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Gene: Nlrp5 (NLR family, pyrin domain containing 5) Rattus norvegicus
Analyze
Symbol:
Nlrp5
Name:
NLR family, pyrin domain containing 5
RGD ID:
1307446
Description:
Predicted to enable tubulin binding activity. Predicted to be a structural constituent of cytoplasmic lattice. Predicted to be involved in several processes, including cortical granule exocytosis; cytoskeleton organization; and protein storage. Predicted to act upstream of or within several processes, including embryo implantation; regulation of RNA stability; and regulation of protein stability. Predicted to be located in several cellular components, including apical cortex; cortical granule; and ooplasm. Predicted to be part of subcortical maternal complex. Predicted to be active in several cellular components, including cell cortex; cytoplasmic lattice; and mitochondrion. Orthologous to human NLRP5 (NLR family pyrin domain containing 5); INTERACTS WITH 1,2-dimethylhydrazine; bisphenol A; DDT.
Type:
protein-coding
RefSeq Status:
MODEL
Previously known as:
LOC308325; NACHT, leucine rich repeat and PYD containing 5; NACHT, LRR and PYD domains-containing protein 5; Nalp5
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 76,811,044 - 76,872,964 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 1 76,810,108 - 77,077,580 (-) Ensembl GRCr8 mRatBN7.2 1 67,778,037 - 67,810,941 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 67,777,948 - 68,023,736 (-) Ensembl mRatBN7.2 Rnor_6.0 1 71,452,184 - 71,490,915 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 71,453,798 - 71,486,790 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 1 72,846,717 - 72,878,799 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 1 66,212,857 - 66,246,286 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 1 65,519,807 - 65,552,240 (-) NCBI Celera RGSC_v3.1 1 66,296,338 - 66,584,794 (-) NCBI Cytogenetic Map 1 q12 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Imported Disease Annotations - OMIM
Only show annotations with direct experimental evidence (0 objects hidden)
Nlrp5 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Nlrp5 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nlrp5 Rat 1,2-dimethylhydrazine increases expression EXP 6480464 1,2-Dimethylhydrazine results in increased expression of NLRP5 mRNA CTD PMID:27840820 Nlrp5 Rat 17beta-estradiol multiple interactions ISO NLRP5 (Homo sapiens) 6480464 [Estradiol co-treated with Progesterone] results in increased expression of NLRP5 mRNA CTD PMID:20660070 Nlrp5 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Nlrp5 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nlrp5 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Nlrp5 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nlrp5 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Nlrp5 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nlrp5 Rat 7,12-dimethyltetraphene affects expression ISO Nlrp5 (Mus musculus) 6480464 9,10-Dimethyl-1,2-benzanthracene affects the expression of NLRP5 mRNA CTD PMID:21785161 Nlrp5 Rat acrylamide increases expression ISO Nlrp5 (Mus musculus) 6480464 Acrylamide results in increased expression of NLRP5 mRNA CTD PMID:36599426|PMID:36997053 Nlrp5 Rat benzo[a]pyrene decreases methylation ISO NLRP5 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of NLRP5 promoter CTD PMID:27901495 Nlrp5 Rat benzo[a]pyrene affects methylation ISO NLRP5 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of NLRP5 intron CTD PMID:30157460 Nlrp5 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of NLRP5 mRNA CTD PMID:26496021 Nlrp5 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NLRP5 mRNA CTD PMID:25181051 Nlrp5 Rat calcitriol increases expression ISO NLRP5 (Homo sapiens) 6480464 Calcitriol results in increased expression of NLRP5 mRNA CTD PMID:21592394 Nlrp5 Rat calcitriol multiple interactions ISO NLRP5 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of NLRP5 mRNA CTD PMID:21592394 Nlrp5 Rat CGP 52608 multiple interactions ISO NLRP5 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to NLRP5 gene] CTD PMID:28238834 Nlrp5 Rat DDT decreases expression EXP 6480464 DDT results in decreased expression of NLRP5 mRNA CTD PMID:30207508 Nlrp5 Rat folic acid decreases expression ISO NLRP5 (Homo sapiens) 6480464 Folic Acid results in decreased expression of NLRP5 mRNA CTD PMID:21867686 Nlrp5 Rat lead diacetate increases expression ISO Nlrp5 (Mus musculus) 6480464 lead acetate results in increased expression of NLRP5 mRNA CTD PMID:22613225 Nlrp5 Rat methotrexate affects expression ISO Nlrp5 (Mus musculus) 6480464 Methotrexate affects the expression of NLRP5 mRNA CTD PMID:18502557 Nlrp5 Rat PCB138 multiple interactions ISO Nlrp5 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Nlrp5 Rat progesterone multiple interactions ISO NLRP5 (Homo sapiens) 6480464 [Estradiol co-treated with Progesterone] results in increased expression of NLRP5 mRNA CTD PMID:20660070 Nlrp5 Rat propanal decreases expression ISO NLRP5 (Homo sapiens) 6480464 propionaldehyde results in decreased expression of NLRP5 mRNA CTD PMID:26079696 Nlrp5 Rat testosterone multiple interactions ISO NLRP5 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of NLRP5 mRNA CTD PMID:21592394 Nlrp5 Rat testosterone increases expression ISO NLRP5 (Homo sapiens) 6480464 Testosterone results in increased expression of NLRP5 mRNA CTD PMID:21592394 Nlrp5 Rat testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of NLRP5 mRNA CTD PMID:26496021 Nlrp5 Rat Theaflavin 3,3'-digallate affects expression ISO NLRP5 (Homo sapiens) 6480464 theaflavin-3,3'-digallate affects the expression of NLRP5 mRNA CTD PMID:34925699 Nlrp5 Rat titanium dioxide increases expression ISO Nlrp5 (Mus musculus) 6480464 titanium dioxide results in increased expression of NLRP5 mRNA CTD PMID:35295148 Nlrp5 Rat vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of NLRP5 mRNA CTD PMID:30207508 Nlrp5 Rat vinclozolin decreases methylation EXP 6480464 vinclozolin results in decreased methylation of NLRP5 gene CTD PMID:31079544
Biological Process
Only show annotations with direct experimental evidence (0 objects hidden)
Nlrp5 Rat actin filament organization involved_in ISO RGD:1316642,MGI:1345193 1624291 PMID:25208553 RGD PMID:25208553 Nlrp5 Rat animal organ morphogenesis acts_upstream_of_or_within ISO RGD:1316642,MGI:1345193 1624291 PMID:10754103 RGD PMID:10754103 Nlrp5 Rat cortical granule exocytosis involved_in ISO RGD:1316642,MGI:1345193 1624291 PMID:31118423 RGD PMID:31118423 Nlrp5 Rat embryo implantation acts_upstream_of_or_within ISO RGD:1316642,MGI:1345193 1624291 MGI:2178449 PMID:18804437 RGD PMID:18804437 Nlrp5 Rat establishment of organelle localization involved_in ISO RGD:1316642,MGI:1345193 1624291 PMID:24374158, PMID:31118423 RGD PMID:24374158|PMID:31118423 Nlrp5 Rat establishment of spindle localization involved_in ISO RGD:1316642,MGI:1345193 1624291 PMID:25208553 RGD PMID:25208553 Nlrp5 Rat exocytosis involved_in ISO RGD:1316642,MGI:1345193 1624291 PMID:24374158 RGD PMID:24374158 Nlrp5 Rat fertilization acts_upstream_of_or_within ISO RGD:1316642,MGI:1345193 1624291 MGI:2178449 PMID:11062459, PMID:18804437 RGD PMID:11062459|PMID:18804437 Nlrp5 Rat immune system process involved_in IEA UniProtKB-KW:KW-0391 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp5 Rat in utero embryonic development acts_upstream_of_or_within ISO RGD:1316642,MGI:1345193 1624291 MGI:2178449 PMID:11062459, PMID:18804437 RGD PMID:11062459|PMID:18804437 Nlrp5 Rat inflammatory response involved_in IEA UniProtKB-KW:KW-0395 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp5 Rat innate immune response involved_in IEA UniProtKB-KW:KW-0399 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp5 Rat intracellular protein localization acts_upstream_of_or_within ISO RGD:1316642,MGI:1345193 1624291 MGI:2178449 PMID:20830304 RGD PMID:20830304 Nlrp5 Rat positive regulation of embryonic development involved_in ISO RGD:1316642,MGI:1345193 1624291 PMID:22357545 RGD PMID:22357545 Nlrp5 Rat protein storage involved_in ISO RGD:1316642,MGI:1345193 1624291 PMID:37922900 RGD PMID:37922900 Nlrp5 Rat protein-containing complex assembly acts_upstream_of_or_within ISO RGD:1316642,MGI:1345193 1624291 MGI:2178449 PMID:18804437 RGD PMID:18804437 Nlrp5 Rat regulation of cell division involved_in ISO RGD:1316642,MGI:1345193 1624291 PMID:25208553 RGD PMID:25208553 Nlrp5 Rat regulation of inflammatory response involved_in IBA MGI:2141990|MGI:2444084|MGI:2653833|MGI:2676630|PANTHER:PTN000647852|UniProtKB:P59044|UniProtKB:P59046|UniProtKB:Q96P20 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp5 Rat regulation of protein localization involved_in ISO RGD:1316642,MGI:1345193 1624291 PMID:22357545 RGD PMID:22357545 Nlrp5 Rat regulation of protein stability acts_upstream_of_or_within ISO RGD:1316642,MGI:1345193 1624291 MGI:2178449 PMID:18057100 RGD PMID:18057100 Nlrp5 Rat regulation of RNA stability acts_upstream_of_or_within ISO RGD:1316642,MGI:1345193 1624291 MGI:2178449 PMID:11062459 RGD PMID:11062459
Cellular Component
Only show annotations with direct experimental evidence (0 objects hidden)
Nlrp5 Rat apical cortex located_in ISO MGI:1345193|RGD:1316642 1624291 PMID:18057100 RGD PMID:18057100 Nlrp5 Rat canonical inflammasome complex part_of IEA UniProtKB-SubCell:SL-0488 1600115 GO_REF:0000044 UniProt GO_REF:0000044 Nlrp5 Rat cell cortex located_in ISO RGD:1316642,MGI:1345193 1624291 PMID:18057100, PMID:18804437, PMID:19376971, PMID:25208553, PMID:31575650 RGD PMID:18057100|PMID:18804437|PMID:19376971|PMID:25208553|PMID:31575650 Nlrp5 Rat cell cortex is_active_in IBA MGI:1345193|PANTHER:PTN000647868|UniProtKB:F1MT67|UniProtKB:Q647I9 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp5 Rat cortical granule located_in ISO NLRP5 (Homo sapiens) 1624291 PMID:19192343 RGD PMID:19192343 Nlrp5 Rat cytoplasm located_in ISO RGD:1316642,MGI:1345193 1624291 PMID:20830304, PMID:28992324, PMID:31575650 RGD PMID:20830304|PMID:28992324|PMID:31575650 Nlrp5 Rat cytoplasm located_in ISO NLRP5 (Homo sapiens) 1624291 PMID:19192343, PMID:19542546, PMID:25542835 RGD PMID:19192343|PMID:19542546|PMID:25542835 Nlrp5 Rat cytoplasmic lattice is_active_in ISO RGD:1316642,MGI:1345193 1624291 PMID:37922900 RGD PMID:37922900 Nlrp5 Rat cytoplasmic lattice is_active_in ISO NLRP5 (Homo sapiens) 1624291 PMID:37922900 RGD PMID:37922900 Nlrp5 Rat cytosol located_in ISO RGD:1316642,MGI:1345193 1624291 PMID:10433232 RGD PMID:10433232 Nlrp5 Rat cytosol is_active_in IBA MGI:1345193|PANTHER:PTN000647868|UniProtKB:F1MT67|UniProtKB:Q647I9 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp5 Rat Golgi apparatus located_in ISO NLRP5 (Homo sapiens) 1624291 PMID:19192343 RGD GO_REF:0000052|PMID:19192343 Nlrp5 Rat mitochondrion located_in ISO RGD:1316642,MGI:1345193 1624291 PMID:14670992 RGD PMID:14670992 Nlrp5 Rat mitochondrion is_active_in IBA MGI:1345193|PANTHER:PTN000647868|UniProtKB:P59047 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp5 Rat mitochondrion located_in ISO NLRP5 (Homo sapiens) 1624291 PMID:19192343 RGD PMID:19192343 Nlrp5 Rat nucleolus located_in ISO RGD:1316642,MGI:1345193 1624291 PMID:14670992 RGD PMID:14670992 Nlrp5 Rat nucleus located_in ISO NLRP5 (Homo sapiens) 1624291 PMID:19192343, PMID:25542835 RGD PMID:19192343|PMID:25542835 Nlrp5 Rat nucleus is_active_in IBA MGI:1345193|PANTHER:PTN000647868|UniProtKB:F1MT67|UniProtKB:P59047|UniProtKB:Q647I9 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp5 Rat protein-containing complex part_of ISO RGD:1316642,MGI:1345193 1624291 PMID:18057100, PMID:18804437 RGD PMID:18057100|PMID:18804437 Nlrp5 Rat subcortical maternal complex part_of ISO NLRP5 (Homo sapiens) 1624291 PMID:25542835 RGD PMID:25542835 Nlrp5 Rat subcortical maternal complex part_of IBA MGI:1345193|PANTHER:PTN000647868|UniProtKB:P59047 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp5 Rat subcortical maternal complex part_of ISO RGD:1316642,MGI:1345193 1624291 PMID:18057100, PMID:18804437, PMID:28992324, PMID:31575650, PMID:32413845, PMID:38177687, PMID:39379527 RGD PMID:18057100|PMID:18804437|PMID:28992324|PMID:31575650|PMID:32413845|PMID:38177687|PMID:39379527
QTLs in Region (GRCr8)
1331732 Srn4 Serum renin concentration QTL 4 4.467 renin activity (VT:0005581) plasma renin activity level (CMO:0000116) 1 43457837 87558729 Rat 1578649 Bmd8 Bone mineral density QTL 8 4.9 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 1 51940904 101229020 Rat 1358359 Sradr1 Stress Responsive Adrenal Weight QTL 1 4.74 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 1 39728272 132889942 Rat 4889929 Bss87 Bone structure and strength QTL 87 6.7 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) 1 46302615 91302615 Rat 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 51941022 208479811 Rat 1331792 Rf29 Renal function QTL 29 4.589 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) 1 43457837 87558729 Rat 2313062 Bmd73 Bone mineral density QTL 73 3.9 0.0001 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) 1 46302615 91302615 Rat 8552900 Pigfal1 Plasma insulin-like growth factor 1 level QTL 1 7.4 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 1 43509952 88509952 Rat 1578654 Bss10 Bone structure and strength QTL 10 4 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) 1 51940904 168768703 Rat 1354643 Foco2 Food consumption QTL 2 7.17 0.0001 eating behavior trait (VT:0001431) food intake rate (CMO:0000427) 1 42122968 87122968 Rat 2313065 Bss67 Bone structure and strength QTL 67 3.1 0.0001 tibia area (VT:1000281) tibia total energy absorbed before break (CMO:0001736) 1 46302615 91302615 Rat 2313069 Bss68 Bone structure and strength QTL 68 2.9 0.0001 tibia size trait (VT:0100001) tibia total energy absorbed before break (CMO:0001736) 1 46302615 91302615 Rat 631495 Bp96 Blood pressure QTL 96 4.52 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 66404680 111404680 Rat 70225 Bp58 Blood pressure QTL 58 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 34184556 172281316 Rat 2313075 Bss66 Bone structure and strength QTL 66 3.4 0.0001 tibia length (VT:0004357) tibia length (CMO:0000450) 1 46302615 91302615 Rat 2298545 Neuinf8 Neuroinflammation QTL 8 4.6 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) 1 66009857 160501508 Rat 10059597 Bp377 Blood pressure QTL 377 3.42 0.025 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 34565911 208798288 Rat 1331778 Rf28 Renal function QTL 28 4.66 urine potassium amount (VT:0010539) urine potassium excretion rate (CMO:0000761) 1 43457837 87558729 Rat 2313077 Bss69 Bone structure and strength QTL 69 3.5 0.0001 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) 1 46302615 91302615 Rat 1302788 Scl19 Serum cholesterol QTL 19 4.6 0.001 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 1 66400974 132889942 Rat 2313402 Anxrr24 Anxiety related response QTL 24 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 1 51511344 153680016 Rat 1331785 Rf27 Renal function QTL 27 4.643 urine sodium amount (VT:0006274) urine sodium level (CMO:0000129) 1 30708375 87558729 Rat 61342 Bp27 Blood pressure QTL 27 3.4 0.0006 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 65405637 96805205 Rat 1300172 Bp172 Blood pressure QTL 172 3.56 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 1 34565726 79565726 Rat 4889962 Bss94 Bone structure and strength QTL 94 3.8 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) 1 51909206 91302615 Rat 6903308 Scl36 Serum cholesterol QTL 36 2 0.0125 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 1 58769992 103769992 Rat 2313092 Bmd72 Bone mineral density QTL 72 2.5 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 1 46302615 91302615 Rat 2300164 Bmd44 Bone mineral density QTL 44 5.4 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 1 66077886 111077886 Rat 2313097 Bss70 Bone structure and strength QTL 70 3.5 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 1 46302615 91302615 Rat 9589820 Insglur3 Insulin/glucose ratio QTL 3 10.75 0.001 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) 1 43509952 88509952 Rat 152025249 Scl82 Serum cholesterol level QTL 82 4.77 blood cholesterol amount (VT:0000180) 1 52891222 109116986 Rat 1354599 Bw29 Body weight QTL 29 3.46 0.001 body mass (VT:0001259) body weight (CMO:0000012) 1 42122968 87122968 Rat 4889919 Bss86 Bone structure and strength QTL 86 4.1 tibia area (VT:1000281) tibia midshaft total cross-sectional area (CMO:0001715) 1 46302615 91302615 Rat 8552948 Pigfal11 Plasma insulin-like growth factor 1 level QTL 11 4.7 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 1 43509952 88509952 Rat