Yars1 (tyrosyl-tRNA synthetase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Yars1 (tyrosyl-tRNA synthetase 1) Rattus norvegicus
Analyze
Symbol: Yars1
Name: tyrosyl-tRNA synthetase 1
RGD ID: 1307616
Description: Predicted to enable small molecule binding activity and tyrosine-tRNA ligase activity. Predicted to be involved in response to starvation and tyrosyl-tRNA aminoacylation. Predicted to be located in nuclear body. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1); PARTICIPATES IN phenylketonuria pathway; tyrosinemia type II pathway; tyrosinemia type III pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313047; MGC112837; tyrosine--tRNA ligase, cytoplasmic; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase; tyrosyl-tRNA synthetase, cytoplasmic; tyrRS; Yars
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,820,163 - 146,848,377 (+)NCBIGRCr8
mRatBN7.25141,535,815 - 141,564,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,535,759 - 141,563,833 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,233,688 - 144,262,170 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,003,509 - 146,031,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,003,105 - 146,031,352 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,375,350 - 147,403,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,375,350 - 147,403,571 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,109,967 - 151,138,479 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,350,363 - 148,378,989 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,360,401 - 148,389,028 (+)NCBI
Celera5140,015,592 - 140,043,428 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars1RatAgenesis of Corpus Callosum  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Corpus callosum and agenesis ofClinVarPMID:29232904
Yars1RatCharcot-Marie-Tooth disease  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth diseaseClinVarPMID:14606043 more ...
Yars1RatCharcot-Marie-Tooth disease dominant intermediate C  ISOYARS1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14606043 more ...
Yars1RatCharcot-Marie-Tooth disease intermediate type  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth and IntermediateClinVarPMID:26467025 and PMID:28492532
Yars1RatDevelopmental Disabilities  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:27633801 and PMID:33490854
Yars1Ratgenetic disease  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:16429158 more ...
Yars1RatInfantile-Onset Multisystem Neurologic, Endocrine, and Pancreatic Disease  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurologic more ...ClinVarPMID:25741868
Yars1RatInfantile-Onset Multisystem Neurologic, Endocrine, and Pancreatic Disease 2  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurologic more ...ClinVarPMID:14606043 more ...
Yars1Ratmetachromatic leukodystrophy  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Metachromatic leukodystrophyClinVarPMID:25741868
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars1RatCharcot-Marie-Tooth disease dominant intermediate C  ISOYARS1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars1RatCharcot-Marie-Tooth disease dominant intermediate C  ISSYars1 (Mus musculus)13592920OMIM:608323MouseDO 

1 to 20 of 145 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of YARS1 mRNA]CTDPMID:31150632
Yars1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOYARS1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of YARS1 mRNACTDPMID:22079256
Yars1Rat(1->4)-beta-D-glucan multiple interactionsISOYars1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of YARS1 mRNACTDPMID:36331819
Yars1Rat1,2-dichloroethane decreases expressionISOYars1 (Mus musculus)6480464ethylene dichloride results in decreased expression of YARS1 mRNACTDPMID:28960355
Yars1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of YARS1 mRNACTDPMID:20551477
Yars1Rat17alpha-ethynylestradiol multiple interactionsISOYars1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YARS1 mRNACTDPMID:17942748
Yars1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of YARS1 mRNACTDPMID:32145629
Yars1Rat17beta-estradiol increases expressionISOYars1 (Mus musculus)6480464Estradiol results in increased expression of YARS1 mRNACTDPMID:39298647
Yars1Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of YARS1 mRNACTDPMID:26496021
Yars1Rat17beta-estradiol increases expressionISOYARS1 (Homo sapiens)6480464Estradiol results in increased expression of YARS1 mRNACTDPMID:20106945 and PMID:31614463
Yars1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOYARS1 (Homo sapiens)64804642 more ...CTDPMID:19095052
Yars1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOYARS1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Yars1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOYars1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YARS1 mRNACTDPMID:17942748
Yars1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of YARS1 mRNACTDPMID:33387578
Yars1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of YARS1 mRNACTDPMID:21346803
Yars1Rat2,6-dimethoxyphenol multiple interactionsISOYARS1 (Homo sapiens)6480464[Furaldehyde co-treated with pyrogallol 1 more ...CTDPMID:38598786
Yars1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of YARS1 mRNACTDPMID:21346803
Yars1Rat2-palmitoylglycerol increases expressionISOYARS1 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of YARS1 mRNACTDPMID:37199045
Yars1Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin analog results in increased expression of YARS1 protein and alpha-Chlorohydrin results in increased expression of YARS1 proteinCTDPMID:26597043 and PMID:34915118
Yars1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOYARS1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of YARS1 mRNACTDPMID:28628672

1 to 20 of 145 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars1Ratresponse to starvation involved_inISOYARS1 (Homo sapiens)1624291 PMID:25533949RGDPMID:25533949
Yars1Rattranslation involved_inIEAUniProtKB-KW:KW-06481600115GO_REF:0000043UniProtGO_REF:0000043
Yars1RattRNA aminoacylation for protein translation involved_inIEAInterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Yars1Rattyrosyl-tRNA aminoacylation involved_inISOYARS1 (Homo sapiens)1624291 PMID:25533949RGDPMID:25533949
Yars1Rattyrosyl-tRNA aminoacylation involved_inIEAInterPro:IPR0023071600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars1Ratcytoplasm is_active_inISOYARS1 (Homo sapiens)1624291 PMID:25533949RGDPMID:25533949
Yars1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Yars1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Yars1Ratcytosol is_active_inISSUniProtKB:P545771600115GO_REF:0000024UniProtGO_REF:0000024
Yars1Ratcytosol is_active_inISOYARS1 (Homo sapiens)1624291 PMID:22291016RGDPMID:22291016
Yars1Ratcytosol located_inISOYARS1 (Homo sapiens)1624291 RGDGO_REF:0000052
Yars1Ratnuclear body located_inISOYARS1 (Homo sapiens)1624291 RGDGO_REF:0000052
Yars1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Yars1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Yars1Ratnucleus is_active_inISOYARS1 (Homo sapiens)1624291 PMID:22291016 and PMID:25533949RGDPMID:22291016 and PMID:25533949
Yars1Ratnucleus is_active_inISSUniProtKB:P545771600115GO_REF:0000024UniProtGO_REF:0000024
1 to 11 of 11 rows

Molecular Function
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars1Rataminoacyl-tRNA ligase activity enablesIEAUniProtKB-KW:KW-00301600115GO_REF:0000043UniProtGO_REF:0000043
Yars1Rataminoacyl-tRNA ligase activity enablesIEAInterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Yars1RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Yars1RatATP binding enablesIEAInterPro:IPR002305 and InterPro:IPR0023071600115GO_REF:0000002InterProGO_REF:0000002
Yars1Ratligase activity enablesIEAUniProtKB-KW:KW-04361600115GO_REF:0000043UniProtGO_REF:0000043
Yars1Ratnucleotide binding enablesIEAInterPro:IPR002305 and InterPro:IPR0023071600115GO_REF:0000002InterProGO_REF:0000002
Yars1Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Yars1Ratprotein binding enablesISOYARS1 (Homo sapiens)1624291UniProtKB:O75925 more ...RGDPMID:24965446 more ...
Yars1RatRNA binding enablesIEAUniProtKB-KW:KW-06941600115GO_REF:0000043UniProtGO_REF:0000043
Yars1RatRNA binding enablesIEAUniRule:UR0004144431600115GO_REF:0000104UniProtGO_REF:0000104
Yars1Ratsmall molecule binding enablesISOYARS1 (Homo sapiens)1624291 PMID:25533949RGDPMID:25533949
Yars1Ratsmall molecule binding enablesISSUniProtKB:P545771600115GO_REF:0000024UniProtGO_REF:0000024
Yars1RattRNA binding enablesIEAUniRule:UR0004144431600115GO_REF:0000104UniProtGO_REF:0000104
Yars1RattRNA binding enablesIEAInterPro:IPR0025471600115GO_REF:0000002InterProGO_REF:0000002
Yars1RattRNA binding enablesIEAUniProtKB-KW:KW-08201600115GO_REF:0000043UniProtGO_REF:0000043
Yars1Rattyrosine-tRNA ligase activity enablesIEAEC:6.1.1.11600115GO_REF:0000003UniProtGO_REF:0000003
Yars1Rattyrosine-tRNA ligase activity enablesIEARHEA:102201600115GO_REF:0000116RHEAGO_REF:0000116
Yars1Rattyrosine-tRNA ligase activity enablesIBAFB:FBgn0027080 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Yars1Rattyrosine-tRNA ligase activity enablesIEAInterPro:IPR0023071600115GO_REF:0000002InterProGO_REF:0000002
Yars1Rattyrosine-tRNA ligase activity enablesISOYARS1 (Homo sapiens)1624291 PMID:22291016 and PMID:25533949RGDPMID:22291016 and PMID:25533949
1 to 20 of 21 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars1Ratphenylketonuria pathway  ISOYARS1 (Homo sapiens)10402751 SMPDBSMP:00206
Yars1Rattyrosinemia type II pathway  ISOYARS1 (Homo sapiens)10402751 SMPDBSMP:00369
Yars1Rattyrosinemia type III pathway  ISOYARS1 (Homo sapiens)10402751 SMPDBSMP:00370

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars1Rataminoacyl-tRNA biosynthetic pathway  IEA 6907045 KEGGrno:00970

BioCyc Pathways


1 to 9 of 9 rows
#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 9 of 9 rows
PMID:12477932   PMID:15489334   PMID:16854843   PMID:22658674   PMID:29289698   PMID:31505169  



Yars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,820,163 - 146,848,377 (+)NCBIGRCr8
mRatBN7.25141,535,815 - 141,564,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,535,759 - 141,563,833 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,233,688 - 144,262,170 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,003,509 - 146,031,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,003,105 - 146,031,352 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,375,350 - 147,403,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,375,350 - 147,403,571 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,109,967 - 151,138,479 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,350,363 - 148,378,989 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,360,401 - 148,389,028 (+)NCBI
Celera5140,015,592 - 140,043,428 (+)NCBICelera
Cytogenetic Map5q36NCBI
YARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,775,239 - 32,817,358 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,775,237 - 32,818,031 (-)EnsemblGRCh38hg38GRCh38
GRCh37133,240,840 - 33,282,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,013,427 - 33,056,220 (-)NCBINCBI36Build 36hg18NCBI36
Build 34132,909,932 - 32,952,726NCBI
Celera131,509,662 - 31,552,283 (-)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,356,139 - 31,399,200 (-)NCBIHuRef
CHM1_1133,356,247 - 33,399,028 (-)NCBICHM1_1
T2T-CHM13v2.0132,635,023 - 32,677,140 (-)NCBIT2T-CHM13v2.0
Yars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,083,595 - 129,113,033 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,083,553 - 129,113,400 (+)EnsemblGRCm39 Ensembl
GRCm384129,189,734 - 129,219,240 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,189,760 - 129,219,607 (+)EnsemblGRCm38mm10GRCm38
MGSCv374128,867,039 - 128,896,851 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364128,692,255 - 128,721,911 (+)NCBIMGSCv36mm8
Celera4127,529,758 - 127,559,623 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.05NCBI
Yars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,046,047 - 11,078,016 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545211,046,047 - 11,078,016 (-)NCBIChiLan1.0ChiLan1.0
YARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21194,004,825 - 194,044,614 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11193,126,810 - 193,166,838 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,068,202 - 32,108,664 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,232,163 - 33,295,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,232,905 - 33,294,558 (-)Ensemblpanpan1.1panPan2
YARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,535,402 - 68,566,197 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,535,447 - 68,565,439 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,115,258 - 65,146,054 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,100,498 - 69,131,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,100,535 - 69,132,060 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,912,002 - 65,942,953 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,934,433 - 66,965,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,926,368 - 67,957,551 (+)NCBIUU_Cfam_GSD_1.0
Yars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,867,056 - 49,896,532 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,691,842 - 15,721,953 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,691,838 - 15,721,308 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl689,088,544 - 89,119,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1689,088,122 - 89,118,837 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2683,115,016 - 83,145,732 (-)NCBISscrofa10.2Sscrofa10.2susScr3
YARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,050,717 - 100,096,719 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20100,052,535 - 100,095,980 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603316,595,637 - 16,639,571 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,898,646 - 15,933,400 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476415,898,648 - 15,933,386 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Yars1
47 total Variants

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:63
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000010674
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 43 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat

1 to 10 of 43 rows
D5Rat97  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85146,838,530 - 146,838,760 (+)Marker Load Pipeline
mRatBN7.25141,554,182 - 141,554,412 (+)MAPPERmRatBN7.2
Rnor_6.05147,393,732 - 147,393,961NCBIRnor6.0
Rnor_5.05151,128,633 - 151,128,862UniSTSRnor5.0
RGSC_v3.45148,369,142 - 148,369,372RGDRGSC3.4
RGSC_v3.45148,369,143 - 148,369,372UniSTSRGSC3.4
RGSC_v3.15148,379,182 - 148,379,411RGD
Celera5140,033,582 - 140,033,811UniSTS
RH 3.4 Map5958.0RGD
RH 3.4 Map5958.0UniSTS
RH 2.0 Map5163.9RGD
SHRSP x BN Map579.6799RGD
FHH x ACI Map578.8RGD
Cytogenetic Map5q36UniSTS
RH130408  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25141,563,717 - 141,563,922 (+)MAPPERmRatBN7.2
Rnor_6.05147,403,267 - 147,403,471NCBIRnor6.0
Rnor_5.05151,138,168 - 151,138,372UniSTSRnor5.0
RGSC_v3.45148,378,678 - 148,378,882UniSTSRGSC3.4
Celera5140,043,117 - 140,043,321UniSTS
Cytogenetic Map5q36UniSTS
RH142596  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25141,536,271 - 141,536,381 (+)MAPPERmRatBN7.2
Rnor_6.05147,375,807 - 147,375,916NCBIRnor6.0
Rnor_5.05151,110,424 - 151,110,533UniSTSRnor5.0
RGSC_v3.45148,350,820 - 148,350,929UniSTSRGSC3.4
Celera5140,016,049 - 140,016,158UniSTS
RH 3.4 Map5957.6UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000010674   ⟹   ENSRNOP00000010674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5141,535,759 - 141,563,833 (+)Ensembl
Rnor_6.0 Ensembl5147,375,350 - 147,403,571 (+)Ensembl
RefSeq Acc Id: NM_001025696   ⟹   NP_001020867
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85146,820,163 - 146,848,377 (+)NCBI
mRatBN7.25141,535,815 - 141,564,029 (+)NCBI
Rnor_6.05147,375,350 - 147,403,578 (+)NCBI
Rnor_5.05151,109,967 - 151,138,479 (+)NCBI
RGSC_v3.45148,350,363 - 148,378,989 (+)RGD
Celera5140,015,592 - 140,043,428 (+)RGD
Sequence:
Protein RefSeqs NP_001020867 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98795 (Get FASTA)   NCBI Sequence Viewer  
  EDL80530 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000107228
GenBank Protein Q4KM49 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020867   ⟸   NM_001025696
- UniProtKB: Q4KM49 (UniProtKB/Swiss-Prot),   A6ISH9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010674   ⟸   ENSRNOT00000010674
tRNA-binding

Name Modeler Protein Id AA Range Protein Structure
AF-Q4KM49-F1-model_v2 AlphaFold Q4KM49 1-528 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694057
Promoter ID:EPDNEW_R4582
Type:initiation region
Name:Yars_1
Description:tyrosyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05147,375,385 - 147,375,445EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-39815 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000007213 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000129477 ENTREZGENE
Gene3D-CATH 2.40.50.140 UniProtKB/Swiss-Prot
  3.40.50.620 UniProtKB/Swiss-Prot
  Tyrosyl-Transfer RNA Synthetase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7375769 IMAGE-MGC_LOAD
InterPro aa-tRNA-synth_Ic UniProtKB/Swiss-Prot
  NA-bd_OB-fold UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
  tRNA-bd_dom UniProtKB/Swiss-Prot
  Tyr-tRNA-ligase UniProtKB/Swiss-Prot
  Tyrosine-tRNA_ligase_regulator UniProtKB/Swiss-Prot
KEGG Report rno:313047 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112837 IMAGE-MGC_LOAD
NCBI Gene 313047 ENTREZGENE
PANTHER TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER UniProtKB/Swiss-Prot
  TYROSINE--TRNA LIGASE, CYTOPLASMIC UniProtKB/Swiss-Prot
Pfam tRNA-synt_1b UniProtKB/Swiss-Prot
  tRNA_bind UniProtKB/Swiss-Prot
PhenoGen Yars1 PhenoGen
PRINTS TRNASYNTHTYR UniProtKB/Swiss-Prot
PROSITE TRBD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007213 RatGTEx
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/Swiss-Prot
  SSF50249 UniProtKB/Swiss-Prot
UniProt A0A0H2UHG0_RAT UniProtKB/TrEMBL
  A6ISH9 ENTREZGENE, UniProtKB/TrEMBL
  Q4KM49 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Yars1  tyrosyl-tRNA synthetase 1  Yars  tyrosyl-tRNA synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Yars  tyrosyl-tRNA synthetase  Yars_predicted  tyrosyl-tRNA synthetase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Yars_predicted  tyrosyl-tRNA synthetase (predicted)      Symbol and Name status set to approved 70820 APPROVED