Ascl4 (achaete-scute family bHLH transcription factor 4) - Rat Genome Database

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Gene: Ascl4 (achaete-scute family bHLH transcription factor 4) Rattus norvegicus
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Symbol: Ascl4
Name: achaete-scute family bHLH transcription factor 4
RGD ID: 1307533
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human ASCL4 (achaete-scute family bHLH transcription factor 4); INTERACTS WITH bisphenol A; ferrostatin-1; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: achaete-scute complex homolog 4; achaete-scute complex homolog 4 (Drosophila); achaete-scute complex-like 4; achaete-scute complex-like 4 (Drosophila); achaete-scute homolog 4; LOC299687
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8719,828,710 - 19,830,952 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl719,828,710 - 19,830,952 (-)EnsemblGRCr8
mRatBN7.2717,940,972 - 17,943,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl717,941,709 - 17,942,146 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx719,903,142 - 19,905,382 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0722,066,431 - 22,068,687 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0721,842,785 - 21,845,025 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0723,946,974 - 23,949,600 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl723,947,765 - 23,948,202 (-)Ensemblrn6Rnor6.0
Rnor_5.0724,096,570 - 24,099,125 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4720,079,914 - 20,080,351 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera715,173,149 - 15,175,774 (-)NCBICelera
RGSC_v3.1720,093,984 - 20,094,989 (-)NCBI
Cytogenetic Map7q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ascl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8719,828,710 - 19,830,952 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl719,828,710 - 19,830,952 (-)EnsemblGRCr8
mRatBN7.2717,940,972 - 17,943,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl717,941,709 - 17,942,146 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx719,903,142 - 19,905,382 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0722,066,431 - 22,068,687 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0721,842,785 - 21,845,025 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0723,946,974 - 23,949,600 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl723,947,765 - 23,948,202 (-)Ensemblrn6Rnor6.0
Rnor_5.0724,096,570 - 24,099,125 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4720,079,914 - 20,080,351 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera715,173,149 - 15,175,774 (-)NCBICelera
RGSC_v3.1720,093,984 - 20,094,989 (-)NCBI
Cytogenetic Map7q13NCBI
ASCL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812107,774,704 - 107,776,644 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12107,774,704 - 107,776,644 (+)Ensemblhg38GRCh38
GRCh3712108,168,481 - 108,170,421 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612106,692,292 - 106,694,545 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412106,670,628 - 106,672,882NCBI
Celera12107,833,712 - 107,835,971 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12105,228,648 - 105,230,907 (+)NCBIHuRef
CHM1_112108,134,114 - 108,136,373 (+)NCBICHM1_1
T2T-CHM13v2.012107,738,195 - 107,740,135 (+)NCBIT2T-CHM13v2.0
Ascl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391085,763,266 - 85,765,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1085,763,545 - 85,782,070 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381085,927,402 - 85,929,649 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1085,927,681 - 85,946,206 (+)Ensemblmm10GRCm38
MGSCv371085,391,236 - 85,392,392 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361085,358,290 - 85,359,167 (+)NCBIMGSCv36mm8
Celera1087,903,088 - 87,904,244 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.8NCBI
ASCL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210115,825,186 - 115,835,323 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112115,821,599 - 115,831,720 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012105,344,528 - 105,346,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112108,743,237 - 108,743,756 (+)NCBIPanPan1.1PanPan1.1panPan2
ASCL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11031,053,716 - 31,056,234 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1031,053,744 - 31,054,265 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1031,036,584 - 31,037,754 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01031,896,305 - 31,897,475 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1031,896,305 - 31,896,832 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11031,635,850 - 31,637,020 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01031,924,911 - 31,926,075 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01032,111,507 - 32,112,676 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ascl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494514,368,536 - 14,370,113 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364927,379,349 - 7,379,918 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364927,378,982 - 7,379,918 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASCL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl512,623,691 - 12,624,209 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1512,623,691 - 12,625,193 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2512,409,905 - 12,412,454 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASCL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111102,993,754 - 103,038,173 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11102,994,906 - 102,995,424 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037142,077,344 - 142,080,344 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ascl4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11162,681,110 - 162,682,501 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ascl4
25 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:83
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000044252
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 3 18 104 34 36 18 74 18 5 218 106 10 90 76 79 18 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000044252   ⟹   ENSRNOP00000051020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl717,941,709 - 17,942,146 (-)Ensembl
Rnor_6.0 Ensembl723,947,765 - 23,948,202 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150876   ⟹   ENSRNOP00000111403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl719,828,710 - 19,830,952 (-)Ensembl
RefSeq Acc Id: NM_001399717   ⟹   NP_001386646
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8719,828,710 - 19,830,952 (-)NCBI
mRatBN7.2717,940,972 - 17,943,215 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386646 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000111403
  ENSRNOP00000111403.1
Ensembl Acc Id: ENSRNOP00000051020   ⟸   ENSRNOT00000044252
RefSeq Acc Id: NP_001386646   ⟸   NM_001399717
- UniProtKB: D3ZS54 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111403   ⟸   ENSRNOT00000150876

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS54-F1-model_v2 AlphaFold D3ZS54 1-145 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307533 AgrOrtholog
BioCyc Gene G2FUF-34637 BioCyc
Ensembl Genes ENSRNOG00000031493 Ensembl
  ENSRNOG00000086355 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000150876 ENTREZGENE
  ENSRNOT00000150876.1 UniProtKB/TrEMBL
NCBI Gene 299687 ENTREZGENE
PhenoGen Ascl4 PhenoGen
RatGTEx ENSRNOG00000031493 RatGTEx
  ENSRNOG00000086355 RatGTEx
UniProt A0ABK0M7F4_RAT UniProtKB/TrEMBL
  D3ZS54 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Ascl4  achaete-scute family bHLH transcription factor 4  Ascl4  achaete-scute complex homolog 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Ascl4  achaete-scute complex homolog 4 (Drosophila)  Ascl4_predicted  achaete-scute complex-like 4 (Drosophila) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Ascl4_predicted  achaete-scute complex-like 4 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED