Kank4 (KN motif and ankyrin repeat domains 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Kank4 (KN motif and ankyrin repeat domains 4) Rattus norvegicus
Analyze
Symbol: Kank4
Name: KN motif and ankyrin repeat domains 4
RGD ID: 1307635
Description: Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human KANK4 (KN motif and ankyrin repeat domains 4); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BC060737; cDNA BC060737; KN motif and ankyrin repeat domain-containing protein 4; LOC313385
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85118,516,994 - 118,581,024 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5118,517,971 - 118,581,002 (-)EnsemblGRCr8
mRatBN7.25113,401,491 - 113,465,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5113,402,468 - 113,465,555 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5115,982,110 - 116,044,799 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05117,707,448 - 117,770,138 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05117,769,979 - 117,832,673 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05117,376,425 - 117,440,643 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5117,376,423 - 117,440,254 (-)Ensemblrn6Rnor6.0
Rnor_5.05121,317,410 - 121,381,170 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45119,170,131 - 119,233,181 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5111,969,381 - 112,032,141 (-)NCBICelera
RGSC_v3.15119,175,934 - 119,201,440 (-)NCBI
Cytogenetic Map5q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
calcium silicate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
fenamidone  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydralazine  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
propanal  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytoskeleton  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25961457  


Genomics

Comparative Map Data
Kank4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85118,516,994 - 118,581,024 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5118,517,971 - 118,581,002 (-)EnsemblGRCr8
mRatBN7.25113,401,491 - 113,465,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5113,402,468 - 113,465,555 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5115,982,110 - 116,044,799 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05117,707,448 - 117,770,138 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05117,769,979 - 117,832,673 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05117,376,425 - 117,440,643 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5117,376,423 - 117,440,254 (-)Ensemblrn6Rnor6.0
Rnor_5.05121,317,410 - 121,381,170 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45119,170,131 - 119,233,181 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5111,969,381 - 112,032,141 (-)NCBICelera
RGSC_v3.15119,175,934 - 119,201,440 (-)NCBI
Cytogenetic Map5q33NCBI
KANK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,236,165 - 62,319,434 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,236,165 - 62,319,434 (-)Ensemblhg38GRCh38
GRCh37162,701,837 - 62,785,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,474,425 - 62,557,671 (-)NCBIBuild 36Build 36hg18NCBI36
Celera160,990,829 - 61,074,105 (-)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef160,814,486 - 60,897,665 (-)NCBIHuRef
CHM1_1162,817,196 - 62,900,410 (-)NCBICHM1_1
T2T-CHM13v2.0162,114,742 - 62,197,930 (-)NCBIT2T-CHM13v2.0
Kank4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39498,643,129 - 98,706,295 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl498,643,135 - 98,705,774 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38498,754,892 - 98,818,058 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl498,754,898 - 98,817,537 (-)Ensemblmm10GRCm38
MGSCv37498,421,583 - 98,484,228 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36498,246,916 - 98,309,555 (-)NCBIMGSCv36mm8
Celera497,114,470 - 97,178,203 (-)NCBICelera
Cytogenetic Map4C6NCBI
cM Map445.6NCBI
Kank4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542327,328,634 - 27,366,506 (+)Ensembl
ChiLan1.0NW_00495542327,328,795 - 27,363,484 (+)NCBIChiLan1.0ChiLan1.0
KANK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21164,532,380 - 164,621,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,681,962 - 163,770,665 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,489,350 - 61,578,025 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,305,534 - 63,393,716 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,307,644 - 63,350,546 (-)EnsemblpanPan2panpan1.1
KANK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1547,771,672 - 47,839,768 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl547,771,547 - 47,837,971 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha547,832,489 - 47,900,615 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0547,955,592 - 48,023,557 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl547,955,294 - 48,021,758 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1547,910,165 - 47,978,115 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0547,857,009 - 47,924,995 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0548,119,219 - 48,187,413 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
KANK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6150,143,912 - 150,184,120 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16150,106,628 - 150,185,667 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26138,305,276 - 138,384,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KANK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12070,733,211 - 70,824,093 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2070,782,499 - 70,821,950 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603346,598,887 - 46,720,949 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kank4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474231,491,314 - 31,504,711 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474231,472,023 - 31,505,418 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kank4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1155,736,435 - 55,768,320 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kank4
446 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:265
Count of miRNA genes:177
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000066139
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1298077Bp157Blood pressure QTL 157arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5114474223121056531Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Got244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,426,023 - 113,426,167 (+)MAPPERmRatBN7.2
Rnor_6.05117,400,985 - 117,401,125NCBIRnor6.0
Rnor_5.05121,341,970 - 121,342,110UniSTSRnor5.0
RGSC_v3.45119,193,686 - 119,193,829UniSTSRGSC3.4
Celera5111,992,935 - 111,993,078UniSTS
Cytogenetic Map5q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 70 59 6 334 170 11 138 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000066139   ⟹   ENSRNOP00000061603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,517,971 - 118,580,841 (-)Ensembl
mRatBN7.2 Ensembl5113,402,468 - 113,428,606 (-)Ensembl
Rnor_6.0 Ensembl5117,376,423 - 117,440,254 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095602   ⟹   ENSRNOP00000087738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,520,859 - 118,581,002 (-)Ensembl
mRatBN7.2 Ensembl5113,402,468 - 113,465,555 (-)Ensembl
RefSeq Acc Id: NM_001107947   ⟹   NP_001101417
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,517,971 - 118,580,734 (-)NCBI
mRatBN7.25113,402,468 - 113,465,234 (-)NCBI
Rnor_6.05117,377,402 - 117,440,185 (-)NCBI
Rnor_5.05121,317,410 - 121,381,170 (-)NCBI
RGSC_v3.45119,170,131 - 119,233,181 (-)RGD
Celera5111,969,381 - 112,032,141 (-)RGD
Sequence:
RefSeq Acc Id: XM_008763868   ⟹   XP_008762090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,516,994 - 118,581,021 (-)NCBI
mRatBN7.25113,401,491 - 113,465,523 (-)NCBI
Rnor_6.05117,376,425 - 117,440,643 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109903   ⟹   XP_038965831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,518,682 - 118,581,022 (-)NCBI
mRatBN7.25113,403,177 - 113,465,524 (-)NCBI
RefSeq Acc Id: XM_063287641   ⟹   XP_063143711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,536,253 - 118,581,024 (-)NCBI
RefSeq Acc Id: NP_001101417   ⟸   NM_001107947
- UniProtKB: D4A6X3 (UniProtKB/TrEMBL),   A6JRL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762090   ⟸   XM_008763868
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9C5 (UniProtKB/TrEMBL),   D4A6X3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061603   ⟸   ENSRNOT00000066139
RefSeq Acc Id: XP_038965831   ⟸   XM_039109903
- Peptide Label: isoform X2
- UniProtKB: D4A6X3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087738   ⟸   ENSRNOT00000095602
RefSeq Acc Id: XP_063143711   ⟸   XM_063287641
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A6X3-F1-model_v2 AlphaFold D4A6X3 1-1010 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307635 AgrOrtholog
BioCyc Gene G2FUF-40586 BioCyc
Ensembl Genes ENSRNOG00000007779 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066139 ENTREZGENE
  ENSRNOT00000066139.4 UniProtKB/TrEMBL
  ENSRNOT00000095602 ENTREZGENE
  ENSRNOT00000095602.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  KANK1-4 UniProtKB/TrEMBL
  KN_motif UniProtKB/TrEMBL
KEGG Report rno:313385 UniProtKB/TrEMBL
NCBI Gene 313385 ENTREZGENE
PANTHER KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING UniProtKB/TrEMBL
  KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  KN_motif UniProtKB/TrEMBL
PhenoGen Kank4 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007779 RatGTEx
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt A0A8I6A9C5 ENTREZGENE, UniProtKB/TrEMBL
  A6JRL0 ENTREZGENE, UniProtKB/TrEMBL
  D4A6X3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Kank4  KN motif and ankyrin repeat domains 4  BC060737_predicted  cDNA BC060737 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 BC060737_predicted  cDNA BC060737 (predicted)      Symbol and Name status set to approved 70820 APPROVED