Txndc11 (thioredoxin domain containing 11) - Rat Genome Database

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Gene: Txndc11 (thioredoxin domain containing 11) Rattus norvegicus
Analyze
Symbol: Txndc11
Name: thioredoxin domain containing 11
RGD ID: 1307538
Description: Orthologous to human TXNDC11 (thioredoxin domain containing 11); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC302899; RGD1307538; similar to RIKEN cDNA 2810408E11; thioredoxin domain-containing protein 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,022,464 - 5,079,958 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl105,022,435 - 5,079,950 (+)EnsemblGRCr8
mRatBN7.2104,515,457 - 4,572,999 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,515,478 - 4,572,989 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx109,212,160 - 9,269,624 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0108,733,238 - 8,790,727 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,371,490 - 4,428,972 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0104,578,469 - 4,635,963 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,578,469 - 4,635,953 (+)Ensemblrn6Rnor6.0
Rnor_5.0103,408,243 - 3,465,320 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4104,404,433 - 4,486,095 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera103,538,992 - 3,596,484 (+)NCBICelera
RGSC_v3.1104,404,416 - 4,449,756 (+)NCBI
Cytogenetic Map10q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Txndc11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,022,464 - 5,079,958 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl105,022,435 - 5,079,950 (+)EnsemblGRCr8
mRatBN7.2104,515,457 - 4,572,999 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,515,478 - 4,572,989 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx109,212,160 - 9,269,624 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0108,733,238 - 8,790,727 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,371,490 - 4,428,972 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0104,578,469 - 4,635,963 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,578,469 - 4,635,953 (+)Ensemblrn6Rnor6.0
Rnor_5.0103,408,243 - 3,465,320 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4104,404,433 - 4,486,095 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera103,538,992 - 3,596,484 (+)NCBICelera
RGSC_v3.1104,404,416 - 4,449,756 (+)NCBI
Cytogenetic Map10q11NCBI
TXNDC11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,679,083 - 11,742,857 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1611,679,079 - 11,742,907 (-)Ensemblhg38GRCh38
GRCh371611,772,939 - 11,836,713 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,680,444 - 11,744,149 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341611,680,443 - 11,744,149NCBI
Celera1611,947,285 - 12,011,000 (-)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,688,976 - 11,752,680 (-)NCBIHuRef
CHM1_11611,772,871 - 11,836,587 (-)NCBICHM1_1
T2T-CHM13v2.01611,715,131 - 11,778,900 (-)NCBIT2T-CHM13v2.0
Txndc11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,892,775 - 10,952,541 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,892,775 - 10,952,514 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381611,074,911 - 11,134,645 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1611,074,911 - 11,134,650 (-)Ensemblmm10GRCm38
MGSCv371611,075,004 - 11,134,625 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361610,988,489 - 11,048,110 (-)NCBIMGSCv36mm8
Celera1611,705,173 - 11,764,791 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map166.33NCBI
Txndc11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554426,889,442 - 6,959,216 (+)Ensembl
ChiLan1.0NW_0049554426,887,538 - 6,959,324 (+)NCBIChiLan1.0ChiLan1.0
TXNDC11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21812,228,111 - 12,291,847 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11615,998,927 - 16,062,458 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01610,620,475 - 10,684,001 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11611,846,673 - 11,909,702 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1611,846,782 - 11,913,437 (-)EnsemblpanPan2panpan1.1
TXNDC11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,073,748 - 31,137,818 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,073,377 - 31,137,817 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha632,453,799 - 32,517,981 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0631,251,956 - 31,316,287 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl631,251,664 - 31,316,287 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1631,065,772 - 31,130,355 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0630,940,495 - 31,004,547 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0631,363,828 - 31,428,923 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Txndc11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344111,647,287 - 111,706,668 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365309,492,728 - 9,552,107 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365309,492,728 - 9,552,109 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNDC11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl331,376,510 - 31,445,632 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1331,376,515 - 31,447,377 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TXNDC11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1511,143,652 - 11,206,469 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl511,143,768 - 11,206,506 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606818,940,133 - 19,003,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txndc11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247826,575,355 - 6,638,053 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247826,575,263 - 6,637,778 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Txndc11
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1911,196,075 - 11,251,281 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Txndc11
172 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:20
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000003332
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
1549898Neuinf3Neuroinflammation QTL 326.4nervous system integrity trait (VT:0010566)MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)1015893911Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
D10Rat67  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2104,521,788 - 4,521,990 (+)MAPPERmRatBN7.2
Rnor_6.0104,584,761 - 4,584,962NCBIRnor6.0
Rnor_5.0103,414,536 - 3,414,737UniSTSRnor5.0
RGSC_v3.4104,410,725 - 4,410,926UniSTSRGSC3.4
RGSC_v3.4104,410,724 - 4,410,926RGDRGSC3.4
Celera103,545,192 - 3,545,393UniSTS
RGSC_v3.1104,410,725 - 4,410,926RGD
RH 3.4 Map1035.0RGD
RH 3.4 Map1035.0UniSTS
FHH x ACI Map104.56RGD
FHH x ACI Map104.56UniSTS
Cytogenetic Map10q11UniSTS
D10Bda4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2104,573,069 - 4,573,243 (+)MAPPERmRatBN7.2
Rnor_6.0104,636,034 - 4,636,207NCBIRnor6.0
Rnor_5.0103,465,400 - 3,465,573UniSTSRnor5.0
RGSC_v3.4104,486,175 - 4,486,348UniSTSRGSC3.4
Celera103,596,564 - 3,596,737UniSTS
Cytogenetic Map10q11UniSTS
RH136895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2104,573,035 - 4,573,226 (+)MAPPERmRatBN7.2
Rnor_6.0104,636,000 - 4,636,190NCBIRnor6.0
Rnor_5.0103,465,366 - 3,465,556UniSTSRnor5.0
RGSC_v3.4104,486,141 - 4,486,331UniSTSRGSC3.4
Celera103,596,530 - 3,596,720UniSTS
Cytogenetic Map10q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003332   ⟹   ENSRNOP00000003332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl105,022,435 - 5,079,950 (+)Ensembl
mRatBN7.2 Ensembl104,515,497 - 4,572,989 (+)Ensembl
Rnor_6.0 Ensembl104,578,469 - 4,635,953 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102060   ⟹   ENSRNOP00000082589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl105,022,455 - 5,079,950 (+)Ensembl
mRatBN7.2 Ensembl104,515,478 - 4,572,989 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104854   ⟹   ENSRNOP00000080370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl105,022,464 - 5,079,950 (+)Ensembl
mRatBN7.2 Ensembl104,519,139 - 4,572,989 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111065   ⟹   ENSRNOP00000096337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl105,022,435 - 5,036,543 (+)Ensembl
mRatBN7.2 Ensembl104,515,497 - 4,529,579 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117172   ⟹   ENSRNOP00000080601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl104,520,199 - 4,555,223 (+)Ensembl
RefSeq Acc Id: NM_001127532   ⟹   NP_001121004
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,022,464 - 5,079,949 (+)NCBI
mRatBN7.2104,515,497 - 4,572,990 (+)NCBI
Rnor_6.0104,578,469 - 4,635,954 (+)NCBI
Rnor_5.0103,408,243 - 3,465,320 (+)NCBI
RGSC_v3.4104,404,433 - 4,486,095 (+)RGD
Celera103,538,992 - 3,596,484 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767481   ⟹   XP_008765703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,028,127 - 5,079,958 (+)NCBI
mRatBN7.2104,521,164 - 4,572,999 (+)NCBI
Rnor_6.0104,585,384 - 4,635,963 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085803   ⟹   XP_038941731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,036,422 - 5,079,958 (+)NCBI
mRatBN7.2104,529,453 - 4,572,999 (+)NCBI
RefSeq Acc Id: XR_010055165
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,022,588 - 5,069,493 (+)NCBI
RefSeq Acc Id: NP_001121004   ⟸   NM_001127532
- UniProtKB: B2RYB1 (UniProtKB/TrEMBL),   E9PSP7 (UniProtKB/TrEMBL),   A0A8I5ZQI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765703   ⟸   XM_008767481
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G9N1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003332   ⟸   ENSRNOT00000003332
RefSeq Acc Id: XP_038941731   ⟸   XM_039085803
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000096337   ⟸   ENSRNOT00000111065
Ensembl Acc Id: ENSRNOP00000080601   ⟸   ENSRNOT00000117172
Ensembl Acc Id: ENSRNOP00000082589   ⟸   ENSRNOT00000102060
Ensembl Acc Id: ENSRNOP00000080370   ⟸   ENSRNOT00000104854
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYB1-F1-model_v2 AlphaFold B2RYB1 1-947 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696936
Promoter ID:EPDNEW_R7460
Type:initiation region
Name:Txndc11_1
Description:thioredoxin domain containing 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0104,578,488 - 4,578,548EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307538 AgrOrtholog
BioCyc Gene G2FUF-26159 BioCyc
Ensembl Genes ENSRNOG00000002452 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003332 ENTREZGENE
  ENSRNOT00000003332.8 UniProtKB/TrEMBL
  ENSRNOT00000102060.2 UniProtKB/TrEMBL
  ENSRNOT00000104854.2 UniProtKB/TrEMBL
  ENSRNOT00000111065.2 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7930724 IMAGE-MGC_LOAD
InterPro Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_dom-contain_11 UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report rno:302899 UniProtKB/TrEMBL
MGC_CLONE MGC:188414 IMAGE-MGC_LOAD
NCBI Gene 302899 ENTREZGENE
PANTHER THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11 UniProtKB/TrEMBL
  THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11 UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/TrEMBL
PhenoGen Txndc11 PhenoGen
PROSITE THIOREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002452 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A0A8I5ZQI0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALL2_RAT UniProtKB/TrEMBL
  A0A8I6G9N1 ENTREZGENE, UniProtKB/TrEMBL
  B2RYB1 ENTREZGENE, UniProtKB/TrEMBL
  E9PSP7 ENTREZGENE
UniProt Secondary E9PSP7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Txndc11  thioredoxin domain containing 11   Txndc11_predicted  thioredoxin domain containing 11 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Txndc11_predicted  thioredoxin domain containing 11 (predicted)  RGD1307538_predicted  similar to RIKEN cDNA 2810408E11 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1307538_predicted  similar to RIKEN cDNA 2810408E11 (predicted)  LOC302899_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC302899_predicted  similar to RIKEN cDNA 2810408E11 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL