Larp1b (La ribonucleoprotein 1B) - Rat Genome Database

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Gene: Larp1b (La ribonucleoprotein 1B) Rattus norvegicus
Analyze
Symbol: Larp1b
Name: La ribonucleoprotein 1B
RGD ID: 1307509
Description: Predicted to enable RNA binding activity. Orthologous to human LARP1B (La ribonucleoprotein 1B); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: La ribonucleoprotein domain family, member 1B; la-related protein 1B; LOC310348; RGD1307509; similar to RIKEN cDNA 1700108L22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82125,860,935 - 125,897,189 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2125,863,997 - 125,897,189 (+)EnsemblGRCr8
mRatBN7.22123,936,057 - 123,969,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2123,935,983 - 123,968,896 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2130,507,583 - 130,539,342 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02128,620,013 - 128,651,768 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02123,249,168 - 123,280,922 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02127,845,034 - 127,876,793 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2127,845,034 - 127,876,793 (+)Ensemblrn6Rnor6.0
Rnor_5.02147,446,540 - 147,478,244 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42127,891,415 - 127,923,341 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2118,845,280 - 118,877,005 (+)NCBICelera
RGSC_v3.12127,841,331 - 127,873,256 (+)NCBI
Cytogenetic Map2q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clorgyline  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
phenylmercury acetate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac  (EXP)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:21630459   PMID:22681889  


Genomics

Comparative Map Data
Larp1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82125,860,935 - 125,897,189 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2125,863,997 - 125,897,189 (+)EnsemblGRCr8
mRatBN7.22123,936,057 - 123,969,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2123,935,983 - 123,968,896 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2130,507,583 - 130,539,342 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02128,620,013 - 128,651,768 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02123,249,168 - 123,280,922 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02127,845,034 - 127,876,793 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2127,845,034 - 127,876,793 (+)Ensemblrn6Rnor6.0
Rnor_5.02147,446,540 - 147,478,244 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42127,891,415 - 127,923,341 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2118,845,280 - 118,877,005 (+)NCBICelera
RGSC_v3.12127,841,331 - 127,873,256 (+)NCBI
Cytogenetic Map2q26NCBI
LARP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384128,060,789 - 128,222,926 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4128,060,801 - 128,222,931 (+)Ensemblhg38GRCh38
GRCh374128,981,944 - 129,144,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364129,201,953 - 129,351,739 (+)NCBIBuild 36Build 36hg18NCBI36
Celera4126,363,570 - 126,513,216 (+)NCBICelera
Cytogenetic Map4q28.2NCBI
HuRef4124,714,047 - 124,863,569 (+)NCBIHuRef
CHM1_14128,958,877 - 129,108,768 (+)NCBICHM1_1
T2T-CHM13v2.04131,364,692 - 131,527,023 (+)NCBIT2T-CHM13v2.0
Larp1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39340,904,198 - 40,994,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl340,904,263 - 40,994,669 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38340,949,770 - 41,040,207 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl340,949,828 - 41,040,234 (+)Ensemblmm10GRCm38
MGSCv37340,754,553 - 40,781,715 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36341,046,327 - 41,135,803 (+)NCBIMGSCv36mm8
Celera340,679,915 - 40,707,074 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map319.61NCBI
Larp1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542813,319,322 - 13,427,932 (-)NCBIChiLan1.0ChiLan1.0
LARP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23125,831,054 - 125,977,959 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14126,097,231 - 126,251,028 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04120,230,897 - 120,383,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14131,533,612 - 131,678,775 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4131,533,028 - 131,678,775 (+)EnsemblpanPan2panpan1.1
LARP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11912,775,096 - 12,895,778 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1912,775,821 - 12,894,970 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1912,963,829 - 13,093,838 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01912,864,551 - 12,994,773 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1912,864,573 - 12,994,835 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11912,837,563 - 12,967,809 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01913,123,287 - 13,253,207 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01913,585,738 - 13,715,764 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Larp1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530161,359,186 - 61,448,198 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366422,652,054 - 2,742,108 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366422,652,009 - 2,742,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LARP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl896,751,303 - 96,856,006 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1896,751,295 - 96,856,069 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28103,622,877 - 103,722,845 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LARP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1775,189,782 - 75,343,852 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl775,204,960 - 75,342,059 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603754,331,105 - 54,485,297 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Larp1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247778,943,605 - 8,982,852 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Larp1b
191 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:891
Count of miRNA genes:322
Interacting mature miRNAs:415
Transcripts:ENSRNOT00000044804
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
D2Rat255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22123,943,856 - 123,944,072 (+)MAPPERmRatBN7.2
Rnor_6.02127,851,753 - 127,851,968NCBIRnor6.0
Rnor_5.02147,453,204 - 147,453,419UniSTSRnor5.0
RGSC_v3.42127,898,300 - 127,898,516RGDRGSC3.4
RGSC_v3.42127,898,301 - 127,898,516UniSTSRGSC3.4
Celera2118,851,972 - 118,852,189UniSTS
RGSC_v3.12127,848,092 - 127,848,517RGD
FHH x ACI Map257.7699RGD
FHH x ACI Map257.7699UniSTS
Cytogenetic Map2q26UniSTS
BE107714  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22123,967,372 - 123,967,572 (+)MAPPERmRatBN7.2
Rnor_6.02127,875,268 - 127,875,467NCBIRnor6.0
Rnor_5.02147,476,719 - 147,476,918UniSTSRnor5.0
RGSC_v3.42127,921,816 - 127,922,015UniSTSRGSC3.4
Celera2118,875,480 - 118,875,679UniSTS
RH 3.4 Map2661.7UniSTS
Cytogenetic Map2q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000044804   ⟹   ENSRNOP00000040850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2123,937,138 - 123,968,896 (+)Ensembl
Rnor_6.0 Ensembl2127,845,034 - 127,876,793 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090861   ⟹   ENSRNOP00000082890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2123,950,120 - 123,968,896 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098004   ⟹   ENSRNOP00000091977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2125,863,997 - 125,897,189 (+)Ensembl
mRatBN7.2 Ensembl2123,937,138 - 123,968,896 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110414   ⟹   ENSRNOP00000083292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2125,863,997 - 125,897,189 (+)Ensembl
mRatBN7.2 Ensembl2123,935,983 - 123,968,896 (+)Ensembl
RefSeq Acc Id: NM_001014036   ⟹   NP_001014058
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82125,864,975 - 125,897,189 (+)NCBI
mRatBN7.22123,937,035 - 123,969,254 (+)NCBI
Rnor_6.02127,845,034 - 127,876,793 (+)NCBI
Rnor_5.02147,446,540 - 147,478,244 (+)NCBI
RGSC_v3.42127,891,415 - 127,923,341 (+)RGD
Celera2118,845,280 - 118,877,005 (+)RGD
Sequence:
RefSeq Acc Id: NM_001415051   ⟹   NP_001401980
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82125,863,997 - 125,897,189 (+)NCBI
mRatBN7.22123,936,057 - 123,969,254 (+)NCBI
RefSeq Acc Id: XM_039102244   ⟹   XP_038958172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82125,860,935 - 125,894,004 (+)NCBI
mRatBN7.22123,936,074 - 123,963,560 (+)NCBI
RefSeq Acc Id: XM_039102245   ⟹   XP_038958173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82125,860,935 - 125,887,703 (+)NCBI
mRatBN7.22123,936,078 - 123,959,640 (+)NCBI
RefSeq Acc Id: XM_039102246   ⟹   XP_038958174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82125,864,960 - 125,895,227 (+)NCBI
mRatBN7.22123,937,010 - 123,969,254 (+)NCBI
RefSeq Acc Id: XM_039102247   ⟹   XP_038958175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82125,864,959 - 125,895,227 (+)NCBI
mRatBN7.22123,937,010 - 123,969,254 (+)NCBI
RefSeq Acc Id: NP_001014058   ⟸   NM_001014036
- Peptide Label: isoform 2
- UniProtKB: Q66HE8 (UniProtKB/TrEMBL),   A6II43 (UniProtKB/TrEMBL),   A0A8I5ZVS3 (UniProtKB/TrEMBL),   F7FP27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040850   ⟸   ENSRNOT00000044804
RefSeq Acc Id: XP_038958172   ⟸   XM_039102244
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958173   ⟸   XM_039102245
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038958174   ⟸   XM_039102246
- Peptide Label: isoform X3
- UniProtKB: Q66HE8 (UniProtKB/TrEMBL),   A6II43 (UniProtKB/TrEMBL),   A0A8I5ZVS3 (UniProtKB/TrEMBL),   F7FP27 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958175   ⟸   XM_039102247
- Peptide Label: isoform X3
- UniProtKB: Q66HE8 (UniProtKB/TrEMBL),   A6II43 (UniProtKB/TrEMBL),   A0A8I5ZVS3 (UniProtKB/TrEMBL),   F7FP27 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091977   ⟸   ENSRNOT00000098004
Ensembl Acc Id: ENSRNOP00000083292   ⟸   ENSRNOT00000110414
Ensembl Acc Id: ENSRNOP00000082890   ⟸   ENSRNOT00000090861
RefSeq Acc Id: NP_001401980   ⟸   NM_001415051
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZWA7 (UniProtKB/TrEMBL)
Protein Domains
HTH La-type RNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HE8-F1-model_v2 AlphaFold Q66HE8 1-335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307509 AgrOrtholog
BioCyc Gene G2FUF-53251 BioCyc
Ensembl Genes ENSRNOG00000038366 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000098004.2 UniProtKB/TrEMBL
  ENSRNOT00000110414 ENTREZGENE
  ENSRNOT00000110414.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110249 IMAGE-MGC_LOAD
InterPro La_dom_prot UniProtKB/TrEMBL
  Lupus_La_RNA_bd UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:310348 UniProtKB/TrEMBL
MGC_CLONE MGC:93806 IMAGE-MGC_LOAD
NCBI Gene 310348 ENTREZGENE
PANTHER LA-RELATED PROTEIN 1B UniProtKB/TrEMBL
  PTHR22792 UniProtKB/TrEMBL
Pfam PF05383 UniProtKB/TrEMBL
PharmGKB LARP2 RGD
PhenoGen Larp1b PhenoGen
PROSITE HTH_LA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038366 RatGTEx
SMART SM00715 UniProtKB/TrEMBL
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A8I5ZVS3 ENTREZGENE
  A0A8I5ZWA7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFL0_RAT UniProtKB/TrEMBL
  A6II43 ENTREZGENE, UniProtKB/TrEMBL
  F7FP27 ENTREZGENE, UniProtKB/TrEMBL
  Q66HE8 ENTREZGENE
UniProt Secondary Q66HE8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Larp1b  La ribonucleoprotein 1B  Larp1b  La ribonucleoprotein domain family, member 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-16 Larp1b  La ribonucleoprotein domain family, member 1B  RGD1307509  similar to RIKEN cDNA 1700108L22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1307509  similar to RIKEN cDNA 1700108L22  RGD1307509_predicted  similar to RIKEN cDNA 1700108L22 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307509_predicted  similar to RIKEN cDNA 1700108L22 (predicted)  LOC310348_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310348_predicted  similar to RIKEN cDNA 1700108L22 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL