Rabl6 (RAB, member RAS oncogene family-like 6) - Rat Genome Database

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Gene: Rabl6 (RAB, member RAS oncogene family-like 6) Rattus norvegicus
Analyze
Symbol: Rabl6
Name: RAB, member RAS oncogene family-like 6
RGD ID: 1307615
Description: Predicted to enable GTP binding activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human RABL6 (RAB, member RAS oncogene family like 6); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC362084; LOC362084; rab-like protein 6; RGD1307615; similar to hypothetical protein FLJ13045; uncharacterized protein LOC362084
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,800,802 - 28,826,722 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,800,802 - 28,826,722 (-)EnsemblGRCr8
mRatBN7.238,402,666 - 8,428,588 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,402,672 - 8,428,611 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,507,841 - 11,533,746 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,094,067 - 20,119,972 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,283,913 - 18,309,819 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,806,777 - 2,832,697 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,806,777 - 2,832,697 (-)Ensemblrn6Rnor6.0
Rnor_5.032,788,190 - 2,814,110 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,754,687 - 3,780,607 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,227,617 - 3,253,537 (-)NCBICelera
RGSC_v3.133,754,691 - 3,777,741 (-)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17962191  


Genomics

Comparative Map Data
Rabl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,800,802 - 28,826,722 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,800,802 - 28,826,722 (-)EnsemblGRCr8
mRatBN7.238,402,666 - 8,428,588 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,402,672 - 8,428,611 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,507,841 - 11,533,746 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,094,067 - 20,119,972 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,283,913 - 18,309,819 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,806,777 - 2,832,697 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,806,777 - 2,832,697 (-)Ensemblrn6Rnor6.0
Rnor_5.032,788,190 - 2,814,110 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,754,687 - 3,780,607 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,227,617 - 3,253,537 (-)NCBICelera
RGSC_v3.133,754,691 - 3,777,741 (-)NCBI
Cytogenetic Map3p13NCBI
RABL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,807,948 - 136,841,187 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,807,927 - 136,841,187 (+)Ensemblhg38GRCh38
GRCh379139,702,400 - 139,735,639 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,822,195 - 138,855,460 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349136,978,210 - 137,011,476NCBI
Celera9110,216,142 - 110,249,429 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,161,664 - 109,194,942 (+)NCBIHuRef
CHM1_19139,850,905 - 139,884,360 (+)NCBICHM1_1
T2T-CHM13v2.09149,042,110 - 149,075,389 (+)NCBIT2T-CHM13v2.0
Rabl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,473,029 - 25,498,493 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,473,030 - 25,498,533 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38225,583,017 - 25,608,481 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,583,018 - 25,608,521 (-)Ensemblmm10GRCm38
MGSCv37225,438,538 - 25,463,966 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36225,405,027 - 25,430,455 (-)NCBIMGSCv36mm8
Celera225,311,207 - 25,336,645 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.46NCBI
Rabl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,904,958 - 4,922,599 (+)Ensembl
ChiLan1.0NW_0049555134,904,659 - 4,923,225 (+)NCBIChiLan1.0ChiLan1.0
RABL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,561,439 - 2,593,866 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,563,774 - 2,596,190 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,865,764 - 107,898,073 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,836,671 - 136,867,298 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,849,527 - 136,868,545 (+)EnsemblpanPan2panpan1.1
RABL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,746,363 - 48,767,529 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,594,845 - 48,770,844 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,959,975 - 47,981,289 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,624,520 - 49,645,844 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,624,055 - 49,645,881 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,400,620 - 48,421,933 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,699,325 - 48,720,626 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,746,295 - 48,767,610 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rabl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,272,660 - 202,299,502 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,075,218 - 1,102,404 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,075,556 - 1,102,404 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RABL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21313,920,698 - 313,929,670 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RABL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,348,082 - 1,379,779 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,348,742 - 1,379,518 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660583,894,402 - 3,927,277 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rabl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,009,270 - 1,028,929 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247601,008,723 - 1,029,070 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rabl6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1511,570,226 - 11,595,956 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rabl6
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:235
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000065410
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH141629  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,402,686 - 8,402,906 (+)MAPPERmRatBN7.2
Rnor_6.032,806,798 - 2,807,017NCBIRnor6.0
Rnor_5.032,788,211 - 2,788,430UniSTSRnor5.0
RGSC_v3.433,754,708 - 3,754,927UniSTSRGSC3.4
Celera33,227,638 - 3,227,857UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000065410   ⟹   ENSRNOP00000060618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,800,802 - 28,826,722 (-)Ensembl
mRatBN7.2 Ensembl38,402,672 - 8,428,611 (-)Ensembl
Rnor_6.0 Ensembl32,806,777 - 2,832,697 (-)Ensembl
RefSeq Acc Id: NM_001108573   ⟹   NP_001102043
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,800,802 - 28,826,722 (-)NCBI
mRatBN7.238,402,666 - 8,428,588 (-)NCBI
Rnor_6.032,806,777 - 2,832,697 (-)NCBI
Rnor_5.032,788,190 - 2,814,110 (-)NCBI
RGSC_v3.433,754,687 - 3,780,607 (-)RGD
Celera33,227,617 - 3,253,537 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105351   ⟹   XP_038961279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,800,807 - 28,816,817 (-)NCBI
mRatBN7.238,403,232 - 8,418,682 (-)NCBI
RefSeq Acc Id: XM_039105353   ⟹   XP_038961281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,800,807 - 28,810,154 (-)NCBI
mRatBN7.238,403,232 - 8,412,029 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102043 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961279 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961281 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93560 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060618
  ENSRNOP00000060618.2
RefSeq Acc Id: NP_001102043   ⟸   NM_001108573
- UniProtKB: D3ZKQ4 (UniProtKB/TrEMBL),   A6JT87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060618   ⟸   ENSRNOT00000065410
RefSeq Acc Id: XP_038961279   ⟸   XM_039105351
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961281   ⟸   XM_039105353
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKQ4-F1-model_v2 AlphaFold D3ZKQ4 1-731 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691885
Promoter ID:EPDNEW_R2409
Type:initiation region
Name:Rabl6_1
Description:RAB, member RAS oncogene family-like 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,832,717 - 2,832,777EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307615 AgrOrtholog
BioCyc Gene G2FUF-50437 BioCyc
Ensembl Genes ENSRNOG00000016795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065410 ENTREZGENE
  ENSRNOT00000065410.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  RABL6 UniProtKB/TrEMBL
KEGG Report rno:362084 UniProtKB/TrEMBL
NCBI Gene 362084 ENTREZGENE
PANTHER PTHR14932 UniProtKB/TrEMBL
  RAB-LIKE PROTEIN 6 UniProtKB/TrEMBL
Pfam Roc UniProtKB/TrEMBL
PhenoGen Rabl6 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016795 RatGTEx
SMART RAB UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A6JT87 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKQ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Rabl6  RAB, member RAS oncogene family-like 6  RGD1307615  similar to hypothetical protein FLJ13045  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1307615  similar to hypothetical protein FLJ13045   RGD1307615_predicted  similar to hypothetical protein FLJ13045 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1307615_predicted  similar to hypothetical protein FLJ13045 (predicted)  LOC362084_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362084_predicted  similar to hypothetical protein FLJ13045 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL