Erhl1 (ERH, mRNA splicing and mitosis factor like 1) - Rat Genome Database

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Gene: Erhl1 (ERH, mRNA splicing and mitosis factor like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Erhl1
Name: ERH, mRNA splicing and mitosis factor like 1
RGD ID: 1307595
Description: Orthologous to human ERH (ERH mRNA splicing and mitosis factor); INTERACTS WITH 3,7-dihydropurine-6-thione; copper atom; copper(0).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Enhancer of rudimentary homolog-like; hypothetical protein LOC295019; LOC295019; RGD1307595; similar to RIKEN cDNA 1700018B24; uncharacterized protein LOC295019
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82134,631,796 - 134,635,102 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2134,629,172 - 134,645,681 (-)EnsemblGRCr8
mRatBN7.22132,570,276 - 132,573,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2132,570,285 - 132,573,604 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2139,186,946 - 139,190,235 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02137,299,483 - 137,302,772 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02131,928,646 - 131,931,935 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02138,194,136 - 138,197,442 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2138,194,136 - 138,197,442 (+)Ensemblrn6Rnor6.0
Rnor_5.02157,678,584 - 157,681,890 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42137,166,345 - 137,169,651 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2127,288,830 - 127,292,136 (+)NCBICelera
RGSC_v3.12137,116,331 - 137,119,671 (-)NCBI
Cytogenetic Map2q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Erhl1
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:24
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000014928
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH137963  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map16440.3UniSTS
Cytogenetic Map2q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 9 2 37 17 15 8 6 8 33 13 33 1 52 7

Sequence


Ensembl Acc Id: ENSRNOT00000014928   ⟹   ENSRNOP00000014928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2134,631,774 - 134,645,681 (-)Ensembl
mRatBN7.2 Ensembl2132,570,285 - 132,573,604 (-)Ensembl
Rnor_6.0 Ensembl2138,194,136 - 138,197,442 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126154   ⟹   ENSRNOP00000107918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2134,629,172 - 134,635,189 (-)Ensembl
RefSeq Acc Id: NM_001134511   ⟹   NP_001127983
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82134,631,796 - 134,635,102 (-)NCBI
mRatBN7.22132,570,276 - 132,573,582 (-)NCBI
Rnor_6.02138,194,136 - 138,197,442 (+)NCBI
Rnor_5.02157,678,584 - 157,681,890 (+)NCBI
RGSC_v3.42137,166,345 - 137,169,651 (-)RGD
Celera2127,288,830 - 127,292,136 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001127983 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83011 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014928.5
  ENSRNOP00000107918.1
RefSeq Acc Id: NP_001127983   ⟸   NM_001134511
- UniProtKB: D4A5C2 (UniProtKB/TrEMBL),   A6KRP3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014928   ⟸   ENSRNOT00000014928
Ensembl Acc Id: ENSRNOP00000107918   ⟸   ENSRNOT00000126154

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5C2-F1-model_v2 AlphaFold D4A5C2 1-105 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691313
Promoter ID:EPDNEW_R1837
Type:initiation region
Name:RGD1307595_1
Description:similar to RIKEN cDNA 1700018B24
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02138,194,136 - 138,194,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307595 AgrOrtholog
BioCyc Gene G2FUF-53156 BioCyc
Ensembl Genes ENSRNOG00000011239 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014928.7 UniProtKB/TrEMBL
  ENSRNOT00000126154.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2260.10 UniProtKB/TrEMBL
InterPro EHR_sf UniProtKB/TrEMBL
  Enh_rudimentary UniProtKB/TrEMBL
KEGG Report rno:295019 UniProtKB/TrEMBL
NCBI Gene 295019 ENTREZGENE
PANTHER Enh_rudimentary UniProtKB/TrEMBL
  ENHANCER OF RUDIMENTARY HOMOLOG UniProtKB/TrEMBL
Pfam PF01133 UniProtKB/TrEMBL
PhenoGen Erhl1 PhenoGen
PIRSF Enh_rudimentary UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011239 RatGTEx
Superfamily-SCOP SSF143875 UniProtKB/TrEMBL
UniProt A6KRP3 ENTREZGENE, UniProtKB/TrEMBL
  D4A5C2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Erhl1  ERH, mRNA splicing and mitosis factor like 1  RGD1307595  similar to RIKEN cDNA 1700018B24  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1307595  similar to RIKEN cDNA 1700018B24   RGD1307595_predicted  similar to RIKEN cDNA 1700018B24 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1307595_predicted  similar to RIKEN cDNA 1700018B24 (predicted)  LOC295019_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC295019_predicted  similar to RIKEN cDNA 1700018B24 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL