Dazap2 (DAZ associated protein 2) - Rat Genome Database

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Gene: Dazap2 (DAZ associated protein 2) Rattus norvegicus
Analyze
Symbol: Dazap2
Name: DAZ associated protein 2
RGD ID: 1307407
Description: Predicted to enable several functions, including WW domain binding activity; enzyme binding activity; and p53 binding activity. Predicted to be involved in protein destabilization and stress granule assembly. Predicted to be located in cytoplasmic stress granule and nuclear speck. Predicted to be part of protein-containing complex. Orthologous to human DAZAP2 (DAZ associated protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DAZ-associated protein 2; deleted in azoospermia-associated protein 2; LOC300235
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,593,503 - 133,599,044 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7133,593,512 - 133,599,047 (+)EnsemblGRCr8
mRatBN7.27131,714,749 - 131,720,266 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,714,745 - 131,720,265 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7133,516,759 - 133,522,236 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,742,342 - 135,747,819 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,656,004 - 135,661,480 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,238,780 - 142,244,301 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,239,035 - 142,243,241 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,043,449 - 140,048,956 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,362,248 - 139,367,387 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,190,356 - 128,195,495 (+)NCBICelera
RGSC_v3.17139,438,684 - 139,443,823 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytoplasmic stress granule  (IEA,ISO,ISS)
nuclear body  (IEA,ISO,ISS)
nuclear speck  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10857750   PMID:11342538   PMID:15489334   PMID:16189514   PMID:18762249   PMID:25416956  


Genomics

Comparative Map Data
Dazap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,593,503 - 133,599,044 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7133,593,512 - 133,599,047 (+)EnsemblGRCr8
mRatBN7.27131,714,749 - 131,720,266 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,714,745 - 131,720,265 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7133,516,759 - 133,522,236 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,742,342 - 135,747,819 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,656,004 - 135,661,480 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,238,780 - 142,244,301 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,239,035 - 142,243,241 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,043,449 - 140,048,956 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,362,248 - 139,367,387 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,190,356 - 128,195,495 (+)NCBICelera
RGSC_v3.17139,438,684 - 139,443,823 (+)NCBI
Cytogenetic Map7q36NCBI
DAZAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,238,826 - 51,246,717 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,238,724 - 51,271,362 (+)Ensemblhg38GRCh38
GRCh371251,632,610 - 51,640,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361249,918,893 - 49,923,834 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341249,918,892 - 49,923,833NCBI
Celera1250,433,966 - 50,441,964 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1248,665,512 - 48,673,510 (+)NCBIHuRef
CHM1_11251,598,686 - 51,606,683 (+)NCBICHM1_1
T2T-CHM13v2.01251,201,722 - 51,209,619 (+)NCBIT2T-CHM13v2.0
Dazap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,513,543 - 100,518,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,513,230 - 100,518,642 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3815100,615,662 - 100,620,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,615,349 - 100,620,761 (+)Ensemblmm10GRCm38
MGSCv3715100,446,093 - 100,451,192 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615100,443,696 - 100,448,795 (+)NCBIMGSCv36mm8
Celera15102,769,390 - 102,774,462 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.36NCBI
Dazap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555471,736,809 - 1,741,623 (+)Ensembl
ChiLan1.0NW_0049555471,736,945 - 1,741,623 (+)NCBIChiLan1.0ChiLan1.0
DAZAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,943,003 - 42,948,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,939,760 - 42,944,815 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01237,510,449 - 37,515,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11238,393,419 - 38,398,471 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,367,216 - 38,398,471 (-)EnsemblpanPan2panpan1.1
DAZAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,617,346 - 3,621,592 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,615,726 - 3,621,587 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2742,633,911 - 42,638,171 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,665,057 - 3,669,321 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,646,331 - 3,669,314 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,632,269 - 3,636,529 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,618,818 - 3,623,072 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,030,970 - 43,035,233 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dazap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,321,921 - 64,326,333 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365128,838,469 - 8,842,951 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365128,838,469 - 8,842,904 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAZAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2517,304,309 - 17,308,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DAZAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,437,957 - 47,443,042 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,437,746 - 47,443,243 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037198,653,823 - 198,658,933 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dazap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248161,020,382 - 1,024,808 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248161,020,074 - 1,024,834 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dazap2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11262,491,590 - 262,497,114 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dazap2
24 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:122
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000006239
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH127546  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,719,950 - 131,720,150 (+)MAPPERmRatBN7.2
Rnor_6.07142,243,986 - 142,244,185NCBIRnor6.0
Rnor_5.07140,048,641 - 140,048,840UniSTSRnor5.0
RGSC_v3.47139,367,077 - 139,367,276UniSTSRGSC3.4
Celera7128,195,185 - 128,195,384UniSTS
RH 3.4 Map71075.3UniSTS
Cytogenetic Map7q36UniSTS
RH134787  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,713,410 - 131,713,598 (+)MAPPERmRatBN7.2
Rnor_6.07142,237,446 - 142,237,633NCBIRnor6.0
Rnor_5.07140,042,101 - 140,042,288UniSTSRnor5.0
RGSC_v3.47139,360,537 - 139,360,724UniSTSRGSC3.4
Celera7128,188,645 - 128,188,832UniSTS
RH 3.4 Map71064.8UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006239   ⟹   ENSRNOP00000006239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7133,593,512 - 133,599,047 (+)Ensembl
mRatBN7.2 Ensembl7131,714,745 - 131,720,265 (+)Ensembl
Rnor_6.0 Ensembl7142,239,035 - 142,243,241 (+)Ensembl
RefSeq Acc Id: NM_001395672   ⟹   NP_001382601
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,593,537 - 133,599,044 (+)NCBI
mRatBN7.27131,714,754 - 131,720,261 (+)NCBI
RefSeq Acc Id: NM_001395673   ⟹   NP_001382602
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,593,537 - 133,599,044 (+)NCBI
mRatBN7.27131,714,754 - 131,720,261 (+)NCBI
RefSeq Acc Id: XM_039078934   ⟹   XP_038934862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,593,503 - 133,599,044 (+)NCBI
mRatBN7.27131,714,749 - 131,720,266 (+)NCBI
Ensembl Acc Id: ENSRNOP00000006239   ⟸   ENSRNOT00000006239
RefSeq Acc Id: XP_038934862   ⟸   XM_039078934
- Peptide Label: isoform X1
- UniProtKB: P60486 (UniProtKB/Swiss-Prot),   A0A0H2UHD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382601   ⟸   NM_001395672
- Peptide Label: isoform 1
- UniProtKB: P60486 (UniProtKB/Swiss-Prot),   A0A0H2UHD1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001382602   ⟸   NM_001395673
- Peptide Label: isoform 2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60486-F1-model_v2 AlphaFold P60486 1-108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695661
Promoter ID:EPDNEW_R6185
Type:initiation region
Name:Dazap2_1
Description:DAZ associated protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,239,107 - 142,239,167EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307407 AgrOrtholog
BioCyc Gene G2FUF-32014 BioCyc
Ensembl Genes ENSRNOG00000004628 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006239 ENTREZGENE
  ENSRNOT00000006239.8 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598966 IMAGE-MGC_LOAD
InterPro DAZ_assoc-2 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72595 IMAGE-MGC_LOAD
NCBI Gene 300235 ENTREZGENE
PANTHER DAZ-ASSOCIATED PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR31638 UniProtKB/Swiss-Prot
Pfam DAZAP2 UniProtKB/Swiss-Prot
PhenoGen Dazap2 PhenoGen
RatGTEx ENSRNOG00000004628 RatGTEx
UniProt A0A0H2UHD1 ENTREZGENE
  DAZP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0H2UHD1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Dazap2  DAZ associated protein 2  Dazap2_predicted  DAZ associated protein 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dazap2_predicted  DAZ associated protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED