id:

ENSRNOP00000069969 ⟸ ENSRNOT00000082186

RefSeq Acc Id:	XP_038950402 ⟸ XM_039094474
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A7L2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000087636 ⟸ ENSRNOT00000111644

RefSeq Acc Id:	XP_063131435 ⟸ XM_063275365
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4FZU6-F1-model_v2	AlphaFold	Q4FZU6	1-327	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699954

Promoter ID:

EPDNEW_R10478

Type:

initiation region

Name:

Anxa8_1

Description:

annexin A8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	10,417,213 - 10,417,273	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307719	AgrOrtholog
BioCyc Gene	G2FUF-12077	BioCyc
Ensembl Genes	ENSRNOG00000060949	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055010413	UniProtKB/Swiss-Prot
	ENSRNOG00060013185	UniProtKB/Swiss-Prot
	ENSRNOG00065014015	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000082186.2	UniProtKB/Swiss-Prot
	ENSRNOT00000111644.1	UniProtKB/TrEMBL
	ENSRNOT00055017617	UniProtKB/Swiss-Prot
	ENSRNOT00060022468	UniProtKB/Swiss-Prot
	ENSRNOT00065023146	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.220.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7460531	IMAGE-MGC_LOAD
InterPro	Annexin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Annexin_repeat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Annexin_repeat_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Annexin_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANX8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:306283	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116246	IMAGE-MGC_LOAD
NCBI Gene	306283	ENTREZGENE
PANTHER	ANNEXIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10502:SF133	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Annexin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Anxa8	PhenoGen
PRINTS	ANNEXIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANNEXINVIII	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ANNEXIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANNEXIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000060949	RatGTEx
	ENSRNOG00055010413	RatGTEx
	ENSRNOG00060013185	RatGTEx
	ENSRNOG00065014015	RatGTEx
SMART	ANX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47874	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A7L2	ENTREZGENE, UniProtKB/TrEMBL
	A6KFT2_RAT	UniProtKB/TrEMBL
	ANXA8_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Anxa8	annexin A8	Anxa8_predicted	annexin A8 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Anxa8_predicted	annexin A8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar