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Gene: Mbd3 (methyl-CpG binding domain protein 3) Rattus norvegicus

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Symbol:

Mbd3

Name:

methyl-CpG binding domain protein 3

RGD ID:

1307389

Description:

Predicted to enable methyl-CpG binding activity. Involved in several processes, including response to bisphenol A; response to estradiol; and ventricular cardiac muscle tissue development. Predicted to be located in cytoplasm and heterochromatin. Predicted to be part of NuRD complex. Predicted to be active in nucleus. Biomarker of transient cerebral ischemia. Orthologous to human MBD3 (methyl-CpG binding domain protein 3); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC362834; methyl-CpG-binding domain protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MBD3 (methyl-CpG binding domain protein 3)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Mbd3 (methyl-CpG binding domain protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mbd3 (methyl-CpG binding domain protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MBD3 (methyl-CpG binding domain protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MBD3 (methyl-CpG binding domain protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mbd3 (methyl-CpG binding domain protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MBD3 (methyl-CpG binding domain protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MBD3 (methyl-CpG binding domain protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mbd3 (methyl-CpG binding domain protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mbd3 (methyl-CpG binding domain protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MBD2 (methyl-CpG binding domain protein 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	MBD3 (methyl-CpG binding domain protein 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MBD3 (methyl-CpG binding domain protein 3)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mbd3 (methyl-CpG binding domain protein 3)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mbd3a (methyl-CpG binding domain protein 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	mbd3a (methyl-CpG binding domain protein 3a)	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mbd3b (methyl-CpG binding domain protein 3b)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mbd-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	mbd-2	Alliance	DIOPT (Hieranoid\|OrthoFinder\|SonicParanoid)
Drosophila melanogaster (fruit fly):	MBD-like	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	MBD-like	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mbd3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	mbd3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Related Pseudogenes:

Mbd3l2

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,961,053 - 9,970,845 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	9,963,797 - 9,970,265 (+)	Ensembl				GRCr8
mRatBN7.2	7	9,312,961 - 9,320,166 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,313,098 - 9,320,165 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	12,189,440 - 12,196,639 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,064,780 - 14,071,979 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,932,473 - 11,939,678 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,179,046 - 12,186,251 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,179,203 - 12,186,656 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	12,349,101 - 12,356,306 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	10,824,260 - 10,831,460 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	7,491,653 - 7,498,865 (+)	NCBI		Celera
RGSC_v3.1	7	10,824,538 - 10,830,878 (+)	NCBI
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Experimental Seizures (IEP)

transient cerebral ischemia (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

5-aza-2'-deoxycytidine (ISO)

aflatoxin B1 (ISO)

arsenous acid (ISO)

auramine O (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenthion (ISO)

finasteride (EXP)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

glafenine (EXP)

inulin (ISO)

iron dichloride (ISO)

ivermectin (ISO)

lead diacetate (ISO)

leflunomide (EXP)

maneb (ISO)

methapyrilene (ISO)

methidathion (ISO)

methotrexate (ISO)

morphine (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nimesulide (EXP)

nitrates (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sulindac (EXP)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zebularine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA,ISO)

DNA methylation-dependent constitutive heterochromatin formation (IBA)

embryonic organ development (IEP)

epigenetic regulation of gene expression (IEP)

in utero embryonic development (ISO)

negative regulation of transcription by RNA polymerase II (IBA)

response to bisphenol A (IEP)

response to estradiol (IEP)

response to nutrient levels (IEP)

tissue development (ISO)

ventricular cardiac muscle tissue development (IEP)

Cellular Component

chromatin (IEA,ISO)

cytoplasm (IEA,ISO)

heterochromatin (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

NuRD complex (IEA,ISO)

protein-containing complex (IEA,ISO)

Molecular Function

DNA binding (IEA,ISO)

methyl-CpG binding (IBA,IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

CHD family mediated chromatin remodeling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The nucleosome remodeling and deacetylase complex in development and disease.	Basta J and Rauchman M, Transl Res. 2014 May 10. pii: S1931-5244(14)00166-2. doi: 10.1016/j.trsl.2014.05.003.
2.	Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus.	Francis J, etal., Neuroscience. 2002;113(1):79-87.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.	Ghoshal K, etal., J Nutr. 2006 Jun;136(6):1522-7.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Differential expression of methyl CpG-binding domain containing factor MBD3 in the developing and adult rat brain.	Jung BP, etal., J Neurobiol. 2003 May;55(2):220-32.
7.	Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus.	Jung BP, etal., Neuroscience. 2002;115(2):515-24.
8.	Epigenetic regulation of neonatal cardiomyocytes differentiation.	Kou CY, etal., Biochem Biophys Res Commun. 2010 Sep 17;400(2):278-83. doi: 10.1016/j.bbrc.2010.08.064. Epub 2010 Aug 22.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life.	Tang WY, etal., Endocrinology. 2012 Jan;153(1):42-55. doi: 10.1210/en.2011-1308. Epub 2011 Nov 22.

Additional References at PubMed

PMID:9774669	PMID:12477932	PMID:14643676	PMID:16217013	PMID:16462733	PMID:17287250	PMID:17546630	PMID:19796622	PMID:20720167	PMID:22770845	PMID:24307175	PMID:24991957
PMID:27650712

Genomics

Comparative Map Data

Mbd3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,961,053 - 9,970,845 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	9,963,797 - 9,970,265 (+)	Ensembl				GRCr8
mRatBN7.2	7	9,312,961 - 9,320,166 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,313,098 - 9,320,165 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	12,189,440 - 12,196,639 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,064,780 - 14,071,979 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,932,473 - 11,939,678 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,179,046 - 12,186,251 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,179,203 - 12,186,656 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	12,349,101 - 12,356,306 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	10,824,260 - 10,831,460 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	7,491,653 - 7,498,865 (+)	NCBI		Celera
RGSC_v3.1	7	10,824,538 - 10,830,878 (+)	NCBI
Cytogenetic Map	7	q11	NCBI

MBD3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	1,573,596 - 1,592,865 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	1,573,596 - 1,592,869 (-)	Ensembl			hg38	GRCh38
GRCh37	19	1,573,595 - 1,592,864 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	1,527,678 - 1,543,652 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	1,527,677 - 1,543,652	NCBI
Celera	19	1,511,530 - 1,527,508 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	1,350,749 - 1,366,844 (-)	NCBI		HuRef
CHM1_1	19	1,576,471 - 1,592,573 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	1,544,415 - 1,563,688 (-)	NCBI		T2T-CHM13v2.0

Mbd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	80,228,373 - 80,235,365 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	80,228,373 - 80,235,384 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	80,392,539 - 80,399,531 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	80,392,539 - 80,399,550 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	79,855,286 - 79,862,224 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	79,795,670 - 79,802,608 (-)	NCBI		MGSCv36	mm8
Celera	10	81,409,909 - 81,416,847 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Mbd3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	6,336,367 - 6,389,056 (+)	Ensembl
ChiLan1.0	NW_004955495	6,385,449 - 6,388,911 (+)	NCBI	ChiLan1.0	ChiLan1.0

MBD3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	5,941,427 - 5,957,966 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	5,172,300 - 5,188,854 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	19	1,549,184 - 1,565,601 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	1,549,184 - 1,559,254 (-)	Ensembl			panPan2	panpan1.1

MBD3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	57,296,713 - 57,312,988 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	57,296,713 - 57,307,110 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	57,088,646 - 57,104,853 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	58,027,199 - 58,043,634 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	58,027,121 - 58,039,063 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	57,084,174 - 57,100,376 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	57,563,503 - 57,579,656 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	57,765,346 - 57,781,556 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mbd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	216,960,330 - 216,969,737 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	864,867 - 874,923 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	865,046 - 873,821 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MBD3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	76,906,644 - 76,923,432 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	76,913,880 - 76,923,435 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	78,156,278 - 78,165,819 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MBD3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	1,357,388 - 1,371,835 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	1,357,204 - 1,371,777 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666081	7,475,254 - 7,491,681 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mbd3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	7,132,274 - 7,144,964 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624828	7,132,228 - 7,144,599 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mbd3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	154,483,378 - 154,490,480 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mbd3
27 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	202
Count of miRNA genes:	126
Interacting mature miRNAs:	137
Transcripts:	ENSRNOT00000049170
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	9460877	54460877	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Markers in Region

RH126839

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	25,501,662 - 25,501,882 (+)	MAPPER	mRatBN7.2
mRatBN7.2	7	9,319,929 - 9,320,149 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	23,926,119 - 23,926,338	NCBI	Rnor6.0
Rnor_6.0	7	12,186,015 - 12,186,234	NCBI	Rnor6.0
Rnor_5.0	7	12,356,070 - 12,356,289	UniSTS	Rnor5.0
Rnor_5.0	2	43,097,162 - 43,097,381	UniSTS	Rnor5.0
RGSC_v3.4	2	24,571,860 - 24,572,079	UniSTS	RGSC3.4
RGSC_v3.4	7	10,831,227 - 10,831,446	UniSTS	RGSC3.4
Celera	7	7,498,632 - 7,498,851	UniSTS
Celera	2	21,573,686 - 21,573,905	UniSTS
Cytogenetic Map	7	q11	UniSTS
Cytogenetic Map	2	q12	UniSTS

RH133854

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	25,501,655 - 25,501,870 (+)	MAPPER	mRatBN7.2
mRatBN7.2	7	9,319,922 - 9,320,137 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	23,926,112 - 23,926,326	NCBI	Rnor6.0
Rnor_6.0	7	12,186,008 - 12,186,222	NCBI	Rnor6.0
Rnor_5.0	7	12,356,063 - 12,356,277	UniSTS	Rnor5.0
Rnor_5.0	2	43,097,155 - 43,097,369	UniSTS	Rnor5.0
RGSC_v3.4	2	24,571,853 - 24,572,067	UniSTS	RGSC3.4
RGSC_v3.4	7	10,831,220 - 10,831,434	UniSTS	RGSC3.4
Celera	7	7,498,625 - 7,498,839	UniSTS
Celera	2	21,573,679 - 21,573,893	UniSTS
Cytogenetic Map	7	q11	UniSTS
Cytogenetic Map	2	q12	UniSTS

BE121221

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	9,312,170 - 9,312,327 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	12,178,256 - 12,178,412	NCBI	Rnor6.0
Rnor_5.0	7	12,348,311 - 12,348,467	UniSTS	Rnor5.0
RGSC_v3.4	7	10,823,470 - 10,823,626	UniSTS	RGSC3.4
Celera	7	7,490,863 - 7,491,019	UniSTS
RH 3.4 Map	7	27.7	UniSTS
Cytogenetic Map	7	q11	UniSTS

Mbd3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	25,501,527 - 25,501,865 (+)	MAPPER	mRatBN7.2
mRatBN7.2	7	9,319,794 - 9,320,132 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	23,925,984 - 23,926,321	NCBI	Rnor6.0
Rnor_6.0	7	12,185,880 - 12,186,217	NCBI	Rnor6.0
Rnor_5.0	7	12,355,935 - 12,356,272	UniSTS	Rnor5.0
Rnor_5.0	2	43,097,027 - 43,097,364	UniSTS	Rnor5.0
RGSC_v3.4	2	24,571,725 - 24,572,062	UniSTS	RGSC3.4
RGSC_v3.4	7	10,831,092 - 10,831,429	UniSTS	RGSC3.4
Celera	7	7,498,497 - 7,498,834	UniSTS
Celera	2	21,573,551 - 21,573,888	UniSTS
Cytogenetic Map	7	q11	UniSTS
Cytogenetic Map	2	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001439497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001439498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001439499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001439500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC167041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000049170 ⟹ ENSRNOP00000041242

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	9,963,797 - 9,970,265 (+)	Ensembl
mRatBN7.2 Ensembl	7	9,313,098 - 9,320,158 (+)	Ensembl
Rnor_6.0 Ensembl	7	12,179,203 - 12,186,656 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100050 ⟹ ENSRNOP00000094795

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	9,963,798 - 9,970,265 (+)	Ensembl
mRatBN7.2 Ensembl	7	9,316,921 - 9,320,165 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103593 ⟹ ENSRNOP00000094225

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	9,316,821 - 9,320,165 (+)	Ensembl

RefSeq Acc Id:

NM_001108735 ⟹ NP_001102205

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	9,963,640 - 9,970,842 (+)	NCBI
mRatBN7.2	7	9,312,961 - 9,320,163 (+)	NCBI
Rnor_6.0	7	12,179,046 - 12,186,248 (+)	NCBI
Rnor_5.0	7	12,349,101 - 12,356,306 (+)	NCBI
RGSC_v3.4	7	10,824,260 - 10,831,460 (+)	RGD
Celera	7	7,491,653 - 7,498,865 (+)	RGD

Sequence:

show sequence

TCCCCCCGGGGAGGAGGGGCGGGGCCCACTCCGCGCCTGCGCAGACGAGTCCCACGCGCGGGCG
GGTGGGCGGAGCGGCCCCCCTAGCGGGGGCTGTGAAGCACGGGGAGGGGGCCGAGCGGGTGGCA
AAGCCGGCGCGCGCCCGGCTGGGGGCGGAGGCCCGCGGGACGGAACAGCCGCGGCGAGTGGTGG
TGGCGGCGAAGGGAACCGAGCCGGCGACGAGCCCGGGGGTCGCGACTTGCAGAAGCGGCGGCGG
CATCGGCGGCGGCAGGCCCGAAGGCGGGCGGAGAGCCGGGGCGCAATGGAGCGGAAGAGGTGGG
AGTGCCCGGCGCTCCCGCAGGGCTGGGAAAGGGAAGAAGTGCCCAGGAGGTCGGGGCTGTCGGC
CGGCCACAGGGATGTCTTTTACTATAGCCCCAGCGGGAAGAAGTTTCGCAGCAAGCCACAGCTG
GCACGGTACCTGGGCGGCTCCATGGATCTCAGCACCTTCGATTTCCGCACGGGAAAGATGCTGA
TGAACAAGATGAATAAGAGCCGCCAGCGCGTGCGCTATGACTCCTCCAACCAGGTCAAGGGCAA
GCCTGACCTGAACACTGCACTGCCTGTACGGCAGACTGCATCCATCTTCAAGCAACCGGTGACC
AAGATCACCAACCACCCCAGCAACAAGGTCAAGAGCGACCCACAGAAGGCAGTGGACCAGCCGA
GGCAGCTTTTCTGGGAGAAGAAACTGAGTGGACTGAGTGCCTTCGACATTGCGGAAGAACTGGT
CAGAACCATGGACTTGCCCAAGGGCCTGCAGGGGGTAGGCCCCGGCTGCACAGATGAGACGCTG
CTGTCCGCCATCGCCAGTGCGCTGCACACCAGCACCCTGCCCATTACAGGCCAGCTCTCTGCGG
CTGTGGAGAAGAACCCTGGTGTGTGGCTGAACACTGCGCAGCCACTGTGCAAAGCCTTCATGGT
GACAGATGACGACATCAGGAAGCAGGAGGAGCTGGTACAGCAGGTGCGCAAGCGCCTGGAGGAG
GCGCTGATGGCGGACATGCTGGCGCATGTGGAGGAGCTGGCCCGTGATGGGGAGGCACCACTGG
ACAAGGCCTGTGCTGAGGAGGAGGAGGAAGAAGAGGAGGAAGAGGAAGAGGAACCGGAGCCGGA
GCGTGTGTAGCATAGGTACCTGCCACAGGCCAGGATGTTGGATGTCAGCCATCCTCTAGTCAGG
CTGCTAACAGCTTCCCTTCTGCCTTGCAGATGCCCTGCCCAAGTCTGGGCTGCAGACCACCTCC
CATGGCCACCTCCAGACTTCTCAGCCTTGCCTGGACTAGGTGGGGACCAGGCCAGCAAGAGGCA
GGCATCCATCTTCTTCCCAAGGCTGCCTCCTCCCAGGTCTCAGTGCAGGGAGCCCCTGTGGACC
TTGAACTCGCTTGTCCCTGCACTGCCTGGCAGGGAGCTCACACTGACAACTGAAGAGCAGTGCC
CCAACTGAGAGGCCACTTTGACACCGTCACCTCCCTGCTTCCTTACCATAGGACAAGGCCCTGC
TTGGCACCAAGGAGCTGTGGGCCTTGCTGGGCACTGGAGGAAGTTTCTGGAAACACACCTGGCT
ATGCCTACCTTGCATTGTCCCTAAGGCTGTTACGGGCCAGGGTCTGAACTGCTCCTGCCCATAG
GGCTGCCCAGCCTCTCCATGCTGAGGGCCAGCAGCCAACCAGGAAGTCACTTTCCTTCAATAAA
CTGATGGTAGGAACTT

hide sequence

RefSeq Acc Id:

XM_006240965 ⟹ XP_006241027

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	9,961,053 - 9,970,845 (+)	NCBI
mRatBN7.2	7	9,312,966 - 9,320,166 (+)	NCBI
Rnor_6.0	7	12,179,052 - 12,186,251 (+)	NCBI
Rnor_5.0	7	12,349,101 - 12,356,306 (+)	NCBI

Sequence:

show sequence

CGGGGAGGAGGGGCGGGGCCCACTCCGCGCCTGCGCAGACGAGTCCCACGCGCGGGCGGGTGGG
CGGAGCGGCCCCCCTAGCGGGGGCTGTGAAGCACGGGGAGGGGGCCGAGCGGGTGGCAAAGCCG
GCGCGCGCCCGGCTGGGGGCGGAGGCCCGCGGGACGGAACAGCCGCGGCGAGTGGTGGTGGCGG
CGAAGGGAACCGAGCCGGCGACGAGCCCGGGGGTCGCGACTTGCAGAAGCGGCGGCGGCATCGG
CGGCGGCAGGCCCGAAGGCGGGCGGAGAGCCGGGGCGCAATGGAGCGGAAGAGGTGGGAGTGCC
CGGCGCTCCCGCAGGGCTGGGAAAGGGAAGAAGTGCCCAGGAGGTCGGGGCTGTCGGCCGGCCA
CAGGGATGTCTTTTACTATAGCCCCAGCGGGAAGAAGTTTCGCAGCAAGCCACAGCTGGCACGG
TACCTGGGCGGCTCCATGGATCTCAGCACCTTCGATTTCCGCACGGGAAAGATGCTGATGAACA
AGATGAATAAGAGCCGCCAGCGCGTGCGCTATGACTCCTCCAACCAGGTCAAGGGCAAGCCTGA
CCTGAACACTGCACTGCCTGTACGGCAGACTGCATCCATCTTCAAGCAACCGGTGACCAAGATC
ACCAACCACCCCAGCAACAAGGTCAAGAGCGACCCACAGAAGGCAGTGGACCAGCCGAGGCAGC
TTTTCTGGGAGAAGAAACTGAGTGGACTGAGTGCCTTCGACATTGCGGAAGAACTGGTCAGAAC
CATGGACTTGCCCAAGGGCCTGCAGGGGGTAGGCCCCGGCTGCACAGATGAGACGCTGCTGTCC
GCCATCGCCAGTGCGCTGCACACCAGCACCCTGCCCATTACAGGCCAGCTCTCTGCGGCTGTGG
AGAAGAACCCTGGTGTGTGGCTGAACACTGCGCAGCCACTGTGCAAAGCCTTCATGGTGACAGA
TGACGACATCAGGAAGCAGGAGGAGCTGGTACAGCAGGTGCGCAAGCGCCTGGAGGAGGCGCTG
ATGGCGGACATGCTGGCGCATGTGGAGGAGCTGGCCCGTGATGGGGAGGCACCACTGGACAAGG
CCTGTGCTGAGGAGGAGGAGGAAGAAGAGGAGGAAGAGGAAGAGGAACCGGAGCCGGAGCGTGT
GTAGCATAGATGCCCTGCCCAAGTCTGGGCTGCAGACCACCTCCCATGGCCACCTCCAGACTTC
TCAGCCTTGCCTGGACTAGGTGGGGACCAGGCCAGCAAGAGGCAGGCATCCATCTTCTTCCCAA
GGCTGCCTCCTCCCAGGTCTCAGTGCAGGGAGCCCCTGTGGACCTTGAACTCGCTTGTCCCTGC
ACTGCCTGGCAGGGAGCTCACACTGACAACTGAAGAGCAGTGCCCCAACTGAGAGGCCACTTTG
ACACCGTCACCTCCCTGCTTCCTTACCATAGGACAAGGCCCTGCTTGGCACCAAGGAGCTGTGG
GCCTTGCTGGGCACTGGAGGAAGTTTCTGGAAACACACCTGGCTATGCCTACCTTGCATTGTCC
CTAAGGCTGTTACGGGCCAGGGTCTGAACTGCTCCTGCCCATAGGGCTGCCCAGCCTCTCCATG
CTGAGGGCCAGCAGCCAACCAGGAAGTCACTTTCCTTCAATAAACTGATGGTAGGAACTTCTA

hide sequence

RefSeq Acc Id:

XM_006240966 ⟹ XP_006241028

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	9,961,053 - 9,970,845 (+)	NCBI
mRatBN7.2	7	9,312,972 - 9,320,166 (+)	NCBI
Rnor_6.0	7	12,179,057 - 12,186,251 (+)	NCBI
Rnor_5.0	7	12,349,101 - 12,356,306 (+)	NCBI

Sequence:

show sequence

AGGAGGGGCGGGGCCCACTCCGCGCCTGCGCAGACGAGTCCCACGCGCGGGCGGGTGGGCGGAG
CGGCCCCCCTAGCGGGGGCTGTGAAGCACGGGGAGGGGGCCGAGCGGGTGGCAAAGCCGGCGCG
CGCCCGGCTGGGGGCGGAGGCCCGCGGGACGGAACAGCCGCGGCGAGTGGTGGTGGCGGCGAAG
GGAACCGAGCCGGCGACGAGCCCGGGGGTCGCGACTTGCAGAAGCGGCGGCGGCATCGGCGGCG
GCAGGCCCGAAGGCGGGCGGAGAGCCGGGGCGCAATGGAGCGGAAGAGCCCCAGCGGGAAGAAG
TTTCGCAGCAAGCCACAGCTGGCACGGTACCTGGGCGGCTCCATGGATCTCAGCACCTTCGATT
TCCGCACGGGAAAGATGCTGATGAACAAGATGAATAAGAGCCGCCAGCGCGTGCGCTATGACTC
CTCCAACCAGGTCAAGGGCAAGCCTGACCTGAACACTGCACTGCCTGTACGGCAGACTGCATCC
ATCTTCAAGCAACCGGTGACCAAGATCACCAACCACCCCAGCAACAAGGTCAAGAGCGACCCAC
AGAAGGCAGTGGACCAGCCGAGGCAGCTTTTCTGGGAGAAGAAACTGAGTGGACTGAGTGCCTT
CGACATTGCGGAAGAACTGGTCAGAACCATGGACTTGCCCAAGGGCCTGCAGGGGGTAGGCCCC
GGCTGCACAGATGAGACGCTGCTGTCCGCCATCGCCAGTGCGCTGCACACCAGCACCCTGCCCA
TTACAGGCCAGCTCTCTGCGGCTGTGGAGAAGAACCCTGGTGTGTGGCTGAACACTGCGCAGCC
ACTGTGCAAAGCCTTCATGGTGACAGATGACGACATCAGGAAGCAGGAGGAGCTGGTACAGCAG
GTGCGCAAGCGCCTGGAGGAGGCGCTGATGGCGGACATGCTGGCGCATGTGGAGGAGCTGGCCC
GTGATGGGGAGGCACCACTGGACAAGGCCTGTGCTGAGGAGGAGGAGGAAGAAGAGGAGGAAGA
GGAAGAGGAACCGGAGCCGGAGCGTGTGTAGCATAGATGCCCTGCCCAAGTCTGGGCTGCAGAC
CACCTCCCATGGCCACCTCCAGACTTCTCAGCCTTGCCTGGACTAGGTGGGGACCAGGCCAGCA
AGAGGCAGGCATCCATCTTCTTCCCAAGGCTGCCTCCTCCCAGGTCTCAGTGCAGGGAGCCCCT
GTGGACCTTGAACTCGCTTGTCCCTGCACTGCCTGGCAGGGAGCTCACACTGACAACTGAAGAG
CAGTGCCCCAACTGAGAGGCCACTTTGACACCGTCACCTCCCTGCTTCCTTACCATAGGACAAG
GCCCTGCTTGGCACCAAGGAGCTGTGGGCCTTGCTGGGCACTGGAGGAAGTTTCTGGAAACACA
CCTGGCTATGCCTACCTTGCATTGTCCCTAAGGCTGTTACGGGCCAGGGTCTGAACTGCTCCTG
CCCATAGGGCTGCCCAGCCTCTCCATGCTGAGGGCCAGCAGCCAACCAGGAAGTCACTTTCCTT
CAATAAACTGATGGTAGGAACTTCTA

hide sequence

RefSeq Acc Id:

XM_008765120 ⟹ XP_008763342

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	9,963,712 - 9,970,845 (+)	NCBI
mRatBN7.2	7	9,313,119 - 9,320,166 (+)	NCBI
Rnor_6.0	7	12,179,222 - 12,186,251 (+)	NCBI

Sequence:

show sequence

CCGCGGCGAGTGGTGGTGGCGGCGAAGGGAACCGAGCCGGCGACGAGCCCGGGGGTCGCGACTT
GCAGAAGCGGCGGCGGCATCGGCGGCGGCAGGCCCGAAGGCGGGCGGAGAGCCGGGGCGCAATG
GAGCGGAAGAGCCCCAGCGGGAAGAAGTTTCGCAGCAAGCCACAGCTGGCACGGTACCTGGGCG
GCTCCATGGATCTCAGCACCTTCGATTTCCGCACGGGAAAGATGCTGATGAACAAGATGAATAA
GAGCCGCCAGCGCGTGCGCTATGACTCCTCCAACCAGGTCAAGGCTCTGGCTAAGCACCTCCCT
GGCCCCTCCAACCCTTCATGGACCCCGGTCGGAGCGGCCCGCTGCAGAGTCTTCTCCCCCCAGG
GCAAGCCTGACCTGAACACTGCACTGCCTGTACGGCAGACTGCATCCATCTTCAAGCAACCGGT
GACCAAGATCACCAACCACCCCAGCAACAAGGTCAAGAGCGACCCACAGAAGGCAGTGGACCAG
CCGAGGCAGCTTTTCTGGGAGAAGAAACTGAGTGGACTGAGTGCCTTCGACATTGCGGAAGAAC
TGGTCAGAACCATGGACTTGCCCAAGGGCCTGCAGGGGGTAGGCCCCGGCTGCACAGATGAGAC
GCTGCTGTCCGCCATCGCCAGTGCGCTGCACACCAGCACCCTGCCCATTACAGGCCAGCTCTCT
GCGGCTGTGGAGAAGAACCCTGGTGTGTGGCTGAACACTGCGCAGCCACTGTGCAAAGCCTTCA
TGGTGACAGATGACGACATCAGGAAGCAGGAGGAGCTGGTACAGCAGGTGCGCAAGCGCCTGGA
GGAGGCGCTGATGGCGGACATGCTGGCGCATGTGGAGGAGCTGGCCCGTGATGGGGAGGCACCA
CTGGACAAGGCCTGTGCTGAGGAGGAGGAGGAAGAAGAGGAGGAAGAGGAAGAGGAACCGGAGC
CGGAGCGTGTGTAGCATAGATGCCCTGCCCAAGTCTGGGCTGCAGACCACCTCCCATGGCCACC
TCCAGACTTCTCAGCCTTGCCTGGACTAGGTGGGGACCAGGCCAGCAAGAGGCAGGCATCCATC
TTCTTCCCAAGGCTGCCTCCTCCCAGGTCTCAGTGCAGGGAGCCCCTGTGGACCTTGAACTCGC
TTGTCCCTGCACTGCCTGGCAGGGAGCTCACACTGACAACTGAAGAGCAGTGCCCCAACTGAGA
GGCCACTTTGACACCGTCACCTCCCTGCTTCCTTACCATAGGACAAGGCCCTGCTTGGCACCAA
GGAGCTGTGGGCCTTGCTGGGCACTGGAGGAAGTTTCTGGAAACACACCTGGCTATGCCTACCT
TGCATTGTCCCTAAGGCTGTTACGGGCCAGGGTCTGAACTGCTCCTGCCCATAGGGCTGCCCAG
CCTCTCCATGCTGAGGGCCAGCAGCCAACCAGGAAGTCACTTTCCTTCAATAAACTGATGGTAG
GAACTTCTA

hide sequence

RefSeq Acc Id:

XM_039079396 ⟹ XP_038935324

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	9,963,684 - 9,970,845 (+)	NCBI
mRatBN7.2	7	9,313,119 - 9,320,166 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102205	(Get FASTA)	NCBI Sequence Viewer
	NP_001426426	(Get FASTA)	NCBI Sequence Viewer
	NP_001426427	(Get FASTA)	NCBI Sequence Viewer
	NP_001426428	(Get FASTA)	NCBI Sequence Viewer
	NP_001426429	(Get FASTA)	NCBI Sequence Viewer
	XP_006241027	(Get FASTA)	NCBI Sequence Viewer
	XP_006241028	(Get FASTA)	NCBI Sequence Viewer
	XP_008763342	(Get FASTA)	NCBI Sequence Viewer
	XP_038935324	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67041	(Get FASTA)	NCBI Sequence Viewer
	EDL89279	(Get FASTA)	NCBI Sequence Viewer
	EDL89280	(Get FASTA)	NCBI Sequence Viewer
	EDL89281	(Get FASTA)	NCBI Sequence Viewer
	EDL89282	(Get FASTA)	NCBI Sequence Viewer
	EDL89283	(Get FASTA)	NCBI Sequence Viewer
	EDL89284	(Get FASTA)	NCBI Sequence Viewer
	EDL89285	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000041242
	ENSRNOP00000041242.7
	ENSRNOP00000094795
	ENSRNOP00000094795.2

RefSeq Acc Id:

NP_001102205 ⟸ NM_001108735

- UniProtKB:

A6K8L1 (UniProtKB/TrEMBL), A0A8I6ANN7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDF
RTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQ
KAVDQPRQLFWEKKLSGLSAFDIAEELVRTMDLPKGLQGVGPGCTDETLLSAIASALHTSTLPI
TGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELAR
DGEAPLDKACAEEEEEEEEEEEEEPEPERV

hide sequence

RefSeq Acc Id:

XP_006241027 ⟸ XM_006240965

- Peptide Label:

isoform X1

- Sequence:

show sequence

MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDF
RTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQ
KAVDQPRQLFWEKKLSGLSAFDIAEELVRTMDLPKGLQGVGPGCTDETLLSAIASALHTSTLPI
TGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELAR
DGEAPLDKACAEEEEEEEEEEEEEPEPERV

hide sequence

RefSeq Acc Id:

XP_006241028 ⟸ XM_006240966

- Peptide Label:

isoform X3

- Sequence:

show sequence

MERKSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLN
TALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLSAFDIAEELVRTMD
LPKGLQGVGPGCTDETLLSAIASALHTSTLPITGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDD
IRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEEEEEEEEEEEEEPEPERV

hide sequence

RefSeq Acc Id:

XP_008763342 ⟸ XM_008765120

- Peptide Label:

isoform X2

- Sequence:

show sequence

MERKSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMNKMNKSRQRVRYDSSNQVKALAKHL
PGPSNPSWTPVGAARCRVFSPQGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVD
QPRQLFWEKKLSGLSAFDIAEELVRTMDLPKGLQGVGPGCTDETLLSAIASALHTSTLPITGQL
SAAVEKNPGVWLNTAQPLCKAFMVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEA
PLDKACAEEEEEEEEEEEEEPEPERV

hide sequence

Ensembl Acc Id:

ENSRNOP00000041242 ⟸ ENSRNOT00000049170

RefSeq Acc Id:	XP_038935324 ⟸ XM_039079396
- Peptide Label:	isoform X4

Ensembl Acc Id:

ENSRNOP00000094795 ⟸ ENSRNOT00000100050

Ensembl Acc Id:

ENSRNOP00000094225 ⟸ ENSRNOT00000103593

Protein Domains

MBD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7EY92-F1-model_v2	AlphaFold	F7EY92	1-254	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695019

Promoter ID:

EPDNEW_R5544

Type:

initiation region

Name:

Mbd3_1

Description:

methyl-CpG binding domain protein 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	12,179,117 - 12,179,177	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307389	AgrOrtholog
BioCyc Gene	G2FUF-34941	BioCyc
Ensembl Genes	ENSRNOG00000028956	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000049170	ENTREZGENE
	ENSRNOT00000049170.7	UniProtKB/TrEMBL
	ENSRNOT00000100050	ENTREZGENE
	ENSRNOT00000100050.2	UniProtKB/TrEMBL
Gene3D-CATH	Methyl-cpg-binding Protein 2, Chain A	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8363656	IMAGE-MGC_LOAD
InterPro	DNA-bd_integrase-typ	UniProtKB/TrEMBL
	MBD2/MBD3_p55-bd	UniProtKB/TrEMBL
	MeCpG_bd_2/3_C_dom	UniProtKB/TrEMBL
	Methyl_CpG_DNA-bd	UniProtKB/TrEMBL
KEGG Report	rno:362834	UniProtKB/TrEMBL
MGC_CLONE	MGC:189306	IMAGE-MGC_LOAD
NCBI Gene	362834	ENTREZGENE
PANTHER	METHYL-CPG BINDING PROTEIN, MBD	UniProtKB/TrEMBL
	PTHR12396:SF12	UniProtKB/TrEMBL
Pfam	MBD	UniProtKB/TrEMBL
	MBD_C	UniProtKB/TrEMBL
	MBDa	UniProtKB/TrEMBL
PhenoGen	Mbd3	PhenoGen
PROSITE	MBD	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000028956	RatGTEx
SMART	MBD	UniProtKB/TrEMBL
Superfamily-SCOP	DNA-binding_integrase-type	UniProtKB/TrEMBL
UniProt	A0A8I6ANN7	ENTREZGENE, UniProtKB/TrEMBL
	A6K8L1	ENTREZGENE, UniProtKB/TrEMBL
	A6K8L3	ENTREZGENE, UniProtKB/TrEMBL
	B2RZ64_RAT	UniProtKB/TrEMBL
	F7EY92	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Mbd3	methyl-CpG binding domain protein 3	Mbd3_predicted	methyl-CpG binding domain protein 3 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mbd3_predicted	methyl-CpG binding domain protein 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations