Cgm4 (carcinoembryonic antigen gene family 4) - Rat Genome Database

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Gene: Cgm4 (carcinoembryonic antigen gene family 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cgm4
Name: carcinoembryonic antigen gene family 4
RGD ID: 1307652
Description: Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in regulation of immune system process and signal transduction. Predicted to be active in cell surface and plasma membrane. Orthologous to human CEACAM21 (CEA cell adhesion molecule 21); CEACAM3 (CEA cell adhesion molecule 3); and CEACAM4 (CEA cell adhesion molecule 4); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cea; CEA4; CEA5; Cear; CGM4AA; LOC292664; pregnancy specific glycoprotein 16; pregnancy specific glycoprotein 16 (predicted); Psg16; Psg16_predicted
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,904,526 - 86,917,487 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,904,526 - 86,917,475 (+)EnsemblGRCr8
mRatBN7.2177,776,447 - 77,789,408 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,776,447 - 77,789,396 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx183,157,058 - 83,168,864 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,721,117 - 91,732,923 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,912,161 - 84,923,967 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,030,291 - 79,043,259 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,030,291 - 79,080,881 (+)Ensemblrn6Rnor6.0
Rnor_5.0180,277,477 - 80,290,359 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,441,013 - 77,453,826 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera172,262,123 - 72,274,662 (+)NCBICelera
RGSC_v3.1177,519,123 - 77,531,927 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2335509   PMID:2708349   PMID:8889548   PMID:12477932  


Genomics

Variants

.
Variants in Cgm4
68 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:87
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000037086
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
D1Mco20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,780,614 - 77,780,723 (+)MAPPERmRatBN7.2
Rnor_6.0179,034,466 - 79,034,574NCBIRnor6.0
Rnor_5.0180,281,565 - 80,281,673UniSTSRnor5.0
RGSC_v3.4177,445,031 - 77,445,140RGDRGSC3.4
RGSC_v3.4177,445,032 - 77,445,140UniSTSRGSC3.4
Celera172,266,036 - 72,266,144UniSTS
RGSC_v3.1177,523,142 - 77,523,251RGD
Cytogenetic Map1q21UniSTS
RH127372  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,788,900 - 77,789,087 (+)MAPPERmRatBN7.2
Rnor_6.0179,042,752 - 79,042,938NCBIRnor6.0
Rnor_5.0180,289,852 - 80,290,038UniSTSRnor5.0
RGSC_v3.4177,453,319 - 77,453,505UniSTSRGSC3.4
Celera172,274,155 - 72,274,341UniSTS
RH 3.4 Map1795.3UniSTS
Cytogenetic Map1q21UniSTS
RH142825  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8186,909,661 - 86,909,772 (+)Marker Load Pipeline
mRatBN7.2177,781,582 - 77,781,693 (+)MAPPERmRatBN7.2
Rnor_6.0179,035,434 - 79,035,544NCBIRnor6.0
Rnor_5.0180,282,533 - 80,282,643UniSTSRnor5.0
RGSC_v3.4177,446,000 - 77,446,110UniSTSRGSC3.4
Celera172,267,004 - 72,267,114UniSTS
RH 3.4 Map1795.6UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 2 6 2 3 7 15 9 6 4 11 3

Sequence


Ensembl Acc Id: ENSRNOT00000037086   ⟹   ENSRNOP00000033854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,904,526 - 86,917,475 (+)Ensembl
mRatBN7.2 Ensembl177,776,447 - 77,789,396 (+)Ensembl
RefSeq Acc Id: NM_012525   ⟹   NP_036657
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,904,526 - 86,917,487 (+)NCBI
mRatBN7.2177,776,447 - 77,789,408 (+)NCBI
Rnor_6.0179,030,291 - 79,043,259 (+)NCBI
Rnor_5.0180,277,477 - 80,290,359 (+)NCBI
RGSC_v3.4177,441,013 - 77,453,826 (+)RGD
Celera172,262,123 - 72,274,662 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036657 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40911 (Get FASTA)   NCBI Sequence Viewer  
  AAA40912 (Get FASTA)   NCBI Sequence Viewer  
  AAA66038 (Get FASTA)   NCBI Sequence Viewer  
  AAH97366 (Get FASTA)   NCBI Sequence Viewer  
  EDM08278 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033854
  ENSRNOP00000033854.4
RefSeq Acc Id: NP_036657   ⟸   NM_012525
- UniProtKB: Q4V8J0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033854   ⟸   ENSRNOT00000037086
Protein Domains
Ig-like   Immunoglobulin   Immunoglobulin V-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8J0-F1-model_v2 AlphaFold Q4V8J0 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307652 AgrOrtholog
BioCyc Gene G2FUF-60576 BioCyc
Ensembl Genes ENSRNOG00000042250 Ensembl
  ENSRNOG00000062787 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037086 ENTREZGENE
  ENSRNOT00000037086.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7443149 IMAGE-MGC_LOAD
InterPro CEA_cell_adhesion UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
KEGG Report rno:24257 UniProtKB/TrEMBL
MGC_CLONE MGC:114399 IMAGE-MGC_LOAD
NCBI Gene Cgm4 ENTREZGENE
PANTHER CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1 UniProtKB/TrEMBL
  CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 UniProtKB/TrEMBL
  PREGNANCY-SPECIFIC GLYCOPROTEIN 18-RELATED UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Cgm4 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042250 RatGTEx
  ENSRNOG00000062787 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A6J8F6_RAT UniProtKB/TrEMBL
  Q4V8J0 ENTREZGENE, UniProtKB/TrEMBL
  Q63112_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-12-11 Cgm4  carcinoembryonic antigen gene family 4  Psg16_predicted  pregnancy specific glycoprotein 16 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Psg16_predicted  pregnancy specific glycoprotein 16 (predicted)      Symbol and Name status set to approved 70820 APPROVED