Il21 (interleukin 21) - Rat Genome Database

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Gene: Il21 (interleukin 21) Rattus norvegicus
Analyze
Symbol: Il21
Name: interleukin 21
RGD ID: 1307384
Description: Predicted to enable interleukin-2 receptor binding activity. Involved in response to dsDNA. Predicted to be located in extracellular space. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency 11; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH bisphenol A; D-penicillamine; 1-chloro-2,4-dinitrobenzene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-21; interleukin-21; LOC365769
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Iddm32
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,045,240 - 122,055,142 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2122,045,240 - 122,055,142 (-)EnsemblGRCr8
mRatBN7.22120,117,105 - 120,127,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2126,682,458 - 126,689,816 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,794,962 - 124,802,318 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,423,940 - 119,431,294 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,965,021 - 123,972,356 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)Ensemblrn6Rnor6.0
Rnor_5.02143,573,215 - 143,580,530 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42123,774,331 - 123,781,697 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2115,067,969 - 115,075,326 (-)NCBICelera
RGSC_v3.12123,697,822 - 123,750,231 (-)NCBI
Cytogenetic Map2q25NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis. Abe K, etal., Springerplus. 2016 Jun 18;5(1):777. doi: 10.1186/s40064-016-2512-y. eCollection 2016.
2. Possible role of interleukin 21 and interleukin 33 in patients with genital warts. Abu El-Hamd M, etal., Dermatol Ther. 2019 Sep;32(5):e13063. doi: 10.1111/dth.13063. Epub 2019 Aug 29.
3. Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis. Andersson A, etal., PLoS One. 2008;3(11):e3682. Epub 2008 Nov 10.
4. Interleukin-21-dependent modulation of T cell antigen receptor reactivity towards low affinity peptide ligands in autoreactive CD8(+) T lymphocytes. Bobbala D, etal., Cytokine. 2016 Sep;85:83-91. doi: 10.1016/j.cyto.2016.06.011. Epub 2016 Jun 11.
5. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. Caruso R, etal., J Immunol. 2007 May 1;178(9):5957-65. doi: 10.4049/jimmunol.178.9.5957.
6. A common exonic variant of interleukin21 confers susceptibility to atopic asthma. Chatterjee R, etal., Int Arch Allergy Immunol. 2009;148(2):137-46. Epub 2008 Sep 19.
7. Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk. Einarsdottir E, etal., Tissue Antigens. 2011 Dec;78(6):428-37. doi: 10.1111/j.1399-0039.2011.01791.x.
8. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. Eto D, etal., PLoS One. 2011 Mar 14;6(3):e17739. doi: 10.1371/journal.pone.0017739.
9. HCV-specific interleukin-21+CD4+ T cells responses associated with viral control through the modulation of HCV-specific CD8+ T cells function in chronic hepatitis C patients. Feng G, etal., Mol Cells. 2013 Oct;36(4):362-7. doi: 10.1007/s10059-013-0181-z. Epub 2013 Oct 22.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Promotion of a functional B cell germinal center response after Leishmania species co-infection is associated with lesion resolution. Gibson-Corley KN, etal., Am J Pathol. 2012 May;180(5):2009-17. doi: 10.1016/j.ajpath.2012.01.012. Epub 2012 Mar 17.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Combinatory gene therapy with electrotransfer of midkine promoter-HSV-TK and interleukin-21. Hanari N, etal., Anticancer Res. 2007 Jul-Aug;27(4B):2305-10.
14. Antitumor efficacy of viable tumor vaccine modified by heterogenetic ESAT-6 antigen and cytokine IL-21 in melanomatous mouse. He X, etal., Immunol Res. 2012 Jun;52(3):240-9. doi: 10.1007/s12026-012-8332-4.
15. Association of IL-17, IL-21, and IL-23R gene polymorphisms with HBV infection in kidney transplant patients. Hejr S, etal., Viral Immunol. 2013 Jun;26(3):201-6. doi: 10.1089/vim.2013.0007. Epub 2013 May 8.
16. IL-21 administration into the nostril alleviates murine allergic rhinitis. Hiromura Y, etal., J Immunol. 2007 Nov 15;179(10):7157-65.
17. Interleukin-21 mRNA expression during virus infections. Holm C, etal., Cytokine. 2006 Jan 7;33(1):41-5. doi: 10.1016/j.cyto.2005.11.014. Epub 2006 Jan 5.
18. Immunization with DNA vaccine expressing herpes simplex virus type 1 gD and IL-21 protects against mouse herpes keratitis. Hu K, etal., Immunol Invest. 2011;40(3):265-78. doi: 10.3109/08820139.2010.534219. Epub 2011 Jan 4.
19. Interleukin-21 is upregulated in hepatitis B-related acute-on-chronic liver failure and associated with severity of liver disease. Hu X, etal., J Viral Hepat. 2011 Jul;18(7):458-67. doi: 10.1111/j.1365-2893.2011.01475.x. Epub 2011 Jun 1.
20. Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections. Kratholm SK, etal., PLoS One. 2013 Dec 16;8(12):e81790. doi: 10.1371/journal.pone.0081790. eCollection 2013.
21. Gene-gene and gene-sex epistatic interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in systemic lupus erythematosus. Leng RX, etal., PLoS One. 2012;7(12):e51090. doi: 10.1371/journal.pone.0051090. Epub 2012 Dec 7.
22. Interleukin-21 responses in patients with chronic hepatitis B. Li J, etal., J Interferon Cytokine Res. 2015 Feb;35(2):134-42. doi: 10.1089/jir.2013.0119. Epub 2014 Sep 22.
23. IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection. Li N, etal., Hum Immunol. 2013 May;74(5):567-73. doi: 10.1016/j.humimm.2013.01.005. Epub 2013 Jan 24.
24. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
25. Interleukin-21 Is Associated with Early Antiviral Response in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease. Liu X, etal., J Interferon Cytokine Res. 2016 Jun;36(6):367-73. doi: 10.1089/jir.2015.0129. Epub 2016 Feb 3.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection. Moretto MM and Khan IA, J Immunol. 2016 Jan 1;196(1):375-84. doi: 10.4049/jimmunol.1501258. Epub 2015 Nov 23.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Increased levels of IL-21 responses are associated with the severity of liver injury in patients with chronic active hepatitis B. Pan Q, etal., J Viral Hepat. 2014;21(9):e78-88. doi: 10.1111/jvh.12242. Epub 2014 Mar 10.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria. Pérez-Mazliah D, etal., PLoS Pathog. 2015 Mar 12;11(3):e1004715. doi: 10.1371/journal.ppat.1004715. eCollection 2015 Mar.
32. Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Rajaei T, etal., Med Microbiol Immunol. 2017 Jun;206(3):195-201. doi: 10.1007/s00430-017-0492-3. Epub 2017 Apr 4.
33. Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1. Ren G, etal., AIDS. 2012 Nov 13;26(17):2145-53. doi: 10.1097/QAD.0b013e328359b7ae.
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. IL-21 and IL-15 cytokine DNA augments HSV specific effector and memory CD8+ T cell response. Rodrigues L, etal., Mol Immunol. 2009 Apr;46(7):1494-504. doi: 10.1016/j.molimm.2008.12.033. Epub 2009 Feb 23.
38. Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes. Rydén AK, etal., J Autoimmun. 2017 Nov;84:65-74. doi: 10.1016/j.jaut.2017.07.006. Epub 2017 Jul 12.
39. IL-21-based therapies induce clearance of hepatitis B virus persistence in mouse models. Shen Z, etal., Theranostics. 2019 May 31;9(13):3798-3811. doi: 10.7150/thno.35331. eCollection 2019.
40. Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection. Shen Z, etal., Theranostics. 2020 Apr 25;10(12):5600-5612. doi: 10.7150/thno.44715. eCollection 2020.
41. IL-21 promotes the pathologic immune response to pneumovirus infection. Spolski R, etal., J Immunol. 2012 Feb 15;188(4):1924-32. Epub 2012 Jan 11.
42. IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection. Stumhofer JS, etal., PLoS One. 2013 May 7;8(5):e62889. doi: 10.1371/journal.pone.0062889. Print 2013.
43. Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal dysbiosis in rats through T helper 17/T regulatory cell signaling pathway. Sun Z, etal., J Tradit Chin Med. 2020 Feb;40(1):38-48.
44. Interleukin 21 Reinvigorates the Antiviral Activity of Hepatitis B Virus (HBV)-Specific CD8+ T Cells in Chronic HBV Infection. Tang L, etal., J Infect Dis. 2019 Feb 15;219(5):750-759. doi: 10.1093/infdis/jiy576.
45. Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. Tang R, etal., Immunotherapy. 2018 Mar;10(3):189-200. doi: 10.2217/imt-2017-0060.
46. Dynamics of interleukin-21 production during the clinical course of primary and secondary dengue virus infections. Vivanco-Cid H, etal., Immunol Lett. 2014 Sep;161(1):89-95. doi: 10.1016/j.imlet.2014.05.006. Epub 2014 May 22.
47. Immune correlates of hepatitis B surface antigen spontaneous seroconversion in hepatitis B e antigen negative chronic hepatitis B patients. Vyas AK, etal., Liver Int. 2018 Jan;38(1):38-49. doi: 10.1111/liv.13475. Epub 2017 Jun 1.
48. Dysregulated Response of Follicular Helper T Cells to Hepatitis B Surface Antigen Promotes HBV Persistence in Mice and Associates With Outcomes of Patients. Wang X, etal., Gastroenterology. 2018 Jun;154(8):2222-2236. doi: 10.1053/j.gastro.2018.03.021. Epub 2018 Mar 12.
49. Role of interleukin-21 and interleukin-21 receptor polymorphisms in the treatment of HBeAg-positive chronic hepatitis B patients with peginterferon. Wang X, etal., Medicine (Baltimore). 2018 Jun;97(23):e10891. doi: 10.1097/MD.0000000000010891.
50. Cerebrospinal fluid IL-21 levels in Neuromyelitis Optica and multiple sclerosis. Wu A, etal., Can J Neurol Sci. 2012 Nov;39(6):813-20. doi: 10.1017/s0317167100015663.
51. Increased frequency of follicular helper T cells in mice viral myocarditis is relevant with anti-ANT antoantibody. Yang F, etal., Virol J. 2015 Feb 11;12:20. doi: 10.1186/s12985-015-0257-9.
52. Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population. Yao JY, etal., World J Gastroenterol. 2015 Apr 14;21(14):4232-9. doi: 10.3748/wjg.v21.i14.4232.
53. Interleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to Helicobacter pylori and Modulates T Lymphocyte IL-17A Expression in Peyer's Patches during Infection. Yasmin S, etal., Infect Immun. 2019 Oct 18;87(11). pii: IAI.00237-19. doi: 10.1128/IAI.00237-19. Print 2019 Nov.
54. Fusobacterium Nucleatum Subspecies Animalis Influences Proinflammatory Cytokine Expression and Monocyte Activation in Human Colorectal Tumors. Ye X, etal., Cancer Prev Res (Phila). 2017 Jul;10(7):398-409. doi: 10.1158/1940-6207.CAPR-16-0178. Epub 2017 May 8.
55. IL-21 promotes late activator APC-mediated T follicular helper cell differentiation in experimental pulmonary virus infection. Yoo JK and Braciale TJ, PLoS One. 2014 Sep 24;9(9):e105872. doi: 10.1371/journal.pone.0105872. eCollection 2014.
Additional References at PubMed
PMID:11081504   PMID:12244150   PMID:12504082   PMID:14635054   PMID:14764669   PMID:15207081   PMID:16482511   PMID:17673207   PMID:18005035   PMID:19322899   PMID:38194747   PMID:38728237  


Genomics

Comparative Map Data
Il21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,045,240 - 122,055,142 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2122,045,240 - 122,055,142 (-)EnsemblGRCr8
mRatBN7.22120,117,105 - 120,127,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2126,682,458 - 126,689,816 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,794,962 - 124,802,318 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,423,940 - 119,431,294 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,965,021 - 123,972,356 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)Ensemblrn6Rnor6.0
Rnor_5.02143,573,215 - 143,580,530 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42123,774,331 - 123,781,697 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2115,067,969 - 115,075,326 (-)NCBICelera
RGSC_v3.12123,697,822 - 123,750,231 (-)NCBI
Cytogenetic Map2q25NCBI
IL21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,610,108 - 122,621,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,610,108 - 122,621,066 (-)Ensemblhg38GRCh38
GRCh374123,531,263 - 123,542,221 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,739,272 - 123,761,662 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344123,891,388 - 123,899,817NCBI
Celera4120,916,832 - 120,925,261 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4119,260,228 - 119,268,550 (-)NCBIHuRef
CHM1_14123,510,250 - 123,518,679 (-)NCBICHM1_1
T2T-CHM13v2.04125,914,209 - 125,925,168 (-)NCBIT2T-CHM13v2.0
Il21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,276,908 - 37,286,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,276,908 - 37,286,785 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38337,222,759 - 37,232,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,222,759 - 37,232,636 (-)Ensemblmm10GRCm38
MGSCv37337,121,681 - 37,131,540 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36337,107,141 - 37,117,000 (-)NCBIMGSCv36mm8
MGSCv36337,414,308 - 37,424,167 (-)NCBIMGSCv36mm8
Celera337,106,874 - 37,116,609 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.36NCBI
Il21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,057,096 - 18,065,492 (+)Ensembl
ChiLan1.0NW_00495542818,057,096 - 18,065,492 (+)NCBIChiLan1.0ChiLan1.0
IL21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,394,845 - 120,405,796 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,660,750 - 120,671,701 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04114,795,979 - 114,806,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14125,940,979 - 125,951,915 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,943,495 - 125,951,915 (-)EnsemblpanPan2panpan1.1
IL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,641,833 - 17,651,275 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,641,833 - 17,651,266 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1917,860,011 - 17,869,452 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01917,760,158 - 17,769,609 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,760,158 - 17,769,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,712,780 - 17,722,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,993,018 - 18,002,469 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,463,313 - 18,472,753 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,422,896 - 65,429,900 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,689,879 - 1,696,883 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366621,689,879 - 1,696,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,532,531 - 101,541,713 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18101,532,742 - 101,540,712 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,688,772 - 108,696,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,859,793 - 69,872,237 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl769,863,535 - 69,872,025 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603748,822,863 - 48,834,392 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,054,368 - 3,061,304 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247773,054,368 - 3,061,304 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il21
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13116,779,438 - 116,787,031 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il21
32 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:62
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000023348
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
11 5 50 97 43 46 22 84 22 5 232 152 6 88 43 79 24

Sequence


Ensembl Acc Id: ENSRNOT00000023348   ⟹   ENSRNOP00000023348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2122,047,773 - 122,055,142 (-)Ensembl
mRatBN7.2 Ensembl2120,119,638 - 120,126,996 (-)Ensembl
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110753   ⟹   ENSRNOP00000097142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2122,045,240 - 122,055,142 (-)Ensembl
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)Ensembl
RefSeq Acc Id: NM_001108943   ⟹   NP_001102413
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82122,045,240 - 122,055,142 (-)NCBI
mRatBN7.22120,117,105 - 120,127,012 (-)NCBI
Rnor_6.02123,965,021 - 123,972,356 (-)NCBI
Rnor_5.02143,573,215 - 143,580,530 (-)NCBI
RGSC_v3.42123,774,331 - 123,781,697 (-)RGD
Celera2115,067,969 - 115,075,326 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102413 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A3QPB9 (Get FASTA)   NCBI Sequence Viewer  
  ABD52001 (Get FASTA)   NCBI Sequence Viewer  
  CBE74756 (Get FASTA)   NCBI Sequence Viewer  
  EDM01297 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000097142
  ENSRNOP00000097142.1
RefSeq Acc Id: NP_001102413   ⟸   NM_001108943
- Peptide Label: precursor
- UniProtKB: A3QPB9 (UniProtKB/Swiss-Prot),   A6IHZ9 (UniProtKB/TrEMBL),   A0A8L2QC17 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023348   ⟸   ENSRNOT00000023348
Ensembl Acc Id: ENSRNOP00000097142   ⟸   ENSRNOT00000110753

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A3QPB9-F1-model_v2 AlphaFold A3QPB9 1-146 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307384 AgrOrtholog
BioCyc Gene G2FUF-53308 BioCyc
Ensembl Genes ENSRNOG00000017376 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000110753 ENTREZGENE
  ENSRNOT00000110753.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.70 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-15/IL-21_fam UniProtKB/Swiss-Prot
KEGG Report rno:365769 UniProtKB/Swiss-Prot
NCBI Gene 365769 ENTREZGENE
PANTHER INTERLEUKIN-21 UniProtKB/Swiss-Prot
  PTHR14356 UniProtKB/Swiss-Prot
PhenoGen Il21 PhenoGen
RatGTEx ENSRNOG00000017376 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A0A8L2QC17 ENTREZGENE, UniProtKB/TrEMBL
  A3QPB9 ENTREZGENE
  A6IHZ9 ENTREZGENE, UniProtKB/TrEMBL
  IL21_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Il21  interleukin 21   Il21_predicted  interleukin 21 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Il21_predicted  interleukin 21 (predicted)      Symbol and Name status set to approved 70820 APPROVED