Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | ISO | ATP8B3 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of ATP8B3 mRNA and Estradiol promotes the reaction [ESR2 protein affects the expression of ATP8B3 mRNA] | CTD | PMID:20404318 and PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ATP8B3 mRNA | CTD | PMID:33387578 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 4,4'-sulfonyldiphenol | decreases expression | ISO | Atp8b3 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of ATP8B3 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | increases methylation | ISO | ATP8B3 (Homo sapiens) | 6480464 | bisphenol S results in increased methylation of ATP8B3 gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Atp8b3 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of ATP8B3 exon | CTD | PMID:33297965 | aflatoxin B1 | decreases methylation | ISO | ATP8B3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ATP8B3 intron | CTD | PMID:30157460 | benzo[a]pyrene | increases mutagenesis | ISO | ATP8B3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of ATP8B3 gene | CTD | PMID:25435355 | benzo[a]pyrene | increases methylation | ISO | ATP8B3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ATP8B3 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | benzo[e]pyrene | increases methylation | ISO | ATP8B3 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of ATP8B3 intron | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of ATP8B3 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ATP8B3 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | ATP8B3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ATP8B3 gene | CTD | PMID:31601247 | bisphenol A | decreases methylation | ISO | ATP8B3 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of ATP8B3 gene | CTD | PMID:31601247 | butanal | increases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of ATP8B3 mRNA | CTD | PMID:26079696 | CGP 52608 | multiple interactions | ISO | ATP8B3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ATP8B3 gene] | CTD | PMID:28238834 | cisplatin | decreases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of ATP8B3 mRNA | CTD | PMID:27594783 | dorsomorphin | multiple interactions | ISO | ATP8B3 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | multiple interactions | ISO | ATP8B3 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP8B3 mRNA | CTD | PMID:27188386 | entinostat | increases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | entinostat results in increased expression of ATP8B3 mRNA | CTD | PMID:26272509 and PMID:27188386 | epoxiconazole | increases expression | ISO | Atp8b3 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of ATP8B3 mRNA | CTD | PMID:35436446 | fentin chloride | decreases expression | EXP | | 6480464 | triphenyltin chloride results in decreased expression of ATP8B3 mRNA | CTD | PMID:37156404 | fulvestrant | multiple interactions | ISO | ATP8B3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ATP8B3 gene | CTD | PMID:31601247 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of ATP8B3 mRNA | CTD | PMID:33387578 | hydrogen peroxide | affects expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of ATP8B3 mRNA | CTD | PMID:20044591 | methapyrilene | increases methylation | ISO | ATP8B3 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of ATP8B3 intron | CTD | PMID:30157460 | methotrexate | decreases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of ATP8B3 mRNA | CTD | PMID:24449571 | N-nitrosodiethylamine | increases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Diethylnitrosamine results in increased expression of ATP8B3 mRNA | CTD | PMID:21527772 | panobinostat | multiple interactions | ISO | ATP8B3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP8B3 mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | panobinostat results in increased expression of ATP8B3 mRNA | CTD | PMID:26272509 | paracetamol | decreases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of ATP8B3 mRNA | CTD | PMID:29067470 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of ATP8B3 mRNA | CTD | PMID:33387578 | pentanal | increases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | pentanal results in increased expression of ATP8B3 mRNA | CTD | PMID:26079696 | perfluorooctanoic acid | increases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of ATP8B3 mRNA | CTD | PMID:37738295 | propanal | increases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of ATP8B3 mRNA | CTD | PMID:26079696 | Ptaquiloside | decreases expression | ISO | Atp8b3 (Mus musculus) | 6480464 | ptaquiloside results in decreased expression of ATP8B3 mRNA | CTD | PMID:23274088 | SB 431542 | multiple interactions | ISO | ATP8B3 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of ATP8B3 mRNA | CTD | PMID:25895662 | sunitinib | decreases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of ATP8B3 mRNA | CTD | PMID:31533062 | thimerosal | decreases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of ATP8B3 mRNA | CTD | PMID:27188386 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of ATP8B3 mRNA | CTD | PMID:33387578 | triptonide | affects expression | ISO | Atp8b3 (Mus musculus) | 6480464 | triptonide affects the expression of ATP8B3 mRNA | CTD | PMID:33045310 | valproic acid | increases methylation | ISO | ATP8B3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of ATP8B3 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ATP8B3 mRNA | CTD | PMID:19101580 more ... | valproic acid | multiple interactions | ISO | ATP8B3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP8B3 mRNA | CTD | PMID:27188386 | valproic acid | affects expression | ISO | ATP8B3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ATP8B3 mRNA | CTD | PMID:25979313 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of ATP8B3 mRNA | CTD | PMID:23555832 | |