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Gene: Fbxo4 (F-box protein 4) Rattus norvegicus

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Symbol:

Fbxo4

Name:

F-box protein 4

RGD ID:

1307580

Description:

Predicted to enable protein homodimerization activity; ubiquitin protein ligase activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of macromolecule metabolic process; and protein polyubiquitination. Predicted to act upstream of or within several processes, including common myeloid progenitor cell proliferation; positive regulation of protein metabolic process; and protein destabilization. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXO4 (F-box protein 4); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

F-box only protein 4; LOC310363

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FBXO4 (F-box protein 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fbxo4 (F-box protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fbxo4 (F-box protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FBXO4 (F-box protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FBXO4 (F-box protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fbxo4 (F-box protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FBXO4 (F-box protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FBXO4 (F-box protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fbxo4 (F-box protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Fbxo4 (F-box protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FBXO4 (F-box protein 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fbxo4 (F-box protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fbxo4 (F-box protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fbxo4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fbxo4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	54,902,394 - 54,915,388 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	54,902,394 - 54,915,388 (-)	Ensembl				GRCr8
mRatBN7.2	2	53,174,798 - 53,187,792 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	53,174,798 - 53,187,792 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	60,273,074 - 60,286,042 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	58,331,816 - 58,344,784 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	53,363,530 - 53,376,542 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	53,797,954 - 53,811,134 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	53,797,954 - 53,811,134 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	72,830,881 - 72,844,061 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	53,871,746 - 53,884,722 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	48,852,920 - 48,865,913 (-)	NCBI		Celera
RGSC_v3.1	2	53,800,345 - 53,812,541 (-)	NCBI
Cytogenetic Map	2	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

glycidol (EXP)

glycidyl methacrylate (ISO)

GSK-J4 (ISO)

indometacin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylmercury chloride (ISO)

N-acetyl-beta-D-glucosamine (ISO)

N-acetyl-D-glucosamine (ISO)

nefazodone (EXP)

nickel sulfate (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

temozolomide (ISO)

testosterone (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular homeostasis (ISO)

cellular response to ionizing radiation (ISO)

cellular senescence (ISO)

common myeloid progenitor cell proliferation (ISO)

negative regulation of fibroblast proliferation (ISO)

negative regulation of protein localization to nucleus (ISO)

positive regulation of protein polyubiquitination (ISO)

positive regulation of protein ubiquitination (IEA,ISO)

positive regulation of telomere maintenance via telomerase (IEA,ISO)

post-transcriptional regulation of gene expression (ISO)

protein destabilization (ISO)

protein polyubiquitination (IBA,IEA,ISO)

protein ubiquitination (IEA,ISO)

regulation of DNA damage checkpoint (ISO)

regulation of macromolecule biosynthetic process (IEA)

regulation of protein stability (IEA,ISO)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IBA,IEA,ISO)

telomere maintenance (ISO)

ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

cytoplasm (IEA,ISO)

SCF ubiquitin ligase complex (IBA,IEA,ISO)

ubiquitin ligase complex (IEA,ISO)

Molecular Function

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

ubiquitin protein ligase activity (IEA,ISO)

ubiquitin-like ligase-substrate adaptor activity (IEA,ISO)

ubiquitin-protein transferase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10531035	PMID:16275645	PMID:19028597	PMID:20159592	PMID:20181953	PMID:21378169	PMID:21911473	PMID:24389012

Genomics

Comparative Map Data

Fbxo4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	54,902,394 - 54,915,388 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	54,902,394 - 54,915,388 (-)	Ensembl				GRCr8
mRatBN7.2	2	53,174,798 - 53,187,792 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	53,174,798 - 53,187,792 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	60,273,074 - 60,286,042 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	58,331,816 - 58,344,784 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	53,363,530 - 53,376,542 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	53,797,954 - 53,811,134 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	53,797,954 - 53,811,134 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	72,830,881 - 72,844,061 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	53,871,746 - 53,884,722 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	48,852,920 - 48,865,913 (-)	NCBI		Celera
RGSC_v3.1	2	53,800,345 - 53,812,541 (-)	NCBI
Cytogenetic Map	2	q16	NCBI

FBXO4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	41,925,281 - 42,040,404 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	41,925,210 - 41,941,743 (+)	Ensembl			hg38	GRCh38
GRCh37	5	41,925,383 - 41,941,845 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	41,961,113 - 41,977,429 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	41,961,112 - 41,970,940	NCBI
Celera	5	41,813,649 - 41,829,966 (+)	NCBI		Celera
Cytogenetic Map	5	p13.1	NCBI
HuRef	5	41,878,053 - 41,894,370 (+)	NCBI		HuRef
CHM1_1	5	41,927,215 - 41,943,529 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	42,181,685 - 42,298,494 (+)	NCBI		T2T-CHM13v2.0

Fbxo4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	3,993,046 - 4,009,055 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	3,994,927 - 4,009,055 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	3,963,564 - 3,979,573 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	3,965,445 - 3,979,573 (-)	Ensembl			mm10	GRCm38
MGSCv37	15	3,913,564 - 3,929,573 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	3,915,461 - 3,929,573 (-)	NCBI		MGSCv36	mm8
Celera	15	3,825,238 - 3,841,215 (-)	NCBI		Celera
Cytogenetic Map	15	A1	NCBI
cM Map	15	1.84	NCBI

Fbxo4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	26,046,742 - 26,063,388 (+)	Ensembl
ChiLan1.0	NW_004955426	26,046,742 - 26,066,747 (+)	NCBI	ChiLan1.0	ChiLan1.0

FBXO4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	68,209,415 - 68,425,734 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	66,441,446 - 66,579,338 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	68,336,673 - 68,474,481 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	73,500,841 - 73,517,051 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	73,500,850 - 73,517,051 (-)	Ensembl			panPan2	panpan1.1

FBXO4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	67,620,947 - 67,664,862 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	67,651,275 - 67,664,915 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	67,304,401 - 67,348,302 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	68,132,595 - 68,177,003 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	68,149,420 - 68,176,917 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	67,874,636 - 67,918,514 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	68,005,389 - 68,049,230 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	68,544,850 - 68,589,223 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Fbxo4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	230,497,928 - 230,516,528 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	854,721 - 874,018 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936518	855,304 - 873,927 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBXO4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	26,707,470 - 26,752,024 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	26,707,470 - 26,751,134 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	27,971,745 - 27,988,034 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FBXO4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	40,682,063 - 40,698,364 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	40,682,333 - 40,698,370 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666071	31,118,629 - 31,134,667 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbxo4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	13,017,815 - 13,046,883 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624759	13,019,929 - 13,047,744 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Fbxo4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	176,169,094 - 176,182,005 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Fbxo4
43 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	46
Interacting mature miRNAs:	52
Transcripts:	ENSRNOT00000020925
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	13325041	58325041	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	24117813	69117813	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	36750344	81750344	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1579916	Bp270	Blood pressure QTL 270		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	16051883	61051883	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	14368707	59368707	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	44904355	85286097	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	51266859	96266859	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	36868643	81868643	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	44904355	89904355	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	33269996	78269996	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Markers in Region

AI851261

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	53,175,103 - 53,175,218 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	53,798,260 - 53,798,374	NCBI	Rnor6.0
Rnor_5.0	2	72,831,187 - 72,831,301	UniSTS	Rnor5.0
RGSC_v3.4	2	53,872,052 - 53,872,166	UniSTS	RGSC3.4
Celera	2	48,853,226 - 48,853,340	UniSTS
Cytogenetic Map	2	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	88	59	6	352	188	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107672	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020925 ⟹ ENSRNOP00000020925

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	54,902,394 - 54,915,388 (-)	Ensembl
mRatBN7.2 Ensembl	2	53,174,798 - 53,187,792 (-)	Ensembl
Rnor_6.0 Ensembl	2	53,797,954 - 53,811,134 (-)	Ensembl

RefSeq Acc Id:

NM_001107672 ⟹ NP_001101142

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	54,902,394 - 54,915,388 (-)	NCBI
mRatBN7.2	2	53,174,798 - 53,187,792 (-)	NCBI
Rnor_6.0	2	53,797,954 - 53,811,134 (-)	NCBI
Rnor_5.0	2	72,830,881 - 72,844,061 (-)	NCBI
RGSC_v3.4	2	53,871,746 - 53,884,722 (-)	RGD
Celera	2	48,852,920 - 48,865,913 (-)	RGD

Sequence:

show sequence

AGTCAGCCAAGGTCAATGTCATTAATAACAGATGGGACTTTTTGGAGCACTTTAGTTCCACAGG
CTCTTGATCGTCTCCATGTTTTTGCTAAACTCCAGTAAAGCGGTAGATTGCTGATTCCAAAACA
CAGAAGCACACATACAGCCTACTTAATACCTAACTCTTAAGGGGAAGCAAGTGTTAGAACCAAG
ATTACAGAAAAAGGGTTGGCTGTTCCACAAGCCCTAGCTCCCTGCTCCTTGTGGTGGTGCCTAG
AGCCAGGGACCTAGAGGATATGTAGTCTGGGTTAACATCAGCGGTCATTCGGCCAAGGGTTTGT
GCTAACCGGGATGAGTCATTCCGGGCCACCTCGGCCTGGAGCCGCGCCCAGCAGACCAGCCTGG
CTCGTCCCAGCGGGGCGGGCGGAGACGGAGGCCGAGCGGCTGGGAAACCGGTGCGCCCGGCCGT
GTCTCGCGGAGCCCGCAGCCATGGCTGGAAGCGAGCCCCGCGGAGCCGGCTCCCCGCCGCCCGC
CAGCGACTGGGGCCGCCTGGAGGCTGCTATCCTGAGCGGCTGGAGGACCTTCTGGAATTCGGTG
GGCAAGGAGCGGGCGACGCGGACGGCCTCCCGGAAGGAGGAGGCGGAGGAGACGAGCGCGCTGA
CGCGGCTGCCGATTGATGTGCAGCTGTATATCTTGTCATTTCTTTCACCCCATGACCTGTGCCA
GTTGGGAAGTACAGATCACTATTGGAATGAAACTGTAAGAGACCCAATTCTCTGGAGATACTTT
CTGTTTCGAGATCTCCCTTCTTGGTCCTCTGTTGATTGGAAGTCACTTCCGGATCTAGAGATAT
TAAAAAAGCCCATATCTGAGGTCACCGACAGCACATGTTTTGATTACATGGAGGTTTATAAAAT
GTGCTGTCCATATACGAGAAGAGCCTTGAAAGCCAGCCGTCCTATGTATGGAGCGGTTACCTCT
TTCTTACACTCACTGATCATTCAGAATGAACCCCGGTTTGCTATGTTTGGACCAGGTTTGGAAG
AACTGAACACATCTTTGGTGTTGAGTTTGATGTCTTCTGAGGATCTTTGCCCAACTGCTGGTTT
ACCTCATAGACAGATTGACGGTATTGGATCTGGAGTCAGTTTCCAGTTGAGCAATCAACACAAA
TTCAACATCCTGATACTGTACTCAACTACCAGAAAGGAAAGAGACAGAGCGAGGGAGGAGCACA
CAAGCACGGTTAACAAGATGTTCAGCCTACAGAGCGAGGGAGACGAGCAACAGGGGAGCCGCTA
CAGCGTTATCCCACAGATTCAGAAAGTGTGTGAGGTTGTAGATGGGTTTATCTACGTGGCAAAT
GCTGAAGCTCATAGACGTCATGAATGGCAAGATGAATTTTCTCGTATTATGGCCATGACAGATC
CAGCTTTTGGATCTTCAGGAAGACCAATGCTGGTTTTATCTTGTATTTCTCAAGCAGATGTAAA
AAGAATGCCTTGTTTTTATTTAGCTCATGAACTTCGTCTCAGTCTTCTGAACCACCCATGGATG
GTCCAGGATACAGAGGCTGAGACTCTGACTGGTTTCTTGAATGGCATTGAGTGGATTCTTGAAG
AAGTAGAATCTAAGCATGCGAAATGAAGTTCCTTTGGGACCCTGGGAAGCCGCACGTCATGGTG
TATGTGTTTCCGGTCCCTCCTGTTCCTGCCTCTCTGGAGGAGGGCTGTTTACTGGACAGCTACT
ACAGCTGGGCTTCTGACACTTTACCATGAATCAGCAGCAAGCTTCAATCCTACTACTTTTCCAC
AAAATGAACTCTCACATTTTTGATAATTTTATATTTTCTGTCTTTTTGAAAATATTAAATTCTG
TAAAACCAAAGTTTGTGGTTCTTTCATTTCTCATGGTCTCTCTTTTGCTATCAAGGTGGCCCCA
CTAGGAAGCAGTAAGCCTGCTTAGCACACCATGGGATCGTTAGGATCTTTCAAGGACTCACTAA
CTGCTTATC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101142	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL75742	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020925
	ENSRNOP00000020925.6

RefSeq Acc Id:

NP_001101142 ⟸ NM_001107672

- UniProtKB:

D3ZIH4 (UniProtKB/TrEMBL), A6KGC3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSHSGPPRPGAAPSRPAWLVPAGRAETEAERLGNRCARPCLAEPAAMAGSEPRGAGSPPPASDW
GRLEAAILSGWRTFWNSVGKERATRTASRKEEAEETSALTRLPIDVQLYILSFLSPHDLCQLGS
TDHYWNETVRDPILWRYFLFRDLPSWSSVDWKSLPDLEILKKPISEVTDSTCFDYMEVYKMCCP
YTRRALKASRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEDLCPTAGLPHR
QIDGIGSGVSFQLSNQHKFNILILYSTTRKERDRAREEHTSTVNKMFSLQSEGDEQQGSRYSVI
PQIQKVCEVVDGFIYVANAEAHRRHEWQDEFSRIMAMTDPAFGSSGRPMLVLSCISQADVKRMP
CFYLAHELRLSLLNHPWMVQDTEAETLTGFLNGIEWILEEVESKHAK

hide sequence

Ensembl Acc Id:

ENSRNOP00000020925 ⟸ ENSRNOT00000020925

Protein Domains

F-box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZIH4-F1-model_v2	AlphaFold	D3ZIH4	1-431	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307580	AgrOrtholog
BioCyc Gene	G2FUF-54194	BioCyc
Ensembl Genes	ENSRNOG00000015622	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020925	ENTREZGENE
	ENSRNOT00000020925.8	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1280.50	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	F-box_dom_cyclin-like	UniProtKB/TrEMBL
	F-box_dom_like	UniProtKB/TrEMBL
	FBXO4	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	rno:310363	UniProtKB/TrEMBL
NCBI Gene	310363	ENTREZGENE
PANTHER	F-BOX ONLY PROTEIN 4	UniProtKB/TrEMBL
	PTHR16008	UniProtKB/TrEMBL
Pfam	F-box-like	UniProtKB/TrEMBL
PhenoGen	Fbxo4	PhenoGen
PROSITE	FBOX	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015622	RatGTEx
SMART	FBOX	UniProtKB/TrEMBL
Superfamily-SCOP	F-box_dom_Skp2-like	UniProtKB/TrEMBL
UniProt	A6KGC3	ENTREZGENE, UniProtKB/TrEMBL
	D3ZIH4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Fbxo4	F-box protein 4	Fbxo4_predicted	F-box only protein 4 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Fbxo4_predicted	F-box only protein 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)