L3mbtl1 (L3MBTL histone methyl-lysine binding protein 1) - Rat Genome Database

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Pathways
Gene: L3mbtl1 (L3MBTL histone methyl-lysine binding protein 1) Rattus norvegicus
Analyze
Symbol: L3mbtl1
Name: L3MBTL histone methyl-lysine binding protein 1
RGD ID: 1307316
Description: Predicted to enable several functions, including SAM domain binding activity; histone binding activity; and histone reader activity. Predicted to be involved in several processes, including negative regulation of macromolecule biosynthetic process; regulation of megakaryocyte differentiation; and regulation of mitotic nuclear division. Predicted to be located in chromatin; condensed chromosome; and nucleoplasm. Predicted to be part of chromatin lock complex. Predicted to be active in nucleus. Orthologous to human L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; INTERACTS WITH atrazine; bisphenol A; lead diacetate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H-l(3)mbt protein; L(3)mbt protein homolog; l(3)mbt-like (Drosophila); l(3)mbt-like 1; l(3)mbt-like 1 (Drosophila); L3mbtl; L3MBTL1, histone methyl-lysine binding protein; lethal(3)malignant brain tumor-like protein; lethal(3)malignant brain tumor-like protein 1; LOC311613; RGD1307316; similar to KIAA0681 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,014,774 - 172,053,181 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3172,021,416 - 172,053,181 (+)EnsemblGRCr8
mRatBN7.23151,597,903 - 151,633,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3151,602,980 - 151,631,233 (+)EnsemblmRatBN7.2
Rnor_6.03159,316,580 - 159,348,914 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,321,310 - 159,347,631 (+)Ensemblrn6Rnor6.0
Rnor_5.03165,513,621 - 165,545,362 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43153,811,334 - 153,836,990 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3150,258,873 - 150,290,717 (+)NCBICelera
RGSC_v3.13153,713,787 - 153,743,026 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Double-strand break repair: 53BP1 comes into focus. Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
3. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
4. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1. Zeng H, etal., Breast Cancer Res Treat. 2012 May;133(1):127-35. doi: 10.1007/s10549-011-1716-7. Epub 2011 Aug 12.
Additional References at PubMed
PMID:10445843   PMID:12588862   PMID:15334543   PMID:17540172   PMID:18408754   PMID:18474616   PMID:19144645   PMID:20622853   PMID:22120668  


Genomics

Comparative Map Data
L3mbtl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,014,774 - 172,053,181 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3172,021,416 - 172,053,181 (+)EnsemblGRCr8
mRatBN7.23151,597,903 - 151,633,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3151,602,980 - 151,631,233 (+)EnsemblmRatBN7.2
Rnor_6.03159,316,580 - 159,348,914 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,321,310 - 159,347,631 (+)Ensemblrn6Rnor6.0
Rnor_5.03165,513,621 - 165,545,362 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43153,811,334 - 153,836,990 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3150,258,873 - 150,290,717 (+)NCBICelera
RGSC_v3.13153,713,787 - 153,743,026 (+)NCBI
Cytogenetic Map3q42NCBI
L3MBTL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382043,507,697 - 43,550,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2043,489,442 - 43,550,954 (+)Ensemblhg38GRCh38
GRCh372042,136,337 - 42,179,594 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362041,576,467 - 41,603,949 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342041,576,487 - 41,603,242NCBI
Celera2038,850,523 - 38,878,002 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2038,872,453 - 38,906,163 (+)NCBIHuRef
CHM1_12042,040,166 - 42,074,338 (+)NCBICHM1_1
T2T-CHM13v2.02045,240,962 - 45,284,158 (+)NCBIT2T-CHM13v2.0
L3mbtl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392162,784,260 - 162,819,726 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2162,785,392 - 162,816,442 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382162,942,333 - 162,977,806 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2162,943,472 - 162,974,522 (+)Ensemblmm10GRCm38
MGSCv372162,769,201 - 162,800,258 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362162,634,906 - 162,665,963 (+)NCBIMGSCv36mm8
Celera2168,890,449 - 168,921,538 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map283.88NCBI
L3mbtl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544513,621,791 - 13,645,799 (-)Ensembl
ChiLan1.0NW_00495544513,621,007 - 13,645,809 (-)NCBIChiLan1.0ChiLan1.0
L3MBTL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22149,247,805 - 49,291,112 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12049,240,906 - 49,284,213 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02039,846,011 - 39,889,267 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12040,947,112 - 40,984,160 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2040,946,487 - 40,974,309 (+)EnsemblpanPan2panpan1.1
L3MBTL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12431,238,787 - 31,266,062 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2431,217,184 - 31,265,291 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2430,877,015 - 30,909,735 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02431,941,094 - 31,973,823 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2431,940,208 - 31,973,827 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12431,204,815 - 31,237,493 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02431,316,163 - 31,348,842 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02431,856,564 - 31,889,296 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
L3mbtl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640180,236,745 - 180,267,353 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365303,038,847 - 3,069,494 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365303,038,873 - 3,069,724 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
L3MBTL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1746,136,013 - 46,173,944 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11746,135,567 - 46,176,967 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21751,529,650 - 51,562,094 (+)NCBISscrofa10.2Sscrofa10.2susScr3
L3MBTL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1220,253,598 - 20,299,022 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605068,995,758 - 69,041,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
L3mbtl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479010,761,632 - 10,791,891 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479010,762,340 - 10,799,228 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
L3mbtl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15155,007,706 - 155,034,100 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:89
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000045677, ENSRNOT00000063906
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
AU049239  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83172,028,450 - 172,028,700 (+)Marker Load Pipeline
mRatBN7.23151,608,921 - 151,609,170 (+)MAPPERmRatBN7.2
Rnor_6.03159,325,333 - 159,325,581NCBIRnor6.0
Rnor_5.03165,521,773 - 165,522,021UniSTSRnor5.0
RGSC_v3.43153,814,687 - 153,814,935UniSTSRGSC3.4
Celera3150,267,125 - 150,267,373UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 11 63 162 83 82 51 77 51 6 324 173 11 141 79 91 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_230849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000045677   ⟹   ENSRNOP00000049326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3172,021,416 - 172,053,181 (+)Ensembl
mRatBN7.2 Ensembl3151,602,980 - 151,631,233 (+)Ensembl
Rnor_6.0 Ensembl3159,321,310 - 159,347,631 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000063906   ⟹   ENSRNOP00000059126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3159,321,328 - 159,340,332 (+)Ensembl
RefSeq Acc Id: NM_001419616   ⟹   NP_001406545
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,021,416 - 172,053,181 (+)NCBI
mRatBN7.23151,601,883 - 151,633,657 (+)NCBI
RefSeq Acc Id: XM_017592280   ⟹   XP_017447769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,014,774 - 172,053,181 (+)NCBI
mRatBN7.23151,597,903 - 151,633,657 (+)NCBI
Rnor_6.03159,316,580 - 159,348,914 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592281   ⟹   XP_017447770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,014,774 - 172,053,181 (+)NCBI
mRatBN7.23151,597,903 - 151,633,657 (+)NCBI
Rnor_6.03159,316,580 - 159,348,914 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106720   ⟹   XP_038962648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,021,358 - 172,053,181 (+)NCBI
mRatBN7.23151,601,825 - 151,633,657 (+)NCBI
RefSeq Acc Id: XM_039106721   ⟹   XP_038962649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,021,459 - 172,053,181 (+)NCBI
mRatBN7.23151,602,868 - 151,633,657 (+)NCBI
RefSeq Acc Id: XM_039106722   ⟹   XP_038962650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,014,774 - 172,041,240 (+)NCBI
mRatBN7.23151,597,903 - 151,620,066 (+)NCBI
RefSeq Acc Id: XM_230849   ⟹   XP_230849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,014,774 - 172,053,181 (+)NCBI
mRatBN7.23151,597,903 - 151,633,657 (+)NCBI
Rnor_6.03159,316,580 - 159,348,914 (+)NCBI
Rnor_5.03165,513,621 - 165,545,362 (+)NCBI
RGSC_v3.43153,811,334 - 153,836,990 (+)RGD
Sequence:
RefSeq Acc Id: XP_230849   ⟸   XM_230849
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017447769   ⟸   XM_017592280
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447770   ⟸   XM_017592281
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000049326   ⟸   ENSRNOT00000045677
Ensembl Acc Id: ENSRNOP00000059126   ⟸   ENSRNOT00000063906
RefSeq Acc Id: XP_038962650   ⟸   XM_039106722
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038962648   ⟸   XM_039106720
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038962649   ⟸   XM_039106721
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001406545   ⟸   NM_001419616
- UniProtKB: D3ZWK4 (UniProtKB/Swiss-Prot),   D4A6H6 (UniProtKB/Swiss-Prot)
Protein Domains
SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWK4-F1-model_v2 AlphaFold D3ZWK4 1-826 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307316 AgrOrtholog
BioCyc Gene G2FUF-46927 BioCyc
Ensembl Genes ENSRNOG00000007044 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045677 ENTREZGENE
  ENSRNOT00000045677.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  2.30.30.140 UniProtKB/Swiss-Prot
  4.10.320.30 UniProtKB/Swiss-Prot
InterPro Mbt UniProtKB/Swiss-Prot
  MBT_L3MBTL1_rpt1 UniProtKB/Swiss-Prot
  MBT_L3MBTL1_rpt3 UniProtKB/Swiss-Prot
  PcG_chromatin_remod_factors UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  Znf_C2H2C UniProtKB/Swiss-Prot
  Znf_C2H2C_sf UniProtKB/Swiss-Prot
NCBI Gene 311613 ENTREZGENE
PANTHER LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
  POLYCOMB GROUP PROTEIN UniProtKB/Swiss-Prot
Pfam MBT UniProtKB/Swiss-Prot
  SAM_1 UniProtKB/Swiss-Prot
  zf-C2HC UniProtKB/Swiss-Prot
PhenoGen L3mbtl1 PhenoGen
PROSITE MBT UniProtKB/Swiss-Prot
  SAM_DOMAIN UniProtKB/Swiss-Prot
  ZF_CCHHC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007044 RatGTEx
SMART MBT UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103637 UniProtKB/Swiss-Prot
  SSF47769 UniProtKB/Swiss-Prot
  Tudor/PWWP/MBT UniProtKB/Swiss-Prot
UniProt D3ZWK4 ENTREZGENE
  D4A6H6 ENTREZGENE
  LMBL1_RAT UniProtKB/Swiss-Prot
UniProt Secondary D4A6H6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 L3mbtl1  L3MBTL histone methyl-lysine binding protein 1  L3mbtl1  L3MBTL1, histone methyl-lysine binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-06-21 L3mbtl1  L3MBTL1, histone methyl-lysine binding protein  L3mbtl1  l(3)mbt-like 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 L3mbtl1  l(3)mbt-like 1 (Drosophila)  L3mbtl  l(3)mbt-like (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 L3mbtl  l(3)mbt-like (Drosophila)  RGD1307316_predicted  similar to KIAA0681 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1307316_predicted  similar to KIAA0681 protein (predicted)  LOC311613_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC311613_predicted  similar to KIAA0681 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL