Oasl2 (2'-5' oligoadenylate synthetase-like 2) - Rat Genome Database

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Gene: Oasl2 (2'-5' oligoadenylate synthetase-like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Oasl2
Name: 2'-5' oligoadenylate synthetase-like 2
RGD ID: 1307351
Description: Predicted to enable 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Predicted to be involved in defense response to virus and negative regulation of viral genome replication. Predicted to be active in cytosol; membrane; and nucleoplasm.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2'-5' oligoadenylate synthetase 2-like; 2'-5'-oligoadenylate synthase-like protein 2; 54 kDa 2'-5'-oligoadenylate synthase-like protein 2; LOC304549
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,369,829 - 47,383,337 (-)NCBIGRCr8
mRatBN7.21241,710,072 - 41,722,687 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,709,435 - 41,722,547 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,878,354 - 42,890,638 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,491,936 - 43,504,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,552,419 - 42,564,702 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,470,074 - 47,483,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,469,598 - 47,482,961 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,263,348 - 49,282,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,996,518 - 43,009,338 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,859,914 - 42,872,726 (-)NCBI
Celera1243,326,342 - 43,338,567 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA)
membrane  (IBA,IEA)
nucleoplasm  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla. Perelygin AA, etal., J Mol Evol. 2006 Oct;63(4):562-76. Epub 2006 Oct 5.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Oasl2
134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:34
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000001600
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
BF387545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,718,309 - 41,718,494 (+)MAPPERmRatBN7.2
Rnor_6.01247,478,710 - 47,478,894NCBIRnor6.0
Rnor_5.01249,272,030 - 49,272,214UniSTSRnor5.0
RGSC_v3.41243,005,101 - 43,005,285UniSTSRGSC3.4
Celera1243,334,330 - 43,334,514UniSTS
RH 3.4 Map12773.72UniSTS
Cytogenetic Map12q16UniSTS
BF413523  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,711,774 - 41,711,966 (+)MAPPERmRatBN7.2
Rnor_6.01247,472,180 - 47,472,371NCBIRnor6.0
Rnor_5.01249,265,300 - 49,265,491UniSTSRnor5.0
RGSC_v3.41242,998,054 - 42,998,245UniSTSRGSC3.4
Celera1243,327,876 - 43,328,067UniSTS
RH 3.4 Map12778.22UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 19 3 19 3 1 14 9 11
Low 39 38 38 38 8 11 73 21 32 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001600   ⟹   ENSRNOP00000001600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,709,435 - 41,722,547 (-)Ensembl
Rnor_6.0 Ensembl1247,469,598 - 47,482,961 (-)Ensembl
RefSeq Acc Id: NM_001009682   ⟹   NP_001009682
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,370,881 - 47,383,185 (-)NCBI
mRatBN7.21241,710,236 - 41,722,547 (-)NCBI
Rnor_6.01247,470,644 - 47,482,947 (-)NCBI
Rnor_5.01249,263,348 - 49,282,330 (-)NCBI
RGSC_v3.41242,996,518 - 43,009,338 (-)RGD
Celera1243,326,342 - 43,338,567 (-)RGD
Sequence:
RefSeq Acc Id: XM_008769327   ⟹   XP_008767549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,369,829 - 47,383,337 (-)NCBI
mRatBN7.21241,710,072 - 41,722,684 (-)NCBI
Rnor_6.01247,470,074 - 47,483,131 (-)NCBI
Sequence:
RefSeq Acc Id: XR_010056394
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,371,486 - 47,383,324 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001009682 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767549 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP70315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001600
  ENSRNOP00000001600.6
GenBank Protein Q5MYT9 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001009682   ⟸   NM_001009682
- UniProtKB: Q5MYT9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767549   ⟸   XM_008769327
- Peptide Label: isoform X1
- UniProtKB: A0A140TA92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001600   ⟸   ENSRNOT00000001600
Protein Domains
Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5MYT9-F1-model_v2 AlphaFold Q5MYT9 1-511 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698706
Promoter ID:EPDNEW_R9230
Type:initiation region
Name:Oasl2_1
Description:2'-5' oligoadenylate synthetase-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01247,482,986 - 47,483,046EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307351 AgrOrtholog
BioCyc Gene G2FUF-18967 BioCyc
Ensembl Genes ENSRNOG00000028814 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001600.7 UniProtKB/TrEMBL
Gene3D-CATH 2'-5'-oligoadenylate synthetase 1, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.460.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 2-5-oligoadenylate_synth_CS UniProtKB/Swiss-Prot
  2-5-oligoadenylate_synth_N UniProtKB/Swiss-Prot
  2-5-oligoAdlate_synth_1_dom2/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2-5OAS_C_CS UniProtKB/TrEMBL
  2-5OAS_N_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NT_2-5OAS_ClassI-CCAase UniProtKB/TrEMBL
  NT_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin_dom UniProtKB/Swiss-Prot
KEGG Report rno:304549 UniProtKB/Swiss-Prot
NCBI Gene 304549 ENTREZGENE
PANTHER 2'-5'-OLIGOADENYLATE SYNTHASE-LIKE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11258 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OAS1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ubiquitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oasl2 PhenoGen
PROSITE 25A_SYNTH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  25A_SYNTH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  25A_SYNTH_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028814 RatGTEx
SMART UBQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PAP/OAS1 substrate-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81301 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TA92 ENTREZGENE, UniProtKB/TrEMBL
  OASL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Oasl2  2'-5' oligoadenylate synthetase-like 2  Oasl2_predicted  2'-5' oligoadenylate synthetase-like 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Oasl2_predicted  2'-5' oligoadenylate synthetase-like 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED